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Description: This public session provides access to a track hub featuring 25,000 predicted forebrain enhancers within the hg19 human genome assembly, identified using a DNA-sequence-based prediction pipeline that incorporates tissue-specific transcription factor occupancy patterns. These enhancers, crucial for regulating gene expression during brain development, were evaluated using chromatin marks, DNase hypersensitivity data, GWAS-based SNP data, and in vivo zebrafish models. The track hub enables researchers to explore the gene regulatory basis of brain-related diseases and development, as well as investigate the role of these predicted enhancers in mammalian and primate brain evolution. For citation, refer to the paper: Shireen et al. (2024), FEBS Letters. Author: abbasiam Session Name: Predicted human forebrain enhancers_hg19 Genome Assembly: hg19 Creation Date: 2025-01-16 Views: 74
Description: te Author: aryanzandi123 Session Name: Polycomb and Chromatin-Binding Proteins Window Genome Assembly: hg38 Creation Date: 2024-12-11 Views: 52
Description: CTCF and SMC1 ChIP-seq data for Crewe et al submission to NAR Author: Morgan.Crewe Session Name: NAR_CTCF_SMC1_Data Genome Assembly: mm10 Creation Date: 2024-12-10 Views: 466
Description: A new study in Nature reveals how the absence of a small gene segment due to alternative splicing in CPEB4 leads to the deregulation of 200 genes associated with autism spectrum disorders: https://www.nature.com/articles/s41586-024-08289-w An earlier work by the same authors identified this mRNA as a factor in the autism-like phenotype: https://www.nature.com/articles/s41586-018-0423-5 The work took place at IRB Barcelona: https://www.irbbarcelona.org/en/news/scientific/key-breakthrough-autism-pivotal-role-cpeb4-condensates-revealed: “Our results suggest that even small decreases in the percentage of microexon inclusion can have significant effects. This would explain why some individuals without a gene mutation develop idiopathic autism.” UCSC Genome Browser Session Author: brianlee Session Name: CPEB4_GCAAGGACATATGGGCGAAGGAGA Genome Assembly: hg38 Creation Date: 2024-12-05 Views: 84