Sessions allow users to save snapshots of the Genome Browser and its current configuration, including displayed tracks, position, and custom track data. The Public Sessions tool allows users to easily share those sessions that they deem interesting with the rest of the world's researchers. You can add your own sessions to this list by checking the appropriate box on the Session Management page.
Description: hg38
Used for primer design to show the variants from dbSNP155, Gnomad, SNPedia and 1000 genome Author: vvenugopal Session Name: hg38_primer_design Genome Assembly: hg38 Creation Date: 2025-04-08 Views: 151
Description: The CLOCK gene that regulates circadian rhythms, using human genome GRCh38/hg38. Author: sjacques Session Name: circadian_for_submission Genome Assembly: hg38 Creation Date: 2025-04-03 Views: 32
Description: RNA-seq, ChIP-seq and ATAC-seq data in the study "The SAS Chromatin-Remodeling Complex Mediates Inflorescence-Specific Chromatin Accessibility for Transcription Factor Binding". Author: GuoJ Session Name: NAR_SAS_sdl_ifl_all_data Genome Assembly: hub_2660163_GCF_000001735.4 Creation Date: 2025-03-29 Views: 56
Description: Exonic enhancers (EEs) are a newly characterized class of dual-function regulatory elements that reside in protein-coding regions yet retain bona fide enhancer activity. In our study, we integrated transcription factor (TF) binding profiles (ReMap), chromatin accessibility data (DNase, ATAC), and high-throughput reporter assays (STARR-seq, luciferase) to show that many exons can act as cis-regulatory modules. These EEs display hallmark epigenomic signatures, often form long-range interactions with promoters, and are sensitive to both nonsynonymous and synonymous mutations. Functional assays, including CRISPR-based silencing, demonstrate their involvement in regulating host and distal genes. Large-scale cancer genomics analyses reveal that EE variants are associated with dysregulated gene expression and clinical outcomes, underscoring their importance in disease. Evolutionary comparisons further indicate that EEs combine deep sequence conservation with lineage-specific innovation, revealing how coding regions can simultaneously encode protein domains and regulatory activities.
This UCSC public session provides direct visualization of these findings, featuring our custom track hub: https://remap.univ-amu.fr/storage/public/hubEE/hub.txt.
Researchers can explore TF occupancy, open chromatin marks, STARR-seq signals, and EE annotations genome-wide, offering a comprehensive resource to investigate how exons function as both protein-coding and cis-regulatory elements. Author: Benoit Ballester Session Name: hg38_ExonEnhancers_gnomAD Genome Assembly: hg38 Creation Date: 2025-03-21 Views: 371
Description: Exonic enhancers (EEs) are a newly characterized class of dual-function regulatory elements that reside in protein-coding regions yet retain bona fide enhancer activity. In our study, we integrated transcription factor (TF) binding profiles (ReMap), chromatin accessibility data (DNase, ATAC), and high-throughput reporter assays (STARR-seq, luciferase) to show that many exons can act as cis-regulatory modules. These EEs display hallmark epigenomic signatures, often form long-range interactions with promoters, and are sensitive to both nonsynonymous and synonymous mutations. Functional assays, including CRISPR-based silencing, demonstrate their involvement in regulating host and distal genes. Large-scale cancer genomics analyses reveal that EE variants are associated with dysregulated gene expression and clinical outcomes, underscoring their importance in disease. Evolutionary comparisons further indicate that EEs combine deep sequence conservation with lineage-specific innovation, revealing how coding regions can simultaneously encode protein domains and regulatory activities.
This UCSC public session provides direct visualization of these findings, featuring our custom track hub: https://remap.univ-amu.fr/storage/public/hubEE/hub.txt.
Researchers can explore TF occupancy, open chromatin marks, STARR-seq signals, and EE annotations genome-wide, offering a comprehensive resource to investigate how exons function as both protein-coding and cis-regulatory elements. Author: Benoit Ballester Session Name: hg19_ExonEnhancers_TCGA Genome Assembly: hg19 Creation Date: 2025-03-21 Views: 276
US Server
