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HSPG2 — MUC1

Text-mined interactions from Literome

Fischer et al., Am J Respir Cell Mol Biol 1999 : Increased mucin secretion and increased cGMP production in response to TNF-alpha both appeared to be mediated by a phospholipase C that hydrolyzes phosphatidylcholine ( PC-PLC ), and by protein kinase C ( PKC ), since both responses were attenuated by either D609 ( 10 and 20 microg/ml ), a specific PC-PLC inhibitor, or by each of three PKC inhibitors : Calphostin C ( 0.3 and 0.5 microM ), bisindoylmaleimide ( GF 109203X, Go 6850 ; 20 nM ), or Ro31-8220 ( 10 microM )
Kerschner et al., Laryngoscope 2006 : Epithelial cultures exposed to IL-1beta demonstrate an increase in mucin secretion that is blocked by specific inhibitors of PC-PLC , PKC, and NOS, but not by inhibitors of calmodulin ... PC-PLC , PKC, and NOS pathways play a role in the increased secretion of mucin in middle ear epithelial cells after exposure to IL-1beta
Abdullah et al., Am J Physiol Lung Cell Mol Physiol 2007 : Hence, PLC signaling may play a key role in regulated mucin secretion, whether the event is initiated by mediators interacting with GPCRs or RYKs
Culp et al., J Dent Res 2011 : We found that muscarinic induced mucin secretion by rat sublingual tubulo-acini was dependent upon PLC activation and the subsequent increase in [ Ca ( 2+ ) ] ( i ), and further identified a transient PKC independent component of secretion dependent upon Ca ( 2+ ) release from intracellular stores, whereas sustained secretion required entry of extracellular Ca ( 2+ )