Description
DNA methylation is essential for normal development and is
associated with silencing large regions of DNA through processes such
as imprinting and X-chromosome inactivation. The majority of CpG
dinucleotides are methylated in mammals. Unmethylated CpGs occur
in segments called "CpG islands", which often lie upstream of
genes in the regulatory regions and impact transcription.
Display Conventions
These tracks are multi-view composite tracks that contains multiple
data types (views). Each view within each track
has separate display controls, as described here.
Most ENCODE tracks contain multiple subtracks, corresponding to
multiple experimental conditions. If a track contains a large
number of subtracks, only some subtracks will be displayed by default.
The user can select which subtracks are displayed via the display controls
on the track details pages.
Credits
These data were generated and analyzed as part of the ENCODE project, a
genome-wide consortium project with the aim of cataloging all
functional elements in the human genome. This effort includes
collecting a variety of data across related experimental conditions, to
facilitate integrative analysis. Consequently, additional ENCODE tracks
may contain data that is relevant to the data in these tracks.
References
Illingworth RS, Bird AP. CpG islands--'a rough guide'.
FEBS Lett. 2009 Jun 5;583(11):1713-20.
Caiafa P, Zampieri M. DNA methylation and
chromatin structure: the puzzling CpG islands. J Cell Biochem.
2005 Feb 1;94(2):257-65.
Latham T, Gilbert N, Ramsahoye B. DNA methylation in mouse embryonic stem
cells and development. Cell Tissue Res. 2008
Jan;331(1):31-55.
Data Release Policy
Data users may freely use ENCODE data, but may not, without prior
consent, submit publications that use an unpublished ENCODE dataset
until nine months following the release of the dataset. This date is
listed in the Restricted Until column on the track configuration page
and the download page. The full data release policy for ENCODE is
available here.
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