Human methylome studies SRP000941 Track Settings
 
UCSD Human Reference Epigenome Mapping Project [Adipose, Adipose Tissue, Adrenal Gland, Aorta, Bladder, Esophagus, Gastric, Generic Sample From, IMR90 Cells, Left Ventricle, Liver, Lung, Ovary, Pancreas, Psoas Muscle, Right Atrium, Right Ventricle, Sigmoid Colon, Small Intestine, Spleen, Thymus]

Track collection: Human methylome studies

+  All tracks in this collection (424)

Maximum display mode:       Reset to defaults   
Select views (Help):
HMR       PMD       CpG methylation ▾       AMR       CpG reads ▾      
Select subtracks by views and experiment:
 All views HMR  PMD  CpG methylation  AMR  CpG reads 
experiment
SRX006239 
SRX006240 
SRX006782 
SRX006783 
SRX006784 
SRX006785 
SRX006786 
SRX006787 
SRX006788 
SRX006789 
SRX027685 
SRX027686 
SRX027687 
SRX027688 
SRX027689 
SRX027690 
SRX043404 
SRX043405 
SRX043406 
SRX043407 
SRX043408 
SRX056687 
SRX056688 
SRX056691 
SRX056692 
SRX056693 
SRX056694 
SRX056695 
SRX101206 
SRX101207 
SRX101208 
SRX101209 
SRX116603 
SRX116604 
SRX175348 
SRX175349 
SRX175350 
SRX175351 
SRX175352 
SRX175353 
SRX175354 
SRX175355 
SRX190150 
SRX190151 
SRX190152 
SRX190153 
SRX190155 
SRX190156 
SRX190158 
SRX190159 
SRX190160 
SRX190161 
SRX213279 
SRX213280 
SRX213911 
SRX263874 
SRX263875 
SRX263876 
SRX263877 
SRX263878 
SRX263879 
SRX263880 
SRX263881 
SRX263882 
SRX263883 
SRX263884 
SRX263885 
SRX263886 
SRX263887 
SRX263888 
SRX263889 
SRX263890 
SRX263891 
SRX263892 
SRX263893 
SRX388732 
SRX388733 
SRX388734 
SRX388735 
SRX388736 
SRX388737 
SRX388738 
SRX388739 
SRX388740 
SRX388741 
SRX388742 
SRX388743 
SRX388744 
SRX388745 
SRX388746 
SRX388747 
experiment
 All views HMR  PMD  CpG methylation  AMR  CpG reads 
List subtracks: only selected/visible    all    ()
  experiment↓1 views↓2   Track Name↓3  
hide
 SRX006239  HMR  Generic Sample From / SRX006239 (HMR)   Data format 
hide
 Configure
 SRX006239  CpG methylation  Generic Sample From / SRX006239 (CpG methylation)   Data format 
hide
 SRX006240  HMR  Generic Sample From / SRX006240 (HMR)   Data format 
hide
 Configure
 SRX006240  CpG methylation  Generic Sample From / SRX006240 (CpG methylation)   Data format 
hide
 Configure
 SRX006782  CpG methylation  Generic Sample From / SRX006782 (CpG methylation)   Data format 
hide
 Configure
 SRX006783  CpG methylation  IMR90 Cells / SRX006783 (CpG methylation)   Data format 
hide
 Configure
 SRX006784  CpG methylation  IMR90 Cells / SRX006784 (CpG methylation)   Data format 
hide
 Configure
 SRX006785  CpG methylation  IMR90 Cells / SRX006785 (CpG methylation)   Data format 
hide
 Configure
 SRX006786  CpG methylation  IMR90 Cells / SRX006786 (CpG methylation)   Data format 
hide
 Configure
 SRX006787  CpG methylation  IMR90 Cells / SRX006787 (CpG methylation)   Data format 
hide
 Configure
 SRX006788  CpG methylation  IMR90 Cells / SRX006788 (CpG methylation)   Data format 
hide
 Configure
 SRX006789  CpG methylation  Generic Sample From / SRX006789 (CpG methylation)   Data format 
hide
 SRX027685  HMR  Generic Sample From / SRX027685 (HMR)   Data format 
hide
 Configure
 SRX027685  CpG methylation  Generic Sample From / SRX027685 (CpG methylation)   Data format 
hide
 SRX027686  HMR  Generic Sample From / SRX027686 (HMR)   Data format 
hide
 Configure
 SRX027686  CpG methylation  Generic Sample From / SRX027686 (CpG methylation)   Data format 
hide
 SRX027687  HMR  Generic Sample From / SRX027687 (HMR)   Data format 
hide
 Configure
 SRX027687  CpG methylation  Generic Sample From / SRX027687 (CpG methylation)   Data format 
hide
 SRX027688  HMR  Generic Sample From / SRX027688 (HMR)   Data format 
hide
 Configure
 SRX027688  CpG methylation  Generic Sample From / SRX027688 (CpG methylation)   Data format 
hide
 SRX027689  HMR  Generic Sample From / SRX027689 (HMR)   Data format 
hide
 Configure
 SRX027689  CpG methylation  Generic Sample From / SRX027689 (CpG methylation)   Data format 
hide
 SRX027690  HMR  Generic Sample From / SRX027690 (HMR)   Data format 
hide
 Configure
 SRX027690  CpG methylation  Generic Sample From / SRX027690 (CpG methylation)   Data format 
hide
 SRX043404  HMR  Generic Sample From / SRX043404 (HMR)   Data format 
hide
 Configure
 SRX043404  CpG methylation  Generic Sample From / SRX043404 (CpG methylation)   Data format 
hide
 SRX043405  HMR  Generic Sample From / SRX043405 (HMR)   Data format 
hide
 Configure
 SRX043405  CpG methylation  Generic Sample From / SRX043405 (CpG methylation)   Data format 
hide
 SRX043406  HMR  Generic Sample From / SRX043406 (HMR)   Data format 
hide
 Configure
 SRX043406  CpG methylation  Generic Sample From / SRX043406 (CpG methylation)   Data format 
hide
 SRX043407  HMR  Generic Sample From / SRX043407 (HMR)   Data format 
hide
 Configure
 SRX043407  CpG methylation  Generic Sample From / SRX043407 (CpG methylation)   Data format 
hide
 SRX043408  HMR  Generic Sample From / SRX043408 (HMR)   Data format 
hide
 Configure
 SRX043408  CpG methylation  Generic Sample From / SRX043408 (CpG methylation)   Data format 
hide
 SRX056687  HMR  Generic Sample From / SRX056687 (HMR)   Data format 
hide
 Configure
 SRX056687  CpG methylation  Generic Sample From / SRX056687 (CpG methylation)   Data format 
hide
 SRX056688  HMR  Generic Sample From / SRX056688 (HMR)   Data format 
hide
 Configure
 SRX056688  CpG methylation  Generic Sample From / SRX056688 (CpG methylation)   Data format 
hide
 SRX056691  HMR  Generic Sample From / SRX056691 (HMR)   Data format 
hide
 Configure
 SRX056691  CpG methylation  Generic Sample From / SRX056691 (CpG methylation)   Data format 
hide
 SRX056692  HMR  Generic Sample From / SRX056692 (HMR)   Data format 
hide
 Configure
 SRX056692  CpG methylation  Generic Sample From / SRX056692 (CpG methylation)   Data format 
hide
 SRX056693  HMR  Generic Sample From / SRX056693 (HMR)   Data format 
hide
 Configure
 SRX056693  CpG methylation  Generic Sample From / SRX056693 (CpG methylation)   Data format 
hide
 SRX056694  HMR  Generic Sample From / SRX056694 (HMR)   Data format 
hide
 Configure
 SRX056694  CpG methylation  Generic Sample From / SRX056694 (CpG methylation)   Data format 
hide
 SRX056695  HMR  Generic Sample From / SRX056695 (HMR)   Data format 
hide
 Configure
 SRX056695  CpG methylation  Generic Sample From / SRX056695 (CpG methylation)   Data format 
hide
 SRX101206  HMR  Generic Sample From / SRX101206 (HMR)   Data format 
hide
 Configure
 SRX101206  CpG methylation  Generic Sample From / SRX101206 (CpG methylation)   Data format 
hide
 SRX101207  HMR  Generic Sample From / SRX101207 (HMR)   Data format 
hide
 Configure
 SRX101207  CpG methylation  Generic Sample From / SRX101207 (CpG methylation)   Data format 
hide
 SRX101208  HMR  Generic Sample From / SRX101208 (HMR)   Data format 
hide
 Configure
 SRX101208  CpG methylation  Generic Sample From / SRX101208 (CpG methylation)   Data format 
hide
 SRX101209  HMR  Generic Sample From / SRX101209 (HMR)   Data format 
hide
 Configure
 SRX101209  CpG methylation  Generic Sample From / SRX101209 (CpG methylation)   Data format 
hide
 SRX116603  HMR  Generic Sample From / SRX116603 (HMR)   Data format 
hide
 Configure
 SRX116603  CpG methylation  Generic Sample From / SRX116603 (CpG methylation)   Data format 
hide
 SRX116604  HMR  Generic Sample From / SRX116604 (HMR)   Data format 
hide
 Configure
 SRX116604  CpG methylation  Generic Sample From / SRX116604 (CpG methylation)   Data format 
hide
 SRX175348  HMR  Sigmoid Colon / SRX175348 (HMR)   Data format 
hide
 Configure
 SRX175348  CpG methylation  Sigmoid Colon / SRX175348 (CpG methylation)   Data format 
hide
 SRX175349  HMR  Small Intestine / SRX175349 (HMR)   Data format 
hide
 Configure
 SRX175349  CpG methylation  Small Intestine / SRX175349 (CpG methylation)   Data format 
hide
 SRX175350  HMR  Lung / SRX175350 (HMR)   Data format 
hide
 Configure
 SRX175350  CpG methylation  Lung / SRX175350 (CpG methylation)   Data format 
hide
 SRX175351  HMR  Aorta / SRX175351 (HMR)   Data format 
hide
 Configure
 SRX175351  CpG methylation  Aorta / SRX175351 (CpG methylation)   Data format 
hide
 SRX175352  HMR  Esophagus / SRX175352 (HMR)   Data format 
hide
 Configure
 SRX175352  CpG methylation  Esophagus / SRX175352 (CpG methylation)   Data format 
hide
 SRX175353  HMR  Left Ventricle / SRX175353 (HMR)   Data format 
hide
 Configure
 SRX175353  CpG methylation  Left Ventricle / SRX175353 (CpG methylation)   Data format 
hide
 SRX175354  HMR  Pancreas / SRX175354 (HMR)   Data format 
hide
 Configure
 SRX175354  CpG methylation  Pancreas / SRX175354 (CpG methylation)   Data format 
hide
 SRX175355  HMR  Spleen / SRX175355 (HMR)   Data format 
hide
 Configure
 SRX175355  CpG methylation  Spleen / SRX175355 (CpG methylation)   Data format 
hide
 SRX190150  HMR  Left Ventricle / SRX190150 (HMR)   Data format 
hide
 Configure
 SRX190150  CpG methylation  Left Ventricle / SRX190150 (CpG methylation)   Data format 
hide
 SRX190151  HMR  Thymus / SRX190151 (HMR)   Data format 
hide
 Configure
 SRX190151  CpG methylation  Thymus / SRX190151 (CpG methylation)   Data format 
hide
 SRX190152  HMR  Ovary / SRX190152 (HMR)   Data format 
hide
 Configure
 SRX190152  CpG methylation  Ovary / SRX190152 (CpG methylation)   Data format 
hide
 SRX190153  HMR  Adrenal Gland / SRX190153 (HMR)   Data format 
hide
 Configure
 SRX190153  CpG methylation  Adrenal Gland / SRX190153 (CpG methylation)   Data format 
hide
 SRX190155  HMR  Adipose Tissue / SRX190155 (HMR)   Data format 
hide
 Configure
 SRX190155  CpG methylation  Adipose Tissue / SRX190155 (CpG methylation)   Data format 
hide
 SRX190156  HMR  Gastric / SRX190156 (HMR)   Data format 
hide
 Configure
 SRX190156  CpG methylation  Gastric / SRX190156 (CpG methylation)   Data format 
hide
 SRX190158  HMR  Psoas Muscle / SRX190158 (HMR)   Data format 
hide
 Configure
 SRX190158  CpG methylation  Psoas Muscle / SRX190158 (CpG methylation)   Data format 
hide
 SRX190159  HMR  Right Atrium / SRX190159 (HMR)   Data format 
hide
 Configure
 SRX190159  CpG methylation  Right Atrium / SRX190159 (CpG methylation)   Data format 
hide
 SRX190160  HMR  Right Ventricle / SRX190160 (HMR)   Data format 
hide
 Configure
 SRX190160  CpG methylation  Right Ventricle / SRX190160 (CpG methylation)   Data format 
hide
 SRX190161  HMR  Sigmoid Colon / SRX190161 (HMR)   Data format 
hide
 Configure
 SRX190161  CpG methylation  Sigmoid Colon / SRX190161 (CpG methylation)   Data format 
hide
 SRX213279  HMR  Bladder / SRX213279 (HMR)   Data format 
hide
 Configure
 SRX213279  CpG methylation  Bladder / SRX213279 (CpG methylation)   Data format 
hide
 SRX213280  HMR  Liver / SRX213280 (HMR)   Data format 
hide
 Configure
 SRX213280  CpG methylation  Liver / SRX213280 (CpG methylation)   Data format 
hide
 SRX213911  HMR  Right Ventricle / SRX213911 (HMR)   Data format 
hide
 Configure
 SRX213911  CpG methylation  Right Ventricle / SRX213911 (CpG methylation)   Data format 
hide
 SRX263874  HMR  Bladder / SRX263874 (HMR)   Data format 
hide
 Configure
 SRX263874  CpG methylation  Bladder / SRX263874 (CpG methylation)   Data format 
hide
 SRX263875  HMR  Left Ventricle / SRX263875 (HMR)   Data format 
hide
 Configure
 SRX263875  CpG methylation  Left Ventricle / SRX263875 (CpG methylation)   Data format 
hide
 SRX263876  HMR  Left Ventricle / SRX263876 (HMR)   Data format 
hide
 Configure
 SRX263876  CpG methylation  Left Ventricle / SRX263876 (CpG methylation)   Data format 
hide
 SRX263877  HMR  Small Intestine / SRX263877 (HMR)   Data format 
hide
 Configure
 SRX263877  CpG methylation  Small Intestine / SRX263877 (CpG methylation)   Data format 
hide
 SRX263878  HMR  Thymus / SRX263878 (HMR)   Data format 
hide
 Configure
 SRX263878  CpG methylation  Thymus / SRX263878 (CpG methylation)   Data format 
hide
 SRX263879  HMR  Ovary / SRX263879 (HMR)   Data format 
hide
 Configure
 SRX263879  CpG methylation  Ovary / SRX263879 (CpG methylation)   Data format 
hide
 SRX263880  HMR  Adrenal Gland / SRX263880 (HMR)   Data format 
hide
 Configure
 SRX263880  CpG methylation  Adrenal Gland / SRX263880 (CpG methylation)   Data format 
hide
 SRX263881  HMR  Adrenal Gland / SRX263881 (HMR)   Data format 
hide
 Configure
 SRX263881  CpG methylation  Adrenal Gland / SRX263881 (CpG methylation)   Data format 
hide
 SRX263882  HMR  Aorta / SRX263882 (HMR)   Data format 
hide
 Configure
 SRX263882  CpG methylation  Aorta / SRX263882 (CpG methylation)   Data format 
hide
 SRX263883  HMR  Aorta / SRX263883 (HMR)   Data format 
hide
 Configure
 SRX263883  CpG methylation  Aorta / SRX263883 (CpG methylation)   Data format 
hide
 SRX263884  HMR  Aorta / SRX263884 (HMR)   Data format 
hide
 Configure
 SRX263884  CpG methylation  Aorta / SRX263884 (CpG methylation)   Data format 
hide
 SRX263885  HMR  Aorta / SRX263885 (HMR)   Data format 
hide
 Configure
 SRX263885  CpG methylation  Aorta / SRX263885 (CpG methylation)   Data format 
hide
 SRX263886  HMR  Adipose Tissue / SRX263886 (HMR)   Data format 
hide
 Configure
 SRX263886  CpG methylation  Adipose Tissue / SRX263886 (CpG methylation)   Data format 
hide
 SRX263887  HMR  Adipose Tissue / SRX263887 (HMR)   Data format 
hide
 Configure
 SRX263887  CpG methylation  Adipose Tissue / SRX263887 (CpG methylation)   Data format 
hide
 SRX263888  HMR  Gastric / SRX263888 (HMR)   Data format 
hide
 Configure
 SRX263888  CpG methylation  Gastric / SRX263888 (CpG methylation)   Data format 
hide
 SRX263889  HMR  Gastric / SRX263889 (HMR)   Data format 
hide
 Configure
 SRX263889  CpG methylation  Gastric / SRX263889 (CpG methylation)   Data format 
hide
 SRX263890  HMR  Right Atrium / SRX263890 (HMR)   Data format 
hide
 Configure
 SRX263890  CpG methylation  Right Atrium / SRX263890 (CpG methylation)   Data format 
hide
 SRX263891  HMR  Right Atrium / SRX263891 (HMR)   Data format 
hide
 Configure
 SRX263891  CpG methylation  Right Atrium / SRX263891 (CpG methylation)   Data format 
hide
 SRX263892  HMR  Right Ventricle / SRX263892 (HMR)   Data format 
hide
 Configure
 SRX263892  CpG methylation  Right Ventricle / SRX263892 (CpG methylation)   Data format 
hide
 SRX263893  HMR  Right Ventricle / SRX263893 (HMR)   Data format 
hide
 Configure
 SRX263893  CpG methylation  Right Ventricle / SRX263893 (CpG methylation)   Data format 
hide
 SRX388732  HMR  Adipose / SRX388732 (HMR)   Data format 
hide
 Configure
 SRX388732  CpG methylation  Adipose / SRX388732 (CpG methylation)   Data format 
hide
 SRX388733  HMR  Gastric / SRX388733 (HMR)   Data format 
hide
 Configure
 SRX388733  CpG methylation  Gastric / SRX388733 (CpG methylation)   Data format 
hide
 SRX388734  HMR  Lung / SRX388734 (HMR)   Data format 
hide
 Configure
 SRX388734  CpG methylation  Lung / SRX388734 (CpG methylation)   Data format 
hide
 SRX388735  HMR  Psoas Muscle / SRX388735 (HMR)   Data format 
hide
 Configure
 SRX388735  CpG methylation  Psoas Muscle / SRX388735 (CpG methylation)   Data format 
hide
 SRX388736  HMR  Right Ventricle / SRX388736 (HMR)   Data format 
hide
 Configure
 SRX388736  CpG methylation  Right Ventricle / SRX388736 (CpG methylation)   Data format 
hide
 SRX388737  HMR  Spleen / SRX388737 (HMR)   Data format 
hide
 Configure
 SRX388737  CpG methylation  Spleen / SRX388737 (CpG methylation)   Data format 
hide
 SRX388738  HMR  Adrenal Gland / SRX388738 (HMR)   Data format 
hide
 Configure
 SRX388738  CpG methylation  Adrenal Gland / SRX388738 (CpG methylation)   Data format 
hide
 SRX388739  HMR  Aorta / SRX388739 (HMR)   Data format 
hide
 Configure
 SRX388739  CpG methylation  Aorta / SRX388739 (CpG methylation)   Data format 
hide
 SRX388740  HMR  Esophagus / SRX388740 (HMR)   Data format 
hide
 Configure
 SRX388740  CpG methylation  Esophagus / SRX388740 (CpG methylation)   Data format 
hide
 SRX388741  HMR  Adipose / SRX388741 (HMR)   Data format 
hide
 Configure
 SRX388741  CpG methylation  Adipose / SRX388741 (CpG methylation)   Data format 
hide
 SRX388742  HMR  Gastric / SRX388742 (HMR)   Data format 
hide
 Configure
 SRX388742  CpG methylation  Gastric / SRX388742 (CpG methylation)   Data format 
hide
 SRX388743  HMR  Pancreas / SRX388743 (HMR)   Data format 
hide
 Configure
 SRX388743  CpG methylation  Pancreas / SRX388743 (CpG methylation)   Data format 
hide
 SRX388744  HMR  Psoas Muscle / SRX388744 (HMR)   Data format 
hide
 Configure
 SRX388744  CpG methylation  Psoas Muscle / SRX388744 (CpG methylation)   Data format 
hide
 SRX388745  HMR  Small Intestine / SRX388745 (HMR)   Data format 
hide
 Configure
 SRX388745  CpG methylation  Small Intestine / SRX388745 (CpG methylation)   Data format 
hide
 SRX388746  HMR  Spleen / SRX388746 (HMR)   Data format 
hide
 Configure
 SRX388746  CpG methylation  Spleen / SRX388746 (CpG methylation)   Data format 
hide
 SRX388747  HMR  Small Intestine / SRX388747 (HMR)   Data format 
hide
 Configure
 SRX388747  CpG methylation  Small Intestine / SRX388747 (CpG methylation)   Data format 
    
Assembly: Human Dec. 2013 (GRCh38/hg38)

Study title: UCSD Human Reference Epigenome Mapping Project
SRA: SRP000941
GEO: GSE16256
Pubmed: 19829295

Experiment Label Methylation Coverage HMRs HMR size AMRs AMR size PMDs PMD size Conversion Title
SRX006239 Generic Sample From 0.818 8.6 29924 1374.4 1409 22275.4 1791 12530.1 0.980 Whole genome shotgun bisulfite sequencing of the H1 cell line
SRX006240 Generic Sample From 0.827 7.3 29670 1395.0 1083 28037.2 1805 12034.3 0.980 Whole genome shotgun bisulfite sequencing of the H1 cell line
SRX006782 Generic Sample From 0.843 6.3 24528 1461.5 529 53377.7 1510 19542.4 0.980 Whole genome shotgun bisulfite sequencing of the H1 cell line
SRX006783 IMR90 Cells 0.672 6.9 57627 10359.5 855 35438.8 1936 621376.5 0.996 Whole genome shotgun bisulfite sequencing of the IMR90 cell line
SRX006784 IMR90 Cells 0.675 6.6 57157 10432.1 723 41532.7 1937 620468.5 0.996 Whole genome shotgun bisulfite sequencing of the IMR90 cell line
SRX006785 IMR90 Cells 0.684 2.1 44821 10221.1 178 155724.0 1276 891963.3 0.996 Whole genome shotgun bisulfite sequencing of the IMR90 cell line
SRX006786 IMR90 Cells 0.675 7.1 57550 10640.8 1084 28524.6 1950 623323.8 0.995 Whole genome shotgun bisulfite sequencing of the IMR90 cell line
SRX006787 IMR90 Cells 0.676 8.3 60160 10184.6 1690 19067.7 1995 612219.1 0.995 Whole genome shotgun bisulfite sequencing of the IMR90 cell line
SRX006788 IMR90 Cells 0.682 2.8 48567 10828.7 239 117258.1 1439 814241.5 0.996 Whole genome shotgun bisulfite sequencing of the IMR90 cell line
SRX006789 Generic Sample From 0.832 6.1 23312 1510.7 469 61704.8 1466 15963.1 0.972 Whole genome shotgun bisulfite sequencing of the H1 cell line
SRX027685 Generic Sample From 0.821 14.8 40630 1024.5 7448 5161.4 2123 13647.9 0.988 Whole genome shotgun bisulfite sequencing of the H1 cell line treated with BMP4 for 5 days
SRX027686 Generic Sample From 0.825 6.2 33031 1214.2 1179 24757.3 1136 17212.7 0.989 Whole genome shotgun bisulfite sequencing of the H1 cell line treated with BMP4 for 5 days
SRX027687 Generic Sample From 0.808 5.6 31372 1268.0 1057 27141.5 954 22173.1 0.985 Whole genome shotgun bisulfite sequencing of the H1 cell line treated with BMP4 for 5 days
SRX027688 Generic Sample From 0.813 6.8 33523 1199.3 1629 1821.6 963 16372.5 0.990 Whole genome shotgun bisulfite sequencing of the H1 cell line treated with BMP4 for 5 days
SRX027689 Generic Sample From 0.810 6.9 33379 1202.5 1734 1907.0 1006 15839.1 0.990 Whole genome shotgun bisulfite sequencing of the H1 cell line treated with BMP4 for 5 days
SRX027690 Generic Sample From 0.810 7.4 34451 1175.3 1910 11195.0 1042 15815.7 0.990 Whole genome shotgun bisulfite sequencing of the H1 cell line treated with BMP4 for 5 days
SRX043404 Generic Sample From 0.843 6.5 36123 1125.3 836 23799.5 1534 37623.6 0.994 Whole genome shotgun bisulfite sequencing of the H1 cell line differentiated into neural progenitor cells
SRX043405 Generic Sample From 0.846 6.7 36683 1113.2 884 22944.5 1466 39521.1 0.994 Whole genome shotgun bisulfite sequencing of the H1 cell line differentiated into neural progenitor cells
SRX043406 Generic Sample From 0.841 6.8 36933 1103.6 993 29544.2 1389 40023.8 0.994 Whole genome shotgun bisulfite sequencing of the H1 cell line differentiated into neural progenitor cells
SRX043407 Generic Sample From 0.855 10.6 40586 1039.5 1791 17998.5 2217 36784.7 0.994 Whole genome shotgun bisulfite sequencing of the H1 cell line differentiated into neural progenitor cells
SRX043408 Generic Sample From 0.852 8.6 37974 1085.2 1271 24438.0 2093 35347.3 0.994 Whole genome shotgun bisulfite sequencing of the H1 cell line differentiated into neural progenitor cells
SRX056687 Generic Sample From 0.827 22.5 40442 1078.9 15850 3399.6 4000 7598.0 0.984 Whole genome shotgun bisulfite sequencing of the iPS cell line clone 19.11 derived from reprogramming of foreskin fibroblasts
SRX056688 Generic Sample From 0.822 17.2 38591 1095.1 9293 4612.7 3752 7318.7 0.983 Whole genome shotgun bisulfite sequencing of the iPS cell line clone 19.11 derived from reprogramming of foreskin fibroblasts
SRX056691 Generic Sample From 0.836 17.7 38554 1114.4 6622 5953.0 4266 7294.1 0.983 Whole genome shotgun bisulfite sequencing of the iPS cell line clone 6.9 derived from reprogramming of foreskin fibroblasts
SRX056692 Generic Sample From 0.835 13.5 36538 1148.2 3585 9609.5 4199 7067.0 0.983 Whole genome shotgun bisulfite sequencing of the iPS cell line clone 6.9 derived from reprogramming of foreskin fibroblasts
SRX056693 Generic Sample From 0.842 5.3 31529 1266.5 754 2156.9 1691 36467.5 0.989 Whole genome shotgun bisulfite sequencing of the H9 cell line
SRX056694 Generic Sample From 0.844 12.9 38972 1079.3 3622 9244.5 4552 15215.3 0.989 Whole genome shotgun bisulfite sequencing of the H9 cell line
SRX056695 Generic Sample From 0.824 12.2 38747 1108.8 3953 8852.2 4079 10839.5 0.987 Whole genome shotgun bisulfite sequencing of the H9 cell line
SRX101206 Generic Sample From 0.840 8.6 33680 1236.0 1221 17208.1 2091 14903.7 0.991 Whole genome shotgun bisulfite sequencing of the H1 mesendoderm cell line
SRX101207 Generic Sample From 0.841 10.7 35539 1180.0 1901 16736.7 4208 8150.7 0.991 Whole genome shotgun bisulfite sequencing of the H1 mesendoderm cell line
SRX101208 Generic Sample From 0.838 8.9 34676 1211.1 1448 7839.2 1957 14850.3 0.991 Whole genome shotgun bisulfite sequencing of the H1 mesendoderm cell line
SRX101209 Generic Sample From 0.838 2.2 25692 1602.0 80 2005.8 579 33269.0 0.992 Whole genome shotgun bisulfite sequencing of the H1 mesendoderm cell line
SRX116603 Generic Sample From 0.789 30.7 50253 949.0 56554 2915.5 4070 37507.0 0.994 Whole genome shotgun bisulfite sequencing of mesenchymal cells derived from H1 embryonic stem cells
SRX116604 Generic Sample From 0.779 15.5 41662 1050.2 18625 4814.6 1957 216307.5 0.993 Whole genome shotgun bisulfite sequencing of mesenchymal cells derived from H1 embryonic stem cells
SRX175348 Sigmoid Colon 0.799 64.2 49650 1101.5 203815 3389.4 3775 11645.6 0.995 Whole Genome Shotgun Bisulfite Sequencing of Sigmoid Colon Cells from Human STL001
SRX175349 Small Intestine 0.775 58.7 49125 1094.0 209886 3456.5 3279 11959.7 0.995 Whole Genome Shotgun Bisulfite Sequencing of Small Bowel Cells from Human STL001
SRX175350 Lung 0.792 59.7 55202 1215.8 215901 3253.3 3376 18035.0 0.995 Whole Genome Shotgun Bisulfite Sequencing of Lung Cells from Human STL002
SRX175351 Aorta 0.771 64.4 88021 1122.7 135196 2775.5 3399 16054.9 0.995 Whole Genome Shotgun Bisulfite Sequencing of Aorta Cells from Human STL003
SRX175352 Esophagus 0.776 61.7 59436 1250.3 213125 3458.3 3144 12551.8 0.996 Whole Genome Shotgun Bisulfite Sequencing of Esophagus Cells from Human STL003
SRX175353 Left Ventricle 0.778 62.1 61971 1166.2 206742 3327.5 3065 18790.4 0.995 Whole Genome Shotgun Bisulfite Sequencing of Left Ventricle Cells from Human STL003
SRX175354 Pancreas 0.704 60.1 64996 1696.6 237450 4971.4 2145 431169.8 0.995 Whole Genome Shotgun Bisulfite Sequencing of Pancreas Cells from Human STL003
SRX175355 Spleen 0.779 59.6 60938 1000.8 211231 3307.4 3205 11014.2 0.996 Whole Genome Shotgun Bisulfite Sequencing of Spleen Cells from Human STL003
SRX190150 Left Ventricle 0.800 39.6 57850 1121.0 130182 3093.1 3330 20275.2 0.995 Whole Genome Shotgun Bisulfite Sequencing of Left Ventricle Cells from Human STL001
SRX190151 Thymus 0.861 48.3 61605 1036.4 59241 2223.9 4092 14917.8 0.996 Whole Genome Shotgun Bisulfite Sequencing of Thymus Cells from Human STL001
SRX190152 Ovary 0.764 46.4 90613 1231.4 86943 2520.7 2843 20837.3 0.996 Whole Genome Shotgun Bisulfite Sequencing of Ovary Cells from Human STL002
SRX190153 Adrenal Gland 0.775 31.3 49107 1041.5 113412 2902.0 2604 16306.6 0.996 Whole Genome Shotgun Bisulfite Sequencing of Adrenal Cells from Human STL003
SRX190155 Adipose Tissue 0.803 33.6 54956 1071.4 118687 2902.6 3154 13709.8 0.996 Whole Genome Shotgun Bisulfite Sequencing of Fat Cells from Human STL003
SRX190156 Gastric 0.784 38.8 68083 1256.6 143263 2950.7 3388 12814.5 0.996 Whole Genome Shotgun Bisulfite Sequencing of Gastric Cells from Human STL003
SRX190158 Psoas Muscle 0.770 51.0 76888 1269.3 160119 3116.0 3135 16422.9 0.995 Whole Genome Shotgun Bisulfite Sequencing of Psoas Cells from Human STL003
SRX190159 Right Atrium 0.782 42.1 63269 1134.4 156447 3127.4 2786 17601.3 0.995 Whole Genome Shotgun Bisulfite Sequencing of Right Atrium Cells from Human STL003
SRX190160 Right Ventricle 0.787 34.3 57324 1096.6 124253 2982.2 3049 17884.9 0.995 Whole Genome Shotgun Bisulfite Sequencing of Right Ventricle Cells from Human STL003
SRX190161 Sigmoid Colon 0.771 58.3 79452 1229.1 167111 3081.1 3105 12864.6 0.996 Whole Genome Shotgun Bisulfite Sequencing of Sigmoid Colon Cells from Human STL003
SRX213279 Bladder 0.793 51.7 67088 1197.0 154387 3011.6 2980 16710.5 0.995 Whole Genome Shotgun Bisulfite Sequencing of Bladder Cells from Human STL001
SRX213280 Liver 0.786 52.6 57709 1266.2 177055 3192.1 3072 219045.1 0.995 Whole Genome Shotgun Bisulfite Sequencing of Liver Cells from Human STL011
SRX213911 Right Ventricle 0.792 7.8 40664 1225.3 5546 11827.5 1594 28885.7 0.994 Whole Genome Shotgun Bisulfite Sequencing of Right Ventricle Cells from Human STL003
SRX263874 Bladder 0.793 4.0 36286 1444.8 279 66566.4 1190 31939.8 0.995 Whole Genome Shotgun Bisulfite Sequencing of Bladder Cells from Human STL001
SRX263875 Left Ventricle 0.798 8.7 41073 1204.4 8362 3872.0 2692 20045.3 0.994 Whole Genome Shotgun Bisulfite Sequencing of Left Ventricle Cells from Human STL001
SRX263876 Left Ventricle 0.796 4.2 35472 1425.5 419 44930.6 1129 47673.1 0.994 Whole Genome Shotgun Bisulfite Sequencing of Left Ventricle Cells from Human STL001
SRX263877 Small Intestine 0.791 4.4 32034 1456.2 632 1740.0 1153 23859.4 0.996 Whole Genome Shotgun Bisulfite Sequencing of Small Bowel Cells from Human STL001
SRX263878 Thymus 0.861 3.8 37579 1266.6 225 2270.0 1278 31893.0 0.996 Whole Genome Shotgun Bisulfite Sequencing of Thymus Cells from Human STL001
SRX263879 Ovary 0.759 3.8 46399 1544.9 234 79462.4 988 37623.1 0.995 Whole Genome Shotgun Bisulfite Sequencing of Ovary Cells from Human STL002
SRX263880 Adrenal Gland 0.772 8.2 35306 1270.9 5089 6902.8 2350 14035.6 0.995 Whole Genome Shotgun Bisulfite Sequencing of Adrenal Cells from Human STL003
SRX263881 Adrenal Gland 0.771 8.1 35454 1265.4 5057 6909.3 2614 13502.2 0.995 Whole Genome Shotgun Bisulfite Sequencing of Adrenal Cells from Human STL003
SRX263882 Aorta 0.787 9.4 60961 1161.2 2641 12198.6 2931 14109.4 0.995 Whole Genome Shotgun Bisulfite Sequencing of Aorta Cells from Human STL003
SRX263883 Aorta 0.786 9.7 61530 1154.4 2908 18434.9 2644 15218.1 0.995 Whole Genome Shotgun Bisulfite Sequencing of Aorta Cells from Human STL003
SRX263884 Aorta 0.787 9.5 60939 1170.7 2650 11818.3 2796 14688.4 0.995 Whole Genome Shotgun Bisulfite Sequencing of Aorta Cells from Human STL003
SRX263885 Aorta 0.783 9.2 59811 1173.2 2443 12699.6 2630 14868.3 0.995 Whole Genome Shotgun Bisulfite Sequencing of Aorta Cells from Human STL003
SRX263886 Adipose Tissue 0.798 8.8 37726 1223.6 8990 3841.7 2450 13084.7 0.995 Whole Genome Shotgun Bisulfite Sequencing of Fat Cells from Human STL003
SRX263887 Adipose Tissue 0.806 8.9 39018 1194.4 9948 6515.0 2821 12078.3 0.995 Whole Genome Shotgun Bisulfite Sequencing of Fat Cells from Human STL003
SRX263888 Gastric 0.792 4.3 39344 1499.0 453 2055.9 1169 24935.7 0.996 Whole Genome Shotgun Bisulfite Sequencing of Gastric Cells from Human STL003
SRX263889 Gastric 0.793 8.3 46403 1302.2 5963 4800.7 2818 11459.3 0.996 Whole Genome Shotgun Bisulfite Sequencing of Gastric Cells from Human STL003
SRX263890 Right Atrium 0.784 4.6 36518 1423.1 631 30411.8 1057 37683.4 0.995 Whole Genome Shotgun Bisulfite Sequencing of Right Atrium Cells from Human STL003
SRX263891 Right Atrium 0.784 4.5 36789 1416.5 552 49493.1 1122 35612.1 0.995 Whole Genome Shotgun Bisulfite Sequencing of Right Atrium Cells from Human STL003
SRX263892 Right Ventricle 0.783 4.3 34743 1465.9 481 56413.8 1154 40920.2 0.994 Whole Genome Shotgun Bisulfite Sequencing of Right Ventricle Cells from Human STL003
SRX263893 Right Ventricle 0.795 8.8 41302 1210.9 8745 3825.6 2675 16364.7 0.994 Whole Genome Shotgun Bisulfite Sequencing of Right Ventricle Cells from Human STL003
SRX388732 Adipose 0.770 21.9 49251 1140.1 54361 3244.2 2512 23182.5 0.995 Whole Genome Shotgun Bisulfite Sequencing of Fat Cells from Human STL001
SRX388733 Gastric 0.794 25.7 48865 1127.6 95875 2577.8 3108 13753.8 0.995 Whole Genome Shotgun Bisulfite Sequencing of Gastric Cells from Human STL001
SRX388734 Lung 0.831 23.2 59979 1021.8 55463 3002.5 3562 13809.2 0.996 Whole Genome Shotgun Bisulfite Sequencing of Lung Cells from Human STL001
SRX388735 Psoas Muscle 0.799 22.7 55970 1096.5 59618 3038.7 2934 17399.7 0.993 Whole Genome Shotgun Bisulfite Sequencing of Psoas Cells from Human STL001
SRX388736 Right Ventricle 0.804 25.6 56927 1088.7 76146 2961.0 3072 21377.4 0.994 Whole Genome Shotgun Bisulfite Sequencing of Right Ventricle Cells from Human STL001
SRX388737 Spleen 0.835 25.5 54463 1012.7 62913 2469.6 3425 13472.2 0.995 Whole Genome Shotgun Bisulfite Sequencing of Spleen Cells from Human STL001
SRX388738 Adrenal Gland 0.791 26.2 50513 1114.7 86571 2507.9 3639 18516.1 0.995 Whole Genome Shotgun Bisulfite Sequencing of Adrenal Cells from Human STL002
SRX388739 Aorta 0.779 22.9 85261 1080.1 19921 3191.1 2992 17968.3 0.995 Whole Genome Shotgun Bisulfite Sequencing of Aorta Cells from Human STL002
SRX388740 Esophagus 0.786 23.3 42454 1172.1 88863 2622.2 2711 15843.0 0.995 Whole Genome Shotgun Bisulfite Sequencing of Esophagus Cells from Human STL002
SRX388741 Adipose 0.800 24.5 51616 1119.5 89980 2569.8 3298 15638.1 0.996 Whole Genome Shotgun Bisulfite Sequencing of Fat Cells from Human STL002
SRX388742 Gastric 0.781 27.1 64556 1266.4 91296 2583.2 3045 16659.3 0.995 Whole Genome Shotgun Bisulfite Sequencing of Gastric Cells from Human STL002
SRX388743 Pancreas 0.759 23.3 56250 1290.4 52123 2740.8 3087 196824.5 0.995 Whole Genome Shotgun Bisulfite Sequencing of Pancreas Cells from Human STL002
SRX388744 Psoas Muscle 0.779 23.4 68187 1205.7 64355 2562.3 2988 19298.2 0.994 Whole Genome Shotgun Bisulfite Sequencing of Psoas Cells from Human STL002
SRX388745 Small Intestine 0.771 20.8 49598 1271.8 70257 2563.7 2756 13286.1 0.996 Whole Genome Shotgun Bisulfite Sequencing of Small Bowel Cells from Human STL002
SRX388746 Spleen 0.804 27.6 53921 1060.3 88064 2512.6 3218 15663.0 0.995 Whole Genome Shotgun Bisulfite Sequencing of Spleen Cells from Human STL002
SRX388747 Small Intestine 0.775 21.7 71460 1190.3 35742 2139.3 3156 12325.0 0.996 Whole Genome Shotgun Bisulfite Sequencing of Small Bowel Cells from Human STL003

Methods

All analysis was done using a bisulfite sequnecing data analysis pipeline DNMTools developed in the Smith lab at USC.

Mapping reads from bisulfite sequencing: Bisulfite treated reads are mapped to the genomes with the abismal program. Input reads are filtered by their quality, and adapter sequences in the 3' end of reads are trimmed. This is done with cutadapt. Uniquely mapped reads with mismatches/indels below given threshold are retained. For pair-end reads, if the two mates overlap, the overlapping part of the mate with lower quality is discarded. After mapping, we use the format command in dnmtools to merge mates for paired-end reads. We use the dnmtools uniq command to randomly select one from multiple reads mapped exactly to the same location. Without random oligos as UMIs, this is our best indication of PCR duplicates.

Estimating methylation levels: After reads are mapped and filtered, the dnmtools counts command is used to obtain read coverage and estimate methylation levels at individual cytosine sites. We count the number of methylated reads (those containing a C) and the number of unmethylated reads (those containing a T) at each nucleotide in a mapped read that corresponds to a cytosine in the reference genome. The methylation level of that cytosine is estimated as the ratio of methylated to total reads covering that cytosine. For cytosines in the symmetric CpG sequence context, reads from the both strands are collapsed to give a single estimate. Very rarely do the levels differ between strands (typically only if there has been a substitution, as in a somatic mutation), and this approach gives a better estimate.

Bisulfite conversion rate: The bisulfite conversion rate for an experiment is estimated with the dnmtools bsrate command, which computes the fraction of successfully converted nucleotides in reads (those read out as Ts) among all nucleotides in the reads mapped that map over cytosines in the reference genome. This is done either using a spike-in (e.g., lambda), the mitochondrial DNA, or the nuclear genome. In the latter case, only non-CpG sites are used. While this latter approach can be impacted by non-CpG cytosine methylation, in practice it never amounts to much.

Identifying hypomethylated regions (HMRs): In most mammalian cells, the majority of the genome has high methylation, and regions of low methylation are typically the interesting features. (This seems to be true for essentially all healthy differentiated cell types, but not cells of very early embryogenesis, various germ cells and precursors, and placental lineage cells.) These are valleys of low methylation are called hypomethylated regions (HMR) for historical reasons. To identify the HMRs, we use the dnmtools hmr command, which uses a statistical model that accounts for both the methylation level fluctations and the varying amounts of data available at each CpG site.

Partially methylated domains: Partially methylated domains are large genomic regions showing partial methylation observed in immortalized cell lines and cancerous cells. The pmd program is used to identify PMDs.

Allele-specific methylation: Allele-Specific methylated regions refers to regions where the parental allele is differentially methylated compared to the maternal allele. The program allelic is used to compute allele-specific methylation score can be computed for each CpG site by testing the linkage between methylation status of adjacent reads, and the program amrfinder is used to identify regions with allele-specific methylation.

For more detailed description of the methods of each step, please refer to the DNMTools documentation.