Mouse methylome studies SRP339793 Track Settings

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Somatic Dnmt3a deletion in murine hematopoietic cells [B-cells, CMP, GMP, Lineage Negative Kit Positive Sca1 Positive, MEP, Myeloid Cells, T-cells, Whole Bone Marrow]

Track collection: Mouse methylome studies

All tracks in this collection (575)

Common	Common methbase tracks for the mm39 assembly
DRP000505	Mouse DNA methylome (MethylC-seq) [Blastocyst, Embryonic Stem (ES) Cell, Sperm]
DRP000598	Mouse oocyte methylome [Dnmt1-deficient GV Oocyte, Dnmt3L-deficient GV Oocyte, Dnmt3a-deficient GV Oocyte, Dnmt3b-deficient GV Oocyte, Wild-Type GV Oocyte, Wild-Type NG Oocyte]
DRP000638	Mouse PGC DNA methylome (PBAT) [E10.5fPGC, E10.5mPGC, E13.5fPGC, E13.5mPGC, E16.5fPGC, E16.5mPGC]
DRP002386	Methylome and gene expression of neonatal prospermatogonia and early postnatal undifferentiated and differentiating spermatogonia [Testes]
DRP003273	Methylome and transcriptome dynamics during mouse germ cell specification/differentiation in vitro
DRP003407	Software updates in the Illumina HiSeq platform affect whole-genome bisulfite sequencing [EpiLC, IMR-90, Spermatogonia]
DRP003544	Mouse NS/PCs DNA methylome (PBAT) [Astrocyte, Embryonic Stem Cell, Neural Stem/Progenitor Cell, Neuron, Oligodendrocyte]
DRP003670	Methylome of expanded mouse primordial germ cell-like cells [BVSC]
DRP004153	Mouse blactocyst methylome [Blastocyst, Parthenogenetic Blastocyst]
DRP004308	MIWI2 targets RNAs transcribed from piRNA-dependently methylated regions in mouse gonocytes [Gonocyte]
DRP006395	The role of DNMT3B in inflammation-related hepatocarcinogenesis [Dnmt3bKO_NoTAA_1_WGBS, Dnmt3bWT_NoTAA_1_WGBS]
DRP008086	DNA methylation analysis of oocytes in a PCOS mouse model [Oocyte]
DRP008292	Whole genome bisulfite sequence of tissue and organoid [JB_colon_2, JB_colon_3, JB_colon_O2_Or, JB_colon_O3_Or]
DRP008439	The DNMT3A ADD domain recognizing histone H3K4me0 is essential for processive DNA methylation and maternal imprinting in mouse oocytes [Embryo E10.5, Oocyte, Parthenogenesis Blastocyst]
DRP008539	Investigation of the effects of sperm DNA methylation disturbance by testicular histone hyperacetylation on the next generation in mouse [Sperm]
DRP010625	The identification of differentially methylated genes between hepatocytes and skeletal muscle of wild-type mice [Hepatocyte_01, Hepatocyte_02, Hepatocyte_03, Skeletal_Muscle_01, Skeletal_Muscle_02, Skeletal_Muscle_03]
DRP010881	Role of Tet3 in DNA demethylation in mouse SCNT embryos [SCNT Embryo]
DRP011267	whole genome bisulfite sequencing of colon and colon-derived organoids [Colon, Colon-Derived Organoid]
DRP011537	Tracking hematopoietic stem cell aging reveals its heterogeneous composition [Bone Marrow]
ERP001204	DNA_methylation_reprogramming_in_PGCs [Embryonic Stem Cells, Epiblast Cells, Primordial Germ Cells]
ERP001632	B_Cell_Methylome [B Cells]
ERP001953	The dynamics of genome-wide DNA methylation reprogramming in mouse primordial germ cells [Epiblast, J1 ES Cell, Primordial Germ Cell]
ERP003744	DNMT3_KO_BS_seq [EPC, Epiblast]
ERP003907	Methylome_and_Hydroxymethylome_of_iPSC [2769STDY6182410-sc-2382182, 2769STDY6182411-sc-2382183, BSeq_MEF1-sc-1861756, BSeq_MEF2-sc-1861757, BSeq_MEF3-sc-1861758, BSeq_P29_iPSC44-sc-2014730, BSeq_P29_iPSC45-sc-2014731, BSeq_P29_iPSC66-sc-2014732, BSeq_P29_iPSC67-sc-2014733, BSeq_P29_iPSC72-sc-2014734, BSeq_P29_iPSC73-sc-2014735, BSeq_P8_iPSC67-sc-1861783, BSeq_P8_iPSC73-sc-1861785, BSeq_TMBD1-sc-1861759, BSeq_TMBD2-sc-1861760, BSeq_TMBD3-sc-1861761, BSeq_T_S_Exp10-sc-1861768, BSeq_T_S_Exp10-sc-1861769, BSeq_T_S_Exp11-sc-1861770, BSeq_T_S_Exp11-sc-1861771, BSeq_T_S_Exp16-sc-1861772, BSeq_T_S_Exp16-sc-1861773, TMBD10_BS-sc-2013-09-18T12:28:21Z-1692906, TMBD10_oxBS-sc-2013-09-18T12:28:31Z-1692907, iPSC19_BS-sc-2013-09-18T12:30:10Z-1692914, iPSC19_oxBS-sc-2013-09-18T12:31:26Z-1692918, iPSC20_BS-sc-2013-09-18T12:31:06Z-1692915, iPSC20_oxBS-sc-2013-09-18T12:30:31Z-1692919, iPSC27_BS-sc-2013-09-18T12:28:40Z-1692908, iPSC27_oxBS-sc-2013-09-18T12:29:46Z-1692911, iPSC28_BS-sc-2013-09-18T12:30:17Z-1692909, iPSC28_oxBS-sc-2013-09-18T12:29:53Z-1692912, iPSC29_BS-sc-2013-09-18T12:30:24Z-1692910, iPSC29_oxBS-sc-2013-09-18T12:30:03Z-1692913, iPSC37_BS-sc-2013-09-18T12:31:14Z-1692916, iPSC37_oxBS-sc-2013-09-18T12:30:37Z-1692920, iPSC38_BS-sc-2013-09-18T12:31:20Z-1692917, iPSC38_oxBS-sc-2013-09-18T12:30:43Z-1692921, oxBSeq_MEF1-sc-1861762, oxBSeq_MEF2-sc-1861763, oxBSeq_MEF3-sc-1861764, oxBSeq_P29_iPSC44-sc-2014736, oxBSeq_P29_iPSC45-sc-2014737, oxBSeq_P29_iPSC66-sc-2014738, oxBSeq_P29_iPSC67-sc-2014739, oxBSeq_P29_iPSC72-sc-2014740, oxBSeq_P29_iPSC73-sc-2014741, oxBSeq_TMBD1-sc-1861765, oxBSeq_TMBD2-sc-1861766, oxBSeq_TMBD3-sc-1861767, oxBSeq_T_S_Exp10-sc-1861774, oxBSeq_T_S_Exp10-sc-1861775, oxBSeq_T_S_Exp11-sc-1861776, oxBSeq_T_S_Exp11-sc-1861777, oxBSeq_T_S_Exp16-sc-1861778, oxBSeq_T_S_Exp16-sc-1861779, pMEFAIDKO_BS-sc-2013-09-18T12:31:41Z-1692923, pMEFAIDKO_oxBS-sc-2013-09-18T12:31:54Z-1692925, pMEFWt_BS-sc-2013-09-18T12:31:34Z-1692922, pMEFWt_oxBS-sc-2013-09-18T12:31:48Z-1692924]
ERP004116	Whole genome bisulfite sequencing of samples reprogramming to iPSC [1iPSC, 2MEF, 2iPSC, D11H, D16H, D16L, D18H, D21L, D21L0, D2H, D5H, D8H, ESC]
ERP004476	Reprogramming_around_an_epigenetic_barrier_with_TET1 [2_KLF4_2a-sc-2117074]
ERP005247	DNA methylation is required for the control of stem cell differentiation in the small intestine [Differentiated Intestinal Epithelium, Intestinal Stem Cell (LGR5 Positive)]
ERP008742	Germ_cell_methylation_dynamics [056202C0-C771-11E6-Bf9C-68B59976A384, 056B78A0-C771-11E6-Bf9C-68B59976A384, 05727D80-C771-11E6-Bf9C-68B59976A384, 0Ec6Eaf0-5Fb7-11E6-B4F3-68B59976A384, 0Ee5Bd90-5Fb7-11E6-B4F3-68B59976A384, 11____EB2_B_-sc-2176524, 12____EB2_BS_-sc-2176525, 25Ab5C60-5Fb7-11E6-9477-68B599768938, 2Fe8D220-5Fb7-11E6-B4F6-68B59976A384, 2Ff491F0-5Fb7-11E6-B4F7-68B59976A384, 2Ffde0C0-5Fb7-11E6-B4F7-68B59976A384, 3F12Cf30-5Fb7-11E6-9477-68B599768938, 3F2015A0-5Fb7-11E6-9477-68B599768938, 47Ad1C40-5Fb7-11E6-B4F7-68B59976A384, 6Fc872F0-1B75-11E6-B065-68B59976A384, 6Ffc7B40-1B75-11E6-B065-68B59976A384, 83494700-1B75-11E6-B769-68B599768938, 835Db960-1B75-11E6-B769-68B599768938, 9____EB1_BS_-sc-2176522, A3_mPGCLC1-sc-2383193, C3_mPGCLC2-sc-2383195, D2_mPGCLC1-sc-2383188, D3_mPGCLC2-sc-2383196, Df89Bf70-C770-11E6-Bf9C-68B59976A384, Dfc31Ef0-C770-11E6-Bf9C-68B59976A384, Dfca9900-C770-11E6-Bf9C-68B59976A384, E3_mPGCLC2-sc-2383197, F1_hPGCLC1-sc-2383182, F28250B0-C770-11E6-83A1-68B599768938, F2895590-C770-11E6-83A1-68B599768938, F2978660-C770-11E6-83A1-68B599768938, F2_mPGCLC1-sc-2383190, F3_mPGCLC2-sc-2383198, G2_mPGCLC1-sc-2383191, G3_mPGCLC2-sc-2383199, H3_mPGCLC2-sc-2383200, PBAT20150318_S1-sc-2268397, PBAT20150318_S2-sc-2268398, PBAT20150318_S22-sc-2268418, PBAT20150318_S5-sc-2268401, PBAT20150318_S6-sc-2268402, hES1-sc-2351342, hES2-sc-2351343, hES3-sc-2351344, hKSR2-sc-2351346, hKSR3-sc-2351347]
ERP010942	We present the first genome-scale analysis of the effect of CpG methylation on DNA-binding of TFs. [Embryonic Cell, Embryonic Cell Deficient In Tet1, Tet2 And Tet3, GP5D Cell, LHSAR Cell, LHSAR Cell With HOXB13 Transduced, LoVo Cell, VCap Cell]
ERP012781	Mice deficient of Myc super-enhancer region reveal a differential control mechanism between normal and pathological growth [Null_Fib-Bis-1, Null_Fib-Bis-2, WT_Fib-Bisseq-1, WT_Fib-Bisseq-2]
ERP015660	Quantifying epigenotype variations between mouse B and CD4+ T lymphocytes [CD4-positive, Alpha-Beta T Cell, Mature B Cell]
ERP016240	Genome-wide DNA methylation landscape defines specialization of regulatory T cells in tissues [Fat_Treg_R1, LN_Tconv_R2, LN_Tconv_R3, LN_Treg_R2, LN_Treg_R3, Liver_Treg_R1, Skin_Treg_R1, Skin_Treg_R2, Skin_Treg_R3]
ERP022031	Epigenetic regulation and transcriptional repression by Tet1 in the early post-implantation mouse embryo: WG Bisulfite sequencing
ERP022077	A MILI independent piRNA biogenesis pathway residually loads MIWI2 empowering partial germline reprogramming activity. [Undifferentiated Spermatogonia]
ERP107409	Defective germline reprogramming rewires the spermatogonial transcriptome [Undifferentiated Spermatogonia]
ERP107948	DEEP data release for IHEC/EpiRR 2018 data freeze. [Fibroblast, Hepatocyte, Liver, White Adipocyte]
ERP110807	Methylation_profiles_in_cancer_induced_mouse_liver_tumours [Eea28C50-B5A6-11E8-9Efc-68B59976A384, Eeab22A2-B5A6-11E8-9Efc-68B59976A384, Eeb10690-B5A6-11E8-9Efc-68B59976A384, Eebf133E-B5A6-11E8-9Efc-68B59976A384, Eeced512-B5A6-11E8-9Efc-68B59976A384, Eed4Cb20-B5A6-11E8-9Efc-68B59976A384, Eedadf7E-B5A6-11E8-9Efc-68B59976A384, Eee12E74-B5A6-11E8-9Efc-68B59976A384, Eee7C87E-B5A6-11E8-9Efc-68B59976A384, Eeee2660-B5A6-11E8-9Efc-68B59976A384, Eef7663A-B5A6-11E8-9Efc-68B59976A384, Eefea85A-B5A6-11E8-9Efc-68B59976A384, Ef04C618-B5A6-11E8-9Efc-68B59976A384, Ef1E8A62-B5A6-11E8-9Efc-68B59976A384, Ef24Bbd0-B5A6-11E8-9Efc-68B59976A384, Ef2Ad826-B5A6-11E8-9Efc-68B59976A384, Ef30D4B0-B5A6-11E8-9Efc-68B59976A384, Ef3Fe72A-B5A6-11E8-9Efc-68B59976A384, Ef46105A-B5A6-11E8-9Efc-68B59976A384, Ef4C7B52-B5A6-11E8-9Efc-68B59976A384, Ef703Fd8-B5A6-11E8-9Efc-68B59976A384, Ef764356-B5A6-11E8-9Efc-68B59976A384, Ef89B832-B5A6-11E8-9Efc-68B59976A384, Ef942A06-B5A6-11E8-9Efc-68B59976A384, Ef9Eba34-B5A6-11E8-9Efc-68B59976A384, Efa444D6-B5A6-11E8-9Efc-68B59976A384, Efa91B82-B5A6-11E8-9Efc-68B59976A384, Efaeaec6-B5A6-11E8-9Efc-68B59976A384, Efc13Ea6-B5A6-11E8-9Efc-68B59976A384, Efe65754-B5A6-11E8-9Efc-68B59976A384, F01B9838-B5A6-11E8-9Efc-68B59976A384, F027766C-B5A6-11E8-9Efc-68B59976A384, F031Def4-B5A6-11E8-9Efc-68B59976A384, F04855E4-B5A6-11E8-9Efc-68B59976A384, F0629Aee-B5A6-11E8-9Efc-68B59976A384, F06D826A-B5A6-11E8-9Efc-68B59976A384, F07934A2-B5A6-11E8-9Efc-68B59976A384, F083A63A-B5A6-11E8-9Efc-68B59976A384, F08F6Ae2-B5A6-11E8-9Efc-68B59976A384, F099A6A6-B5A6-11E8-9Efc-68B59976A384, F0A5C68E-B5A6-11E8-9Efc-68B59976A384, F0B08C4A-B5A6-11E8-9Efc-68B59976A384, F0Baffc2-B5A6-11E8-9Efc-68B59976A384, F0C76F3C-B5A6-11E8-9Efc-68B59976A384, F0D4E266-B5A6-11E8-9Efc-68B59976A384, F0D985F0-B5A6-11E8-9Efc-68B59976A384, F0E139Bc-B5A6-11E8-9Efc-68B59976A384, F0Eb69E6-B5A6-11E8-9Efc-68B59976A384, F0F772Ea-B5A6-11E8-9Efc-68B59976A384, F10215Ec-B5A6-11E8-9Efc-68B59976A384]
ERP120304	Multi-omics characterization of MEK inhibitor resistant pancreatic cancer based on a genetically engineered mouse model-derived in vitro system [1, 2, 3, 4, 6, 7, 8, 9]
ERP126361	DNA methylation profiles of mouse sperm in response to antibiotic-induced gut microbiota dysbiosis using whole-genome bisulfite sequencing [Cauda Epididymal Sperm]
ERP128231	CpG island reconfiguration for the establishment and synchronization of polycomb functions upon exit from naive pluripotency [MT-SL WGBS, WT-SL WGBS]
ERP130901	Epigenomic rewiring of mouse hippocampus after resistance and endurance exercise training [Hippocampus]
ERP138895	Study of a mouse model of angioimmunoblastic T-cell lymphoma [ena-SAMPLE-TAB-05-07-2022-16:18:22:259-81379, ena-SAMPLE-TAB-05-07-2022-16:18:22:259-81380, ena-SAMPLE-TAB-05-07-2022-16:18:22:259-81381, ena-SAMPLE-TAB-05-07-2022-16:18:22:259-81382]
ERP139499	Whole genome bisulfite sequencing of liver samples of five mammals (human, rhesus macaque, mouse, rat and dog) [Liver]
ERP155689	Whole Genome Bisulfite Sequencing of CLDN6High vs CLDN6Low Sorted EpiSCs and APSD, and WT vs Pbx1-KO EpiSCs [24H Differentiation, Epiblast Cell]
SRP004162	Dynamic epigenomic oscillations in differentiated cells
SRP007354	DNA binding factors shape the mouse methylome at distal regulatory regions [BIS_seq] [ES-derived Neuronal Progenitor Cells, Embryonic Stem Cells]
SRP011945	Base Resolution Analysis of 5-Hydroxymethylcytosine in the Mammalian Genome [E14Tg2A, H1]
SRP013702	Dnmt3a protects active chromosome domains against cancer-associated hypomethylation [Healthy Lung Tissue, Lung Tumors]
SRP013703	GSE57230: Widespread contribution of transposable elements to the innovation of gene regulatory networks [mouse ENCODE] [Bone Marrow, Cerebellum, Cerebral Cortex, Embryonic Facial Prominence, Forebrain, Heart, Hindbrain, Intestine, Kidney, Large Intestine, Limb, Liver, Lung, Midbrain, Neural Tube, Olfactory Bulb, Small Intestine, Spleen, Stomach, Thymus]
SRP016893	Whole-genome bisulfite sequencing of two distinct interconvertible DNA methylomes of mouse embryonic stem cells [ES-cells]
SRP017139	Dnmt2-dependent methylomes lack biologically relevant DNA methylation patterns [ES Cells]
SRP017350	Density and methylation state of CpG dinucleotides define histone variant specific retention of nucleosomes in mouse spermatozoa [Sperm]
SRP017503	Tissue-specific methylomes reveal epigenetic memory in adult mouse tissue [Bone Marrow, Cerebellum, Colon, Cortex, Heart, Intestine, Kidney, Liver, Lung, Olfactory Bulb, Pancreas, Placenta, Skin, Spleen, Stomach, Thymus, Uterus]
SRP017572	FGF Signaling Inhibition in ESCs Drives Rapid Genome-wide Demethylation to the Epigenetic Ground State of Pluripotency [E14 ES]
SRP018523	Bisulfite-Seq profiling of undifferentiated ESCs, and in vitro derived primordial germ cells (iPGCs) [ESCs- V6.5, ESCs-Rosa26-GFP, iPGCs, iPGCs-Rosa26-GFP, iPGCs-V6.5]
SRP018963	High resolution nulceotide level methylation map of female mouse primary keratinocytes [Primary Keratinocytes]
SRP019026	CG methylated microarrays identify novel methylated sequence bound by the CEBPB\|ATF4 heterodimer that are active in vivo [Primary Dermal Fibroblasts]
SRP020633	Mus musculus Epigenomics [General Sample From]
SRP025152	Epigenetic and genetic changes during mouse hematopoietic stem cell aging [Bisulfite-Seq] [Bone Marrow Derived Primary HSCs]
SRP025993	Maintenance of DNA methylation in embryonic stem cells depends on the histone H3K9 methyltransferases (K9 KO Methyl-Seq) [Embryonic Stem Cells]
SRP025996	Maintenance of DNA methylation in embryonic stem cells depends on the histone H3K9 methyltransferases (Dnmt3ab KO Methyl-Seq) [Embryonic Stem Cells]
SRP026048	Global epigenomic reconfiguration during mammalian brain development [Brain (Cerebral Cortex), Brain (Dorsal Prefrontal Cortex), Brain (Frontal Cortex), Brain (Middle Frontal Gyrus), Embryonic Stem Cells]
SRP026536	5mC Oxidation by Tet2 Modulates Enhancer Activity and Timing of Transcriptome Reprogramming during Differentiation [Embryonic Stem Cells]
SRP028709	Large conserved domains of low DNA methylation maintained by 5-hydroxymethycytosine and Dnmt3a [Bisulfite-Seq] [Bone Marrow Derived Primary HSCs]
SRP028826	Gene expression and chromatin analysis of fused mouse-rat cells [Immortalized Tail Fibroblast]
SRP029721	Genome-wide regulatory domains and their interactions in Mus musculus [Hematopoetic Stem Cells, Splenic B Cells]
SRP029902	Role of de novo DNA methyltransferases in hematopoietic stem cells (WGBS) [Bone Marrow Derived Primary HSCs]
SRP032967	Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain (Bisulfite-seq) [Dentate Gyrus]
SRP033288	Dynamic DNA methylation in cardiac myocyte development, maturation and disease [Cardiac Myocyte, Cardiac Tissue]
SRP033304	The complete methylome of hematopoietic stem cells and their immediate progeny [HSC (LSK, CD34-, CD48-, CD150+), MPP (LSK, CD34+, CD48+, CD150-), MPP1 (LSK, CD34+, CD48-, CD150+), MPP2 (LSK, CD34+, CD48+, CD150+)]
SRP034857	Large conserved domains of low DNA methylation maintained by 5-hydroxymethycytosine and Dnmt3a (CMS bisulfite-seq) [Bone Marrow Derived Primary HSCs]
SRP037785	Two waves of de novo methylation during mouse germ cell development [Germ Cells]
SRP039504	Single base resolution analysis of 5-formyl and 5-carboxyl cytosine reveals the actual promoter DNA methylation dynamics in embryonic stem cells [MAB-Seq] [Embryonic Stem Cells]
SRP040524	CG hypomethylation in Lsh-/- mouse embryonic fibroblasts is associated with de novo H3K4me1 formation and altered cellular plasticity [Cell Line, Primary MEFs]
SRP040627	Imprinted expression is different in visceral yolk sac and cystic embryoid body endoderm [Visceral Yolk Sac Endoderm]
SRP041083	Programming and inheritance of parental DNA methylomes in mammals [2-Cell Embryo, 4-Cell Embryo, E13.5 Female PGC, E13.5 Male PGC, E3.5 Embryo, E6.5 Embryo, E7.5 Embryo, Inner Cell Mass, MII Oocyte, Sperm]
SRP041257	Single-Cell Whole-Genome Bisulfite Sequencing for Analysis of Epigenetic Heterogeneity [ESCs (E14)]
SRP041376	Tet proteins in DNA demethylation and cell fate restriction [ES Cell Line E14Tg2a]
SRP041760	Genomic profiling of DNA methyltransferases reveals a role for DNMT3B in genic methylation [Bisulfite-Seq] [Embryonic Stem Cells]
SRP041847	Altered epigenetic programming links intestinal inflammation to colon cancer (Bisulfite-seq) [Colon Epithel]
SRP042360	Dnmt3L-histone H3 binding is necessary for male fertility and non-CG methylation [DNMT3 A/A, Wild Type]
SRP042409	Rlf, a widely-spaced zinc finger protein, is involved in maintaining epigenetic marks at CpG island shores and enhancer elements across the genome [E10.5 Embryo Rep1, E10.5 Embryo Rep2, E14.5 Liver Rep1, E14.5 Liver Rep2, E18.5 Liver Rep1, E18.5 Liver Rep2]
SRP043370	Tet1 and Tet2 mediate epigenetic regulation of developmental genes by protecting DNA methylation canyons against hypermethylation [Bisulfite-Seq] [Embryonic Fibroblasts]
SRP045054	The developmental potential of iPSCs is greatly influenced by the selection of the reprogramming factors [Embryonic Stem Cells, Induced Pluripotent Stem Cells]
SRP045179	Gender-specific post-natal demethylation and establishment of epigenetic memory [Liver]
SRP045747	Setdb1 is required for persistence of H3K9me3 and repression of endogenous retroviruses in mouse primordial germ cells [SSEA1+ Primordial Germ Cells]
SRP047165	Distinct roles of DNMT1-dependent and –independent methylation patterns in the genome of mouse ES cells [Embryonic Stem Cells]
SRP047397	Genome-wide characterization of DNMT-deficient mouse ESCs reveals dynamicity of differentially-methylated-regions and its impact on bivalency composition [ES Cell]
SRP049191	Single-base resolution analysis of active DNA demethylation using methylase-assisted bisulfite sequencing [E14Tg2A, V6.5]
SRP049223	Transcription and Imprinting Dynamics in Developing Postnatal Male Germline Stem Cells [Spermatogonia]
SRP049674	Epigenomic Signatures of Neuronal Diversity in the Mammalian Brain [Brain (Neocortex), Excitatory Pyramidal Neurons, Parvalbumin-Positive (PV) Inhibitory Neurons]
SRP049697	DNA methylation status of Individual 4T1 Clonal Populations [4T1 Mammary Cancer Cell Line, Parental Cell Line]
SRP049936	DNA methylation in mammalian placentas [Cerebrum, Cordblood, Extraembryonic Membrane, Placenta, Trophoblasts]
SRP049965	MORC1 represses transposable elements in the mouse male germ line [Sorted Germ Cells]
SRP050145	An alternative pluripotent state confers interspecies chimaeric competency [WGBS] [E5.75 Derived EpiSCs, E5.75 Derived rsEpiSCs]
SRP052235	HP1 is involved in regulating the global impact of DNA methylation on alternative splicing [R1 Embryonic Stem Cells]
SRP055147	Maternal DNA methylation regulates early trophoblast development [Trophoblast]
SRP056705	An epigenetic memory of pregnancy in the mouse mammary gland [Basal Differentiated, Basal Mammary Stem Cells, Basal Progenitor, Luminal Alveolar, Luminal Ductal, Luminal Progenitor, Luminal Total]
SRP057157	Competition between DNA methylation and transcription factors determines binding of NRF1 [Embryonic Stem Cells]
SRP057505	Active DNA demethylation at enhancers during the vertebrate phylotypic period [Brain, Sox10+ Cells, Whole Embryo]
SRP059433	Gender Differences in Global but not Targeted Demethylation in iPSC Reprogramming [BS Seq AIDKO MEF1, BS Seq D21 iPSC Clone3, BS Seq D29 AIDKO iPSC Clone1, BS Seq D29 AIDKO iPSC Clone2, BS Seq D29 MALE iPSC Clone1, BS Seq D29 MALE iPSC Clone2, BS Seq D29 MALE iPSC Clone3, BS Seq D29 iPSC Clone3, BS Seq D6 SSEA1 Positive 1, BS Seq D6 SSEA1 Positive 2, BS Seq D6 SSEA1 Positive 3, BS Seq D6 Thy1 Positive 1, BS Seq D6 Thy1 Positive 2, BS Seq D6 Thy1 Positive 3, BS Seq D60 AIDKO iPSC Clone1, BS Seq D60 MALE iPSC Clone1, BS Seq D60 MALE iPSC Clone2, BS Seq D60 MALE iPSC Clone3, BS Seq D60 iPSC Clone2, BS Seq D60 iPSC Clone3, BS Seq ESC 1, BS Seq ESC 2, BS Seq ESC 3, BS Seq MALE MEF 1, BS Seq MALE MEF 2, BS Seq MALE MEF 3, BS Seq MEF 1, BS Seq MEF 2, BS Seq MEF 3, BS Seq P29 iPSC Clone1, Fibroblast, Reprogramming Fibroblast]
SRP059940	Chromatin dynamics and the role of G9a in gene regulation and enhancer silencing during early mouse development [Epiblast Stem Cells, Epiblast-Like Cells]
SRP060643	De novo DNA methyltransferases DNMT3A and DNMT3B are essential of global DNA methylation maintenance [BS-Seq] [ES-cells]
SRP060646	De novo DNA methyltransferases DNMT3A and DNMT3B are essential of global DNA methylation maintenance [TAB-Seq] [ES-cells]
SRP060660	MIWI2 and MILI have differential effects on piRNA biogenesis and DNA methylation
SRP061339	Sequence Features Accurately Predict Genome-wide MeCP2 Binding in vivo [Olfactory Epithelium]
SRP061876	An epigenetic switch ensures transposon repression upon acute loss of DNA methylation in ES cells (WGBS) [J1 WT ES Cell]
SRP062482	TET proteins regulate lineage specification and TCR-mediated expansion of iNKT cells (WGBS) [iNKT Cells]
SRP062557	DNMT3A and TET2 Compete and Cooperate to Repress Differentiation Lineage-Specific Factors in Hematopoietic Stem Cells [Tet2 Knockout Hematopoietic Stem Cell]
SRP062575	Genetic and epigenetic variation among inbred littermates: identification of metastable epialleles in the mouse [Adult Liver]
SRP062705	Whole genome bisulfite sequencing of sperm from a mouse heterozygous for a mutation in Setdb1 (MommeD13) and a wildtype mouse. [Sperm]
SRP063015	Epigenomic Landscapes of Retinal Rods and Cones [Rd7 Rod Photoreceptors, WT Cone Photoreceptors, WT Rod Photoreceptors]
SRP063093	Acute loss of TET function results in aggressive myeloid cancer in mice [WGBS] [LSK Cells]
SRP063275	New roles for DNA cytosine modification, eRNA, anchors and super-anchors in developing B cell progenitors [Rag1 Deficient pro-B, Tcf3(E2A) Deficient pre-pro-B]
SRP063453	Unique Broad Histone Lysine 4 Methylation Domains in Mouse Oocytes and Dynamic Regulation during Maternal to Zygotic Transition [P12 Oocyte, P15 Oocyte]
SRP065034	Mus musculus and Mus spretus sperm methylation [Testis]
SRP065509	Trans-effects of sub-chromosomal duplications on DNA methylation patterns in mouse models of Down syndrome: whole genome bisulfite sequencing of cerebral samples from Dp(10)1Yey and Dp(16)1Yey mouse models.
SRP065556	Dynamic Changes in Histone Modifications Precede de novo DNA Methylation in Oocytes [Oocyte]
SRP066668	genomic DNA from MEF cells [Cultured MEF Cells]
SRP067094	Chromatin decompaction coupled MuERVL endogenous retrovirus activation induces genome-wide DNA demethylation [E14 Cell Line Untransfected Negative Control, MuERVL+_Zscan4+]
SRP067341	DNA methylation oscillations at CpG poor enhancers in primed embryonic stem cells [PBAT Bisfulfite-seq] [E14 Embryonic Stem Cell]
SRP067447	Genetic and Epigenetic Variation, but Not Diet, Shape the Sperm Methylome [Spermatozoa]
SRP068043	Dynamic epigenomic landscapes during early lineage specification in mouse embryos [Ectoderm, Embryonic Stem Cell, Endoderm, Epiblast, Inner Cell Mass, Mesoderm, Primitive Streak, Trophectoderm, Visceral Endoderm]
SRP068730	Epigenetic reprogramming enables the primordial germ cell-to-gonocyte transition (WGBS) [PGC]
SRP069120	Mus musculus strain:C57BL/6 Epigenomics [Liver, MEFs In Culture]
SRP069139	ZFP57 maintains the parent-of-origin-specific expression of the imprinted genes and differentially affects non-imprinted targets in mouse embryonic stem cells (BS-seq and RRBS) [Embryonic Stem Cells]
SRP069154	Isoform switch of TET1 regulates DNA demethylation and mouse development [mESCs]
SRP070637	Single-cell multi-omics sequencing of mouse early embryos and embryonic stem cells [Embryonic Stem Cell]
SRP070642	Methylation and gene expression profiling in Dnmt3a-deficient chronic lymphocytic leukemia and peripheral T-cell lymphoma in mice. [Spleen]
SRP071233	Iron-Heme-Bach1 Axis Is Involved In Erythroblast Adaptation To Iron Deficiency [Erthroblast (Bach1 KO), Erthroblast (WT)]
SRP071782	Mammalian sperm exhibit epigenetic priming of embryonic and adult regulatory landscapes (BS-Seq) [Sperm]
SRP074072	WGBS assessment of global methylation alterations in Dnmt3aKO/FLT3-ITD lymphoid leukemia [Leukemic Cells, Thymus Derived CD4/CD8 Double Positive T Cells]
SRP074379	Genome-wide map of DNA methylation to unravel the function of EBF1 C-terminus domain [Ebf1-/- c-Kit+ Fetal Liver Cells]
SRP075309	Mus musculus Epigenomics [ES]
SRP075981	GEO accession GSE82125 is currently private and is scheduled to be released on May 30, 2017. [ES-derived Neural Progenitor Cells, Embryonic Stem Cells]
SRP076056	Role of Tet proteins in B cell development [Pro B Cells]
SRP077875	Allele-Specific Non-CG Methylation Marks Domains of Active Chromatin in Mouse Brain [Brain (Prefrontal Cortex)]
SRP077894	Single base resolution of the complete 5-mC and 5-hmC cardiac methylome in heart failure [Whole Heart]
SRP078059	The de novo DNA methyltransferase DNMT3C protects male fertility from transposon activity (Bisulfite-seq). [10 Dpp Total Germ Cells]
SRP078072	Derivation of ground-state female ESCs maintaining gamete-derived DNA methylation [ES Cells]
SRP078328	Epigenetic restriction of embryonic and extraembryonic lineages mirrors the somatic transition to cancer (WGBS) [Extraembryonic Ectoderm, Inner Cell Mass, Precompacted 8 Cell Stage Embryos, Proximal Epiblast, Trophectoderm]
SRP078445	DNA Methylation Divergence and Tissue Specialization in the Developing Mouse Placenta [Whole Placenta]
SRP078848	Whole genome bisulfite and TAB-Sequencing from sorted neurons in the adult mouse brain [NeuN+ Neuronal Nuclei]
SRP078871	Whole genome bisulfite sequencing of adult hypothalamus male mouse brain [Mixed Brain Cells]
SRP078942	Cis-regulatory landscape of four cell types of the retina [Cones, Horizontal Cells, Rods, Starbust Amacrine Cells]
SRP080866	DNA methyltransferase 3b regulates articular cartilage homeostasis by altering chondrocyte metabolism [Primary Articular Chondrocytes]
SRP081004	Postnatal DNA demethylation and its role in tissue maturation [Hepatocyte]
SRP081133	DNA methylation repels binding of hypoxia-inducible transcription factors to maintain tumour immunotolerance [WGBS] [Inner Cell Mass]
SRP081312	DNA methylation regulates intron retention via altered MeCP2-mediated splicing factor recruitment [Granulocytes, Promyelocytes]
SRP081475	Methylomes of wild-type and MeCP2 knockout brain cells [Whole Brain]
SRP082360	Epigenetic memory of obesity in mouse colonic epithelium [Colon]
SRP083753	LKB1 loss links the serine metabolic network to DNA methylation and tumourigenesis [bisulfite-seq] [Primary Pancreatic Ductal Epithelial Cells]
SRP083895	Transcription and chromatin determinants of the rate of de novo DNA methylation in oocytes [60-65Um Oocytes]
SRP089825	Enhanced Pluripotent Cell Function through miR-203-mediated Control of DNA Methylation [Ebs, iPs WT Long After DOX, iPs WT Short After DOX, iPs WT T=0, iPs miR-203 KI-N5 (T=0), iPs miR-203 KI-N5 Long After DOX, iPs miR-203 KI-N5 Short After DOX, iPs miR-203 KI-N9 (T=0), iPs miR-203 KI-N9 Long After DOX, iPs miR-203 KI-N9 Short After DOX]
SRP089858	A novel requirement for Drosha in maintenance of mammalian CG methylation [Embryonic Stem Cells (ES Cells)]
SRP090139	Analyzing whole genome bisulfite sequencing data from highly divergent genotypes [Liver]
SRP090219	The Dynamic Epigenetic Landscape of the Retina During Development, Reprogramming, and Tumorigenesis [WGBS_Mm] [Derived iPSCs fMG02, Derived iPSCs fMG03, Embryonic Fibroblasts Cell, Embryonic Stem Cell, Immature Retinal-Derived iPSCs 8601, Mature Retinal-Derived iPSCs 3302, Mature Retinal-Derived iPSCs 7602, Retina]
SRP090249	Whole Genome Bisulfite Sequencing in Pax7-reprogrammed corticotropes AtT-20 cells [Pituitary Corticotroph Cell]
SRP090505	DNA methylation profiling of vascular maturation [Endothelial Cells]
SRP090698	Epigenetic Memory Underlies Cell Autonomous Heterogeneous Behavior of Hematopoietic Stem Cells [LKS SLAM Cells]
SRP090852	Vitamin C induced epigenomic remodeling in IDH1 mutant acute myeloid leukemia [HOXA9 Immortalized Bone Marrow]
SRP091011	Tracking of dCas9-methyltransferase footprints [mESCs]
SRP091938	Increased H3K9 methylation and impaired expression of Protocadherins are associated with the cognitive dysfunctions of the Kleefstra syndrome [Brain]
SRP092244	Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions (WGBS 1) [Hepatocytes]
SRP092247	Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions (WGBS 2) [Hepatocytes]
SRP092540	WGBS assessment of global methylation alterations in hematopoietic stem and progenitor cells [methyl-seq] [Intermediate-Term Hematopoietic Stem Cell, Long-Term Hematopoietic Stem Cell, Multi-Potent Progenitor, Short-Term Hematopoeitic Stem Cell]
SRP094653	ncRNA transcription-induced changes in nuclear architecture directs with high precision enhancer-promoter interaction [In-Vitro DN2 Cells]
SRP095235	Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism [Liver]
SRP095627	DNA methylomes at base resolution of mouse embryonic fibroblasts in G1 and G2 phase of cell cycle [Embryonic Fibroblasts (MEFs)]
SRP097054	DNA methylation of SAMP8 and SAMR1 mice [Cerebral?Cortex]
SRP097617	MLL2 conveys transcription-independent H3K4me3 in the oocyte [Germinal Vesicle Oocytes]
SRP099007	Microglia isolated from juvenile offspring of dams with allergic asthma exhibit methylation and transcriptional alterations to autism risk genes [WGBS] [Acutely Isolated Microglia, P35 Brain]
SRP099066	The BLUEPRINT Murine Lymphocyte Epigenome Reference Resource. [Whole Genome Bisulfite-Seq] [CD4+CD62L+ T Cells, CD43- B Cells]
SRP099067	The BLUEPRINT Murine Lymphocyte Epigenome Reference Resource. [Whole Genome Bisulfite-Seq_OX] [From CD4+CD62L+ T Cells, From CD43- B Cells]
SRP100972	5-hydroxymethylcytosine Accumulation in Postmitotic Neurons Results in Functional Demethylation of Expressed Genes [MethylC-Seq and oxBS-Seq] [Cerebellar Granule Cells]
SRP101416	Whole-genome bisulfite-seq (WGBS) on Lin-Sca1+Kit+ (LSK) bone marrow cells from wild-type C57BL/6J mice [Lin-Sca1+Kit- Cells]
SRP101453	Environmental enrichment increases transcriptional and epigenetic differentiation between mouse dorsal and ventral dentate gyrus neurons [Brain (Dentate Gyrus Of The Hippocampus)]
SRP101591	Simultaneous mapping of active DNA demethylation and sister chromatid exchange in single cells [Around 100 Embryonic Stem Cells, E14]
SRP101774	Isoform-specific localization of DNMT3A regulates DNA methylation fidelity at bivalent CpG islands [WGBS] [Embryonic Stem Cells]
SRP103077	Mapping DNA methylation and CTCF/cohesin occupancy on nascent chromatin and DNMT-targeted nascent chromatin [Embryonic Stem Cells]
SRP103763	Whole-genome analysis of 5-hydroxymethylcytosine and 5-methylcytosine at base resolution in the mouse brain [Cerebellum, Cortex, Olfactory Bulb]
SRP105210	Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells in vivo [WGBS] [Hematopoietic Stem Cells]
SRP105270	Reprogramming of H3K9me3-dependent heterochromatin during mammalian early embryo development [WGBS] [4-Cell Embryo, 6.5 Day Embyo Epiblast, 6.5 Day Embyo Extraembryonic Ectoderm, 7.5 Day Embyo Epiblast, 7.5 Day Embyo Extraembryonic Ectoderm, 8-Cell Embryo, Early 2-Cell Embryo, Inner Cell Mass, Late 2-Cell Embryo, Morula Embro, Trophoblast, Zygote]
SRP106356	Activation of Lineage-Regulators and Transposable Elements Across a Pluripotent Spectrum [2I – N2B27_BL6, 2i/LIF – GMEM/10% KSR_BL6, 2i/LIF – GMEM/10% Serum_129, 2i/LIF – N2B27_BL6, Ch/LIF – N2B27_BL6, Pd/LIF – N2B27_BL6, Serum/LIF -GMEM_129, Serum/LIF – Feeders - GMEM_BL6]
SRP108295	De novo epigenetic programs inhibit PD-1 blockade-mediated T-cell rejuvenation [WGBS] [Antigen-specific CD8 T Cells, Naive CD8 T Cells]
SRP108349	Enhancing the Potency of Mouse Embryonic Stem Cells [BS-Seq] [Embryonic Stem Cells]
SRP108476	Whole genome bisulfite sequencing of Ing1/Gadd45a double knockout and wildtype mouse embryonic fibroblasts [Embryonic Fibroblasts (MEFs)]
SRP109758	Cytosine methylation dynamics during spermatogenesis and post-testicular sperm maturation [Caput Sperm, Cauda Sperm, Corpus Sperm, Early Round Spermatids, Later Round Spermatids, Primary Spermatocytes, Vas Deferens Sperm]
SRP109785	Paternal cold exposure enhances brown adipose tissue sensitivity in offspring and ameliorates diet induced obesity [Sperm]
SRP109867	Base-resolution analysis of DNA methylation patterns downstream of Dnmt3a in mouse naïve B cells [Naive B Cells]
SRP110902	DNMT3A haploinsufficiency predisposes hematopoietic cells to myeloid malignancies [Bone Marrow]
SRP111167	DNA methylation dynamics during embryonic development and postnatal maturation of the auditory organ of Corti [Organ Of Corti]
SRP111382	WGBS assessment of global methylation alterations in Dnmt3aKO or Dnmt3bKO mouse embryonic stem cells [Embryonic Stem Cells]
SRP111384	rahu is a mutant allele of Dnmt3c, encoding a DNA methyltransferase homolog required for meiosis and transposon repression in the mouse male germline [WGBS] [Whole Testis]
SRP111470	Whole genome bisulfite sequencing of mouse neural progenitor cells and neurons from the mouse cerebral cortex at day 15.5 of embryonic development [Cortical Neurons, Neural Progenitor Cells]
SRP113186	Integrative Proteomic Profiling Reveals PRC2-Dependent Epigenetic Crosstalk Maintains Ground-State Pluripotency. [ESCs]
SRP113409	Transcriptional and epigenetic profiling of aged mouse SVZ-derived neural stem / progenitor cells [SVZ-derived Neural Stem / Progenitor Cells]
SRP113417	Chromatin and Transcriptional Dynamics in Adult Germline Stem Cells and Mammalian Spermatogenesis [Mature Sperm, Sperm, Spermatids, Spermatocytes, Spermatogonia, Spermatogonia (Thy1+)]
SRP113606	Transient and permanent reconfiguration of chromatin and transcription factor occupancy drive reprogramming [Day12 MEF Reprogramming Intermediates, Day3 MEF Reprogramming Intermediates, Day6 MEF Reprogramming Intermediates, Day9 MEF Reprogramming Intermediates, MEF, MEF Derived Induced Pluripotent Stem Cells]
SRP115607	A role of Polycomb in the maintenance of hypomethylation for DNA methylation valley [mESCs]
SRP116373	Early-life gene expression in neurons modulates lasting epigenetic states. [Bisulfite-seq] [Cortex, Hippocampus]
SRP116554	Snord116-dependent diurnal rhythm of DNA methylation in mouse cortex [Cerebral Cortex]
SRP117079	Transcription factors drive Tet2-mediated enhancer demethylation to reprogram cell fate [Bisulfite-Seq] [Cultured Primary Cells (Short Term), Embryo (Inner Cell Mass), Low Passage (P<10)]
SRP118911	High-Resolution Dissection of Conducive Somatic Cell Reprogramming to Naïve Ground State Pluripotency in Mbd3/NuRD and Gatad2a/NuRD Depleted Systems [WGBS] [Gatad2a-/- Cell Line, Mbd3f/- Cell Line, WT Cell Line]
SRP119143	Transcriptomic and epigenomic analysis during conversion from mouse microglia into induced-neuronal (iN) cells [Microglial Cells]
SRP119366	Long genes linked to autism harbor intragenic super-enhancer-like chromatin domains [Cortical Excitatory Neurons]
SRP119705	DNA hypermethylation encroachment at CpG island borders in cancer is predisposed by H3K4 monomethylation [WGBS_Mm] [Blood (B Cell-Depleted), Spleen Bulk B Cells]
SRP123210	Genetics, sex and life experience influence DNA methylation in the mouse [Liver]
SRP123612	Novel Principles of Cellular Reprogramming Revealed by Prospective Isolation and Characterization of Rare Intermediates Poised to Generate iPSCs [WGBS] [MEF, Reprogramming Intermediate, iPSC]
SRP125227	Next Generation Sequencing for Genome-wide Maps of DNA Methylaton in mES Cells [Embryonic Stem Cells]
SRP125320	Effector CD8 T cells dedifferentiate into long-lived memory cells [Acute GP33-specific CD8 T Cells, Acute Memory Precursor P14 Cells, Acute Terminal Effector P14 Cells, P14 CD8 T Cells]
SRP125421	Dynamic EBF1 occupancy directs sequential epigenetic and transcriptional events in B cell programming [Bisulfite-Seq-Cre] [Ebf1-deficient B Cell Progenitors]
SRP125690	Forniceal deep brain stimulation induces gene expression and splicing changes that promote neurogenesis and synaptic plasticity [Dentate Gyrus]
SRP126875	Differences in cell cycle status underlie transcriptional heterogeneity in the HSC compartment [HSC]
SRP127685	Setd2 deficiency impairs hematopoietic stem cell self-renewal and causes malignant transformation [Bone Marrow LSK Cells]
SRP127792	Single-cell dissection of long non-coding RNAs pivotal for embryonic hematopoietic stem cell development [T1 pre-HSC]
SRP130993	SCNT embryos are defective for H3K27me3 imprinting [RNA-seq]
SRP131922	Analysis of genetically diverse macrophages reveals local and domain-wide mechanisms that control transcription factor binding and function [Bone Marrow Derived Macropages (BMDM)]
SRP132683	DNA (de)methylation in embryonic stem cells controls CTCF-dependent chromatin boundaries [Embryonic Stem Cells]
SRP133323	Extensive recovery of embryonic enhancer and gene memory stored in hypomethylated enhancer DNA. [Embryonic Epithelial Cells, Intestinal Villus Cells]
SRP133565	Genome-wide identification of distinct target loci for de novo DNA methylation by DNMT3A and DNMT3B during mammalian development [MEFs]
SRP133698	Global DNA methylation remodeling during direct reprogramming from fibroblast to neuron [MethylC-seq] [Direct Reprogramming, Embryonic Fibroblast, Neural Progenitor Cells]
SRP135700	Transcriptional and Epigenomic Landscapes of CNS and non-CNS Vascular Endothelial Cells [Vascular Endothelial Cells]
SRP136257	Mammalian ISWI and SWI/SNF selectively mediate binding of distinct groups of transcription factors (Bis-seq data sets) [Embryonic Stem Cells]
SRP136419	WGBS assessment of global methylation alterations in Dnmt3a1KO , Dnmt3a2KO, Dnmt3aKO, Tet1KO and DKO mouse embryonic stem cells [Embryonic Stem Cells]
SRP136449	Comprehensive analysis of H3K9me2 oocytes, together with DNA methylation and expression analysis of G9a conditional KO oocytes and maternal KO preimplantation embryos [2-Cell Embryos, Blastocysts, Fully Grown Oocytes]
SRP136786	Bisulfite-free direct detection of 5-methylcytosine and 5-hydroxymethylcytosine at base resolution [E14 Embryonic Stem Cells]
SRP139083	DNA 5-methylcytosine specific profiling with limited input [ESCs]
SRP139795	Transient reduction of DNA methylation at the onset of meiosis in male mice [Testis]
SRP142028	Mus musculus Epigenomics [Embryonic Fibroblasts (MEFs)]
SRP149052	Single-Cell RNA-Seq Reveals Dynamic Early Embryonic-like Programs during Chemical Reprogramming [CiPSCs, Intermediate Cells, XEN-like Cells]
SRP151020	Inhibition of aberrant DNA re-methylation improves development of cloned embryos (WGBS-Seq) [Cumulus Cell, Embryonic Fibroblast Cell, Nuclear Transfer Embryo, Sertoli Cell]
SRP151137	DNA methylation oscillations at CpG poor enhancers in primed embryonic stem cells [scRNA-Seq, scBS-Seq] [Embryo]
SRP151590	Integrated Genomic Analysis of a Stem Cell Model of Overgrowth Syndrome with Intellectual Disability (WGBS) [J1 ESC, J1 NSC]
SRP151725	Imprecise DNMT1 activity coupled with neighbor-guided correction enables robust yet flexible epigenetic inheritance [mESC, mESC-derived Cell]
SRP154319	Effects of environmental enrichment on postnatal mouse cortex regulome [Homogenate]
SRP154996	Epigenetic changes of the thioredoxin system in the tx-j mouse model and in patients with Wilson disease [Fetal Liver]
SRP155404	A DNMT3A PWWP mutation leads to methylation of bivalent chromatin and postnatal growth retardation in mice [Epiblast, Hypothalamus, Liver]
SRP156136	MethMotif: An integrative cell specific database of transcription factor binding motifs coupled with DNA methylation profiles [Colon, Spleen]
SRP156779	DNA hypermethylation encroachment at CpG island borders in cancer is predisposed by H3K4 monomethylation [mESC_WGBS] [Embryonic Stem Cells]
SRP158409	H3K36me2 recruits DNMT3A and shapes intergenic DNA methylation landscapes [C3H Embryo-Derived Mesenchymal Progenitor Cells]
SRP158977	Methylome assays of E14.5 pancreatic progenitor cells [Endocrine Enrichment]
SRP159191	Long-range epigenetic concordance revealed by simultaneous profiling of DNA methylation and chromosomal conformation changes in bulk and single cell Methyl-HiC [ESC Line]
SRP159665	WGBS (Whole Genome Bisulfite Sequencing) of Wild-type and Math5-/- mouse dLGN (dorsolateral geniculate nucleus) at postnatal day 6 and postnatal day 23 [dLGN (Dorsolateral Geniculate Nucleus)]
SRP160386	Perturbation of the OGT-TET1 interaction in mouse embryonic stem cells (WGBS) [Tet1 D2018A Mutant Knock In Stem Cells, Wild Type Stem Cells]
SRP161525	True 5-methylcytosine profiling of late reprogramming stages during in vitro reprogramming of mouse embryonic fibroblasts (MEFs) to induced pluripotent stem cells (iPSCs) [Day 0 Embryonic Fibroblasts, Day 10 Totalx2 mCherry+/GFP+, Day 10 Totalx2 mCherry+/GFP-, Day 12 Naivex2 mCherry+/GFP+, Day 12 Naivex2 mCherry+/GFP-, Day 14 Naivex2 mCherry+/GFP+, TET1 KO iPSC Clonal Line, Experiment 1, TET1 KO iPSC Clonal Line, Experiment 2, Wild-Type iPSC Clonal Line, Experiment 1, Wild-Type iPSC Clonal Line, Experiment 2]
SRP162035	Activin A and BMP4 Signaling Expands Potency of Mouse Embryonic Stem Cells in Serum Free Media [Embryonic Stem Cell, Epiblast Stem Cell]
SRP162771	Characterization of the DNA methylome in retinal pigment epithelium (RPE) of adult mice [Retinal Pigment Epithelium (RPE)]
SRP163215	Aging of mouse spermatogonial stem cells by Wnt7b-Jnk pathway activation [Bisulfite-seq] [Testis]
SRP165997	Dynamic enhancer partitioning instructs Zdbf2 activation during epigenetic reprogramming [bisulfite-seq] [Epiblast-like Cell]
SRP167689	WGBS in wild-type and MommeD1mut MEFs [MEFs]
SRP167718	Next Generation Sequencing Combined Analysis of DNA Methylome and Transcriptome Reveal Novel Candidate Genes of Neuroprotective with Response to Ischemic Preconditioning [Brain]
SRP168345	Characterization of the DNA methylome in murine Müller glia [Glast+ Cells]
SRP168393	DNA methylation in AgRP neurons regulates voluntary exercise behaviour in mice [Neuron]
SRP168427	Tet inactivation disrupts YY1 binding and long-range chromatin interactions to cause developmental defects in embryonic heart [Embryonic Heart]
SRP170065	Differential roles of Stella in the modulation of DNA methylation during oocyte and zygotic development [Female Pronucleus, Male Pronucleus, Oocyte]
SRP171165	Transcriptonal and epigenetic changes of adult liver cells in vivo and in vitro [Adult DDC Damaged Liver, Adult Healthy Liver]
SRP172778	GR mutation in mice changes the genome-wide epigenome of frontal cortex in a highly sex-specific manner [Frontal Cortex]
SRP173239	DNA methylation estimation using methylation-sensitive restriction enzyme bisulfite sequencing (MREBS) [Embryonic Fibroblasts, Embryonic Stem Cells]
SRP173926	Loss of non-CpG methylation in inhibitory neurons impairs neural function through a mechanism that partially overlaps with Rett syndrome [Inhibitory Neurons]
SRP174096	Endogenous retroviral insertions drive non-canonical imprinting in extra-embryonic tissues [Bisulfite-Seq] [Epiblast, Extra-embryonic Ectoderm]
SRP174255	Effects of combined treatment of EGCG and environmental enrichment on postnatal mouse cortex regulome [Homogenate]
SRP174491	FoxA-dependent demethylation of DNA initiates epigenetic memory of cellular identity [Hepatocytes]
SRP174666	Super-enhancer subregions highly bound by the nuclear receptor ESRRB regulate the exit from naïve pluripotency [Epiblast Stem Cells (EpiSCs)]
SRP174993	ChIP-seq and RNA-seq analysis of histone Kcr in the embryonic forebrain and neural stem/progenitor cells. [Forebrain]
SRP176417	Single cell multi-omics analysis reveals novel roles for DNA methylation in sensory neuron injury responses [DRG Sensory Neuron]
SRP178652	Branched-chain Amino Acid Aminotransferase-1 Regulates Self-Renewal and Pluripotency of Mouse Embryonic Stem Cells through Ras Signaling [mES]
SRP183094	The intestinal microbiota programs DNA methylation to control tissue homeostasis and inflammation [BiSulfite-seq] [Colon Epithelial Cells]
SRP184524	RNA m6A modification mediated by METTL3 is important for IAP heterochromatin integrity in mESCs (WGBS) [Embryonic Stem Cells]
SRP185723	WGBS of WT and Smchd1-KO ES cells [Embryonic Stem Cells]
SRP185738	Characterization of the DNA methylome in embryonic retina, retinal progenitors, and RGCs [Retina]
SRP186631	Epigenetic signatures of chronic social stress in stress-susceptible animals [Nucleus Accumbens]
SRP186642	Genome-wide methyl-cytosine competition by DNMT and TET [ESCs, Embryonic Stem Cell, EpiSCs, HUES64, HUES8, HUES8 Embryonic Stem Cells, In Vitro Derived Motor Neurons]
SRP186720	Association Between Early Life DNA Methylation Patterns with Age-Related Transcriptional Changes [Hippocampus]
SRP187205	Methylome profiling of GADD45 deficient mouse embryonic stem cells [Embryonic Stem Cells (mESC)]
SRP188205	MeCP2 represses the rate of transcriptional initiation of highly methylated long genes (BS-Seq and OxBS-Seq) [Forebrain Tissue]
SRP188734	Downregulation of Uhrf1 activity by TGF-ß signaling controls Foxp3 methylation and iTreg cell differentiation [CD4+ T Cells]
SRP189864	Uncoupling histone H3K4 trimethylation from developmental gene expression via an epigenetic equilibrium of Polycomb, COMPASS and DNA methylation [Embryonic Stem Cell]
SRP191868	Genome-wide analysis of DNA methylation profile in astrocytes isolated from naïve mice or EAE mice transduced with astrocyte-specific Mafg-targeting or non-targeting lentiviruses [WGBS] [Flow Cytometry Sorted Astrocytes]
SRP192143	Setd2 deficiency impaired erythroid differentiation and accelerated Myelodysplastic Syndrome(MDS) - associated leukemogenesis through S100A8 and S100A9 [C-Kit+ Cells, Hematopoietic Stem And Progenitor Cells (HSPCs)]
SRP193267	Allelic histone-to-DNA methylation switch establishes secondary DMR to maintain noncanonical imprinting [E6.5 Extraembryonic Ectoderm]
SRP194541	Whole genome bisulfite genome analysis of OX40L-Jagged-1 expanded Treg and Teff cells [CD4+CD25-Teff Cells, CD4+CD25hi Treg Cells]
SRP195507	Genome-wide roles of DNA methyltransferases in mouse embryos [Whole Embryos]
SRP198282	Hammer-seq to measure kinetics of DNA methylation maintenance in HeLa cells [Embryonic Stem Cell, Epithelial Adenocarcinoma]
SRP199205	Tox reinforces the phenotype and longevity of exhausted T-cells in chronic viral infection [Bisulfite-Seq] [P14 T-cells]
SRP201955	Analysis of dendritic cell differences [Bone Marrow]
SRP212622	Profiling of DNA Methylation during RANKL Induced Osteoclastogenesis using Whole-Genome Bisulfite Sequencing [Bone Marrow]
SRP214596	Dnmt3a and Dnmt3b-mediated decommissioning of fetal enhancers linked to kidney disease [Kidney]
SRP215028	Paradoxical association of TET loss of function with genome-wide hypomethylation [iNKT]
SRP216390	Epigenetic and transcriptional changes in aging mouse rod photoreceptors [WGBS] [Rod Photoreceptors]
SRP217940	Bivalent promoter hypermethylation in cancer is linked to the H327me3/H3K4me3 ratio in embryonic stem cells [ES Cells]
SRP219391	Maternal exposure to a mitochondrial toxicant results in life-long alterations in DNA methylation and gene expression in the offspring [Liver]
SRP221040	Embryonic stem cell-derived neurons as a model system for epigenome maturation during development [mESC Neural Diff 8 Days Induction]
SRP221485	Epigenetic regulator function through mouse gastrulation [Extraembryonic Ectoderm, Proximal Epiblast]
SRP222128	Genome-wide analysis of methylated DNA in control and Tet2/Tet3-deficient B cells [Primary B Cells]
SRP222566	Whole genome bisulfite Sequencing data of four types mouse spermatogenesis [Differentiated Spermatogonia Cells, Pachytene Spermatocytes, Round Spermatids, Undifferentiated Spermatogonia Cells]
SRP223436	Unique Transcription Factor Functions Regulate Epigenetic and Transcriptional Dynamics During Cardiac Reprogramming [alphaMHC-GFP+ Sorted Induced Cardiomyocytes, dsRed+ Sorted Fibroblasts (Control Infection)]
SRP223513	G9a plays distinct roles in maintaining DNA methylation, retrotransposon silencing and chromatin looping [Embryonic Stem Cell]
SRP227031	EED is required for Mouse Primordial Germ Cell Differentiation in the Embryonic Gonad [Primordial Germ Cells]
SRP229336	DeepH&M: Simultaneous determination of single-CpG hydroxymethylation and methylation levels from enrichment and restriction enzyme sequencing methods [Cerebellum, Cortex]
SRP229373	Novel Isoforms of the Epigenetic Regulator TET1 Differentially Control CNS Synaptic Function, Plasticity, and Cognition [Cultured Hippocampal Neurons]
SRP229636	Inducible cell-specific mouse models for paired epigenetic and transcriptomic studies of microglia and astroglia: Whole Genome oxidative bisulfite sequencing data [Brain]
SRP230210	Whole genome bisulfite sequencing (WGBS) of Tex15 wt, Tex15 ht, and Tex15 ko male germ cells at postnatal day 2.5 [Germ Cells]
SRP230428	Tet2 negatively regulates memory fidelity [CA1 Hippocampal Tissue]
SRP233665	The role of Vitamin C and TET dioxygenases in genome-wide features of regulatory T cells [WGBS] [Spleen And Lymph Nodes]
SRP234410	Whole Genome Bisulfite Sequencing Facilitates Quantitative Analysis of DNA Methylation status in sperm from 2 month old and 18 month old mice [Sperm]
SRP234989	Transcriptomic and epigenetic disruptions in excitatory neurons in Dnmt3a conditional knockout mouse [Excitatory Pyramidal Neurons]
SRP237267	Maternal DNMT3A-dependent de novo methylation of the zygotic paternal genome inhibits gene expression in the early embryo [BB_androgenetic_blasto_DNAme, BD_2C_Dnmt3aMatKO_DNAme, BD_2C_Dnmt3aMatWT_DNAme]
SRP239190	DNMTs Play an Important Role in Maintaining the Pluripotency of Leukemia Inhibitory Factor Dependent Embryonic Stem Cells [Embryonic Stem Cell]
SRP239280	Structural basis of epigenetic protection of mouse lymphoid progenitor cells by Dnmt1 [Mouse WGBS] [Lin- Bone Marrow Progenitors]
SRP239769	DNA methylome analysis of directly induced oocyte-like cells (DIOLs) [Embryonic Stem Cells, Fully-grown Directly Induced Oocyte-Like Cells, Non-growing Directly Induced Oocyte-Like Cells]
SRP242576	Epigenetic changes in Langerhans islets preceding the onset of diabetes [Islet]
SRP242612	Whole Genome Bisulfite Sequencing of CD4+ T cells from mice developmentally exposed to vehicle or TCDD prior to and during influenza infection [CD4+ T Cells]
SRP244650	Paradoxical whole genome DNA methylation dynamics of Decitabine in chronic low-dose exposure in mice [Liver, Testes]
SRP246238	Disturbed mitochondrial dynamics in CD8+ TIL reinforce epigenetic programming linked with T cell exhaustion
SRP246664	Autocrine IL6 activates the STAT3-DNMT axis to silence the TNFa-RIP1 necroptosis pathway to sustain myeloid-derived suppressor cell survival and accumulation [CD11b+Gr1+]
SRP246939	Beta cell-specific CD8+ T cells maintain stem-cell memory-associated epigenetic programs during type 1 diabetes (WGBS) [HAART HIV TN CD8 T Cells, Polyclonal Naive CD8 T Cell HD, Polyclonal T1D Naive CD8 T Cells, Polyclonal TCM CD8 T Cells, Polyclonal TEM CD8 T Cells, Polyclonal TSCM CD8 T Cells, Tetramer+ CD8 T Cells, Tetramer+ HAART CD8 T Cells, Tetramer+ T1D CD8 T Cells]
SRP247347	TET2 promotes anti-tumor immunity by governing G-MDSCs and CD8+ T cell numbers
SRP250290	A multivalent signal-transducing model for the DNMT1-mediated maintenance DNA methylation [ES Cells]
SRP251304	Control of Foxp3 induction and maintenance by sequential histone acetylation and DNA demethylation [WGBS] [Wild-type CD4 Effector T Cells, Wild-type Naive CD4 T Cells, Wild-type Regulatory T Cells]
SRP252412	WGBS and RNA-seq of mouse livers and human Hep3B cells [Liver]
SRP254051	Post-implantation developmental defects induced by mtDNA mutation derive from altered DNA methylome in oocytes [D257A Treated Oocyte, Wild Type Oocyte]
SRP254510	Mus musculus musculus strain:Bl6 Raw sequence reads [Enterocytes]
SRP254904	DNMT3A haploinsufficiency results in behavioral deficits and global epigenomic dysregulation shared across neurodevelopment disorders [Bisulfite-Seq] [Cortex]
SRP255391	NSD1-deposited H3K36me2 directs de novo methylation in the mouse male germline and counteracts Polycomb-associated silencing [E16.5 Prospermatogonia, P0 Prospermatogonia]
SRP257580	Altered microRNA expression links IL6 and TNF-induced inflammaging with myeloid malignancy [miR146aKO_LSK_WGBS] [Bone Marrow]
SRP257737	Role of E2F6 in gene expression and DNA methylation during mouse development [E8.5 Whole Embryos]
SRP257778	Characterization of metabolic patterns in mouse oocytes during meiotic maturation [MII Oocytes]
SRP258361	Transgenerational inheritance of obesity correlates with transmission of epigenetic alterations in the Fto gene [BS-seq] [Sperm]
SRP258472	Neuronal activation modulates enhancer activity of genes for excitatory synaptogenesis through de novo DNA methylation [Cultured Hippocampal Neurons (10DIV)]
SRP261467	Epigenetic and chromatin profiling of wild-type and Dnmt3a-deficient B1 and B2 B cells. (methylation) [B1, B2, proB1, proB2]
SRP261529	An activity-mediated transition in transcription in early postnatal neurons [BS-seq] [Cortex]
SRP265159	IGF2R-initiated Proton Rechanneling Dictates an Anti-inflammatory Property in Macrophages [Peritoneal Macrophages]
SRP265261	Cyclosporin A and FGF signaling support the proliferation/survival of mouse primordial germ cell-like cells in vitro [bis-seq] [E9.5 PGC, ESC]
SRP265512	Temporal evolution of cellular heterogeneity during the progression to advanced, AR-negative prostate cancer [RRBS] [Tumor]
SRP266415	Flanking sequence preference modulates de novo DNA methylation in the mouse genome [Embryonic Stem Cells]
SRP266608	Mouse preimplantation imprinting [WGBS] [Blastocyst, Embryonic Stem Cell, Kidney]
SRP267895	Multiomics profiling of young and old quiescent skeletal muscle stem cells [aging WGBS] [Skeletal Muscle Stem Cells]
SRP267967	Characterization of universal features of partially methylated domains across tissues and species [Breast Tumor, Lung]
SRP270999	Hoxa10 is a functional positional memory that governs stem cell function in adult skeletal muscle [Masseter, Tibialis Anterior]
SRP271091	Glucocorticoids sensitive progenitor PDGFRa+ cells switching to white adipocytes cause visceral obese via methylation modification of TEAD1 (Bisultite-seq) [Adipose Progenitors]
SRP271469	Methylation and gene expression data obtained from Dnmt3b+/- peripheral T-cell lymphomas. [Lymph Node]
SRP271532	Formative pluripotent stem cells show features of epiblast cells poised for gastrulation [MethylC_fPSCs_P10]
SRP271992	Methylation and gene expression data obtained from Dnmt3b+/+, Dnmt3bD/D and Dnmt3bCI/CI MYC induced T-cell lymphomas (MTCLs). [Lymph Node]
SRP272852	Epigenetic reprogramming of airway macrophages drives polarization and inflammation in muco-obstructive lung disease (WGBS_BL) [Airway Macrophages]
SRP273163	Atg7-dependent autophagy regulates the naive to primed transition by selective Nanog degradation in mouse embryonic stem cells [WGBS] [E14TG2]
SRP273620	Whole genome bisulfite sequencing of apoptotic and male-differentiated subpopulations of E13.5 wild-type murine male germ cells [Apoptosis-poised (AP) Germ Cell, Male-differentiated (MD) Germ Cell]
SRP278195	Whole genome bisulfite sequencing analysis to measure the effect of EHMT2 (G9a, Bat8) on DNA methylation in the mouse embryo at 9.5 dpc [Embryo]
SRP280273	Fetal origin of sex-bias brain aging [Fetal Brain, Placenta]
SRP281855	YY1 safeguard multidimensional epigenetic landscape associated with extended pluripotency [EPS Cells]
SRP282002	Sperm epigenetic alterations contribute to inter- and transgenerational effects of paternal exposure to long-term psychological stress via evading offspring embryonic reprogramming [Embryo, Sperm]
SRP282126	MicroRNA-29 is an essential regulator of non-CG methylation during brain maturation [Bisulfite-seq] [Cortex]
SRP283863	Foxp3 enhancers synergize to maximize regulatory T cell suppressive capacity [Bisulfite-Seq] [FACS Sorted Regulatory T Cells (CD4+GFP+)]
SRP285138	Dnmt1 has global de novo methylation activity and is specifically targeted to transposable elements [E3.5 Blastocyst, E6.5 Epiblast, mESC]
SRP285604	Muscle regeneration controlled by a designated DNA dioxygenase (Methylation-Seq) [Satellite Cells Derived Myoblasts]
SRP286191	Genome-wide maps of Dnmt1-dependent DNA methylome in adipocytes [Adipocytes]
SRP286409	H3K27me3 shapes DNA methylome by inhibiting UHRF1-mediated H3 ubiquitination [Bisulfite-seq] [E14, HeLa]
SRP288034	DNA methylomes of murine B and T cells from the BLUEPRINT Epigenome project [CD4+CD62L+ T Cells, CD43- B Cells]
SRP288067	Epigenomic profiles of 4T1 cell line in primary, metastasis site and circulating cell type in xenograft mouse model [Circulating Tumor Cell, Fat Pad Xenograft, Lung Metastasis, Mammary Gland]
SRP289001	Depletion of H3K36me2 recapitulates epigenomic and phenotypic changes induced by the H3.3K36M oncohistone mutation [Fibroblast]
SRP289560	Whole-genome bisulfite sequencing analysis of Pten's function in regulating cardiomyocyte differentiation [ES-derived Cardiomyocytes]
SRP291181	Transgenerational inheritance of epigenetic signatures at CpG islands in mice [ESC]
SRP291379	Dnmt3a deficiency in the skin [Skin]
SRP292265	Cell type-specific transcriptomic and eipgenome analysis of diabetic cardiomyopathy [Cardiac Myocyte, Endothelial Cell, Fibroblast, Macrophage]
SRP292587	TET deficiency promotes oncogenesis and DNA damage in B cells by increasing the levels of G-quadruplexes and R-loops [WGBS] [B Cells]
SRP292755	KMT2C Loss Promotes Small Cell Lung Cancer Metastasis through DNMT3A-mediated Epigenetic Reprogramming [Liver, Lung]
SRP292910	The effect of NEIL3 on CA1 DNA methylation [Brain]
SRP294136	Unraveling the functional role of DNA demethylation at specific promoters by targeted steric blockage of DNA methyltansferase with CRISPR/dCas9 [NIH-3T3]
SRP296451	WGBS on prospermatogonia at E18.5
SRP297323	Base-editor-mediated multiplexed inactivation of DNA methyltransferases reveals essential roles of miRNAs in mouse gastrulation [Epiblast, Extraembryonic Ectoderm, Whole Embryo]
SRP297921	Transcriptional and epigenomic profiling identifies YAP signaling as a key regulator of intestinal epithelium maturation [II] [Small Intestinal Epithelium Derived Organoids]
SRP299927	Methylomes of macrophage-DC progenitors (MDPs), monocytes, common monocyte progenitors (cMoPs), common dendritic cell progenitors (CDPs), plasmacytoid dendritic cells (pDCs), and cDC CD8a+ as well as cDC CD11b+ dendritic cells [CDPs, MDPs, Monocytes, cDC CD11b+, cDC CD8a+, cMoPs, pDCs]
SRP300044	Genome-wide maps of DNA methylome during oocyte aging and its transgenerational inheritance [Hippocampus, M2 Oocyte, Sperm]
SRP300086	PDGFRa+ not CD137+ progenitors control visceral obesity via glucocorticoid mediated TEAD1 methylation state [Adipose Progenitors]
SRP300442	Disordered N-Terminal DNMT3A Domain Is Required for Mouse Postnatal Development [Cerebral Cortex, Cortical Neuron Nuclei]
SRP301916	Constitutive loss of DNMT3A causes morbid obesity through misregulation of adipogenesis [Adipose]
SRP302177	Whole genome bisulfite sequencing of E13.0 and E13.5 Tex14 mutant, heterozygote and wild-type murine female germ cells [Germ Cell]
SRP302195	Whole genome bisulfite sequencing of sstr2 knockout mice [Gastric Tissue]
SRP302337	ZFP57 dictates allelic expression switch of target imprinted genes [Total Embryo]
SRP305480	5-hydroxymethylcytosine is required for terminal differentiation of Purkinje neurons [Purkinje Cells]
SRP307526	DNA methylation regulates haematopoietic development [AGM, Bone Marrow, Fetal Liver]
SRP308565	Methylomes of young and aged LT-HSCs [Primary Hematopoietic Stem Cells]
SRP308731	Loss of SETD1B results in the redistribution of genomic H3K4me3 in the oocyte [PBAT] [Germinal Vesicle Oocytes]
SRP309189	Genome-wide methylation analysis of murine innate lymphoid cells [Innate Lymphoid Cells]
SRP309253	In Vitro Reconstitution of the Whole Male Germ-Cell Development from Mouse Pluripotent Stem Cells [PBAT] [Germ Cells Derived]
SRP309373	RNA-seq, ATAC-seq, WGBS, and CUT&RUN of urothelial cells isolated from Naive, Resolved, and Sensitized C3H/HeN mice [Urothelial Stem Cells (USCs)]
SRP309644	DNMT3B supports meso-endoderm differentiation from mouse embryonic stem cells [WGBS] [ES-E14, ES-E14 Derived EpiSC, EpiLC-derived ME]
SRP309709	Epigenetic integrity of paternal imprints enhances the developmental potential of androgenetic haploid embryonic stem cells [Haploid mESCs]
SRP310260	Mouse totipotent stem cells captured and maintained through spliceosomal repression [mESC Cultured In SLP Medium, mESC Cultured In Serum/Lif Medium]
SRP310416	Dnmt3a-Mutant Hematopoietic Stem cells are resistant to inflammatory stress [Donor Derived CD45.2 Cells]
SRP311975	A cis-acting mechanism mediates trancriptional memory at Polycomb target genes in mammals [WGBS] [C-Myc-Immortalized Embryonic Fibroblasts]
SRP312013	Maintenance DNA methylation in pre-meiotic germ cells regulates meiotic prophase by facilitating homologous chromosome pairing [Male Germ Cells]
SRP312491	Placenta and fetal brain share a neurodevelopmental disorder DNA methylation profile in a mouse model of prenatal PCB exposure [WGBS] [Brain, Placenta]
SRP312798	Diverse epigenetic mechanisms maintain parental imprints within the embryonic and extraembryonic lineages [ExE (Extraembryonic Ectoderm)]
SRP313361	Whole Genome Bisulfite Sequencing of miR-143 knock-out mice liver [MIGS Eukaryotic Sample From]
SRP313387	Regnase-1 suppresses TCF-1+ precursor exhausted T cell formation to limit CAR T cell responses against ALL [WGBS] [Regnase-1-deficient CAR T, WT CAR T]
SRP313733	Whole genome bisulfite sequencing of young and old satellite cells [Primary Myoblasts]
SRP314467	Postnatal expansion of the lymph node stromal cell pool towards reticular and CD34+ stromal cell subsets [WGBS] [Gut-Draining Mesenteric Lymph Node, Skin-Draining Mesenteric Lymph Node]
SRP315002	Functional and epigenetic phenotypes of humans and mice with DNMT3A overgrowth syndrome [Whole_Bone_Marrow]
SRP318894	RNA-seq, WGBS, 5hmC-Seal, and ATAC-seq data about TET proteins and skeletal development (WGBS) [Primary Osteoblasts]
SRP319090	Whole genome bisulfite sequencing analysis to examine the effect of the iron chelator deferoxamine on DNA methylation levels in 3T3-L1 pre-adipocyte cells [Preadipocyte Cell Line]
SRP319425	Whole-genome bisulfite sequencing anlaysis of in vitro fertilized mouse hybrid blastocysts [Blastocyst]
SRP321573	Conservation and divergence of DNA methylation patterns and functions in vertebrates [Primary Dermal Fibroblasts, Psoas Muscle]
SRP321876	Genetic variation at mouse and human ribosomal DNA influences associated epigenetic states [Blood, Kidney]
SRP322748	Club cells employ regeneration mechanisms during lung tumorigenesis [Lung]
SRP323244	Tet enzymes are required for mammalian embryonic hematopoiesis [Endothelial Cell, Hematopoietic Stem And Progenitor Cell]
SRP325428	Systematic profiling of DNMT3A variants reveals protein instability mediated by the DCAF8 E3 ubiquitin ligase adaptor [Embryonic Stem Cells, Lymphoblastoid Cell Line]
SRP327113	DNA methylation changes of heart tissue in mouse with alcoholic cardiomyopathy [Heart]
SRP329327	HypoSUMOylation in embryonic stem cells generates head-and-trunk embryo-like structure [Methyl-seq] [ES Cells]
SRP329752	Whole genome bisulfite sequencing (WGBS) analysis of murine splenic DC subtypes [Not Applicable]
SRP329853	Mouse methylome and transcriptome of three brain tissues in aging [Hippocampus, Striatum, Substantia Nigra]
SRP331841	DNA Methylation Status in Mouse Liver Affected by Maternal High-fat, High-sucrose diet [Liver]
SRP336016	Salt induces hepatic inflammatory response through epigenetic modulation of SIRT3 [Bisulfite-seq] [Liver]
SRP336168	Tet2 deficiency altered hematopoietic stem and progenitor cells ageing process [LSK]
SRP336573	Perturbation of TET2 condensation induces genome-wide promiscuous DNA hypomethylation and curtails leukemia cell growth [Embryonic Stem Cells (mESCs), Leukemia Cell Line]
SRP336725	Histone H3K36me2 and H3K36me3 form a chromatin platform essential for DNMT3A-dependent DNA methylation in mouse oocytes [Oocyte]
SRP336812	Differential regulation of mouse hippocampal gene expression sex differences by chromosomal content and gonadal sex: Whole Genome OXBS-Seq Data [Hippocampus]
SRP337056	The DNMT1 inhibitor GSK-3484862 mediates global demethylation in murine embryonic stem cells [Undifferentiated Embryonic Stem Cells]
SRP337411	Examining age-dependent DNA methylation patterns and gene expression in the male and female mouse hippocampus [Dorsal Hippocampus]
SRP339235	9sCa: MSL2 is an allelic dosage sensor in mammals [Neural Progenitor Cells]
SRP339236	BlCa: MSL2 is an allelic dosage sensor in mammals [Neural Progenitor Cells]
SRP339237	CaBl: MSL2 is an allelic dosage sensor in mammals [Neural Progenitor Cells]
SRP339793	Somatic Dnmt3a deletion in murine hematopoietic cells [B-cells, CMP, GMP, Lineage Negative Kit Positive Sca1 Positive, MEP, Myeloid Cells, T-cells, Whole Bone Marrow]
SRP340739	Loss of TET reprograms Wnt signaling through impaired demethylation to promote lung cancer development [Lung]
SRP341070	Promoter repression and 3D-restructuring resolves divergent developmental gene expression in TADs [WGBS] [ESC, Limb]
SRP342398	Next Generation Sequencing Facilitates Quantitative Analysis of ApoE-/-/SAHHWT, ApoE-/-/SAHH+/- mice and ApoE-/-/SAHH+/- +Betaine mice [WGBS] [Vascular]
SRP342541	Maternal SMCHD1 controls both imprinted Xist expression and imprinted X chromosome inactivation [Embryo]
SRP342588	Whole genome bisulfite sequencing of 3T3-L1 preadipocytes and adipocytes [Embryo]
SRP342595	Dynamics of DNA hydroxymethylation and methylation during mouse embryonic and germline development [IVC Epiblast]
SRP342917	Rat and mouse imprintomes (allele-specific DNA methylomes) [EPC, Epiblast]
SRP342995	H3K36 Dimethylation Shapes the Epigenetic Interaction Landscape by Directing Repressive Chromatin Modifications in Embryonic Stem Cells
SRP348783	Sex-specific epigenetic development in the mouse hypothalamic arcuate nucleus pinpoints human genomic regions associated with body mass index [Glia, Neuron]
SRP349681	The distinct effects of MEK and GSK3 inhibition upon the DNA methylome and transcriptome of mouse embryonic stem cells [Embryonic Stem Cells]
SRP350023	Vitamin C deficiency causes cell type-specific epigenetic reprogramming and acute tubular necrosis [Kidney]
SRP350997	GLP is critical for oogenesis exhibiting a G9A-independent role in transcriptional repression [Oocyte]
SRP351062	Whole genome DNA methylation profiling of mouse nucleus accumbens Drd2 medium spiny neurons by using two independent library preparation methods [D2-MSN]
SRP351503	Cell-type specific DNA methylome signatures reveal epigenetic mechanisms for neuronal diversity and neurodevelopmental disorder [GABAergic Neurons, Glutamatergic Neurons, Purkinje Neurons]
SRP353039	WGBS of control and DAC-treated CT26 cells. [CRC Cell Line CT26]
SRP353283	Cancer stem cells, not bulk tumor cells, determine mechanisms of resistance to SMO inhibitors [Not Applicable]
SRP354658	Global DNA methylation analysis of cancer-associated fibroblasts reveals extensive epigenetic rewiring linked with RUNX1 upregulation in breast cancer stroma [WGBS] [Non-immune Stromal Cells]
SRP355808	Somatic Dnmt3a deletion in murine hematopoietic cells [B-cells, CMP, GMP, KLS, MEP, Myeloid, T-cells, WBM]
SRP355886	Whole-genome bisulfite sequencing (WGBS) of stressed and nonstressed breast tumor in mice [Breast Tumor]
SRP356163	PU.1-dependent enhancer inhibition separates clonal hematopoiesis from malignant transformation (oxBS-Seq) [cKit+ Lymph- Ery- HSPC]
SRP357383	DNA methylation landscape and transcriptome of tumor-associated macrophages reveals pathways, transcription factors, and prognostic value relevant for breast cancer patients [methylation] [Bone Marrow-Derived Monocytes, Mammary Gland Macrophages, Tumor-associated Macrophages]
SRP359332	Donor T-cell DNMT3a regulates alloreactivity in murine models of hematopoietic stem cell transplantation [WGBS] [Sorted Splenic Donor T-cells]
SRP360183	Whole genome bisulfite sequencing of WT and Dnmt3a KO HSCs following chronic infection [Hematpoietic Stem Cells]
SRP360425	Role of Dppa3 during primordial germ cell development I [Primordial Germ Cell (PGC)]
SRP361168	Suppression of colorectal cancer by ketogenic diet and beta-hydroxybutyrate (Bisulfite Sequencing Dataset) [Colon]
SRP362787	Genome-wide bisulfite sequencing (GWBS) and RNA-seq in hippocampus of Neil1- and Neil2 deficient mice [Hippocampus]
SRP363476	Dynamic antagonism between key repressive pathways maintains the placental epigenome (WGBS) [Trophoblast Stem Cells]
SRP363630	Modeling methyl-sensitive transcription factor motifs with an expanded epigenetic alphabet [mESC]
SRP364004	Transcriptional regulation of the thymus master regulator Foxn1 [WGBS] [Thymus Epithelial Cell Type 1, Thymus Epithelial Cell Type 2, Thymus Epithelial Cell Type 3, Thymus Epithelial Cell Type 4, Type II Airway Epithelial Cells]
SRP366957	Single substitution in H3.3G34 alters DNMT3A recruitment to cause progressive neurodegeneration [WGBS] [Cortex]
SRP367185	Spatial organization of H3K9me2/3-marked heterochromatin is redundantly maintained by either the H3K9 or H3K27 methylation pathway [MethylC-seq] [iMEFs]
SRP367537	Whole-genome bisulfite sequencing of Dnmt1/3a/3b triple knockout (TKO) embryonic stem cells with or without expression of exogenous Dnmt1 before and after cell differentiation [Embryonic Stem Cells]
SRP367683	TET2 and TET3 loss disrupts small intestine differentiation and homeostasis [Bisulfite-seq] [Small Intestine]
SRP367742	HIV Tat and cocaine interactively alter genome-wide DNA methylation and gene expression and exacerbate learning and memory impairments [Bisulfite-seq] [Brain Hippocampus]
SRP367910	Inflammatory exposure drives permanent impairment of hematopoietic stem cell self-renewal activity and accelerated aging
SRP368317	Genome-wide methylation analysis of murine CD4+ Th1, Th2, and Th17 cells [CD4+ Memory T Cell]
SRP370019	Disturbance on DNA methylation and gene expression levels of mouse plasma leukocytes by low-dose ionizing radiation [Plasma Leukocyte]
SRP371705	MethylC-Seq: Intestinal stem cell aging signature reveals a reprogramming strategy to enhance regenerative potential [Intestinal Stem Cell (ISC)]
SRP371845	Raw WGBS reads of mice zygotes [Oocyte, Sperm, Zygotes]
SRP372616	Global DNA methylation analysis of mouse totipotent potential stem cells, extended pluripotent stem cells and mouse embryonic stem cells [Embryonic Stem Cells, Extended Pluripotent Stem Cells, Totipotent Potential Stem Cells]
SRP373182	TRIM28 establishes skeletal stem cell identity and safeguards skeletogenesis (WGBS) [Rib Caritilage Cells]
SRP375715	Role of Dppa3 during primordial germ cell development II [Fully Grown Oocyte (FGO)]
SRP376172	DNA sequence determines epigenetic bistability at imprinting control regions [WGBS] [Embryonic Stem Cells]
SRP376633	H3K36 methylation maintains cell identity by regulating opposing lineage programs [Reprogramming Intermediate]
SRP376940	Temporally-Divergent Regulatory Mechanisms Govern Neuronal Diversification and Maturation in the Neocortex [WGBS] [Somatosensory Cortex And Motor Cortex]
SRP377658	Genome-wide assessment of DNA methylation alterations induced by superovulation, sexual immaturity and in vitro follicle growth in mouse blastocysts [Blastocyst]
SRP378380	WGBS data of enhanced addictive bahavior in male offspring [Brain-Nucleus Accumbens]
SRP379742	The intrinsic and extrinsic effects of Tet proteins during gastrulation [Sorted Ctrl1 Cells, Sorted Ctrl2 Cells, Sorted TKO1 Cells, Sorted TKO2 Cells]
SRP381882	In vivo loss of TET2 and TET2 results in aberrant differentiation and homeostasis in the small intestine [Colon Epithelial Cells]
SRP384348	Evidence that direct inhibition of transcription factor binding is the prevailing mode of gene and repeat repression by DNA methylation [WGBS-Seq] [Ebryonic Stem Cells, Embryonic Kidney Cells, Ngn2_neurons]
SRP387245	Differences in DNA methylation of HAMP in blood cells predicts the development of type 2 diabetes [WGBS] [Liver]
SRP388596	Decitabine-induced T cell remodeling facilitates a high antitumor response to PD-1 blockade therapy by promoting the expansion and effector function of CD8+ progenitor exhausted T cells [CD8+ T Cells]
SRP388748	Transcriptional and epigenetic reprogramming mediated by chronic IL1ß exposure drives self-renewal ability and myeloid priming in TET2 deficient stem and progenitor cells [Bisulfite-Seq] [Common Myeloid Progenitor, Granulocyte-Macrophage Progenitor, LSK Progenitor Cell]
SRP393350	Whole genome enzymatic methyl-seq of A20 mouse cells using a novel TETact activation of CD4 [A20 B Cell Lymphoma Cell Line]
SRP393405	scNMT-seq of the adult NSC lineage - MAB-seq [Adult Neural Stem Cells And Astrocytes, Neuroblasts, Oligodendrocytes]
SRP395725	Tet2 and Tet3 mediated active cytosine hydroxymethylation in Six2 progenitor cells is critical for nephron progenitor differentiation and nephron endowment [Nephron Progenitor]
SRP395892	DNA dioxygenases Tet2/3 control epithelial differentiation (bisulfite-seq) [Hair Matrix Keratinocytes]
SRP396119	NSD1 deposits Histone H3 lysine 36 dimethylation to pattern non-CG DNA methylation in neurons [WGBS in vitro] [Cultured Cortical Neurons]
SRP396130	NSD1 deposits Histone H3 lysine 36 dimethylation to pattern non-CG DNA methylation in neurons [WGBS in vivo] [Cerebral Cortex]
SRP396513	Rockfish: Detection of 5mC DNA Modifications Using Raw Nanopore Signal [Embryonic Stem Cell, Purified Cardiomyocyte]
SRP397149	Basal cell extrusion primes pluripotent cells for differentiation [Embryo, Pluripotent Stem Cells]
SRP397538	Tet2 regulates Sin3a recruitment at active enhancers in embryonic stem cells [Embryonic Stem Cells]
SRP398423	TET2 lesions enhance the aggressiveness of CEBPA-mutant AML by rebalancing GATA2 expression [WGBS] [AML Blasts]
SRP398560	Whole-genome bisulfite sequencing and histone 3.3 ChIP-seq of microdissected developing mouse lens [Embryonic Lens Epithelium, Embryonic Lens Fiber]
SRP398698	Prenatal exposure to benzo[a]pyrene depletes ovarian reserve and masculinizes embryonic ovarian germ cell transcriptome transgenerationally II [Primordial Germ Cell]
SRP398703	Prenatal exposure to benzo[a]pyrene depletes ovarian reserve and masculinizes embryonic ovarian germ cell transcriptome transgenerationally I [Primordial Germ Cell]
SRP399252	p16 epimutation modulates the tumor microenvironment and promotes malignancy of Apc-mutant colon cancer [Embryonic Fibroblast]
SRP399723	Zmym2 is essential for methylation of germline genes and active transposons in embryogenesis [WGBS-seq] [Whole Embryo]
SRP400264	WGBS WT J1 ESC at D3 of EpiLC differentiation [Embryonic Stem Cells]
SRP400320	Whole genome bisulfite sequencing (WGBS) and RNA-sequencing of preadipocytes from iWAT [Preadipocytes (CD45-, CD31-, TER119-, PDGFRa+)]
SRP400331	DNA methyltransferase inhibition induces dynamic gene expression changes in lung CD4+ T cells of neonatal mice with E. coli pneumonia [RRBS] [CD4+ T Cell]
SRP401089	Dual gene activating and repressive functions of TET1 in germ layer lineage bifurcation distinguished by genomic context and dependence on 5-methylcytosine oxidation [oxWGBS] [CM59, CM69, KO1, KO15, WT34, WT7, WT70, WT72]
SRP403116	Precision pharmacological reversal of strain-specific diet-induced metabolic syndrome in mice informed by epigenetic and transcriptional regulation [Liver]
SRP404930	LN-stem, tumor stem, tumor terminally differentiated CD8 T cells from human kidney cancer [CD8 T Cell, Endo CD8 T Cell, P14 CD8 T Cell]
SRP405758	Comparative analysis of epigenomic evolution in mammals [Liver, Skeleton Muscle]
SRP405928	Optimized bisulfite sequencing reveals the lack of 5-methylcytosine in mammalian mitochondrial DNA [WGBS] [Brain, Breast Cancer Cell, Embryonic Kidney Cell, Embryonic Stem Cell, Hepatocarcinoma Cell, Lung Adenocarcinoma Cell, Melanoma Cell, Neuroblastoma Cell, Platelet]
SRP407097	Sex Chromosomes and Sex Phenotype Contribute to Biased DNA Methylation in Mouse Liver [Liver]
SRP410496	Whole genome bisulfite sequencing and Infinium Mouse Methylation BeadChip using fresh and fresh-frozen mouse epidermis (WGBS) [Epidermis]
SRP412252	Epigenetic changes in food induced anaphylaxis animal model after immunotherapy. [Dendritic Cells]
SRP413488	Methylation state of latent and proliferative metastatic tumor cells [Breast Cancer]
SRP414189	TET activity propagates transcriptional memory through embryonic dormancy [WGBS] [Embryonic Stem Cell]
SRP417057	Whole-genome bisulfite sequencing analysis for intestinal budding organoids derived from induced or tissue-derived intestinal stem cells, and for mouse embryonic fibroblasts [Embryonic Fibroblast (MEF), Intestinal Stem Cell (ISC)]
SRP417480	Inducible disruption of Tet genes results in myeloid malignancy, readthrough transcription, and a heterochromatin-to-euchromatin switch [WGBS] [CD11b+]
SRP418871	Dynamic DNA methylation turnover at the exit of pluripotency epigenetically primes gene regulatory elements for hematopoietic lineage specification [WGBS] [ESC, EpiLC]
SRP421061	DNA methylation in the mouse cochlea promotes maturation of supporting cells and contributes to the failure of hair cell regeneration [Inner Ear Cochlea]
SRP422554	Predicting age in single cells and low coverage DNA methylation data [scBS] [Whole Blood Depleted Of Red Blood Cells]
SRP422816	Distinct disease mutations in DNMT3A result in a spectrum of behavioral, epigenetic, and transcriptional disruptions [Cortex]
SRP423445	Ultrafast Bisulfite Sequencing for Efficient and Accurate 5-Methylcytosine Detection in DNA and RNA [Plasma, Stem Cell, mESC]
SRP424820	Durable and efficient gene silencing in vivo by hit-and-run epigenome editing [WGMS] [Hepatocyte]
SRP425083	T regulatory cells epigenetic changes in food induced anaphylaxis animal model after immunotherapy. [T Regulatory Cells]
SRP425335	Epigenetic evolution of the Ly49 gene family [Bisulfite-Seq] [Natural Killer Cells]
SRP426653	Stem Cell Activity-Coupled Suppression of Endogenous Retrovirus Governs Adult Tissue Regeneration [WGBS] [Anagen Hair Follicle Cells]
SRP431160	Whole genome bisulfite-seq analysis of control and Dnmt3a conditional knockout (cKO) retinal ganglion cells at 2 days post optic nerve crush [Retinal Ganglion Cell]
SRP431846	Histone methylation mediated by NSD1 is required for the establishment and maintenance of neuronal identities [WGBS] [Somatosensory Cortex]
SRP432324	Macrophage recipient WGBS data: Donors infected with Porphyromonas gingivali (WDPg) or sham-infected (WD) and fed a western diet (WD) [Elicited Macrophages]
SRP433931	Prenatal exposure to benzo[a]pyrene depletes ovarian reserve and masculinizes embryonic ovarian germ cell transcriptome transgenerationally [Bisulfite-Seq] [Primordial Germ Cell]
SRP435424	Genome-wide methylated CpG status in WT and IRF8KO microglia [WGBS] [FACS-sorted Microglia]
SRP435461	Cell-specific and shared regulatory elements control a multi-gene locus active in mammary and salivary glands [Bisulfite-seq] [Liver, Mammary Gland]
SRP440315	Transcriptomic and methylomic analyses of liver tissue in nonalcoholic steatohepatitis [Bisulfite-Seq] [Liver]
SRP441169	HDAC6 deacetylates IDH1 to regulate the homeostasis of hematopoietic stem/progenitor cells [WGBS-seq] [Hematopoietic Stem/Progenitor Cells (LSK)]
SRP447137	Single cell methylation, RNA, and ATAC sequencing of brain tissue in inbred mouse strains [Brain]
SRP447781	GEO accession GSE236722 is currently private and is scheduled to be released on Jul 06, 2025. [LUAD, Melanoma]
SRP450385	Catalytic dependent and independent roles of Tet3 in activation of ectodermal and silencing of mesodermal programs during neuroectoderm specification [Neuroectoderm Cells]
SRP451433	Combinational effect of the ADD domains of DNMT3A and DNMT3L on DNA methylation landscapes in mouse germ cells [WGBS] [Fully Grown Oocyte, Sperm]
SRP454736	Sperm DNA methylation defects in a new mouse model of the 5,10-methylenetetrahydrofolate reductase 677C>T variant and correction with moderate dose folic acid supplementation. [Sperm]
SRP455338	Durable and efficient gene silencing in vivo by hit-and-run epigenome editing [WGMS_invitro_revision] [Hepatocyte]
SRP456835	DNMT3A Addback [Bone Marrow]
SRP458075	DNA methylation shapes the Polycomb landscape during the transition from naïve-to-primed pluripotency [Embryonic Stem Cells]
SRP460843	Whole genome bisulfite sequencing (WGBS) of intestinal organoids from mice with graft-versus-host disease [Intestinal Organoids]
SRP461642	Whole genome bisulfite sequencing identifies stage- and subtype-specific DNA methylation signatures in pancreatic cancer [Normal Pancreatic Ductal Organoid, PanIN Organoid, Pancreatic Ductal Adenocarcinoma Organoid]
SRP462875	Mus musculus Genome sequencing and assembly [Liver]
SRP462989	Spatio-temporal X-linked gene reactivation in the mouse germline reveals site-specific retention of epigenetic silencing [WGBS] [Embryo]
SRP463129	Genome-wide DNA methylation pattern changes in ESC, and EPSC after treated with T09 [EPSC, EPSC With T09, ESC, NrESC]
SRP464133	Increased global DNA methylation disrupts skeletal muscle homeostasis, promotes age-related decline in muscle function, and reduces muscle plasticity [Skeletal Muscle, Iibialis Anterior]
SRP466337	Astrocyte-produced HB-EGF limits autoimmune CNS pathology [WGBS] [FACS-sorted Astrocyte]
SRP469813	Whole Genome Bisulphite Sequencing of undifferentiated and differentiated NIH3T3L1 [Fibroblast]
SRP471571	Histone methyltransferase SETDB1 silenced SINE B2 retrotransposons and maintained mitotic cell cycle of neural progenitor cells (WGBS) [Neural Progenitor Cells]
SRP472167	FoxA1/2-dependent epigenomic reprogramming drives lineage switching in lung adenocarcinoma [Bisulfite-Seq] [Lung, Lung Tumors]
SRP473050	Source cell-type epigenetic memory persists in induced pluripotent cells but is lost in subsequently derived germline cells [Embryonic Fibroblasts, Embryonic Stem Cells, Induced Pluripotent Stem Cells, Primordial Germ Cell Like Cells, Primordial Germ Cells, Spermatogonial Stem Cells, Tail Tip Fibroblasts]
SRP473623	Mus musculus strain:C57Bl/6J Raw sequence reads [Placenta, Primordial Germ Cells]
SRP474495	Landscape of TFs binding in mouse early embryos [Bisulfite-seq] [Early 2Cell]
SRP474956	Transcriptomic and epigenomic profiling of Tet TKO neural stem cells to study NSC specification and multipotency [Embryonic Stem Cells, Neural Stem Cells]
SRP475142	DNA methylation memory of acinar-ductal transition state altering Kras-downstream Pi3k and Rho GTPase signaling [ADM, Acinar, Acinar (Recovered), Duct]
SRP476050	Cohesin trajectories shape the epigenetic and transcriptional landscape of clustered Protocadherin genes for single neuron identities [Olfactory Epithilium]
SRP477968	Extraembryonic gut endoderm cells undergo programmed cell death elimination during development (WGBS) [Extraembryonic Endoderm (Distal), Extraembryonic Endoderm (Proximal), Hindgut Endoderm, Midgut Endoderm, Yolk Sac Endoderm]
SRP478001	Global epigenetic stability of liver-resident invariant natural killer T cells in response to cues capable of inducing transcriptional re-programming [Liver iNKT (aGalCer/CD1d Tetramer+)]
SRP480077	Remodeling the step-wise mouse placental development by using totipotent blastomere-like stem cells [WGBS] [mTELCs Induced, mTELSC Cultured In TX Medium, mTELSC-TO Cultured In TO Medium]
SRP482520	OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide (WGBS) [Embrionic Stem Cells]
SRP484966	Antisense transcription can induce expression memory via stable promoter repression [XX ESCs]
SRP486307	An unbiased genome-wide screen reveals that mouse metastable epialleles are extremely rare [Kidney, Liver]
SRP487504	Sex-Specific DNA Methylation and Gene Expression Changes in Mouse Placentas After Early Preimplantation Alcohol Exposure[Methyl-Seq] [Placenta]
SRP490016	Methylation status of CD4+ and CD11b+ cells from Dnmt3a+/+ or Dnmt3aR878/+ mice [CD11b+ Cells, CD4+ Cells]
SRP497496	Increased global DNA methylation by Dnmt3a disrupts skeletal muscle homeostasis, promotes age-related muscle atrophy, and reduces muscle metabolic elasticity [Skeletal Muscle, Gastrocnemius]
SRP497502	The chromatin accessibility landscape of mouse oocytes during configuration transition [BS-seq] [Oocyte]
SRP498773	GEO accession GSE262843 is currently private and is scheduled to be released on Jul 01, 2025. [CD8 T Cells]
SRP500539	Maternal obesity induces the meiotic defects and epigenetic alterations during fetal oocyte development [BiSulfite-seq] [Primordial Germ Cells]
SRP501862	Conserved epigenetic hallmarks of T-cell aging during immunity and malignancy [CD8 T Cells]
SRP503857	Mutant IDH1 inhibition induces reverse transcriptase and dsDNA sensing to activate tumor immunity [mouse WGBS] [Liver Cells, Tumor Cells]
SRP505989	Transgenerational inheritance of diabetes susceptibility in male offspring with maternal hyperandrogenism [WGBS] [SRS21226592, SRS21226593, SRS21226595, SRS21226596]
SRP511326	CXXC5 stabilizes DNA methylation patterns in mouse embryonic stem cells [Bisulfite-Seq] [mESC]
SRP512476	The role of the TET-dependent DNA demethylation pathway in photoreceptor development and pathology [SRS21554452, SRS21554453, SRS21554454, SRS21554455, SRS21554456, SRS21554457]
SRP521262	Whole genome bisulfite sequencing of mice treated by mitochondrial transplantation [Brain, Muscle]
SRP521804	Dnmt3a Controls Hematopoietic Stem Cells via DNA Methylation-Independent Regulation of Telomeres [BM, KSL]
SRP522281	Early Moderate Prenatal Alcohol Exposure and Maternal Diet Impact Offspring DNA Methylation Across Species [Brain, Liver]
SRP526206	Tet3 regulates terminal cell differentiation at the metabolic level [E18.5 Isolated Villi]
SRP526448	Epigenetic regulators of clonal hematopoiesis control CD8 T cell stemness during immunotherapy [Bisulfite-Seq] [CD8 T Cells]
SRP531904	The DNA demethylase TET1 modifies the impact of maternal folic acid status on embryonic brain development [E11.5 Brain]
SRP534659	Erosion of somatic tissue identity with loss of the X-linked intellectual disability factor KDM5C [Embryonic Stem Cell, Extended Epiblast-Like Cell]
SRP540228	The spatial zonation of the placental vasculature is specified by epigenetic mechanisms [WGBS] [Endothelial Cell]
SRP551216	Transcriptome and DNA methylome in oocytes exposed to gestational diabetes [Ovary]
SRP552104	Comparision of Differential methylation between Control and mutant Dnmt3a [KSL]

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SRX12454610
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SRX12454614
SRX12454615
SRX12454616
SRX12454617
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SRX12454628
SRX12454629
SRX12454630
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SRX12454645
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SRX12454653
SRX12454654
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SRX12454656
SRX12454657
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SRX12454661
SRX12454662
SRX12454663
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	experiment^↓1	views^↓2	Track Name^↓3
hide	SRX12454610	HMR	Whole Bone Marrow / SRX12454610 (HMR)	Data format
hide	SRX12454610	AMR	Whole Bone Marrow / SRX12454610 (AMR)	Data format
hide	SRX12454610	PMD	Whole Bone Marrow / SRX12454610 (PMD)	Data format
hide Configure	SRX12454610	CpG methylation	Whole Bone Marrow / SRX12454610 (CpG methylation)	Data format
hide Configure	SRX12454610	CpG reads	Whole Bone Marrow / SRX12454610 (CpG reads)	Data format
hide	SRX12454611	HMR	Whole Bone Marrow / SRX12454611 (HMR)	Data format
hide	SRX12454611	AMR	Whole Bone Marrow / SRX12454611 (AMR)	Data format
hide	SRX12454611	PMD	Whole Bone Marrow / SRX12454611 (PMD)	Data format
hide Configure	SRX12454611	CpG methylation	Whole Bone Marrow / SRX12454611 (CpG methylation)	Data format
hide Configure	SRX12454611	CpG reads	Whole Bone Marrow / SRX12454611 (CpG reads)	Data format
hide	SRX12454612	HMR	Whole Bone Marrow / SRX12454612 (HMR)	Data format
hide	SRX12454612	AMR	Whole Bone Marrow / SRX12454612 (AMR)	Data format
hide	SRX12454612	PMD	Whole Bone Marrow / SRX12454612 (PMD)	Data format
hide Configure	SRX12454612	CpG methylation	Whole Bone Marrow / SRX12454612 (CpG methylation)	Data format
hide Configure	SRX12454612	CpG reads	Whole Bone Marrow / SRX12454612 (CpG reads)	Data format
hide	SRX12454613	HMR	Whole Bone Marrow / SRX12454613 (HMR)	Data format
hide	SRX12454613	AMR	Whole Bone Marrow / SRX12454613 (AMR)	Data format
hide	SRX12454613	PMD	Whole Bone Marrow / SRX12454613 (PMD)	Data format
hide Configure	SRX12454613	CpG methylation	Whole Bone Marrow / SRX12454613 (CpG methylation)	Data format
hide Configure	SRX12454613	CpG reads	Whole Bone Marrow / SRX12454613 (CpG reads)	Data format
hide	SRX12454614	HMR	Whole Bone Marrow / SRX12454614 (HMR)	Data format
hide	SRX12454614	AMR	Whole Bone Marrow / SRX12454614 (AMR)	Data format
hide	SRX12454614	PMD	Whole Bone Marrow / SRX12454614 (PMD)	Data format
hide Configure	SRX12454614	CpG methylation	Whole Bone Marrow / SRX12454614 (CpG methylation)	Data format
hide Configure	SRX12454614	CpG reads	Whole Bone Marrow / SRX12454614 (CpG reads)	Data format
hide	SRX12454615	HMR	Whole Bone Marrow / SRX12454615 (HMR)	Data format
hide	SRX12454615	AMR	Whole Bone Marrow / SRX12454615 (AMR)	Data format
hide	SRX12454615	PMD	Whole Bone Marrow / SRX12454615 (PMD)	Data format
hide Configure	SRX12454615	CpG methylation	Whole Bone Marrow / SRX12454615 (CpG methylation)	Data format
hide Configure	SRX12454615	CpG reads	Whole Bone Marrow / SRX12454615 (CpG reads)	Data format
hide	SRX12454616	HMR	Whole Bone Marrow / SRX12454616 (HMR)	Data format
hide	SRX12454616	AMR	Whole Bone Marrow / SRX12454616 (AMR)	Data format
hide	SRX12454616	PMD	Whole Bone Marrow / SRX12454616 (PMD)	Data format
hide Configure	SRX12454616	CpG methylation	Whole Bone Marrow / SRX12454616 (CpG methylation)	Data format
hide Configure	SRX12454616	CpG reads	Whole Bone Marrow / SRX12454616 (CpG reads)	Data format
hide	SRX12454617	HMR	Whole Bone Marrow / SRX12454617 (HMR)	Data format
hide	SRX12454617	AMR	Whole Bone Marrow / SRX12454617 (AMR)	Data format
hide	SRX12454617	PMD	Whole Bone Marrow / SRX12454617 (PMD)	Data format
hide Configure	SRX12454617	CpG methylation	Whole Bone Marrow / SRX12454617 (CpG methylation)	Data format
hide Configure	SRX12454617	CpG reads	Whole Bone Marrow / SRX12454617 (CpG reads)	Data format
hide	SRX12454618	HMR	Whole Bone Marrow / SRX12454618 (HMR)	Data format
hide	SRX12454618	AMR	Whole Bone Marrow / SRX12454618 (AMR)	Data format
hide	SRX12454618	PMD	Whole Bone Marrow / SRX12454618 (PMD)	Data format
hide Configure	SRX12454618	CpG methylation	Whole Bone Marrow / SRX12454618 (CpG methylation)	Data format
hide Configure	SRX12454618	CpG reads	Whole Bone Marrow / SRX12454618 (CpG reads)	Data format
hide	SRX12454619	HMR	Whole Bone Marrow / SRX12454619 (HMR)	Data format
hide	SRX12454619	AMR	Whole Bone Marrow / SRX12454619 (AMR)	Data format
hide	SRX12454619	PMD	Whole Bone Marrow / SRX12454619 (PMD)	Data format
hide Configure	SRX12454619	CpG methylation	Whole Bone Marrow / SRX12454619 (CpG methylation)	Data format
hide Configure	SRX12454619	CpG reads	Whole Bone Marrow / SRX12454619 (CpG reads)	Data format
hide	SRX12454620	HMR	Whole Bone Marrow / SRX12454620 (HMR)	Data format
hide	SRX12454620	AMR	Whole Bone Marrow / SRX12454620 (AMR)	Data format
hide	SRX12454620	PMD	Whole Bone Marrow / SRX12454620 (PMD)	Data format
hide Configure	SRX12454620	CpG methylation	Whole Bone Marrow / SRX12454620 (CpG methylation)	Data format
hide Configure	SRX12454620	CpG reads	Whole Bone Marrow / SRX12454620 (CpG reads)	Data format
hide	SRX12454621	HMR	Whole Bone Marrow / SRX12454621 (HMR)	Data format
hide	SRX12454621	AMR	Whole Bone Marrow / SRX12454621 (AMR)	Data format
hide	SRX12454621	PMD	Whole Bone Marrow / SRX12454621 (PMD)	Data format
hide Configure	SRX12454621	CpG methylation	Whole Bone Marrow / SRX12454621 (CpG methylation)	Data format
hide Configure	SRX12454621	CpG reads	Whole Bone Marrow / SRX12454621 (CpG reads)	Data format
hide	SRX12454622	HMR	Whole Bone Marrow / SRX12454622 (HMR)	Data format
hide	SRX12454622	AMR	Whole Bone Marrow / SRX12454622 (AMR)	Data format
hide	SRX12454622	PMD	Whole Bone Marrow / SRX12454622 (PMD)	Data format
hide Configure	SRX12454622	CpG methylation	Whole Bone Marrow / SRX12454622 (CpG methylation)	Data format
hide Configure	SRX12454622	CpG reads	Whole Bone Marrow / SRX12454622 (CpG reads)	Data format
hide	SRX12454623	HMR	Whole Bone Marrow / SRX12454623 (HMR)	Data format
hide	SRX12454623	AMR	Whole Bone Marrow / SRX12454623 (AMR)	Data format
hide	SRX12454623	PMD	Whole Bone Marrow / SRX12454623 (PMD)	Data format
hide Configure	SRX12454623	CpG methylation	Whole Bone Marrow / SRX12454623 (CpG methylation)	Data format
hide Configure	SRX12454623	CpG reads	Whole Bone Marrow / SRX12454623 (CpG reads)	Data format
hide	SRX12454624	HMR	Whole Bone Marrow / SRX12454624 (HMR)	Data format
hide	SRX12454624	AMR	Whole Bone Marrow / SRX12454624 (AMR)	Data format
hide	SRX12454624	PMD	Whole Bone Marrow / SRX12454624 (PMD)	Data format
hide Configure	SRX12454624	CpG methylation	Whole Bone Marrow / SRX12454624 (CpG methylation)	Data format
hide Configure	SRX12454624	CpG reads	Whole Bone Marrow / SRX12454624 (CpG reads)	Data format
hide	SRX12454625	HMR	Whole Bone Marrow / SRX12454625 (HMR)	Data format
hide	SRX12454625	AMR	Whole Bone Marrow / SRX12454625 (AMR)	Data format
hide	SRX12454625	PMD	Whole Bone Marrow / SRX12454625 (PMD)	Data format
hide Configure	SRX12454625	CpG methylation	Whole Bone Marrow / SRX12454625 (CpG methylation)	Data format
hide Configure	SRX12454625	CpG reads	Whole Bone Marrow / SRX12454625 (CpG reads)	Data format
hide	SRX12454626	HMR	Whole Bone Marrow / SRX12454626 (HMR)	Data format
hide	SRX12454626	AMR	Whole Bone Marrow / SRX12454626 (AMR)	Data format
hide	SRX12454626	PMD	Whole Bone Marrow / SRX12454626 (PMD)	Data format
hide Configure	SRX12454626	CpG methylation	Whole Bone Marrow / SRX12454626 (CpG methylation)	Data format
hide Configure	SRX12454626	CpG reads	Whole Bone Marrow / SRX12454626 (CpG reads)	Data format
hide	SRX12454627	HMR	Whole Bone Marrow / SRX12454627 (HMR)	Data format
hide	SRX12454627	AMR	Whole Bone Marrow / SRX12454627 (AMR)	Data format
hide	SRX12454627	PMD	Whole Bone Marrow / SRX12454627 (PMD)	Data format
hide Configure	SRX12454627	CpG methylation	Whole Bone Marrow / SRX12454627 (CpG methylation)	Data format
hide Configure	SRX12454627	CpG reads	Whole Bone Marrow / SRX12454627 (CpG reads)	Data format
hide	SRX12454628	HMR	Whole Bone Marrow / SRX12454628 (HMR)	Data format
hide	SRX12454628	AMR	Whole Bone Marrow / SRX12454628 (AMR)	Data format
hide	SRX12454628	PMD	Whole Bone Marrow / SRX12454628 (PMD)	Data format
hide Configure	SRX12454628	CpG methylation	Whole Bone Marrow / SRX12454628 (CpG methylation)	Data format
hide Configure	SRX12454628	CpG reads	Whole Bone Marrow / SRX12454628 (CpG reads)	Data format
hide	SRX12454629	HMR	Whole Bone Marrow / SRX12454629 (HMR)	Data format
hide	SRX12454629	AMR	Whole Bone Marrow / SRX12454629 (AMR)	Data format
hide	SRX12454629	PMD	Whole Bone Marrow / SRX12454629 (PMD)	Data format
hide Configure	SRX12454629	CpG methylation	Whole Bone Marrow / SRX12454629 (CpG methylation)	Data format
hide Configure	SRX12454629	CpG reads	Whole Bone Marrow / SRX12454629 (CpG reads)	Data format
hide	SRX12454630	HMR	Whole Bone Marrow / SRX12454630 (HMR)	Data format
hide	SRX12454630	AMR	Whole Bone Marrow / SRX12454630 (AMR)	Data format
hide	SRX12454630	PMD	Whole Bone Marrow / SRX12454630 (PMD)	Data format
hide Configure	SRX12454630	CpG methylation	Whole Bone Marrow / SRX12454630 (CpG methylation)	Data format
hide Configure	SRX12454630	CpG reads	Whole Bone Marrow / SRX12454630 (CpG reads)	Data format
hide	SRX12454631	HMR	Whole Bone Marrow / SRX12454631 (HMR)	Data format
hide	SRX12454631	AMR	Whole Bone Marrow / SRX12454631 (AMR)	Data format
hide	SRX12454631	PMD	Whole Bone Marrow / SRX12454631 (PMD)	Data format
hide Configure	SRX12454631	CpG methylation	Whole Bone Marrow / SRX12454631 (CpG methylation)	Data format
hide Configure	SRX12454631	CpG reads	Whole Bone Marrow / SRX12454631 (CpG reads)	Data format
hide	SRX12454632	HMR	Whole Bone Marrow / SRX12454632 (HMR)	Data format
hide	SRX12454632	AMR	Whole Bone Marrow / SRX12454632 (AMR)	Data format
hide	SRX12454632	PMD	Whole Bone Marrow / SRX12454632 (PMD)	Data format
hide Configure	SRX12454632	CpG methylation	Whole Bone Marrow / SRX12454632 (CpG methylation)	Data format
hide Configure	SRX12454632	CpG reads	Whole Bone Marrow / SRX12454632 (CpG reads)	Data format
hide	SRX12454633	HMR	Whole Bone Marrow / SRX12454633 (HMR)	Data format
hide	SRX12454633	AMR	Whole Bone Marrow / SRX12454633 (AMR)	Data format
hide	SRX12454633	PMD	Whole Bone Marrow / SRX12454633 (PMD)	Data format
hide Configure	SRX12454633	CpG methylation	Whole Bone Marrow / SRX12454633 (CpG methylation)	Data format
hide Configure	SRX12454633	CpG reads	Whole Bone Marrow / SRX12454633 (CpG reads)	Data format
hide	SRX12454634	HMR	Whole Bone Marrow / SRX12454634 (HMR)	Data format
hide	SRX12454634	AMR	Whole Bone Marrow / SRX12454634 (AMR)	Data format
hide	SRX12454634	PMD	Whole Bone Marrow / SRX12454634 (PMD)	Data format
hide Configure	SRX12454634	CpG methylation	Whole Bone Marrow / SRX12454634 (CpG methylation)	Data format
hide Configure	SRX12454634	CpG reads	Whole Bone Marrow / SRX12454634 (CpG reads)	Data format
hide	SRX12454635	HMR	Lineage Negative Kit Positive Sca1 Positive / SRX12454635 (HMR)	Data format
hide	SRX12454635	AMR	Lineage Negative Kit Positive Sca1 Positive / SRX12454635 (AMR)	Data format
hide	SRX12454635	PMD	Lineage Negative Kit Positive Sca1 Positive / SRX12454635 (PMD)	Data format
hide Configure	SRX12454635	CpG methylation	Lineage Negative Kit Positive Sca1 Positive / SRX12454635 (CpG methylation)	Data format
hide Configure	SRX12454635	CpG reads	Lineage Negative Kit Positive Sca1 Positive / SRX12454635 (CpG reads)	Data format
hide	SRX12454636	HMR	MEP / SRX12454636 (HMR)	Data format
hide	SRX12454636	AMR	MEP / SRX12454636 (AMR)	Data format
hide	SRX12454636	PMD	MEP / SRX12454636 (PMD)	Data format
hide Configure	SRX12454636	CpG methylation	MEP / SRX12454636 (CpG methylation)	Data format
hide Configure	SRX12454636	CpG reads	MEP / SRX12454636 (CpG reads)	Data format
hide	SRX12454637	HMR	CMP / SRX12454637 (HMR)	Data format
hide	SRX12454637	AMR	CMP / SRX12454637 (AMR)	Data format
hide	SRX12454637	PMD	CMP / SRX12454637 (PMD)	Data format
hide Configure	SRX12454637	CpG methylation	CMP / SRX12454637 (CpG methylation)	Data format
hide Configure	SRX12454637	CpG reads	CMP / SRX12454637 (CpG reads)	Data format
hide	SRX12454638	HMR	GMP / SRX12454638 (HMR)	Data format
hide	SRX12454638	AMR	GMP / SRX12454638 (AMR)	Data format
hide	SRX12454638	PMD	GMP / SRX12454638 (PMD)	Data format
hide Configure	SRX12454638	CpG methylation	GMP / SRX12454638 (CpG methylation)	Data format
hide Configure	SRX12454638	CpG reads	GMP / SRX12454638 (CpG reads)	Data format
hide	SRX12454639	HMR	T-cells / SRX12454639 (HMR)	Data format
hide	SRX12454639	AMR	T-cells / SRX12454639 (AMR)	Data format
hide	SRX12454639	PMD	T-cells / SRX12454639 (PMD)	Data format
hide Configure	SRX12454639	CpG methylation	T-cells / SRX12454639 (CpG methylation)	Data format
hide Configure	SRX12454639	CpG reads	T-cells / SRX12454639 (CpG reads)	Data format
hide	SRX12454640	HMR	T-cells / SRX12454640 (HMR)	Data format
hide	SRX12454640	AMR	T-cells / SRX12454640 (AMR)	Data format
hide	SRX12454640	PMD	T-cells / SRX12454640 (PMD)	Data format
hide Configure	SRX12454640	CpG methylation	T-cells / SRX12454640 (CpG methylation)	Data format
hide Configure	SRX12454640	CpG reads	T-cells / SRX12454640 (CpG reads)	Data format
hide	SRX12454641	HMR	B-cells / SRX12454641 (HMR)	Data format
hide	SRX12454641	AMR	B-cells / SRX12454641 (AMR)	Data format
hide	SRX12454641	PMD	B-cells / SRX12454641 (PMD)	Data format
hide Configure	SRX12454641	CpG methylation	B-cells / SRX12454641 (CpG methylation)	Data format
hide Configure	SRX12454641	CpG reads	B-cells / SRX12454641 (CpG reads)	Data format
hide	SRX12454642	HMR	B-cells / SRX12454642 (HMR)	Data format
hide	SRX12454642	AMR	B-cells / SRX12454642 (AMR)	Data format
hide	SRX12454642	PMD	B-cells / SRX12454642 (PMD)	Data format
hide Configure	SRX12454642	CpG methylation	B-cells / SRX12454642 (CpG methylation)	Data format
hide Configure	SRX12454642	CpG reads	B-cells / SRX12454642 (CpG reads)	Data format
hide	SRX12454643	HMR	B-cells / SRX12454643 (HMR)	Data format
hide	SRX12454643	AMR	B-cells / SRX12454643 (AMR)	Data format
hide	SRX12454643	PMD	B-cells / SRX12454643 (PMD)	Data format
hide Configure	SRX12454643	CpG methylation	B-cells / SRX12454643 (CpG methylation)	Data format
hide Configure	SRX12454643	CpG reads	B-cells / SRX12454643 (CpG reads)	Data format
hide	SRX12454644	HMR	Whole Bone Marrow / SRX12454644 (HMR)	Data format
hide	SRX12454644	AMR	Whole Bone Marrow / SRX12454644 (AMR)	Data format
hide	SRX12454644	PMD	Whole Bone Marrow / SRX12454644 (PMD)	Data format
hide Configure	SRX12454644	CpG methylation	Whole Bone Marrow / SRX12454644 (CpG methylation)	Data format
hide Configure	SRX12454644	CpG reads	Whole Bone Marrow / SRX12454644 (CpG reads)	Data format
hide	SRX12454645	HMR	B-cells / SRX12454645 (HMR)	Data format
hide	SRX12454645	AMR	B-cells / SRX12454645 (AMR)	Data format
hide	SRX12454645	PMD	B-cells / SRX12454645 (PMD)	Data format
hide Configure	SRX12454645	CpG methylation	B-cells / SRX12454645 (CpG methylation)	Data format
hide Configure	SRX12454645	CpG reads	B-cells / SRX12454645 (CpG reads)	Data format
hide	SRX12454646	HMR	Myeloid Cells / SRX12454646 (HMR)	Data format
hide	SRX12454646	AMR	Myeloid Cells / SRX12454646 (AMR)	Data format
hide	SRX12454646	PMD	Myeloid Cells / SRX12454646 (PMD)	Data format
hide Configure	SRX12454646	CpG methylation	Myeloid Cells / SRX12454646 (CpG methylation)	Data format
hide Configure	SRX12454646	CpG reads	Myeloid Cells / SRX12454646 (CpG reads)	Data format
hide	SRX12454647	HMR	Myeloid Cells / SRX12454647 (HMR)	Data format
hide	SRX12454647	AMR	Myeloid Cells / SRX12454647 (AMR)	Data format
hide	SRX12454647	PMD	Myeloid Cells / SRX12454647 (PMD)	Data format
hide Configure	SRX12454647	CpG methylation	Myeloid Cells / SRX12454647 (CpG methylation)	Data format
hide Configure	SRX12454647	CpG reads	Myeloid Cells / SRX12454647 (CpG reads)	Data format
hide	SRX12454648	HMR	Whole Bone Marrow / SRX12454648 (HMR)	Data format
hide	SRX12454648	AMR	Whole Bone Marrow / SRX12454648 (AMR)	Data format
hide	SRX12454648	PMD	Whole Bone Marrow / SRX12454648 (PMD)	Data format
hide Configure	SRX12454648	CpG methylation	Whole Bone Marrow / SRX12454648 (CpG methylation)	Data format
hide Configure	SRX12454648	CpG reads	Whole Bone Marrow / SRX12454648 (CpG reads)	Data format
hide	SRX12454649	HMR	Whole Bone Marrow / SRX12454649 (HMR)	Data format
hide	SRX12454649	AMR	Whole Bone Marrow / SRX12454649 (AMR)	Data format
hide	SRX12454649	PMD	Whole Bone Marrow / SRX12454649 (PMD)	Data format
hide Configure	SRX12454649	CpG methylation	Whole Bone Marrow / SRX12454649 (CpG methylation)	Data format
hide Configure	SRX12454649	CpG reads	Whole Bone Marrow / SRX12454649 (CpG reads)	Data format
hide	SRX12454650	HMR	Myeloid Cells / SRX12454650 (HMR)	Data format
hide	SRX12454650	AMR	Myeloid Cells / SRX12454650 (AMR)	Data format
hide	SRX12454650	PMD	Myeloid Cells / SRX12454650 (PMD)	Data format
hide Configure	SRX12454650	CpG methylation	Myeloid Cells / SRX12454650 (CpG methylation)	Data format
hide Configure	SRX12454650	CpG reads	Myeloid Cells / SRX12454650 (CpG reads)	Data format
hide	SRX12454651	HMR	Lineage Negative Kit Positive Sca1 Positive / SRX12454651 (HMR)	Data format
hide	SRX12454651	AMR	Lineage Negative Kit Positive Sca1 Positive / SRX12454651 (AMR)	Data format
hide	SRX12454651	PMD	Lineage Negative Kit Positive Sca1 Positive / SRX12454651 (PMD)	Data format
hide Configure	SRX12454651	CpG methylation	Lineage Negative Kit Positive Sca1 Positive / SRX12454651 (CpG methylation)	Data format
hide Configure	SRX12454651	CpG reads	Lineage Negative Kit Positive Sca1 Positive / SRX12454651 (CpG reads)	Data format
hide	SRX12454652	HMR	Lineage Negative Kit Positive Sca1 Positive / SRX12454652 (HMR)	Data format
hide	SRX12454652	AMR	Lineage Negative Kit Positive Sca1 Positive / SRX12454652 (AMR)	Data format
hide	SRX12454652	PMD	Lineage Negative Kit Positive Sca1 Positive / SRX12454652 (PMD)	Data format
hide Configure	SRX12454652	CpG methylation	Lineage Negative Kit Positive Sca1 Positive / SRX12454652 (CpG methylation)	Data format
hide Configure	SRX12454652	CpG reads	Lineage Negative Kit Positive Sca1 Positive / SRX12454652 (CpG reads)	Data format
hide	SRX12454653	HMR	CMP / SRX12454653 (HMR)	Data format
hide	SRX12454653	AMR	CMP / SRX12454653 (AMR)	Data format
hide	SRX12454653	PMD	CMP / SRX12454653 (PMD)	Data format
hide Configure	SRX12454653	CpG methylation	CMP / SRX12454653 (CpG methylation)	Data format
hide Configure	SRX12454653	CpG reads	CMP / SRX12454653 (CpG reads)	Data format
hide	SRX12454654	HMR	GMP / SRX12454654 (HMR)	Data format
hide	SRX12454654	AMR	GMP / SRX12454654 (AMR)	Data format
hide	SRX12454654	PMD	GMP / SRX12454654 (PMD)	Data format
hide Configure	SRX12454654	CpG methylation	GMP / SRX12454654 (CpG methylation)	Data format
hide Configure	SRX12454654	CpG reads	GMP / SRX12454654 (CpG reads)	Data format
hide	SRX12454655	HMR	Whole Bone Marrow / SRX12454655 (HMR)	Data format
hide	SRX12454655	AMR	Whole Bone Marrow / SRX12454655 (AMR)	Data format
hide	SRX12454655	PMD	Whole Bone Marrow / SRX12454655 (PMD)	Data format
hide Configure	SRX12454655	CpG methylation	Whole Bone Marrow / SRX12454655 (CpG methylation)	Data format
hide Configure	SRX12454655	CpG reads	Whole Bone Marrow / SRX12454655 (CpG reads)	Data format
hide	SRX12454656	HMR	MEP / SRX12454656 (HMR)	Data format
hide	SRX12454656	AMR	MEP / SRX12454656 (AMR)	Data format
hide	SRX12454656	PMD	MEP / SRX12454656 (PMD)	Data format
hide Configure	SRX12454656	CpG methylation	MEP / SRX12454656 (CpG methylation)	Data format
hide Configure	SRX12454656	CpG reads	MEP / SRX12454656 (CpG reads)	Data format
hide	SRX12454657	HMR	B-cells / SRX12454657 (HMR)	Data format
hide	SRX12454657	AMR	B-cells / SRX12454657 (AMR)	Data format
hide	SRX12454657	PMD	B-cells / SRX12454657 (PMD)	Data format
hide Configure	SRX12454657	CpG methylation	B-cells / SRX12454657 (CpG methylation)	Data format
hide Configure	SRX12454657	CpG reads	B-cells / SRX12454657 (CpG reads)	Data format
hide	SRX12454658	HMR	B-cells / SRX12454658 (HMR)	Data format
hide	SRX12454658	AMR	B-cells / SRX12454658 (AMR)	Data format
hide	SRX12454658	PMD	B-cells / SRX12454658 (PMD)	Data format
hide Configure	SRX12454658	CpG methylation	B-cells / SRX12454658 (CpG methylation)	Data format
hide Configure	SRX12454658	CpG reads	B-cells / SRX12454658 (CpG reads)	Data format
hide	SRX12454659	HMR	B-cells / SRX12454659 (HMR)	Data format
hide	SRX12454659	AMR	B-cells / SRX12454659 (AMR)	Data format
hide	SRX12454659	PMD	B-cells / SRX12454659 (PMD)	Data format
hide Configure	SRX12454659	CpG methylation	B-cells / SRX12454659 (CpG methylation)	Data format
hide Configure	SRX12454659	CpG reads	B-cells / SRX12454659 (CpG reads)	Data format
hide	SRX12454660	HMR	Whole Bone Marrow / SRX12454660 (HMR)	Data format
hide	SRX12454660	AMR	Whole Bone Marrow / SRX12454660 (AMR)	Data format
hide	SRX12454660	PMD	Whole Bone Marrow / SRX12454660 (PMD)	Data format
hide Configure	SRX12454660	CpG methylation	Whole Bone Marrow / SRX12454660 (CpG methylation)	Data format
hide Configure	SRX12454660	CpG reads	Whole Bone Marrow / SRX12454660 (CpG reads)	Data format
hide	SRX12454661	HMR	Whole Bone Marrow / SRX12454661 (HMR)	Data format
hide	SRX12454661	AMR	Whole Bone Marrow / SRX12454661 (AMR)	Data format
hide	SRX12454661	PMD	Whole Bone Marrow / SRX12454661 (PMD)	Data format
hide Configure	SRX12454661	CpG methylation	Whole Bone Marrow / SRX12454661 (CpG methylation)	Data format
hide Configure	SRX12454661	CpG reads	Whole Bone Marrow / SRX12454661 (CpG reads)	Data format
hide	SRX12454662	HMR	Whole Bone Marrow / SRX12454662 (HMR)	Data format
hide	SRX12454662	AMR	Whole Bone Marrow / SRX12454662 (AMR)	Data format
hide	SRX12454662	PMD	Whole Bone Marrow / SRX12454662 (PMD)	Data format
hide Configure	SRX12454662	CpG methylation	Whole Bone Marrow / SRX12454662 (CpG methylation)	Data format
hide Configure	SRX12454662	CpG reads	Whole Bone Marrow / SRX12454662 (CpG reads)	Data format
hide	SRX12454663	HMR	Whole Bone Marrow / SRX12454663 (HMR)	Data format
hide	SRX12454663	AMR	Whole Bone Marrow / SRX12454663 (AMR)	Data format
hide	SRX12454663	PMD	Whole Bone Marrow / SRX12454663 (PMD)	Data format
hide Configure	SRX12454663	CpG methylation	Whole Bone Marrow / SRX12454663 (CpG methylation)	Data format
hide Configure	SRX12454663	CpG reads	Whole Bone Marrow / SRX12454663 (CpG reads)	Data format

Assembly: Mouse Jun. 2020 (GRCm39/mm39)

Study title: Somatic Dnmt3a deletion in murine hematopoietic cells
SRA: SRP339793
GEO: not found
Pubmed: not found

Experiment	Label	Methylation	Coverage	HMRs	HMR size	AMRs	AMR size	PMDs	PMD size	Conversion	Title
SRX12454610	Whole Bone Marrow	0.672	18.8	68085	1175.8	629	1063.0	4399	11272.0	0.985	Dnmt3a-/- no dox
SRX12454611	Whole Bone Marrow	0.686	12.2	62844	1237.8	243	956.3	2753	18939.8	0.986	Dnmt3a-/- no dox
SRX12454612	Whole Bone Marrow	0.691	11.1	44962	1176.3	439	1073.0	1132	16599.6	0.985	Dnmt3a-/- with dox
SRX12454613	Whole Bone Marrow	0.686	13.7	50375	1139.9	275	958.1	1508	13636.2	0.986	Dnmt3a-/- with dox
SRX12454614	Whole Bone Marrow	0.659	8.7	41107	1293.0	259	971.6	1235	12465.0	0.986	Dnmt3a-/- with dox
SRX12454615	Whole Bone Marrow	0.701	14.8	50292	1101.6	572	1096.0	1300	13982.5	0.980	Dnmt3a-/- with dox
SRX12454616	Whole Bone Marrow	0.690	4.1	33864	1576.7	45	943.8	480	27662.0	0.986	Dnmt3a-/- with dox
SRX12454617	Whole Bone Marrow	0.686	15.9	47667	1059.3	613	1044.7	1229	12047.8	0.983	Dnmt3a-/- with dox
SRX12454618	Whole Bone Marrow	0.678	13.0	46757	1084.4	622	1000.7	1089	12484.6	0.984	Dnmt3a-/- with dox
SRX12454619	Whole Bone Marrow	0.720	14.7	47187	1029.3	573	1055.8	1318	11241.9	0.984	Dnmt3a-/- with dox
SRX12454620	Whole Bone Marrow	0.739	9.9	48271	1103.1	286	913.8	1555	12139.9	0.985	Dnmt3a fl/fl with tam
SRX12454621	Whole Bone Marrow	0.725	5.9	41806	1308.8	266	1017.6	815	21585.9	0.983	Dnmt3a fl/fl with tam
SRX12454622	Whole Bone Marrow	0.666	14.9	62153	1198.5	532	1100.4	2470	18255.9	0.986	Dnmt3a-/- no dox
SRX12454623	Whole Bone Marrow	0.740	11.1	55559	1081.4	327	925.1	1786	13717.0	0.984	Dnmt3a fl/fl with tam
SRX12454624	Whole Bone Marrow	0.725	11.9	54506	1078.1	351	911.5	1701	13635.6	0.983	Dnmt3a fl/fl with tam
SRX12454625	Whole Bone Marrow	0.691	7.2	44106	1302.8	141	1090.4	1222	16163.3	0.986	Dnmt3a fl/fl with tam
SRX12454626	Whole Bone Marrow	0.671	16.7	57141	1035.7	522	1657.0	2869	8338.3	0.983	Dnmt3a fl/fl with tam
SRX12454627	Whole Bone Marrow	0.692	26.7	67597	937.9	963	850.9	2789	9352.9	0.985	Dnmt3a fl/fl with tam
SRX12454628	Whole Bone Marrow	0.737	10.4	44910	1075.1	295	917.9	1253	11215.5	0.985	Dnmt3a fl/fl no tam
SRX12454629	Whole Bone Marrow	0.764	6.6	41895	1169.7	168	949.6	1047	14086.0	0.985	Dnmt3a fl/fl no tam
SRX12454630	Whole Bone Marrow	0.749	11.0	46647	1059.7	418	872.5	1240	12138.3	0.986	Dnmt3a fl/fl no tam
SRX12454631	Whole Bone Marrow	0.760	10.3	45726	1083.9	302	911.7	1312	11570.6	0.984	Dnmt3a fl/fl no tam
SRX12454632	Whole Bone Marrow	0.733	11.8	45977	1054.5	398	853.7	1210	11587.1	0.984	Dnmt3a fl/fl no tam
SRX12454633	Whole Bone Marrow	0.656	17.4	63572	1157.6	706	1104.0	2684	17317.5	0.984	Dnmt3a-/- no dox
SRX12454634	Whole Bone Marrow	0.760	9.8	51089	1061.1	248	963.5	1560	11781.2	0.986	Dnmt3a fl/fl no tam
SRX12454635	Lineage Negative Kit Positive Sca1 Positive	0.790	13.1	48618	1031.6	547	1005.3	3402	6707.7	0.985	Dnmt3a+/+
SRX12454636	MEP	0.751	12.4	49972	1042.7	447	1026.4	1256	12100.0	0.985	Dnmt3a+/+
SRX12454637	CMP	0.822	13.8	58166	959.4	590	985.5	3630	7299.6	0.985	Dnmt3a+/+
SRX12454638	GMP	0.807	13.8	62939	938.5	633	1029.7	3589	8164.4	0.985	Dnmt3a+/+
SRX12454639	T-cells	0.789	12.6	47655	1085.1	634	1045.6	2507	8658.8	0.984	Dnmt3a+/+
SRX12454640	T-cells	0.788	15.0	51107	1037.2	741	1065.4	2817	8113.2	0.984	Dnmt3a+/+
SRX12454641	B-cells	0.807	15.0	56729	971.3	702	1073.4	3214	7466.6	0.984	Dnmt3a+/+
SRX12454642	B-cells	0.803	13.6	55620	982.5	669	1071.7	2775	7903.3	0.984	Dnmt3a+/+
SRX12454643	B-cells	0.799	6.4	44178	1148.9	256	1017.4	1044	16129.1	0.985	Dnmt3a+/+
SRX12454644	Whole Bone Marrow	0.629	3.3	32620	2441.5	20	965.5	910	47346.7	0.986	Dnmt3a-/- no dox
SRX12454645	B-cells	0.796	6.8	44699	1122.1	191	1021.8	999	15099.5	0.985	Dnmt3a+/+
SRX12454646	Myeloid Cells	0.780	14.5	64707	931.7	655	1734.5	3362	7887.2	0.984	Dnmt3a+/+
SRX12454647	Myeloid Cells	0.778	14.0	63648	933.5	678	1090.0	3287	7764.0	0.984	Dnmt3a+/+
SRX12454648	Whole Bone Marrow	0.729	14.4	48641	1024.1	811	978.8	2450	7617.1	0.984	Dnmt3a+/+
SRX12454649	Whole Bone Marrow	0.715	16.4	50600	995.9	859	1003.8	2338	7692.4	0.984	Dnmt3a+/+
SRX12454650	Myeloid Cells	0.722	12.7	71000	1261.0	516	1113.0	5263	13410.0	0.984	Dnmt3a-/-
SRX12454651	Lineage Negative Kit Positive Sca1 Positive	0.741	10.8	65609	1284.1	383	1098.0	3703	23020.9	0.983	Dnmt3a-/-
SRX12454652	Lineage Negative Kit Positive Sca1 Positive	0.731	13.8	66401	1234.1	558	1057.4	5052	12995.5	0.986	Dnmt3a-/-
SRX12454653	CMP	0.748	12.9	68420	1235.2	472	1098.4	5344	13317.3	0.985	Dnmt3a-/-
SRX12454654	GMP	0.745	13.3	71911	1223.3	533	1117.1	5373	15015.1	0.985	Dnmt3a-/-
SRX12454655	Whole Bone Marrow	0.650	17.2	65164	1149.5	727	1104.3	2591	18068.3	0.982	Dnmt3a-/- no dox
SRX12454656	MEP	0.700	13.8	67733	1218.0	471	1113.9	4644	12358.7	0.985	Dnmt3a-/-
SRX12454657	B-cells	0.708	6.4	50989	1655.6	352	1049.0	2326	31293.7	0.985	Dnmt3a-/-
SRX12454658	B-cells	0.732	6.2	54590	1538.7	214	1120.7	2382	33604.6	0.985	Dnmt3a-/-
SRX12454659	B-cells	0.744	12.3	67531	1278.3	476	1129.2	4892	14033.1	0.984	Dnmt3a-/-
SRX12454660	Whole Bone Marrow	0.673	11.9	63394	1267.8	443	1070.0	2957	18712.6	0.984	Dnmt3a-/- no dox
SRX12454661	Whole Bone Marrow	0.661	11.0	55891	1286.1	429	1125.6	1894	21664.9	0.984	Dnmt3a-/- no dox
SRX12454662	Whole Bone Marrow	0.708	14.3	54226	1182.8	479	1091.5	2936	9754.8	0.985	Dnmt3a-/- with dox
SRX12454663	Whole Bone Marrow	0.718	12.6	53456	1184.6	211	976.1	1609	15692.6	0.985	Dnmt3a-/- with dox

Methods

All analysis was done using a bisulfite sequnecing data analysis pipeline DNMTools developed in the Smith lab at USC.

Mapping reads from bisulfite sequencing: Bisulfite treated reads are mapped to the genomes with the abismal program. Input reads are filtered by their quality, and adapter sequences in the 3' end of reads are trimmed. This is done with cutadapt. Uniquely mapped reads with mismatches/indels below given threshold are retained. For pair-end reads, if the two mates overlap, the overlapping part of the mate with lower quality is discarded. After mapping, we use the format command in dnmtools to merge mates for paired-end reads. We use the dnmtools uniq command to randomly select one from multiple reads mapped exactly to the same location. Without random oligos as UMIs, this is our best indication of PCR duplicates.

Estimating methylation levels: After reads are mapped and filtered, the dnmtools counts command is used to obtain read coverage and estimate methylation levels at individual cytosine sites. We count the number of methylated reads (those containing a C) and the number of unmethylated reads (those containing a T) at each nucleotide in a mapped read that corresponds to a cytosine in the reference genome. The methylation level of that cytosine is estimated as the ratio of methylated to total reads covering that cytosine. For cytosines in the symmetric CpG sequence context, reads from the both strands are collapsed to give a single estimate. Very rarely do the levels differ between strands (typically only if there has been a substitution, as in a somatic mutation), and this approach gives a better estimate.

Bisulfite conversion rate: The bisulfite conversion rate for an experiment is estimated with the dnmtools bsrate command, which computes the fraction of successfully converted nucleotides in reads (those read out as Ts) among all nucleotides in the reads mapped that map over cytosines in the reference genome. This is done either using a spike-in (e.g., lambda), the mitochondrial DNA, or the nuclear genome. In the latter case, only non-CpG sites are used. While this latter approach can be impacted by non-CpG cytosine methylation, in practice it never amounts to much.

Identifying hypomethylated regions (HMRs): In most mammalian cells, the majority of the genome has high methylation, and regions of low methylation are typically the interesting features. (This seems to be true for essentially all healthy differentiated cell types, but not cells of very early embryogenesis, various germ cells and precursors, and placental lineage cells.) These are valleys of low methylation are called hypomethylated regions (HMR) for historical reasons. To identify the HMRs, we use the dnmtools hmr command, which uses a statistical model that accounts for both the methylation level fluctations and the varying amounts of data available at each CpG site.

Partially methylated domains: Partially methylated domains are large genomic regions showing partial methylation observed in immortalized cell lines and cancerous cells. The pmd program is used to identify PMDs.

Allele-specific methylation: Allele-Specific methylated regions refers to regions where the parental allele is differentially methylated compared to the maternal allele. The program allelic is used to compute allele-specific methylation score can be computed for each CpG site by testing the linkage between methylation status of adjacent reads, and the program amrfinder is used to identify regions with allele-specific methylation.

For more detailed description of the methods of each step, please refer to the DNMTools documentation.