Human methylome studies SRP155006 Track Settings
 
Epigenomic signatures in liver and blood of Wilson disease patients include hypermethylation of liver-specific enhancers [Liver, Whole Blood]

Track collection: Human methylome studies

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experiment
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experiment
 All views AMR  CpG reads  HMR  PMD  CpG methylation 
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 SRX4452737  CpG methylation  Liver / SRX4452737 (CpG methylation)   Data format 
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 SRX4452738  HMR  Liver / SRX4452738 (HMR)   Data format 
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 SRX4452738  CpG methylation  Liver / SRX4452738 (CpG methylation)   Data format 
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 SRX4452739  HMR  Liver / SRX4452739 (HMR)   Data format 
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 SRX4452739  CpG methylation  Liver / SRX4452739 (CpG methylation)   Data format 
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 SRX4452740  CpG methylation  Liver / SRX4452740 (CpG methylation)   Data format 
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 SRX4452741  HMR  Liver / SRX4452741 (HMR)   Data format 
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 SRX4452741  CpG methylation  Liver / SRX4452741 (CpG methylation)   Data format 
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 SRX4452742  HMR  Liver / SRX4452742 (HMR)   Data format 
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 SRX4452742  CpG methylation  Liver / SRX4452742 (CpG methylation)   Data format 
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 SRX4452743  CpG methylation  Liver / SRX4452743 (CpG methylation)   Data format 
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 SRX4452744  HMR  Liver / SRX4452744 (HMR)   Data format 
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 SRX4452744  CpG methylation  Liver / SRX4452744 (CpG methylation)   Data format 
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 SRX4452745  HMR  Liver / SRX4452745 (HMR)   Data format 
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 SRX4452745  CpG methylation  Liver / SRX4452745 (CpG methylation)   Data format 
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 SRX4452746  HMR  Liver / SRX4452746 (HMR)   Data format 
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 SRX4452746  CpG methylation  Liver / SRX4452746 (CpG methylation)   Data format 
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 SRX4452747  HMR  Liver / SRX4452747 (HMR)   Data format 
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 SRX4452747  CpG methylation  Liver / SRX4452747 (CpG methylation)   Data format 
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 SRX4452748  HMR  Liver / SRX4452748 (HMR)   Data format 
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 SRX4452748  CpG methylation  Liver / SRX4452748 (CpG methylation)   Data format 
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 SRX4452749  CpG methylation  Liver / SRX4452749 (CpG methylation)   Data format 
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 SRX4452750  CpG methylation  Liver / SRX4452750 (CpG methylation)   Data format 
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 SRX4452751  CpG methylation  Liver / SRX4452751 (CpG methylation)   Data format 
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 SRX4452752  CpG methylation  Liver / SRX4452752 (CpG methylation)   Data format 
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 SRX4452753  CpG methylation  Liver / SRX4452753 (CpG methylation)   Data format 
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 SRX4452754  CpG methylation  Liver / SRX4452754 (CpG methylation)   Data format 
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 SRX4452755  CpG methylation  Liver / SRX4452755 (CpG methylation)   Data format 
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 SRX4452756  CpG methylation  Liver / SRX4452756 (CpG methylation)   Data format 
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 SRX4452757  CpG methylation  Liver / SRX4452757 (CpG methylation)   Data format 
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 SRX4452758  HMR  Whole Blood / SRX4452758 (HMR)   Data format 
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 SRX4452758  CpG methylation  Whole Blood / SRX4452758 (CpG methylation)   Data format 
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 SRX4452759  HMR  Whole Blood / SRX4452759 (HMR)   Data format 
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 SRX4452759  CpG methylation  Whole Blood / SRX4452759 (CpG methylation)   Data format 
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 SRX4452760  HMR  Whole Blood / SRX4452760 (HMR)   Data format 
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 SRX4452760  CpG methylation  Whole Blood / SRX4452760 (CpG methylation)   Data format 
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 SRX4452761  HMR  Whole Blood / SRX4452761 (HMR)   Data format 
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 SRX4452761  CpG methylation  Whole Blood / SRX4452761 (CpG methylation)   Data format 
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 SRX4452762  HMR  Whole Blood / SRX4452762 (HMR)   Data format 
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 SRX4452762  CpG methylation  Whole Blood / SRX4452762 (CpG methylation)   Data format 
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 SRX4452763  HMR  Whole Blood / SRX4452763 (HMR)   Data format 
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 SRX4452763  CpG methylation  Whole Blood / SRX4452763 (CpG methylation)   Data format 
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 SRX4452764  HMR  Whole Blood / SRX4452764 (HMR)   Data format 
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 SRX4452764  CpG methylation  Whole Blood / SRX4452764 (CpG methylation)   Data format 
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 SRX4452765  HMR  Whole Blood / SRX4452765 (HMR)   Data format 
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 SRX4452765  CpG methylation  Whole Blood / SRX4452765 (CpG methylation)   Data format 
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 SRX4452766  HMR  Whole Blood / SRX4452766 (HMR)   Data format 
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 SRX4452766  CpG methylation  Whole Blood / SRX4452766 (CpG methylation)   Data format 
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 SRX4452767  HMR  Whole Blood / SRX4452767 (HMR)   Data format 
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 SRX4452767  CpG methylation  Whole Blood / SRX4452767 (CpG methylation)   Data format 
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 SRX4452768  HMR  Whole Blood / SRX4452768 (HMR)   Data format 
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 SRX4452768  CpG methylation  Whole Blood / SRX4452768 (CpG methylation)   Data format 
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 SRX4452769  HMR  Whole Blood / SRX4452769 (HMR)   Data format 
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 SRX4452769  CpG methylation  Whole Blood / SRX4452769 (CpG methylation)   Data format 
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 SRX4452770  HMR  Whole Blood / SRX4452770 (HMR)   Data format 
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 SRX4452770  CpG methylation  Whole Blood / SRX4452770 (CpG methylation)   Data format 
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 SRX4452771  HMR  Whole Blood / SRX4452771 (HMR)   Data format 
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 SRX4452771  CpG methylation  Whole Blood / SRX4452771 (CpG methylation)   Data format 
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 SRX4452772  HMR  Whole Blood / SRX4452772 (HMR)   Data format 
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 SRX4452772  CpG methylation  Whole Blood / SRX4452772 (CpG methylation)   Data format 
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 SRX4452773  HMR  Whole Blood / SRX4452773 (HMR)   Data format 
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 SRX4452773  CpG methylation  Whole Blood / SRX4452773 (CpG methylation)   Data format 
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 SRX4452774  HMR  Whole Blood / SRX4452774 (HMR)   Data format 
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 SRX4452774  CpG methylation  Whole Blood / SRX4452774 (CpG methylation)   Data format 
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 SRX4452775  HMR  Whole Blood / SRX4452775 (HMR)   Data format 
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 SRX4452775  CpG methylation  Whole Blood / SRX4452775 (CpG methylation)   Data format 
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 SRX4452776  HMR  Whole Blood / SRX4452776 (HMR)   Data format 
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 SRX4452776  CpG methylation  Whole Blood / SRX4452776 (CpG methylation)   Data format 
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 SRX4452777  HMR  Whole Blood / SRX4452777 (HMR)   Data format 
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 SRX4452777  CpG methylation  Whole Blood / SRX4452777 (CpG methylation)   Data format 
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 SRX4452778  HMR  Whole Blood / SRX4452778 (HMR)   Data format 
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 SRX4452778  CpG methylation  Whole Blood / SRX4452778 (CpG methylation)   Data format 
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 SRX4452779  HMR  Whole Blood / SRX4452779 (HMR)   Data format 
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 SRX4452779  CpG methylation  Whole Blood / SRX4452779 (CpG methylation)   Data format 
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 SRX4452780  HMR  Whole Blood / SRX4452780 (HMR)   Data format 
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 SRX4452780  CpG methylation  Whole Blood / SRX4452780 (CpG methylation)   Data format 
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 SRX4452781  HMR  Whole Blood / SRX4452781 (HMR)   Data format 
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 SRX4452781  CpG methylation  Whole Blood / SRX4452781 (CpG methylation)   Data format 
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 SRX4452782  HMR  Whole Blood / SRX4452782 (HMR)   Data format 
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 SRX4452782  CpG methylation  Whole Blood / SRX4452782 (CpG methylation)   Data format 
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 SRX4452783  HMR  Whole Blood / SRX4452783 (HMR)   Data format 
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 SRX4452783  CpG methylation  Whole Blood / SRX4452783 (CpG methylation)   Data format 
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 SRX4452784  HMR  Whole Blood / SRX4452784 (HMR)   Data format 
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 SRX4452784  CpG methylation  Whole Blood / SRX4452784 (CpG methylation)   Data format 
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 SRX4452785  HMR  Whole Blood / SRX4452785 (HMR)   Data format 
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 SRX4452785  CpG methylation  Whole Blood / SRX4452785 (CpG methylation)   Data format 
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 SRX4452786  HMR  Whole Blood / SRX4452786 (HMR)   Data format 
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 SRX4452786  CpG methylation  Whole Blood / SRX4452786 (CpG methylation)   Data format 
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 SRX4452787  HMR  Whole Blood / SRX4452787 (HMR)   Data format 
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 SRX4452787  CpG methylation  Whole Blood / SRX4452787 (CpG methylation)   Data format 
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 SRX4452788  HMR  Whole Blood / SRX4452788 (HMR)   Data format 
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 SRX4452788  CpG methylation  Whole Blood / SRX4452788 (CpG methylation)   Data format 
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 SRX4452789  CpG methylation  Whole Blood / SRX4452789 (CpG methylation)   Data format 
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 SRX4452790  HMR  Whole Blood / SRX4452790 (HMR)   Data format 
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 SRX4452790  CpG methylation  Whole Blood / SRX4452790 (CpG methylation)   Data format 
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 SRX4452791  HMR  Whole Blood / SRX4452791 (HMR)   Data format 
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 SRX4452791  CpG methylation  Whole Blood / SRX4452791 (CpG methylation)   Data format 
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 SRX4452792  CpG methylation  Whole Blood / SRX4452792 (CpG methylation)   Data format 
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 SRX4452793  CpG methylation  Whole Blood / SRX4452793 (CpG methylation)   Data format 
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 SRX4452794  HMR  Whole Blood / SRX4452794 (HMR)   Data format 
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 SRX4452794  CpG methylation  Whole Blood / SRX4452794 (CpG methylation)   Data format 
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 SRX4452795  HMR  Whole Blood / SRX4452795 (HMR)   Data format 
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 SRX4452795  CpG methylation  Whole Blood / SRX4452795 (CpG methylation)   Data format 
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 SRX4452796  CpG methylation  Whole Blood / SRX4452796 (CpG methylation)   Data format 
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 SRX4452797  HMR  Whole Blood / SRX4452797 (HMR)   Data format 
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 SRX4452797  CpG methylation  Whole Blood / SRX4452797 (CpG methylation)   Data format 
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 SRX4452798  HMR  Whole Blood / SRX4452798 (HMR)   Data format 
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 SRX4452798  CpG methylation  Whole Blood / SRX4452798 (CpG methylation)   Data format 
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 SRX4452799  HMR  Whole Blood / SRX4452799 (HMR)   Data format 
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 SRX4452799  CpG methylation  Whole Blood / SRX4452799 (CpG methylation)   Data format 
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 SRX4452800  HMR  Whole Blood / SRX4452800 (HMR)   Data format 
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 SRX4452800  CpG methylation  Whole Blood / SRX4452800 (CpG methylation)   Data format 
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 SRX4452801  HMR  Whole Blood / SRX4452801 (HMR)   Data format 
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 SRX4452801  CpG methylation  Whole Blood / SRX4452801 (CpG methylation)   Data format 
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 SRX4452802  HMR  Whole Blood / SRX4452802 (HMR)   Data format 
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 SRX4452802  CpG methylation  Whole Blood / SRX4452802 (CpG methylation)   Data format 
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 SRX4452803  HMR  Whole Blood / SRX4452803 (HMR)   Data format 
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 SRX4452803  CpG methylation  Whole Blood / SRX4452803 (CpG methylation)   Data format 
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 SRX4452804  HMR  Whole Blood / SRX4452804 (HMR)   Data format 
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 SRX4452804  CpG methylation  Whole Blood / SRX4452804 (CpG methylation)   Data format 
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 SRX4452805  CpG methylation  Whole Blood / SRX4452805 (CpG methylation)   Data format 
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 SRX4452806  HMR  Whole Blood / SRX4452806 (HMR)   Data format 
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 SRX4452806  CpG methylation  Whole Blood / SRX4452806 (CpG methylation)   Data format 
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 SRX4452807  HMR  Whole Blood / SRX4452807 (HMR)   Data format 
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 SRX4452807  CpG methylation  Whole Blood / SRX4452807 (CpG methylation)   Data format 
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 SRX4452808  HMR  Whole Blood / SRX4452808 (HMR)   Data format 
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 SRX4452808  CpG methylation  Whole Blood / SRX4452808 (CpG methylation)   Data format 
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 SRX4452809  HMR  Whole Blood / SRX4452809 (HMR)   Data format 
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 SRX4452809  CpG methylation  Whole Blood / SRX4452809 (CpG methylation)   Data format 
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 SRX4452810  CpG methylation  Whole Blood / SRX4452810 (CpG methylation)   Data format 
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 SRX4452811  CpG methylation  Whole Blood / SRX4452811 (CpG methylation)   Data format 
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 SRX4452812  CpG methylation  Whole Blood / SRX4452812 (CpG methylation)   Data format 
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 SRX4452813  CpG methylation  Whole Blood / SRX4452813 (CpG methylation)   Data format 
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 SRX4452814  CpG methylation  Whole Blood / SRX4452814 (CpG methylation)   Data format 
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 SRX4452815  HMR  Whole Blood / SRX4452815 (HMR)   Data format 
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 SRX4452815  CpG methylation  Whole Blood / SRX4452815 (CpG methylation)   Data format 
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 SRX4452816  HMR  Whole Blood / SRX4452816 (HMR)   Data format 
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 SRX4452816  CpG methylation  Whole Blood / SRX4452816 (CpG methylation)   Data format 
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 SRX4452817  HMR  Whole Blood / SRX4452817 (HMR)   Data format 
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 SRX4452817  CpG methylation  Whole Blood / SRX4452817 (CpG methylation)   Data format 
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 SRX4452818  HMR  Whole Blood / SRX4452818 (HMR)   Data format 
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 SRX4452818  CpG methylation  Whole Blood / SRX4452818 (CpG methylation)   Data format 
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 SRX4452819  HMR  Whole Blood / SRX4452819 (HMR)   Data format 
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 SRX4452819  CpG methylation  Whole Blood / SRX4452819 (CpG methylation)   Data format 
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 SRX4452820  HMR  Whole Blood / SRX4452820 (HMR)   Data format 
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 SRX4452820  CpG methylation  Whole Blood / SRX4452820 (CpG methylation)   Data format 
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 SRX4452821  HMR  Whole Blood / SRX4452821 (HMR)   Data format 
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 SRX4452821  CpG methylation  Whole Blood / SRX4452821 (CpG methylation)   Data format 
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 SRX4452822  HMR  Whole Blood / SRX4452822 (HMR)   Data format 
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 SRX4452822  CpG methylation  Whole Blood / SRX4452822 (CpG methylation)   Data format 
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 SRX4452823  HMR  Whole Blood / SRX4452823 (HMR)   Data format 
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 SRX4452823  CpG methylation  Whole Blood / SRX4452823 (CpG methylation)   Data format 
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 SRX4452824  HMR  Whole Blood / SRX4452824 (HMR)   Data format 
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 SRX4452824  CpG methylation  Whole Blood / SRX4452824 (CpG methylation)   Data format 
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 SRX4452825  HMR  Whole Blood / SRX4452825 (HMR)   Data format 
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 SRX4452825  CpG methylation  Whole Blood / SRX4452825 (CpG methylation)   Data format 
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 SRX4452826  HMR  Whole Blood / SRX4452826 (HMR)   Data format 
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 SRX4452826  CpG methylation  Whole Blood / SRX4452826 (CpG methylation)   Data format 
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 SRX4452827  HMR  Whole Blood / SRX4452827 (HMR)   Data format 
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 SRX4452827  CpG methylation  Whole Blood / SRX4452827 (CpG methylation)   Data format 
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 SRX4452828  HMR  Whole Blood / SRX4452828 (HMR)   Data format 
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 SRX4452828  CpG methylation  Whole Blood / SRX4452828 (CpG methylation)   Data format 
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 SRX4452829  HMR  Whole Blood / SRX4452829 (HMR)   Data format 
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 SRX4452829  CpG methylation  Whole Blood / SRX4452829 (CpG methylation)   Data format 
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 SRX4452830  HMR  Whole Blood / SRX4452830 (HMR)   Data format 
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 SRX4452830  CpG methylation  Whole Blood / SRX4452830 (CpG methylation)   Data format 
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 SRX4452831  HMR  Whole Blood / SRX4452831 (HMR)   Data format 
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 SRX4452831  CpG methylation  Whole Blood / SRX4452831 (CpG methylation)   Data format 
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 SRX4452832  HMR  Whole Blood / SRX4452832 (HMR)   Data format 
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 SRX4452832  CpG methylation  Whole Blood / SRX4452832 (CpG methylation)   Data format 
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 SRX4452833  HMR  Whole Blood / SRX4452833 (HMR)   Data format 
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 SRX4452833  CpG methylation  Whole Blood / SRX4452833 (CpG methylation)   Data format 
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 SRX4452834  HMR  Whole Blood / SRX4452834 (HMR)   Data format 
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 SRX4452834  CpG methylation  Whole Blood / SRX4452834 (CpG methylation)   Data format 
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 SRX4452835  HMR  Whole Blood / SRX4452835 (HMR)   Data format 
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 SRX4452835  CpG methylation  Whole Blood / SRX4452835 (CpG methylation)   Data format 
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 SRX4452836  CpG methylation  Whole Blood / SRX4452836 (CpG methylation)   Data format 
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 SRX4452837  CpG methylation  Whole Blood / SRX4452837 (CpG methylation)   Data format 
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 SRX4452838  CpG methylation  Whole Blood / SRX4452838 (CpG methylation)   Data format 
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 SRX4452839  HMR  Whole Blood / SRX4452839 (HMR)   Data format 
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 SRX4452839  CpG methylation  Whole Blood / SRX4452839 (CpG methylation)   Data format 
    
Assembly: Human Dec. 2013 (GRCh38/hg38)

Study title: Epigenomic signatures in liver and blood of Wilson disease patients include hypermethylation of liver-specific enhancers
SRA: SRP155006
GEO: GSE117593
Pubmed: 30709419

Experiment Label Methylation Coverage HMRs HMR size AMRs AMR size PMDs PMD size Conversion Title
SRX4452737 Liver 0.730 3.8 24339 1460.2 448 1155.8 13 385394.1 0.980 GSM3304382: Liver_HC_01; Homo sapiens; Bisulfite-Seq
SRX4452738 Liver 0.702 4.3 26771 1414.9 1046 1158.3 25 181091.7 0.979 GSM3304383: Liver_HC_02; Homo sapiens; Bisulfite-Seq
SRX4452739 Liver 0.724 3.9 25055 1489.7 590 1129.6 54 164063.9 0.983 GSM3304384: Liver_HC_03; Homo sapiens; Bisulfite-Seq
SRX4452740 Liver 0.747 3.6 24284 1437.5 324 1191.2 63 158612.0 0.982 GSM3304385: Liver_HC_04; Homo sapiens; Bisulfite-Seq
SRX4452741 Liver 0.738 4.6 28083 1359.6 1348 20552.8 46 127261.1 0.981 GSM3304386: Liver_HC_05; Homo sapiens; Bisulfite-Seq
SRX4452742 Liver 0.717 4.5 26855 1512.3 1143 16954.0 84 77479.8 0.982 GSM3304387: Liver_HC_06; Homo sapiens; Bisulfite-Seq
SRX4452743 Liver 0.721 3.7 22979 1382.3 471 39337.2 32 125434.3 0.978 GSM3304388: Liver_NAFLD_01; Homo sapiens; Bisulfite-Seq
SRX4452744 Liver 0.725 4.0 25034 1443.8 571 32666.9 70 148488.7 0.982 GSM3304389: Liver_NAFLD_02; Homo sapiens; Bisulfite-Seq
SRX4452745 Liver 0.716 5.1 28101 1290.5 2682 1233.3 67 91041.0 0.980 GSM3304390: Liver_NAFLD_03; Homo sapiens; Bisulfite-Seq
SRX4452746 Liver 0.736 4.7 28335 1302.3 1582 1144.3 76 119444.4 0.982 GSM3304391: Liver_NAFLD_04; Homo sapiens; Bisulfite-Seq
SRX4452747 Liver 0.727 4.0 25038 1388.8 733 1119.1 22 188161.0 0.981 GSM3304392: Liver_NAFLD_05; Homo sapiens; Bisulfite-Seq
SRX4452748 Liver 0.717 4.6 26767 1321.1 1592 12454.6 78 120684.2 0.980 GSM3304393: Liver_WD_Hep_01; Homo sapiens; Bisulfite-Seq
SRX4452749 Liver 0.725 3.6 23691 1489.2 328 56050.5 47 206449.4 0.982 GSM3304394: Liver_WD_Hep_02; Homo sapiens; Bisulfite-Seq
SRX4452750 Liver 0.736 3.5 22805 1434.0 233 1250.9 51 119079.4 0.982 GSM3304395: Liver_WD_Hep_03; Homo sapiens; Bisulfite-Seq
SRX4452751 Liver 0.721 4.0 24656 1413.6 861 22041.5 33 183980.8 0.979 GSM3304396: Liver_WD_Hep_04; Homo sapiens; Bisulfite-Seq
SRX4452752 Liver 0.713 3.7 22975 1443.2 463 1130.0 31 220722.1 0.981 GSM3304397: Liver_WD_Hep_05; Homo sapiens; Bisulfite-Seq
SRX4452753 Liver 0.735 3.5 21292 1394.1 254 1155.2 24 162912.0 0.982 GSM3304398: Liver_WD_Hep_06; Homo sapiens; Bisulfite-Seq
SRX4452754 Liver 0.725 4.4 24048 1304.4 1266 1125.3 52 92971.3 0.983 GSM3304399: Liver_WD_Hep_07; Homo sapiens; Bisulfite-Seq
SRX4452755 Liver 0.731 3.7 23284 1383.2 379 1129.4 47 119279.6 0.983 GSM3304400: Liver_WD_Hep_08; Homo sapiens; Bisulfite-Seq
SRX4452756 Liver 0.723 3.9 23769 1333.2 738 1092.1 69 101777.9 0.983 GSM3304401: Liver_WD_Hep_09; Homo sapiens; Bisulfite-Seq
SRX4452757 Liver 0.732 3.6 24191 1422.7 355 1087.7 85 155123.1 0.981 GSM3304402: Liver_WD_Hep_10; Homo sapiens; Bisulfite-Seq
SRX4452758 Whole Blood 0.745 4.5 30234 1225.6 545 1287.8 74 77255.5 0.971 GSM3304403: Blood_HC_01; Homo sapiens; Bisulfite-Seq
SRX4452759 Whole Blood 0.738 4.1 29215 1232.1 359 1230.0 70 110932.6 0.972 GSM3304404: Blood_HC_02; Homo sapiens; Bisulfite-Seq
SRX4452760 Whole Blood 0.745 4.1 30233 1218.4 401 1251.5 89 94378.7 0.972 GSM3304405: Blood_HC_03; Homo sapiens; Bisulfite-Seq
SRX4452761 Whole Blood 0.748 4.4 32269 1207.3 509 1167.1 170 76609.6 0.972 GSM3304406: Blood_HC_04; Homo sapiens; Bisulfite-Seq
SRX4452762 Whole Blood 0.748 4.1 30503 1239.3 380 1380.0 86 76895.6 0.974 GSM3304407: Blood_HC_05; Homo sapiens; Bisulfite-Seq
SRX4452763 Whole Blood 0.743 4.4 32090 1196.2 679 1169.0 93 85433.1 0.972 GSM3304408: Blood_HC_06; Homo sapiens; Bisulfite-Seq
SRX4452764 Whole Blood 0.737 4.3 30886 1206.8 609 1227.9 113 85867.0 0.967 GSM3304409: Blood_HC_07; Homo sapiens; Bisulfite-Seq
SRX4452765 Whole Blood 0.733 4.4 29988 1242.1 727 1235.5 96 77525.5 0.968 GSM3304410: Blood_HC_08; Homo sapiens; Bisulfite-Seq
SRX4452766 Whole Blood 0.730 4.0 27691 1274.6 514 1115.3 68 82316.3 0.973 GSM3304411: Blood_HC_09; Homo sapiens; Bisulfite-Seq
SRX4452767 Whole Blood 0.743 4.3 32088 1209.9 641 1336.7 85 84124.2 0.971 GSM3304412: Blood_HC_10; Homo sapiens; Bisulfite-Seq
SRX4452768 Whole Blood 0.743 4.2 29189 1283.3 342 1350.0 91 99196.2 0.967 GSM3304413: Blood_HC_11; Homo sapiens; Bisulfite-Seq
SRX4452769 Whole Blood 0.740 4.1 27931 1246.0 402 1301.6 43 134415.4 0.971 GSM3304414: Blood_HC_12; Homo sapiens; Bisulfite-Seq
SRX4452770 Whole Blood 0.748 4.1 28646 1253.5 408 1580.3 60 118441.7 0.970 GSM3304415: Blood_NAFLD_01; Homo sapiens; Bisulfite-Seq
SRX4452771 Whole Blood 0.741 4.5 31414 1224.7 847 1386.8 158 61675.8 0.971 GSM3304416: Blood_NAFLD_02; Homo sapiens; Bisulfite-Seq
SRX4452772 Whole Blood 0.755 4.3 29214 1229.2 615 1256.2 67 96110.5 0.974 GSM3304417: Blood_NAFLD_03; Homo sapiens; Bisulfite-Seq
SRX4452773 Whole Blood 0.739 4.3 28699 1259.8 528 1351.1 61 88231.2 0.969 GSM3304418: Blood_NAFLD_04; Homo sapiens; Bisulfite-Seq
SRX4452774 Whole Blood 0.755 4.3 27703 1303.1 284 1798.7 62 102881.8 0.964 GSM3304419: Blood_NAFLD_05; Homo sapiens; Bisulfite-Seq
SRX4452775 Whole Blood 0.749 4.4 29384 1252.5 403 1331.5 74 94554.2 0.972 GSM3304420: Blood_NAFLD_06; Homo sapiens; Bisulfite-Seq
SRX4452776 Whole Blood 0.732 4.2 27464 1287.9 423 1163.8 45 96326.1 0.973 GSM3304421: Blood_NAFLD_07; Homo sapiens; Bisulfite-Seq
SRX4452777 Whole Blood 0.748 4.2 29878 1235.1 485 1301.1 78 88807.2 0.972 GSM3304422: Blood_NAFLD_08; Homo sapiens; Bisulfite-Seq
SRX4452778 Whole Blood 0.750 4.5 32461 1196.6 464 1307.5 93 85092.5 0.972 GSM3304423: Blood_NAFLD_09; Homo sapiens; Bisulfite-Seq
SRX4452779 Whole Blood 0.745 4.2 29519 1242.1 501 1341.3 71 98558.6 0.973 GSM3304424: Blood_NAFLD_10; Homo sapiens; Bisulfite-Seq
SRX4452780 Whole Blood 0.756 4.0 28174 1262.4 324 1213.9 75 111207.4 0.970 GSM3304425: Blood_PSC_01; Homo sapiens; Bisulfite-Seq
SRX4452781 Whole Blood 0.736 4.1 29476 1244.7 566 1441.9 136 85740.3 0.971 GSM3304426: Blood_PSC_02; Homo sapiens; Bisulfite-Seq
SRX4452782 Whole Blood 0.725 4.4 29550 1248.4 863 21996.5 56 84279.1 0.968 GSM3304427: Blood_PSC_03; Homo sapiens; Bisulfite-Seq
SRX4452783 Whole Blood 0.745 4.0 31257 1232.1 406 1209.6 72 102236.6 0.969 GSM3304428: Blood_PSC_04; Homo sapiens; Bisulfite-Seq
SRX4452784 Whole Blood 0.740 4.4 30982 1220.2 745 1281.3 95 73237.8 0.974 GSM3304429: Blood_PSC_05; Homo sapiens; Bisulfite-Seq
SRX4452785 Whole Blood 0.750 4.2 29669 1237.1 374 1238.4 69 98385.2 0.972 GSM3304430: Blood_PSC_06; Homo sapiens; Bisulfite-Seq
SRX4452786 Whole Blood 0.747 5.0 32246 1226.4 672 1299.7 118 67265.6 0.967 GSM3304431: Blood_PSC_07; Homo sapiens; Bisulfite-Seq
SRX4452787 Whole Blood 0.746 4.1 27885 1270.3 322 57163.8 52 103116.2 0.970 GSM3304432: Blood_PSC_08; Homo sapiens; Bisulfite-Seq
SRX4452788 Whole Blood 0.761 4.4 30409 1233.0 309 1433.2 68 89039.7 0.968 GSM3304433: Blood_PSC_09; Homo sapiens; Bisulfite-Seq
SRX4452789 Whole Blood 0.745 3.9 24444 1388.5 199 92797.2 30 109656.4 0.960 GSM3304434: Blood_PSC_10; Homo sapiens; Bisulfite-Seq
SRX4452790 Whole Blood 0.749 4.3 31138 1202.9 658 1175.9 168 69476.0 0.970 GSM3304435: Blood_WD_Hep_01; Homo sapiens; Bisulfite-Seq
SRX4452791 Whole Blood 0.733 3.8 26433 1315.1 357 1193.4 58 106805.1 0.972 GSM3304436: Blood_WD_Hep_02; Homo sapiens; Bisulfite-Seq
SRX4452792 Whole Blood 0.735 4.5 31555 1213.3 548 1336.8 95 76818.2 0.973 GSM3304437: Blood_WD_Hep_03; Homo sapiens; Bisulfite-Seq
SRX4452793 Whole Blood 0.742 4.2 29434 1224.6 592 1332.2 137 78105.3 0.970 GSM3304438: Blood_WD_Hep_04; Homo sapiens; Bisulfite-Seq
SRX4452794 Whole Blood 0.739 4.2 31277 1218.4 590 1190.6 75 83454.4 0.973 GSM3304439: Blood_WD_Hep_05; Homo sapiens; Bisulfite-Seq
SRX4452795 Whole Blood 0.748 4.2 32412 1225.8 325 1472.3 89 86135.5 0.971 GSM3304440: Blood_WD_Hep_06; Homo sapiens; Bisulfite-Seq
SRX4452796 Whole Blood 0.741 4.8 32600 1184.5 1079 1215.8 204 56961.9 0.973 GSM3304441: Blood_WD_Hep_07; Homo sapiens; Bisulfite-Seq
SRX4452797 Whole Blood 0.739 4.7 31052 1195.0 1052 1271.7 76 76552.9 0.963 GSM3304442: Blood_WD_Hep_08; Homo sapiens; Bisulfite-Seq
SRX4452798 Whole Blood 0.751 4.7 32956 1190.2 601 1250.5 182 59303.9 0.967 GSM3304443: Blood_WD_Hep_09; Homo sapiens; Bisulfite-Seq
SRX4452799 Whole Blood 0.739 3.9 28205 1269.2 366 1157.4 58 108514.4 0.969 GSM3304444: Blood_WD_Hep_10; Homo sapiens; Bisulfite-Seq
SRX4452800 Whole Blood 0.751 3.6 26370 1299.7 227 1263.4 88 99738.2 0.969 GSM3304445: Blood_WD_Hep_11; Homo sapiens; Bisulfite-Seq
SRX4452801 Whole Blood 0.744 4.1 28997 1270.1 360 1185.9 66 88472.7 0.969 GSM3304446: Blood_WD_Hep_12; Homo sapiens; Bisulfite-Seq
SRX4452802 Whole Blood 0.729 4.6 29242 1237.6 973 1368.2 37 87362.7 0.968 GSM3304447: Blood_WD_Hep_13; Homo sapiens; Bisulfite-Seq
SRX4452803 Whole Blood 0.751 4.4 29549 1248.8 543 1192.2 153 69997.5 0.969 GSM3304448: Blood_WD_Hep_14; Homo sapiens; Bisulfite-Seq
SRX4452804 Whole Blood 0.752 4.4 29423 1234.8 667 1230.2 112 75961.5 0.970 GSM3304449: Blood_WD_Hep_15; Homo sapiens; Bisulfite-Seq
SRX4452805 Whole Blood 0.734 3.9 24234 1392.2 218 1761.3 32 105138.8 0.963 GSM3304450: Blood_WD_Hep_16; Homo sapiens; Bisulfite-Seq
SRX4452806 Whole Blood 0.738 4.2 28839 1249.1 365 1471.1 66 104448.4 0.973 GSM3304451: Blood_WD_Hep_17; Homo sapiens; Bisulfite-Seq
SRX4452807 Whole Blood 0.743 4.4 30273 1217.0 445 1382.7 67 101213.2 0.973 GSM3304452: Blood_WD_Hep_18; Homo sapiens; Bisulfite-Seq
SRX4452808 Whole Blood 0.740 4.4 30707 1223.8 399 1452.6 54 112773.4 0.974 GSM3304453: Blood_WD_Hep_19; Homo sapiens; Bisulfite-Seq
SRX4452809 Whole Blood 0.741 4.4 30114 1218.3 538 1236.9 113 81700.4 0.973 GSM3304454: Blood_WD_Hep_20; Homo sapiens; Bisulfite-Seq
SRX4452810 Whole Blood 0.713 3.4 23089 1339.1 99 1312.9 44 330581.9 0.987 GSM3304455: Blood_WD_Hep_21; Homo sapiens; Bisulfite-Seq
SRX4452811 Whole Blood 0.710 3.4 22941 1358.8 101 1210.9 16 284378.2 0.987 GSM3304456: Blood_WD_Hep_22; Homo sapiens; Bisulfite-Seq
SRX4452812 Whole Blood 0.734 3.5 24255 1296.6 152 1117.4 33 201256.2 0.988 GSM3304457: Blood_WD_Hep_23; Homo sapiens; Bisulfite-Seq
SRX4452813 Whole Blood 0.727 3.7 24284 1308.7 165 1495.7 23 171126.1 0.988 GSM3304458: Blood_WD_Hep_24; Homo sapiens; Bisulfite-Seq
SRX4452814 Whole Blood 0.723 3.3 22793 1390.1 78 1245.5 25 203313.8 0.988 GSM3304459: Blood_WD_Hep_25; Homo sapiens; Bisulfite-Seq
SRX4452815 Whole Blood 0.743 4.5 31332 1210.4 731 1305.5 80 80855.2 0.975 GSM3304460: Blood_WD_Neu_01; Homo sapiens; Bisulfite-Seq
SRX4452816 Whole Blood 0.747 4.4 31659 1196.0 629 1247.1 91 90331.9 0.974 GSM3304461: Blood_WD_Neu_02; Homo sapiens; Bisulfite-Seq
SRX4452817 Whole Blood 0.741 4.5 32807 1198.7 469 1318.1 75 87464.8 0.974 GSM3304462: Blood_WD_Neu_03; Homo sapiens; Bisulfite-Seq
SRX4452818 Whole Blood 0.747 4.3 31122 1199.9 541 1164.0 119 79957.7 0.971 GSM3304463: Blood_WD_Neu_04; Homo sapiens; Bisulfite-Seq
SRX4452819 Whole Blood 0.745 4.2 30071 1219.7 564 1134.9 129 73869.0 0.968 GSM3304464: Blood_WD_Neu_05; Homo sapiens; Bisulfite-Seq
SRX4452820 Whole Blood 0.735 4.0 27402 1272.1 357 1363.7 62 102068.9 0.966 GSM3304465: Blood_WD_Neu_06; Homo sapiens; Bisulfite-Seq
SRX4452821 Whole Blood 0.739 4.5 30646 1206.0 760 1221.8 115 69183.1 0.970 GSM3304466: Blood_WD_Neu_07; Homo sapiens; Bisulfite-Seq
SRX4452822 Whole Blood 0.747 3.8 27670 1287.6 237 1454.0 67 103898.4 0.970 GSM3304467: Blood_WD_Neu_08; Homo sapiens; Bisulfite-Seq
SRX4452823 Whole Blood 0.743 4.4 29340 1247.0 408 1329.6 116 87810.8 0.968 GSM3304468: Blood_WD_Neu_09; Homo sapiens; Bisulfite-Seq
SRX4452824 Whole Blood 0.742 4.1 28096 1274.1 354 1262.6 50 121110.0 0.967 GSM3304469: Blood_WD_Neu_10; Homo sapiens; Bisulfite-Seq
SRX4452825 Whole Blood 0.744 4.5 31396 1232.7 723 1243.9 115 70742.6 0.968 GSM3304470: Blood_WD_Neu_11; Homo sapiens; Bisulfite-Seq
SRX4452826 Whole Blood 0.752 4.0 27404 1298.6 264 1659.3 53 98315.9 0.969 GSM3304471: Blood_WD_Neu_12; Homo sapiens; Bisulfite-Seq
SRX4452827 Whole Blood 0.730 4.2 25726 1363.9 451 1370.6 53 100386.0 0.962 GSM3304472: Blood_WD_Neu_13; Homo sapiens; Bisulfite-Seq
SRX4452828 Whole Blood 0.736 4.1 25541 1358.2 260 1225.8 31 122455.3 0.965 GSM3304473: Blood_WD_Neu_14; Homo sapiens; Bisulfite-Seq
SRX4452829 Whole Blood 0.739 4.3 27282 1314.4 433 1235.3 95 89891.1 0.965 GSM3304474: Blood_WD_Neu_15; Homo sapiens; Bisulfite-Seq
SRX4452830 Whole Blood 0.742 4.1 26337 1322.9 281 1437.7 73 87910.3 0.962 GSM3304475: Blood_WD_Neu_16; Homo sapiens; Bisulfite-Seq
SRX4452831 Whole Blood 0.738 4.2 26825 1319.7 361 1246.6 87 115615.3 0.965 GSM3304476: Blood_WD_Neu_17; Homo sapiens; Bisulfite-Seq
SRX4452832 Whole Blood 0.729 4.3 30427 1230.6 444 1522.9 65 89922.3 0.974 GSM3304477: Blood_WD_Neu_18; Homo sapiens; Bisulfite-Seq
SRX4452833 Whole Blood 0.739 4.2 29469 1212.7 601 1158.0 72 95704.6 0.974 GSM3304478: Blood_WD_Neu_19; Homo sapiens; Bisulfite-Seq
SRX4452834 Whole Blood 0.734 4.0 28166 1246.3 331 1371.7 61 101015.0 0.974 GSM3304479: Blood_WD_Neu_20; Homo sapiens; Bisulfite-Seq
SRX4452835 Whole Blood 0.719 3.7 26459 1267.4 183 1243.6 66 172186.5 0.988 GSM3304480: Blood_WD_Neu_21; Homo sapiens; Bisulfite-Seq
SRX4452836 Whole Blood 0.710 3.5 23649 1364.6 126 1676.4 16 223641.6 0.988 GSM3304481: Blood_WD_Neu_22; Homo sapiens; Bisulfite-Seq
SRX4452837 Whole Blood 0.723 3.4 23500 1355.3 90 1105.7 63 192341.9 0.987 GSM3304482: Blood_WD_Neu_23; Homo sapiens; Bisulfite-Seq
SRX4452838 Whole Blood 0.720 3.5 24767 1321.9 120 1609.6 33 192108.2 0.986 GSM3304483: Blood_WD_Neu_24; Homo sapiens; Bisulfite-Seq
SRX4452839 Whole Blood 0.723 3.7 27207 1277.1 146 1557.4 48 132802.8 0.988 GSM3304484: Blood_WD_Neu_25; Homo sapiens; Bisulfite-Seq

Methods

All analysis was done using a bisulfite sequnecing data analysis pipeline DNMTools developed in the Smith lab at USC.

Mapping reads from bisulfite sequencing: Bisulfite treated reads are mapped to the genomes with the abismal program. Input reads are filtered by their quality, and adapter sequences in the 3' end of reads are trimmed. This is done with cutadapt. Uniquely mapped reads with mismatches/indels below given threshold are retained. For pair-end reads, if the two mates overlap, the overlapping part of the mate with lower quality is discarded. After mapping, we use the format command in dnmtools to merge mates for paired-end reads. We use the dnmtools uniq command to randomly select one from multiple reads mapped exactly to the same location. Without random oligos as UMIs, this is our best indication of PCR duplicates.

Estimating methylation levels: After reads are mapped and filtered, the dnmtools counts command is used to obtain read coverage and estimate methylation levels at individual cytosine sites. We count the number of methylated reads (those containing a C) and the number of unmethylated reads (those containing a T) at each nucleotide in a mapped read that corresponds to a cytosine in the reference genome. The methylation level of that cytosine is estimated as the ratio of methylated to total reads covering that cytosine. For cytosines in the symmetric CpG sequence context, reads from the both strands are collapsed to give a single estimate. Very rarely do the levels differ between strands (typically only if there has been a substitution, as in a somatic mutation), and this approach gives a better estimate.

Bisulfite conversion rate: The bisulfite conversion rate for an experiment is estimated with the dnmtools bsrate command, which computes the fraction of successfully converted nucleotides in reads (those read out as Ts) among all nucleotides in the reads mapped that map over cytosines in the reference genome. This is done either using a spike-in (e.g., lambda), the mitochondrial DNA, or the nuclear genome. In the latter case, only non-CpG sites are used. While this latter approach can be impacted by non-CpG cytosine methylation, in practice it never amounts to much.

Identifying hypomethylated regions (HMRs): In most mammalian cells, the majority of the genome has high methylation, and regions of low methylation are typically the interesting features. (This seems to be true for essentially all healthy differentiated cell types, but not cells of very early embryogenesis, various germ cells and precursors, and placental lineage cells.) These are valleys of low methylation are called hypomethylated regions (HMR) for historical reasons. To identify the HMRs, we use the dnmtools hmr command, which uses a statistical model that accounts for both the methylation level fluctations and the varying amounts of data available at each CpG site.

Partially methylated domains: Partially methylated domains are large genomic regions showing partial methylation observed in immortalized cell lines and cancerous cells. The pmd program is used to identify PMDs.

Allele-specific methylation: Allele-Specific methylated regions refers to regions where the parental allele is differentially methylated compared to the maternal allele. The program allelic is used to compute allele-specific methylation score can be computed for each CpG site by testing the linkage between methylation status of adjacent reads, and the program amrfinder is used to identify regions with allele-specific methylation.

For more detailed description of the methods of each step, please refer to the DNMTools documentation.