Assay Summary H3K27ac Summary Track Settings
 
Roadmap Epigenome H3K27ac Summary for 96 sample type(s)

Track collection: Assay Summary

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     BAC H3K27ac 149  Brain Anterior Caudate H3K27ac Histone Modification by Chip-seq Signal from REMC/Broad (HOTSPOT_SCORE=0.2884 Pcnt=59)    Data format 
     CD4N H3K27ac 101  CD4 Naive Primary Cells H3K27ac Histone Modification by Chip-seq Signal from REMC/Broad (HOTSPOT_SCORE=0.3593 Pcnt=76)    Data format 
     iPS20b H3K27ac 357  iPS-20b H3K27ac Histone Modification by Chip-seq Signal from REMC/Broad (HOTSPOT_SCORE=0.1514 Pcnt=18)    Data format 
     CD4+CD25- H3K27ac 62  CD4+ CD25- CD45RO+ Memory Primary Cells H3K27ac Histone Modification by Chip-seq Signal from REMC/Broad (HOTSPOT_SCORE=0.434 Pcnt=85)    Data format 
     MCD34 H3K27ac RO_01536  Mobilized CD34 Primary Cells H3K27ac Histone Modification by Chip-seq Signal from REMC/Broad (HOTSPOT_SCORE=0.5194 Pcnt=97)    Data format 
     CD8M H3K27ac 100  CD8 Memory Primary Cells H3K27ac Histone Modification by Chip-seq Signal from REMC/Broad (HOTSPOT_SCORE=0.3251 Pcnt=68)    Data format 
     MCD34 H3K27ac RO_01480  Mobilized CD34 Primary Cells H3K27ac Histone Modification by Chip-seq Signal from REMC/Broad (HOTSPOT_SCORE=0.3041 Pcnt=65)    Data format 
     MCD34 H3K27ac RO_01549  Mobilized CD34 Primary Cells H3K27ac Histone Modification by Chip-seq Signal from REMC/Broad (HOTSPOT_SCORE=0.2444 Pcnt=47)    Data format 
     CD4+CD25- H3K27ac 62  CD4+ CD25- IL17- PMA-Ionomycin stimulated MACS purified Th Primary Cells H3K27ac Histone Modification by Chip-seq Signal from REMC/Broad (HOTSPOT_SCORE=0.4794 Pcnt=91)    Data format 
     DSM H3K27ac 160  Duodenum Smooth Muscle H3K27ac Histone Modification by Chip-seq Signal from REMC/Broad (HOTSPOT_SCORE=0.2224 Pcnt=32)    Data format 
     CD4N H3K27ac 100  CD4 Naive Primary Cells H3K27ac Histone Modification by Chip-seq Signal from REMC/Broad (HOTSPOT_SCORE=0.4112 Pcnt=82)    Data format 
     CD8N H3K27ac 100  CD8 Naive Primary Cells H3K27ac Histone Modification by Chip-seq Signal from REMC/Broad (HOTSPOT_SCORE=0.2393 Pcnt=41)    Data format 
     CD4M H3K27ac 100  CD4 Memory Primary Cells H3K27ac Histone Modification by Chip-seq Signal from REMC/Broad (HOTSPOT_SCORE=0.4878 Pcnt=94)    Data format 
     CD8N H3K27ac 101  CD8 Naive Primary Cells H3K27ac Histone Modification by Chip-seq Signal from REMC/Broad (HOTSPOT_SCORE=0.2736 Pcnt=56)    Data format 
     CD4+CD25- H3K27ac 62  CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells H3K27ac Histone Modification by Chip-seq Signal from REMC/Broad (HOTSPOT_SCORE=0.449 Pcnt=88)    Data format 
     BITL H3K27ac 149  Brain Inferior Temporal Lobe H3K27ac Histone Modification by Chip-seq Signal from REMC/Broad (HOTSPOT_SCORE=0.258 Pcnt=50)    Data format 
     CD4M H3K27ac 101  CD4 Memory Primary Cells H3K27ac Histone Modification by Chip-seq Signal from REMC/Broad (HOTSPOT_SCORE=0.2622 Pcnt=53)    Data format 
     CD4+CD25- H3K27ac 62  CD4+ CD25- CD45RA+ Naive Primary Cells H3K27ac Histone Modification by Chip-seq Signal from REMC/Broad (HOTSPOT_SCORE=0.577 Pcnt=100)    Data format 
     BAG H3K27ac 149  Brain Angular Gyrus H3K27ac Histone Modification by Chip-seq Signal from REMC/Broad (HOTSPOT_SCORE=0.2157 Pcnt=26)    Data format 
     BHM H3K27ac 149  Brain Hippocampus Middle H3K27ac Histone Modification by Chip-seq Signal from REMC/Broad (HOTSPOT_SCORE=0.353 Pcnt=74)    Data format 
     iPS18a H3K27ac 349  iPS-18a H3K27ac Histone Modification by Chip-seq Signal from REMC/Broad (HOTSPOT_SCORE=0.0872 Pcnt=6)    Data format 
     BCG H3K27ac 49 17  BI Brain Cingulate Gyrus Histone H3K27ac Donor 149 Library DNA_Lib 617 EA Release 6    Data format 
     BHM H3K27ac 50 84  BI Brain Hippocampus Middle Histone H3K27ac Donor 150 Library DNA_Lib 984 EA Release 6    Data format 
     BMFL H3K27ac 49 12  BI Brain Mid Frontal Lobe Histone H3K27ac Donor 149 Library DNA_Lib 612 EA Release 6    Data format 
     CCCTmem H3K27ac 62 34  BI CD4+ CD25int CD127+ Tmem Primary Cells Histone H3K27ac Donor 62 Library DNA_Lib 734 EA Release 6    Data format 
     IMR90 H3K27ac 35  IMR90 Cell Line H3K27ac Histone Modification by Chip-seq Signal from REMC/UCSD (Hotspot_Score=0.7232 Pcnt=100 Library:LL235)    Data format 
     IMR90 H3K27ac 58  IMR90 Cell Line H3K27ac Histone Modification by Chip-seq Signal from REMC/UCSD (Hotspot_Score=0.7 Pcnt=83 Library:YL58)    Data format 
     H9 H3K27ac 37  H9 Cell Line H3K27ac Histone Modification by Chip-seq Signal from REMC/UCSD (Hotspot_Score=0.1947 Pcnt=33 Library:YL237)    Data format 
     IMR90 H3K27ac 31  IMR90 Cell Line H3K27ac Histone Modification by Chip-seq Signal from REMC/UCSD (Hotspot_Score=0.6371 Pcnt=67 Library:LL231)    Data format 
     H1 H3K27ac 13  H1 Cell Line H3K27ac Histone Modification by Chip-seq Signal from REMC/UCSD (Hotspot_Score=0.3968 Pcnt=50 Library:LL313)    Data format 
     H1 H3K27ac 70  H1 H3K27ac Signal from REMC/UCSD (Hotspot_Score=0.2837 Pcnt=100)    Data format 
     H9 H3K27ac 65  H9 H3K27ac Signal from REMC/UCSD (Hotspot_Score=0.1614 Pcnt=50)    Data format 
     iD19.11 H3K27ac 02  iPS-DF-19.11 H3K27ac Signal from REMC/UCSD (HOTSPOT_SCORE=0.1728 Pcnt=10)    Data format 
     iPS_DF_19.11 H3K27ac SK395  iPS_DF_19.11 H3K27ac Histone Modification by Chip-seq Signal from REMC/UCSD (HOTSPOT_SCORE=0.2 Pcnt=24)    Data format 
     iPS_DF_19.11 H3K27ac SK434  iPS_DF_19.11 H3K27ac Histone Modification by Chip-seq Signal from REMC/UCSD (HOTSPOT_SCORE=0.11 Pcnt=12)    Data format 
     iPS_DF_6.9 H3K27ac SK432  iPS_DF_6.9 H3K27ac Histone Modification by Chip-seq Signal from REMC/UCSD (HOTSPOT_SCORE=0.11 Pcnt=12)    Data format 
     H1-BMP4 H3K27ac SK340  H1-BMP4 H3K27ac Histone Modification by Chip-seq Signal from REMC/UCSD (HOTSPOT_SCORE=0.08 Pcnt=3)    Data format 
     H1-BMP4 H3K27ac AK147  H1-BMP4 H3K27ac Histone Modification by Chip-seq Signal from REMC/UCSD (HOTSPOT_SCORE=0.36 Pcnt=79)    Data format 
     H1-BMP4 H3K27ac SK447  H1-BMP4 H3K27ac Histone Modification by Chip-seq Signal from REMC/UCSD (HOTSPOT_SCORE=0.24 Pcnt=44)    Data format 
     H1-BMP4 H3K27ac SK449  H1-BMP4 H3K27ac Histone Modification by Chip-seq Signal from REMC/UCSD (HOTSPOT_SCORE=0.22 Pcnt=29)    Data format 
     H1DNPCC H3K27ac SK451  H1DNPCC H3K27ac Histone Modification by Chip-seq Signal from REMC/UCSD (HOTSPOT_SCORE=0.17 Pcnt=21)    Data format 
     H1DMSC H3K27ac SK436  H1DMSC H3K27ac Histone Modification by Chip-seq Signal from REMC/UCSD (HOTSPOT_SCORE=0.23 Pcnt=35)    Data format 
     H1DMSC H3K27ac SK438  H1DMSC H3K27ac Histone Modification by Chip-seq Signal from REMC/UCSD (HOTSPOT_SCORE=0.33 Pcnt=71)    Data format 
     H1DNPCC H3K27ac SK504  H1DNPCC H3K27ac Histone Modification by Chip-seq Signal from REMC/UCSD (HOTSPOT_SCORE=0.14 Pcnt=15)    Data format 
     HDNP H3K27ac 20  UCSD H1 Derived Neuronal Progenitor Cultured Cells Histone H3K27ac Library AK220 EA Release 6    Data format 
     HBDM H3K27ac 10  UCSD H1 BMP4 Derived Mesendoderm Cultured Cells Histone H3K27ac Library AK310 EA Release 7    Data format 
     HBDM H3K27ac 13  UCSD H1 BMP4 Derived Mesendoderm Cultured Cells Histone H3K27ac Library AK313 EA Release 7    Data format 
     HBDT H3K27ac 16  UCSD H1 BMP4 Derived Trophoblast Cultured Cells Histone H3K27ac Library AK316 EA Release 7    Data format 
     AN H3K27ac 7 64  BI Adipose Nuclei Histone H3K27ac Donor 7 Library DNA_Lib 1764 EA Release 8    Data format 
     CfBMDMSC H3K27ac 57 48  BI Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Histone H3K27ac Donor 57 Library DNA_Lib 1248 EA Release 8    Data format 
     SM H3K27ac 62 66  BI Skeletal Muscle Histone H3K27ac Donor 62 Library DNA_Lib 1766 EA Release 8    Data format 
     SSM H3K27ac 28 65  BI Stomach Smooth Muscle Histone H3K27ac Donor 28 Library DNA_Lib 1765 EA Release 8    Data format 
     AT H3K27ac 03 45  UCSD Adipose Tissue Histone H3K27ac Donor STL003 Library AK345 EA Release 8    Data format 
     AG H3K27ac 03 21  UCSD Adrenal Gland Histone H3K27ac Donor STL003 Library AK321 EA Release 8    Data format 
     Aorta H3K27ac 03 46  UCSD Aorta Histone H3K27ac Donor STL003 Library AY46 EA Release 8    Data format 
     Esophagus H3K27ac 03 24  UCSD Esophagus Histone H3K27ac Donor STL003 Library AK324 EA Release 8    Data format 
     Gastric H3K27ac 03 39  UCSD Gastric Histone H3K27ac Donor STL003 Library AK339 EA Release 8    Data format 
     HDNP H3K27ac 19  UCSD H1 Derived Neuronal Progenitor Cultured Cells Histone H3K27ac Library AK319 EA Release 8    Data format 
     LV H3K27ac 01 35  UCSD Left Ventricle Histone H3K27ac Donor STL001 Library AK235 EA Release 8    Data format 
     LV H3K27ac 03 50  UCSD Left Ventricle Histone H3K27ac Donor STL003 Library AY50 EA Release 8    Data format 
     Lung H3K27ac 02 48  UCSD Lung Histone H3K27ac Donor STL002 Library AY48 EA Release 8    Data format 
     Pancreas H3K27ac 03 42  UCSD Pancreas Histone H3K27ac Donor STL003 Library AK342 EA Release 8    Data format 
     PM H3K27ac 03 92  UCSD Psoas Muscle Histone H3K27ac Donor STL003 Library AY92 EA Release 8    Data format 
     RA H3K27ac 03 52  UCSD Right Atrium Histone H3K27ac Donor STL003 Library AY52 EA Release 8    Data format 
     RV H3K27ac 03 51  UCSD Right Ventricle Histone H3K27ac Donor STL003 Library AK351 EA Release 8    Data format 
     SC H3K27ac 01 29  UCSD Sigmoid Colon Histone H3K27ac Donor STL001 Library AK229 EA Release 8    Data format 
     SC H3K27ac 03 94  UCSD Sigmoid Colon Histone H3K27ac Donor STL003 Library AY94 EA Release 8    Data format 
     SI H3K27ac 01 23  UCSD Small Intestine Histone H3K27ac Donor STL001 Library AK223 EA Release 8    Data format 
     Spleen H3K27ac 03 48  UCSD Spleen Histone H3K27ac Donor STL003 Library AK348 EA Release 8    Data format 
     PFF H3K27ac 03 70  UCSF-UBC-USC Penis Foreskin Fibroblast Primary Cells Histone H3K27ac Donor skin03 Library A15570 EA Release 8    Data format 
     PFK H3K27ac 03 77  UCSF-UBC-USC Penis Foreskin Keratinocyte Primary Cells Histone H3K27ac Donor skin03 Library A15577 EA Release 8    Data format 
     PFM H3K27ac 03 84  UCSF-UBC-USC Penis Foreskin Melanocyte Primary Cells Histone H3K27ac Donor skin03 Library A15584 EA Release 8    Data format 
     Gastric H3K27ac 01 58  UCSD Gastric Histone H3K27ac Donor STL001 Library CY58 EA Release 9    Data format 
     Lung H3K27ac 01 61  UCSD Lung Histone H3K27ac Donor STL001 Library AY361 EA Release 9    Data format 
     RV H3K27ac 01 54  UCSD Right Ventricle Histone H3K27ac Donor STL001 Library CY54 EA Release 9    Data format 
     Thymus H3K27ac 01 10  UCSD Thymus Histone H3K27ac Donor STL001 Library AY310 EA Release 9    Data format 
     AG H3K27ac 02 60  UCSD Adrenal Gland Histone H3K27ac Donor STL002 Library CY60 EA Release 9    Data format 
     Esophagus H3K27ac 02 36  UCSD Esophagus Histone H3K27ac Donor STL002 Library AY336 EA Release 9    Data format 
     Gastric H3K27ac 02 38  UCSD Gastric Histone H3K27ac Donor STL002 Library AY338 EA Release 9    Data format 
     Pancreas H3K27ac 02 56  UCSD Pancreas Histone H3K27ac Donor STL002 Library CY56 EA Release 9    Data format 
     PM H3K27ac 02 40  UCSD Psoas Muscle Histone H3K27ac Donor STL002 Library AY340 EA Release 9    Data format 
     SI H3K27ac 02 65  UCSD Small Intestine Histone H3K27ac Donor STL002 Library AY365 EA Release 9    Data format 
     Spleen H3K27ac 02 42  UCSD Spleen Histone H3K27ac Donor STL002 Library AY342 EA Release 9    Data format 
     Bladder H3K27ac 03 34  UCSD Bladder Histone H3K27ac Donor STL003 Library AY334 EA Release 9    Data format 
     Spleen H3K27ac 01 63  UCSD Spleen Histone H3K27ac Donor STL001 Library AY363 EA Release 9    Data format 
     PM H3K27ac 01 52  UCSD Psoas Muscle Histone H3K27ac Donor STL001 Library CY52 EA Release 9    Data format 
     SI H3K27ac 03 62  UCSD Small Intestine Histone H3K27ac Donor STL003 Library CY62 EA Release 9    Data format 
     LV H3K27ac 11 69  UCSD Left Ventricle Histone H3K27ac Donor STL011 Library AY369 EA Release 9    Data format 
     HDNP H3K27ac 08  UCSD H1 Derived Neuronal Progenitor Cultured Cells Histone H3K27ac Library AK408 EA Release 9    Data format 
     Ovary H3K27ac 02 08  UCSD Ovary Histone H3K27ac Donor STL002 Library AY308 EA Release 9    Data format 
     PFF H3K27ac 02 61  UCSF-UBC-USC Penis Foreskin Fibroblast Primary Cells Histone H3K27ac Donor skin02 Library A18461 EA Release 9    Data format 
     PI H3K27ac 13 71  UCSF-UBC-USC Pancreatic Islets Histone H3K27ac Donor ZGI 213 Library A22471 EA Release 9    Data format 
     BF H3K27ac 71 45  UCSF-UBC-USC Breast Fibroblast Primary Cells Histone H3K27ac Donor RM071 Library A21645 EA Release 9    Data format 
     PI H3K27ac 73 80  UCSF-UBC-USC Pancreatic Islets Histone H3K27ac Donor ZD4 273 Library A19680 EA Release 9    Data format 
     PFM H3K27ac 01 62  UCSF-UBC-USC Penis Foreskin Melanocyte Primary Cells Histone H3K27ac Donor skin01 Library A18462 EA Release 9    Data format 
     PFM H3K27ac 03 84  UCSF-UBC-USC Penis Foreskin Melanocyte Primary Cells Histone H3K27ac Donor skin03 Library A15584 EA Release 9    Data format 
     PFF H3K27ac 01 60  UCSF-UBC-USC Penis Foreskin Fibroblast Primary Cells Histone H3K27ac Donor skin01 Library A18460 EA Release 9    Data format 
     PFK H3K27ac 03 77  UCSF-UBC-USC Penis Foreskin Keratinocyte Primary Cells Histone H3K27ac Donor skin03 Library A15577 EA Release 9    Data format 
     NGED H3K27ac 04 08  UCSF-UBC-USC Neurosphere Cultured Cells Ganglionic Eminence Derived Histone H3K27ac Donor HuFNSC04 Library A19308 EA Release 9    Data format 
     PA H3K27ac 02 22  UCSF-UBC-USC Placenta Amnion Histone H3K27ac Donor CTL02 Library A21722 EA Release 9    Data format 
     PBM H3K27ac 16 38  UCSF-UBC-USC Peripheral Blood Mononuclear Primary Cells Histone H3K27ac Donor TC016 Library A21638 EA Release 9    Data format 
     PBM H3K27ac 15 31  UCSF-UBC-USC Peripheral Blood Mononuclear Primary Cells Histone H3K27ac Donor TC015 Library A21631 EA Release 9    Data format 
     PCS H3K27ac 02 15  UCSF-UBC-USC Placenta Chorion Smooth Histone H3K27ac Donor CTL02 Library A21715 EA Release 9    Data format 
     HUES6 H3K27ac 35  BI HUES6 Cell Line Histone H3K27ac Library DNA_Lib 835 EA Release 9    Data format 
     HUES64 H3K27ac 34  BI HUES64 Cell Line Histone H3K27ac Library DNA_Lib 834 EA Release 9    Data format 
     HUES6 H3K27ac 37  BI HUES6 Cell Line Histone H3K27ac Library DNA_Lib 837 EA Release 9    Data format 
     BSN H3K27ac 49 60  BI Brain Substantia Nigra Histone H3K27ac Donor 149 Library DNA_Lib 1060 EA Release 9    Data format 
     CM H3K27ac 55 47  BI Colonic Mucosa Histone H3K27ac Donor 155 Library DNA_Lib 1047 EA Release 9    Data format 
     CSM H3K27ac 56 30  BI Colon Smooth Muscle Histone H3K27ac Donor 156 Library DNA_Lib 930 EA Release 9    Data format 
     CfBMDMSC H3K27ac 60 00  BI Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Histone H3K27ac Donor 60 Library DNA_Lib 1000 EA Release 9    Data format 
     CfBMDMSC H3K27ac 59 01  BI Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Histone H3K27ac Donor 59 Library DNA_Lib 1001 EA Release 9    Data format 
     DM H3K27ac 59 48  BI Duodenum Mucosa Histone H3K27ac Donor 159 Library DNA_Lib 1048 EA Release 9    Data format 
     BHM H3K27ac 12 49  BI Brain Hippocampus Middle Histone H3K27ac Donor 112 Library DNA_Lib 1049 EA Release 9    Data format 
     BMDMSC H3K27ac 57 96  BI Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Histone H3K27ac Donor 57 Library DNA_Lib 996 EA Release 9    Data format 
     BMDMSC H3K27ac 58 97  BI Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Histone H3K27ac Donor 58 Library DNA_Lib 997 EA Release 9    Data format 
     CfBMDMSC H3K27ac 58 95  BI Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Histone H3K27ac Donor 58 Library DNA_Lib 995 EA Release 9    Data format 
     RM H3K27ac 29 42  BI Rectal Mucosa Histone H3K27ac Donor 29 Library DNA_Lib 1042 EA Release 9    Data format 
     RSM H3K27ac 30 43  BI Rectal Smooth Muscle Histone H3K27ac Donor 30 Library DNA_Lib 1043 EA Release 9    Data format 
     BMDMSC H3K27ac 59 98  BI Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Histone H3K27ac Donor 59 Library DNA_Lib 998 EA Release 9    Data format 
     BMDMSC H3K27ac 60 99  BI Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Histone H3K27ac Donor 60 Library DNA_Lib 999 EA Release 9    Data format 
     AK H3K27ac 53 46  BI Adult Kidney Histone H3K27ac Donor 153 Library DNA_Lib 1046 EA Release 9    Data format 
     RM H3K27ac 31 44  BI Rectal Mucosa Histone H3K27ac Donor 31 Library DNA_Lib 1044 EA Release 9    Data format 
     CM H3K27ac 32 45  BI Colonic Mucosa Histone H3K27ac Donor 32 Library DNA_Lib 1045 EA Release 9    Data format 
     AK H3K27ac 27 55  BI Adult Kidney Histone H3K27ac Donor 27 Library DNA_Lib 1055 EA Release 9    Data format 
     BAG H3K27ac 12 54  BI Brain Angular Gyrus Histone H3K27ac Donor 112 Library DNA_Lib 1054 EA Release 9    Data format 
     AL H3K27ac 3 57  BI Adult Liver Histone H3K27ac Donor 3 Library DNA_Lib 1057 EA Release 9    Data format 
     AL H3K27ac 4 56  BI Adult Liver Histone H3K27ac Donor 4 Library DNA_Lib 1056 EA Release 9    Data format 
     BMFL H3K27ac 12 51  BI Brain Mid Frontal Lobe Histone H3K27ac Donor 112 Library DNA_Lib 1051 EA Release 9    Data format 
     BAC H3K27ac 12 50  BI Brain Anterior Caudate Histone H3K27ac Donor 112 Library DNA_Lib 1050 EA Release 9    Data format 
     BITL H3K27ac 12 53  BI Brain Inferior Temporal Lobe Histone H3K27ac Donor 112 Library DNA_Lib 1053 EA Release 9    Data format 
     BCG H3K27ac 12 52  BI Brain Cingulate Gyrus Histone H3K27ac Donor 112 Library DNA_Lib 1052 EA Release 9    Data format 
     hDCEcto H3K27ac 94  BI hESC Derived CD56+ Ectoderm Cultured Cells Histone H3K27ac Library DNA_Lib 3194 EA Release 9    Data format 
     hDCM H3K27ac 95  BI hESC Derived CD56+ Mesoderm Cultured Cells Histone H3K27ac Library DNA_Lib 3195 EA Release 9    Data format 
     hDCEcto H3K27ac 91  BI hESC Derived CD56+ Ectoderm Cultured Cells Histone H3K27ac Library DNA_Lib 3191 EA Release 9    Data format 
     hDCE H3K27ac 89  BI hESC Derived CD184+ Endoderm Cultured Cells Histone H3K27ac Library DNA_Lib 3189 EA Release 9    Data format 
     hDCE H3K27ac 88  BI hESC Derived CD184+ Endoderm Cultured Cells Histone H3K27ac Library DNA_Lib 3188 EA Release 9    Data format 
     hDCM H3K27ac 98  BI hESC Derived CD56+ Mesoderm Cultured Cells Histone H3K27ac Library DNA_Lib 3198 EA Release 9    Data format 
     CCCTreg H3K27ac 62 41  BI CD4+ CD25+ CD127- Treg Primary Cells Histone H3K27ac Donor 62 Library DNA_Lib 1841 EA Release 9    Data format 
     CCT H3K27ac 32 75  BI CD4+ CD25- Th Primary Cells Histone H3K27ac Donor 332 Library DNA_Lib 2275 EA Release 9    Data format 
     HUES64 H3K27ac 69  BI HUES64 Cell Line Histone H3K27ac Library DNA_Lib 2069 EA Release 9    Data format 
     HUES48 H3K27ac 68  BI HUES48 Cell Line Histone H3K27ac Library DNA_Lib 2068 EA Release 9    Data format 
     BSN H3K27ac 49 47  BI Brain Substantia Nigra Histone H3K27ac Donor 149 Library DNA_Lib 1847 EA Release 9    Data format 
     CCCTmem H3K27ac 32 69  BI CD4+ CD25int CD127+ Tmem Primary Cells Histone H3K27ac Donor 332 Library DNA_Lib 2269 EA Release 9    Data format 
     CCIPsMpT H3K27ac 32 63  BI CD4+ CD25- IL17- PMA-Ionomycin stimulated MACS purified Th Primary Cells Histone H3K27ac Donor 332 Library DNA_Lib 2263 EA Release 9    Data format 
     CD19 H3K27ac 01 12  UW CD19 Primary Cells Histone H3K27ac Donor RO 01701 Library Histone.DS21712 EA Release 9    Data format 
     CD56 H3K27ac 01 16  UW CD56 Primary Cells Histone H3K27ac Donor RO 01701 Library Histone.DS21716 EA Release 9    Data format 
     FT H3K27ac 44 83  UW Fetal Thymus Histone H3K27ac Donor H-24644 Library Histone.DS21783 EA Release 9    Data format 
     CD3 H3K27ac 01 04  UW CD3 Primary Cells Histone H3K27ac Donor RO 01701 Library Histone.DS21704 EA Release 9    Data format 
     FIL H3K27ac 95 80  UW Fetal Intestine Large Histone H3K27ac Donor H-24595 Library Histone.DS21780 EA Release 9    Data format 
     FIS H3K27ac 95 81  UW Fetal Intestine Small Histone H3K27ac Donor H-24595 Library Histone.DS21781 EA Release 9    Data format 
     FML H3K27ac 44 82  UW Fetal Muscle Leg Histone H3K27ac Donor H-24644 Library Histone.DS21782 EA Release 9    Data format 
     CD8 H3K27ac 79 79  UW CD8 Primary Cells Histone H3K27ac Donor RO 01679 Library Histone.DS21779 EA Release 9    Data format 
     CD14 H3K27ac 21 26  UW CD14 Primary Cells Histone H3K27ac Donor RO 01721 Library Histone.DS22926 EA Release 9    Data format 
     FS H3K27ac 83 29  UW Fetal Stomach Histone H3K27ac Donor H-24683 Library Histone.DS22929 EA Release 9    Data format 
     FP H3K27ac 96 01  UW Fetal Placenta Histone H3K27ac Donor H-24996 Library Histone.DS23301 EA Release 9    Data format 
     FMT H3K27ac 51 03  UW Fetal Muscle Trunk Histone H3K27ac Donor H-24851 Library Histone.DS23303 EA Release 9    Data format 
     FAG H3K27ac 00 04  UW Fetal Adrenal Gland Histone H3K27ac Donor H-24800 Library Histone.DS23304 EA Release 9    Data format 
    
Assembly: Human Feb. 2009 (GRCh37/hg19)

Vizhub @ Wash U built this track, and Roadmap Epigenomics Consortium is responsible for its contents.

Description

These tracks are genome-wide maps on epigenetic marks surveyed by Roadmap Epigenomics Project. Each track is about one type of epigenetic mark, and contains multiple experiments assayed for that mark type. DNA methylation and histone modification are two types of most important epigenetic marks.

DNA methylation of human DNA mostly happens on cytosine bases of CpG dinucleotides. The methylated DNA usually prevent accessibility of regulatory proteins and hampers transcription, while unmethylated DNA is usually indicative of open chromatin. The MeDIP-Seq and MRE-Seq experiments are usually performed on same sample to identify genome-wide DNA methylation pattern. MeDIP-Seq (methylated DNA immunoprecipitation and sequencing) is a ChIP-based approach utilizing antibody against methylated cytosine. This method enriches methylated DNA and high read count indicates high likelihood of underlying region is methylated. The MRE-Seq (methylation restriction enzyme sequencing) uses methylation-sensitive restriction enzymes to digest DNA, and only cut at unmethylated restriction sites. The cut restriction sites will be detected by sequencing where reads aligned to a restriction site on reference genome means the restriction site is unmethylated.

The MethylC-Seq (MethylC sequencing) uses bisulfite to convert methylated cytosines to thymines before sequencing. The percentage of reads with a T versus a C indicates the percentage methylation at the cytosine. Details can be found in this paper Lister R, et al., Nature. 2009 Nov 19;462(7271):315-22. .

RRBS (Reduced-Representation-Bisulfite-Sequencing) is similar to MethylC-seq except RRBS uses restriction enzyme to fragment the genome into fragments suitably-sized for sequencing. While RRBS produces percent methylation similar to MethylC-seq, it is limited to cytosines that are within restriction fragments of a suitable size and then tend to measure CpG dense regions only. Details can be found in this paper: Meissener, A. et al., Nucleic Acids Res. 2005; 33(18): 5868-5877. .

Histone marks are critical epigenetic components. They are covalent modifications of amino acid residues of histone proteins, which modify protein's biochemical property and affect transcription and chromatin state. The histone marks are measured by ChIP-Seq experiments (chromatin immunoprecipitation followed by sequencing).

Display conventions

Each track can be turned on/off individually. Inside each track, sub-tracks are displayed in same vertical space and are overlayed with transparent colors for contrast. All tracks displays read density data in form of wiggle plots. Number of aligned reads is counted at each base pair, and a summarized value is computed for each 20 bp interval for display. Sub-tracks sharing same space use same scale.

Methods

Experimental protocols: follow this link for experimental protocols.

Data processing: EDACC carried out data processing and quality assessment. Details are fully explained here . In brief, sequencing reads were aligned with 'Pash' program to derive read density data. The read density data is prepared into 'wiggle' format files with fixed step length of 20 bp. Data in wiggle and other formats have been deposited in NCBI Gene Expression Omnibus database for public access.

Quality control: the HotSpot was one of the methods used to assess quality of ChIP-Seq experiments. The long track name includes a "Hotspot_Score" field indicates the percentage of sequencing reads found inside hotspot regions. The "Pcnt" field shows the percentile of current experiment score in this type of ChIP-Seq experiments (e.g., all H3K4me3 ChIP-Seq experiments). This value is subject to change in next Data Release. The most comprehensive and up-to-date description on QC Metrics used by the consortium can be found here .

Release Notes

The data is combination of Release II, III, IV, V, VI, VII, VIII and IX which were mapped to human reference genome version hg19. The data is production of Roadmap Epigenomics Project.

Please follow the link for Roadmap Epigenomics data access policy

Credits

These data were generated in labs from participating institutions of Roadmap Epigenomics Project.

Useful links