UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	lgc-39	F09G2.5	0	chrV 7,177,156	C. elegans LGC-39 protein; contains similarity to Pfam domains PF02931 (Neurotransmitter-gated ion-channel ligand binding domain) , PF02932 (Neurotransmitter-gated ion-channel transmembrane region) contains similarity to Interpro domains IPR006028 (Gamma-aminobutyric acid A receptor), IPR006201 (Neurotransmitter-gated ion-channel), IPR006202 (Neurotransmitter-gated ion-channel ligand-binding), IPR006029 (Neurotransmitter-gated ion-channel transmembrane region)
2	nhr-79	T26H2.9	n/a	chrV 19,209,750	C. elegans NHR-79 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
3	C30G12.4	C30G12.4	n/a	chrII 7,262,590	contains similarity to Pfam domain PF02795 Domain of unknown function (DUF225) contains similarity to Interpro domain IPR004024 (Protein of unknown function DUF225)
4	F09G2.3	F09G2.3	n/a	chrV 7,186,673	contains similarity to Pfam domain PF01384 Phosphate transporter family contains similarity to Interpro domain IPR001204 (Phosphate transporter)
5	F37H8.5	F37H8.5	n/a	chrII 11,188,743	contains similarity to Pfam domain PF03227 Gamma interferon inducible lysosomal thiol reductase (GILT) contains similarity to Interpro domain IPR004911 (Gamma interferon inducible lysosomal thiol reductase GILT)
6	srh-284	C47A10.3	n/a	chrV 17,768,552	C. elegans SRH-284 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
7	F01G12.6	F01G12.6	n/a	chrX 16,401,117	contains similarity to Drosophila melanogaster Flybase gene name is CG11727-PA;; FLYBASE:CG11727
8	fipr-15	F13E9.3	n/a	chrIV 10,880,611	C. elegans FIPR-15 protein; contains similarity to Interpro domain IPR005137 (Photosystem I assembly BtpA)
9	T24B8.4	T24B8.4	n/a	chrII 9,067,183	contains similarity to Pfam domain PF02205 WH2 motif contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR003124 (Actin-binding WH2)
10	T07F8.2	T07F8.2	n/a	chrII 7,145,876	contains similarity to Pfam domain PF00001 7 transmembrane receptor (rhodopsin family) contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR000276 (GPCR, rhodopsin-like)
11	rab-6.2	T25G12.4	n/a	chrX 17,223,409	rab-6.2 encodes a small, monomeric Rab GTPase that is most closely related to the Drosophila and mammalian Rab6 GTPases; by homology, RAB-6.2 is predicted to function in the regulation of intracellular membrane trafficking; RNAi experiments indicate that rab-6.2 is required redundantly with rab-6.1 for normal embryonic development and reproduction.
12	W08F4.7	W08F4.7	n/a	chrII 576,333
13	F55H12.2	F55H12.2	n/a	chrI 8,868,112	contains similarity to Interpro domain IPR000242 (Tyrosine specific protein phosphatase)
14	B0478.3	B0478.3	n/a	chrIV 6,964,202	contains similarity to Interpro domains IPR013090 (Phospholipase A2, active site), IPR016090 (Phospholipase A2), IPR001211 (Phospholipase A2, eukaryotic)
15	B0285.1	B0285.1	n/a	chrIII 4,336,901	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR000719 (Protein kinase, core), IPR000694 (Proline-rich region)
16	lin-52	ZK632.13	n/a	chrIII 9,824,348	lin-52 encodes a novel protein that is most closely related to the Drosophila melanogaster CG15929 protein and the human protein XP_040376; lin-52 is a class B synthetic multivulva (synMuv) gene that appears to function with lin-35/Rb to negatively regulate vulval development; in addition, lin-52 is also required for germline and larval development.
17	C05C9.1	C05C9.1	n/a	chrX 11,162,259	contains similarity to Pfam domain PF02886 LBP / BPI / CETP family, C-terminal domain contains similarity to Interpro domain IPR001124 (Lipid-binding serum glycoprotein)
18	F21G4.6	F21G4.6	n/a	chrX 9,913,063	F21G4.6 is orthologous to the human gene HUNTINGTIN (HD; OMIM:143100), which when mutated leads to disease.
19	pxd-1	C36E8.3	n/a	chrIII 4,008,029	C. elegans PXD-1 protein ; contains similarity to Aedes aegypti Tumor endothelial marker 7.; TR:Q16R67
20	T22D1.1	T22D1.1	n/a	chrIV 6,924,455	contains similarity to Pfam domain PF01697 Domain of unknown function contains similarity to Interpro domains IPR008167 (Protein of unknown function DUF23, C-terminal), IPR001711 (Phospholipase C, phosphatidylinositol-specific, Y domain), IPR008166 (Protein of unknown function DUF23)
21	aha-1	C25A1.11	n/a	chrI 10,195,452	aha-1 encodes an ortholog of human aryl-hydrocarbon receptor nuclear translocator; interacts with AHR-1 and HIF-1 in vitro, requires HIF-1 for proper localization, and is expressed ubiquitously.
22	C01H6.2	C01H6.2	n/a	chrI 7,206,143	contains similarity to Pfam domain PF00023 Ankyrin repeat contains similarity to Interpro domain IPR002110 (Ankyrin)
23	nhr-131	T01G6.2	n/a	chrV 495,899	C. elegans NHR-131 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
24	lam-2	C54D1.5	n/a	chrX 7,147,481	lam-2 encodes a laminin gamma subunit; lam-2 activity is required for embryonic development and for regulation of muscle arm extension; loss of lam-2 function via large-scale RNAi screens results in embryonic, larval, and adult lethality, sterility, body morphology defects, and abnormal locomotion.
25	C35D10.12	C35D10.12	n/a	chrIII 4,873,622	contains similarity to Pfam domains PF08242 (Methyltransferase domain) , PF08241 (Methyltransferase domain) contains similarity to Interpro domains IPR011644 (Haem NO binding), IPR013217 (Methyltransferase type 12), IPR013216 (Methyltransferase type 11)
26	cyp-37A1	F01D5.9	n/a	chrII 14,015,298	C. elegans CYP-37A1 protein; contains similarity to Pfam domain PF00067 Cytochrome P450 contains similarity to Interpro domains IPR001128 (Cytochrome P450), IPR002401 (Cytochrome P450, E-class, group I), IPR002402 (Cytochrome P450, E-class, group II), IPR002403 (Cytochrome P450, E-class, group IV)
27	eif-3.G	F22B5.2	n/a	chrII 8,443,436	eif-3.G encodes a homolog of eukaryotic translation initiation factor 3, subunit 4 that affects embryonic viability, fertility, and growth.
28	slt-1	F40E10.4	n/a	chrX 14,678,771	slt-1 encodes the sole C. elegans homolog of Drosophila Split, a secreted extracellular protein containing leucine-rich and EGF-like repeats that functions as a ligand for the Robo receptor; during C. elegans larval development, slt-1 acts via the SAX-3/Robo receptor, and in parallel with UNC-6/Netrin, to direct ventral axon guidance and guidance at the midline; during embryonic development, slt-1 also functions to regulate anterior-posterior migrations of the CAN neurons; slt-1::gfp reporters are initially expressed at high levels in the anterior part of the embryo, with more moderate levels seen in dorsal tail muscles and lower levels seen in cells in the center of the body; in L1 larvae, slt-1::gfp is expressed in both dorsal and ventral muscles, with higher levels seen in dorsal muscle cells; slt-1::gfp is also expressed in a number of additional cells including some neurons, pharyngeal cells, and the anal sphincter muscle.
29	R06A4.8	R06A4.8	n/a	chrII 14,354,036	R06A4.8 is orthologous to the human gene GLYCOGEN DEBRANCHING ENZYME ISOFORM 6 (AGL; OMIM:232400), which when mutated leads to glycogen storage disease, type III.
30	str-214	C31A11.9	n/a	chrV 16,316,238	C. elegans STR-214 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
31	F52G3.1	F52G3.1	n/a	chrX 16,968,223	contains similarity to Pfam domain PF07001 BAT2 N-terminus contains similarity to Interpro domains IPR009738 (BAT2, N-terminal), IPR000694 (Proline-rich region)
32	ugt-52	F56B3.7	n/a	chrIV 781,452	C. elegans UGT-52 protein; contains similarity to Pfam domain PF00201 UDP-glucoronosyl and UDP-glucosyl transferase contains similarity to Interpro domain IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase)
33	F25B4.5	F25B4.5	n/a	chrV 5,680,736	contains similarity to Interpro domain IPR003107 (RNA-processing protein, HAT helix)
34	lam-1	W03F8.5	n/a	chrIV 5,176,291	lam-1 encodes a laminin beta that affects degenerin-induced cell death and is required redundantly with lam-2 for morphogenesis.
35	cyp-33E2	F42A9.5	n/a	chrIV 8,613,501	C. elegans CYP-33E2 protein; contains similarity to Pfam domain PF00067 Cytochrome P450 contains similarity to Interpro domains IPR001128 (Cytochrome P450), IPR002401 (Cytochrome P450, E-class, group I), IPR002403 (Cytochrome P450, E-class, group IV), IPR002397 (Cytochrome P450, B-class)
36	C11E4.6	C11E4.6	n/a	chrX 9,613,728	contains similarity to Pfam domains PF07647 (SAM domain (Sterile alpha motif)) , PF00640 (Phosphotyrosine interaction domain (PTB/PID)) , PF00023 (Ankyrin repeat) (5), PF00536 (SAM domain (Sterile alpha motif)) contains similarity to Interpro domains IPR010993 (Sterile alpha motif homology), IPR011993 (Pleckstrin homology-type), IPR002110 (Ankyrin), IPR013761 (Sterile alpha motif-type), IPR001660 (Sterile alpha motif SAM), IPR011510 (Sterile alpha motif homology 2), IPR006020 (Phosphotyrosine interaction region)
37	K12H4.4	K12H4.4	n/a	chrIII 8,045,336	contains similarity to Pfam domain PF04573 Signal peptidase subunit contains similarity to Interpro domain IPR007653 (Signal peptidase 22 kDa subunit)
38	lst-2	R160.7	n/a	chrX 4,380,673	C. elegans LST-2 protein; contains similarity to Pfam domain PF01363 FYVE zinc finger contains similarity to Interpro domains IPR000306 (Zinc finger, FYVE-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR017455 (Zinc finger, FYVE-related), IPR011011 (Zinc finger, FYVE/PHD-type)
39	F53B6.5	F53B6.5	n/a	chrI 8,950,742	contains similarity to Pfam domain PF00557 metallopeptidase family M24 contains similarity to Interpro domains IPR000994 (Peptidase M24, catalytic core), IPR011991 (Winged helix repressor DNA-binding)
40	cyp-14A4	R04D3.1	n/a	chrX 13,283,058	C. elegans CYP-14A4 protein; contains similarity to Pfam domain PF00067 Cytochrome P450 contains similarity to Interpro domains IPR001128 (Cytochrome P450), IPR002401 (Cytochrome P450, E-class, group I), IPR002403 (Cytochrome P450, E-class, group IV), IPR002397 (Cytochrome P450, B-class)
41	gpb-1	F13D12.7	n/a	chrII 11,745,729	gpb-1 encodes a heterotrimeric G protein beta subunit that is required during embryonic development for the proper orientation of the mitotic spindle during early cell divisions and thus affects the orientation of early cell division axes, and is also required for larval viability, negatively regulates locomotion and egg-laying, and may affect germline development and osmotic balance; expressed in early embryos with highest expression at cell membranes and colocalizes with asters just before and during early cell divisions (this localization is dependent upon G alpha subunits); adults display high levels of expression in neurons with lower expression in the somatic gonad, vulva, and hypodermal seam cells and expression is also detected in the intestine, pharynx, body wall muscles and in the germline.
42	ubc-17	B0403.2	n/a	chrX 7,052,951	C. elegans UBC-17 protein; contains similarity to Pfam domain PF00179 Ubiquitin-conjugating enzyme contains similarity to Interpro domains IPR016135 (Ubiquitin-conjugating enzyme/RWD-like), IPR000608 (Ubiquitin-conjugating enzyme, E2)
43	R03C1.1	R03C1.1	n/a	chrII 14,908,902	contains similarity to Homo sapiens Mucin-5AC precursor (Fragment); ENSEMBL:ENSP00000351148
44	F40F12.4	F40F12.4	n/a	chrIII 9,895,687	contains similarity to Interpro domain IPR000998 (MAM)
45	fce-1	C04F12.10	n/a	chrI 9,711,884	fce-1 encodes an ortholog of 'farnesylated-proteins converting enzyme 1' (FACE-1), and thus probably enables post-translational processing of proteins (such as LET-60/RAS) carrying a C-terminal CaaX motif; FCE-1 protein probably accounts for the EDTA-sensitive, tosylphenylalanylchloromethane-insensitive component of CaaX-proteolytic activity in membrane extracts from C. elegans, and FCE-1 can cleave a farnesylated peptide in vitro; the S. cerevisiae homolog of FCE-1 (Ste24p) cleaves the precursor of yeast a-factor mating pheromone after its farnesylated cysteine residue, and transgenic FCE-1 rescues a mating defect of mutant yeast lacking both the Ste24p and the Rce1p CaaX-proteases.
46	Y18D10A.8	Y18D10A.8	n/a	chrI 12,848,697	contains similarity to Pfam domain PF00013 KH domain contains similarity to Interpro domains IPR016021 (MIF4-like, type 1/2/3), IPR004087 (K Homology), IPR000694 (Proline-rich region), IPR004088 (K Homology, type 1), IPR016024 (Armadillo-type fold)
47	F58H7.2	F58H7.2	n/a	chrIV 942,839	contains similarity to Pfam domain PF01425 Amidase contains similarity to Interpro domains IPR000120 (Amidase signature enzyme), IPR015830 (Amidase, fungi type)
48	H34I24.2	H34I24.2	n/a	chrIII 2,843,610	contains similarity to Homo sapiens Mucin-7 precursor; ENSEMBL:ENSP00000302021
49	twk-30	F36A2.4	n/a	chrI 8,810,320	C. elegans TWK-30 protein; contains similarity to Pfam domains PF00041 (Fibronectin type III domain) (2), PF07885 (Ion channel) (2)contains similarity to Interpro domains IPR003280 (Potassium channel, two pore-domain), IPR008957 (Fibronectin, type III-like fold), IPR003961 (Fibronectin, type III), IPR003938 (Potassium channel, voltage-dependent, EAG/ELK/ERG), IPR003962 (Fibronectin, type III subdomain), IPR013099 (Ion transport 2)
50	grl-29	T24A6.18	n/a	chrV 3,554,921	grl-29 encodes a hedgehog-like protein, with an N-terminal signal sequence, a central low-complexity region, and a C-terminal Ground-like (Grl) domain; GRL-29 is expressed in larval neurons; the Grl domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins.