UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	cpr-1	C52E4.1	0	chrV 11,976,112	cpr-1 encodes a cysteine protease of the cathepsin B-like cysteine protease family; cpr-1 appears to be required for embryogenesis; cpr-1 is specifically expressed in the gut of all stages except the embryo and around developing embryos in the gonad; expression of cpr-1 is regulated by three promoter GATA motifs.
2	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
3	asp-5	F21F8.3	n/a	chrV 8,273,166	C. elegans ASP-5 protein; contains similarity to Pfam domain PF00026 Eukaryotic aspartyl protease contains similarity to Interpro domains IPR009007 (Peptidase aspartic, catalytic), IPR001969 (Peptidase aspartic, active site), IPR001461 (Peptidase A1)
4	rpn-7	F49C12.8	n/a	chrIV 9,317,349	rpn-7 is predicted to encode a non-ATPase subunit of the 19S regulatory complex of the proteasome that affects fertility and embryonic viability.
5	W04E12.7	W04E12.7	n/a	chrV 19,731,742	contains similarity to Pfam domain PF06162 Caenorhabditis elegans protein of unknown function (DUF976) contains similarity to Interpro domains IPR010381 (Protein of unknown function DUF976, Caenorhabditis species), IPR016125 (Peptidase C15, pyroglutamyl peptidase I-like)
6	F47C12.1	F47C12.1	n/a	chrIV 4,001,937	contains similarity to Pfam domains PF00008 (EGF-like domain) (4), PF00754 (F5/8 type C domain) , PF07645 (Calcium binding EGF domain) (2), PF07699 (GCC2 and GCC3) (3), PF00431 (CUB domain) , PF07974 (EGF-like domain) , PF02494 (HYR domain) (2), PF00084 (Sushi domain (SCR repeat)) (6)contains similarity to Interpro domains IPR001438 (EGF-like, type 2), IPR000742 (EGF-like, type 3), IPR003410 (Hyalin), IPR000436 (Sushi/SCR/CCP), IPR006209 (EGF-like), IPR000152 (Aspartic acid and asparagine hydroxylation site), IPR006210 (EGF), IPR002049 (EGF-like, laminin), IPR008979 (Galactose-binding like), IPR000859 (CUB), IPR011641 (GCC2 and GCC3), IPR001881 (EGF-like calcium-binding), IPR016060 (Complement control module), IPR009030 (Growth factor, receptor), IPR013032 (EGF-like region, conserved site), IPR000421 (Coagulation factor 5/8 type, C-terminal), IPR013111 (EGF, extracellular), IPR013091 (EGF calcium-binding)
7	asp-6	F21F8.7	n/a	chrV 8,268,253	aspartic protease.
8	F09C12.6	F09C12.6	n/a	chrII 5,117,137	contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR002651 (Protein of unknown function DUF32)
9	hmp-2	K05C4.6	n/a	chrI 14,741,100	hmp-2 encodes a beta-catenin; HMP-2 activity is required during embryonic development for cell adhesion at adherens junctions, cell migration, and body morphogenesis; as a beta-catenin, HMP-2 likely functions solely as part of a cadherin-catenin complex, as in yeast two-hybrid assays, HMP-2 is the only C. elegans beta-catenin that binds HMP-1/alpha-catenin and HMR-1/cadherin; additionally, in the embryo, HMP-2 co-localizes to sites of epithelial cell contacts with HMP-1 and HMR-1/cadherin; however, despite its normal role in embryonic cell adhesion, HMP-2 can activate transcription and when overexpressed in vivo, can partially rescue vulval defects produced by loss of BAR-1/beta-catenin, suggesting that HMP-2 has retained the ability to interact with the Wnt signaling pathway.
10	pas-2	D1054.2	n/a	chrV 10,770,774	pas-2 encodes a proteasome subunit with highest similarity to vertebrate proteasome alpha 2 subunits.
11	T10C6.7	T10C6.7	n/a	chrV 16,030,594	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
12	pas-4	C36B1.4	n/a	chrI 8,727,906	pas-4 encodes a proteasome alpha-type seven subunit of the core 20S proteasome subcomplex; loss of pas-4 activity via RNAi results in a wide variety of defects including embryonic and larval lethality, sterility, abnormal locomotion, slow growth, and abnormal transgene expression and subcellular localization; loss of pas-4 activity also results in activation of SKN-1, a transcription factor required in adult worms for the acute response to oxidative stress and maternally for embryonic development.
13	cpr-4	F44C4.3	5e-91	chrV 6,615,242	cpr-4 encodes a cathepsin B-like cysteine protease expressed at all life stages.
14	elo-1	F56H11.4	n/a	chrIV 9,527,335	elo-1 encodes a component of C-18 polyunsaturated fatty acid (PUFA) elongase that is required for normal elongation of n-6 and n-3 20-carbon PUFA in vivo; ELO-1 is a condensing enzyme that elongates n-6 and n-7 (and, with less efficiency, n-3) series C18 PUFAs.
15	C13B9.3	C13B9.3	n/a	chrIII 6,623,764	C13B9.3 encodes a delta subunit of the coatomer (COPI) complex; in mass RNAi assays, C13B9.3 is required for fertility and general health.
16	dpf-5	R11E3.8	n/a	chrIV 4,804,689	dpf-5 encodes a putative acylamino-acid-releasing enzyme (AARE; EC 3.4.19.1), orthologous to human APEH, with no obvious function in mass RNAi assays.
17	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
18	ZK1320.3	ZK1320.3	n/a	chrII 9,659,772
19	rpl-6	R151.3	n/a	chrIII 7,209,034	rpl-6 encodes a large ribosomal subunit L6 protein.
20	C01H6.4	C01H6.4	n/a	chrI 7,211,559	contains similarity to Pfam domains PF00070 (Pyridine nucleotide-disulphide oxidoreductase) , PF00743 (Flavin-binding monooxygenase-like) contains similarity to Interpro domains IPR013027 (FAD-dependent pyridine nucleotide-disulphide oxidoreductase), IPR000759 (Adrenodoxin reductase), IPR000960 (Flavin-containing monooxygenase FMO), IPR000103 (Pyridine nucleotide-disulphide oxidoreductase, class-II), IPR001327 (Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region), IPR016040 (NAD(P)-binding), IPR001100 (Pyridine nucleotide-disulphide oxidoreductase, class I)
21	fbxa-131	W04E12.1	n/a	chrV 19,734,294	C. elegans FBXA-131 protein; contains similarity to Pfam domain PF01827 FTH domain contains similarity to Interpro domain IPR002900 (Protein of unknown function DUF38, Caenorhabditis species)
22	C36A4.5	C36A4.5	n/a	chrIII 3,846,247	contains similarity to Interpro domains IPR003993 (Treacher Collins syndrome, treacle), IPR000694 (Proline-rich region), IPR005819 (Histone H5)
23	elo-2	F11E6.5	n/a	chrIV 17,466,787	The elo-2 gene encodes a palmitic acid elongase, homologous to polyunsaturated fatty acid (PUFA) elongases such as ELO-1, that is required for normally rapid growth, normally large body size, fertility, and for the quantitative regulation of the ultradian defecation rhythm; the joint action of ELO-2 with ELO-1 is strongly required for 20-carbon PUFA production and for general viability; elo-2 is most strongly expressed in intestinal cells, as well as other tissues such as the ventral nerve cord, pharyngeal muscles, uterus, and tail.
24	F39H12.3	F39H12.3	n/a	chrX 839,898	contains similarity to Pfam domains PF00612 (IQ calmodulin-binding motif) (3), PF02197 (Regulatory subunit of type II PKA R-subunit) contains similarity to Interpro domains IPR003117 (cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta), IPR000048 (IQ calmodulin-binding region)
25	K05F1.10	K05F1.10	n/a	chrII 5,805,057	K05F1.10 encodes a putative secreted TIL-domain protease inhibitor paralogous to SWM-1, ISL-1, and the products of 11 other C. elegans genes; K05F1.10 and its relatives are collectively similar to other TIL-domain protease inhibitors from nematodes, insects, and vertebrates; although it has no obvious function in mass RNAi assays, K05F1.10 transcription is reproducibly induced by infection, suggesting that it may participate in innate immunity.
26	rde-1	K08H10.7	n/a	chrV 9,989,751	rde-1 encodes a novel, conserved protein that is a member of the PIWI/STING/Argonaute/Zwille/eIF2c family of proteins; rde-1 activity is required for RNA-mediated interference (RNAi), likely at a point after small interfering RNAs (siRNAs) have been produced from dsRNA triggers; RDE-1 interacts with RDE-4 in vivo and its activity is also required for accumulation of dsRNA bound to RDE-4.
27	fshr-1	C50H2.1	n/a	chrV 9,892,316	fshr-1 encodes a putative neuropeptide receptor required for normal acetylcholine secretion by synapses; FSHR-1 is orthologous to human follicle-stimulating hormone receptor (OMIM:136435; mutated in ovarian dysgenesis), thyrotropin receptor (OMIM:603372; mutated in hyperthyroidism), and luteinizing hormone receptor (OMIM:152790, mutated in precocious puberty); fshr-1 mutants have abnormally many GFP::SNB-1 puncta at synapses, suggesting exocytotic defects; the requirement for FSHR-1 and ten other predicted neuropeptide signalling proteins in cholinergic neurotransmission indicates that such signalling is important for regulating acetylcholine release at neuromuscular junctions; possible ligands of FSHR-1 are FLP-1 and NLP-12.
28	rpt-2	F29G9.5	n/a	chrV 6,016,841	C. elegans RPT-2 protein; contains similarity to Pfam domain PF00004 ATPase family associated with various cellular activities (AAA) contains similarity to Interpro domains IPR003959 (AAA ATPase, core), IPR003960 (AAA ATPase, conserved site), IPR005937 (26S proteasome subunit P45), IPR003593 (AAA+ ATPase, core)
29	heh-1	R148.6	n/a	chrIII 3,199,010	tag-79/R148.6 is orthologous to human NPC2 (OMIM:601015, mutated in Niemann-Pick disease type C2)
30	F33H2.6	F33H2.6	n/a	chrI 15,015,710	contains similarity to Interpro domains IPR011990 (Tetratricopeptide-like helical), IPR013026 (Tetratricopeptide region)
31	lys-6	F58B3.3	n/a	chrIV 11,627,398	C. elegans LYS-6 protein; contains similarity to Pfam domain PF01183 Glycosyl hydrolases family 25 contains similarity to Interpro domains IPR017853 (Glycoside hydrolase, catalytic core), IPR013781 (Glycoside hydrolase, subgroup, catalytic core), IPR002053 (Glycoside hydrolase, family 25)
32	stdh-3	C06B3.5	n/a	chrV 13,905,299	stdh-3 encodes a putative steroid dehydrogenase orthologous to human HSD17B3 (OMIM:605573, mutated in pseudohermaphroditism), HSD17B12 (OMIM:609574), and HSDL1, and paralogous to LET-767, STDH-1/-2, and STDH-4; STDH-3 has no obvious function in mass RNAi assays.
33	asp-3	H22K11.1	n/a	chrX 6,791,899	asp-3 encodes an aspartyl protease homolog that is required, in parallel with ASP-4 but downstream of CLP-1 and TRA-3, for degenerative (necrotic-like) cell death in neurons induced by mutations such as mec-4(d), deg-3(d), or gsa-1(gf).
34	C56G2.7	C56G2.7	n/a	chrIII 6,340,161	contains similarity to Pfam domain PF04683 Adhesion regulating molecule conserved region contains similarity to Interpro domain IPR006773 (Adhesion regulating molecule)
35	F45F2.10	F45F2.10	n/a	chrV 8,515,924	contains similarity to Pfam domain PF00023 Ankyrin repeat contains similarity to Interpro domain IPR002110 (Ankyrin)
36	elo-5	F41H10.7	n/a	chrIV 5,375,925	The elo-5 gene encodes a paralog of elo-1 and elo-2, each of which encodes a polyunsaturated fatty acid (PUFA) elongase; ELO-5 is required for normally rapid growth and for normal fatty acid composition.
37	fzo-1	ZK1248.14	n/a	chrII 5,834,733	C. elegans FZO-1 protein; contains similarity to Pfam domain PF04799 fzo-like conserved region contains similarity to Interpro domains IPR006884 (Fzo-like conserved region), IPR001019 (Guanine nucleotide binding protein (G-protein), alpha subunit)
38	T23H2.3	T23H2.3	n/a	chrI 6,444,050	contains similarity to Pfam domains PF00271 (Helicase conserved C-terminal domain) , PF00176 (SNF2 family N-terminal domain) contains similarity to Interpro domains IPR000330 (SNF2-related), IPR014021 (Helicase, superfamily 1 and 2, ATP-binding), IPR014001 (DEAD-like helicase, N-terminal), IPR001650 (DNA/RNA helicase, C-terminal)
39	let-754	C29E4.8	n/a	chrIII 7,950,857	let-754 was identified in screens for ethyl methane sulfonate-induced lethal mutations on chromosome III; the let-754 mutation results in mid larval lethality; the molecular identity of let-754 is not yet known.
40	tag-257	F46G11.3	n/a	chrX 5,784,865	C. elegans TAG-257 protein; contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)
41	W01A11.1	W01A11.1	n/a	chrV 6,500,809	contains similarity to Pfam domains PF06441 (Epoxide hydrolase N terminus) , PF00561 (alpha/beta hydrolase fold) contains similarity to Interpro domains IPR016292 (Epoxide hydrolase), IPR000073 (Alpha/beta hydrolase fold-1), IPR000639 (Epoxide hydrolase-like), IPR010497 (Epoxide hydrolase, N-terminal)
42	mdh-1	F20H11.3	n/a	chrIII 6,607,404	mdh-1 encodes a homolog of malate dehydrogenase that is predicted to be mitochondrial.
43	rpn-3	C30C11.2	n/a	chrIII 8,448,263	C. elegans RPN-3 protein; contains similarity to Pfam domains PF01399 (PCI domain) , PF08375 (Proteasome regulatory subunit C-terminal) contains similarity to Interpro domains IPR013586 (26S proteasome regulatory subunit, C-terminal), IPR013143 (PCI/PINT associated module), IPR000717 (Proteasome component region PCI), IPR015350 (Beta-trefoil)
44	C44C8.4	C44C8.4	n/a	chrIV 891,926	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
45	rps-10	D1007.6	n/a	chrI 4,584,217	rps-10 encodes a small (40S) ribosomal subunit S10 protein; loss of rps-10 activity in adult animals extends lifespan.
46	cyp-35B1	K07C6.4	n/a	chrV 3,940,140	C. elegans CYP-35B1 protein; contains similarity to Pfam domain PF00067 Cytochrome P450 contains similarity to Interpro domains IPR001128 (Cytochrome P450), IPR002401 (Cytochrome P450, E-class, group I), IPR002403 (Cytochrome P450, E-class, group IV), IPR002397 (Cytochrome P450, B-class)
47	pcp-1	ZK112.1	n/a	chrIII 7,759,923	C. elegans PCP-1 protein; contains similarity to Pfam domain PF05577 Serine carboxypeptidase S28 contains similarity to Interpro domain IPR008758 (Peptidase S28)
48	R06B9.3	R06B9.3	n/a	chrII 13,759,726	contains similarity to Pfam domains PF00339 (Arrestin (or S-antigen), N-terminal domain) , PF02752 (Arrestin (or S-antigen), C-terminal domain) contains similarity to Interpro domains IPR014756 (Immunoglobulin E-set), IPR011022 (Arrestin-like, C-terminal), IPR000694 (Proline-rich region), IPR000698 (Arrestin), IPR014752 (Arrestin, C-terminal), IPR011021 (Arrestin-like, N-terminal)
49	VF13D12L.3	VF13D12L.3	n/a	chrII 11,709,716	VF13D12L.3 is orthologous to the human gene ARGININOSUCCINATE SYNTHETASE (ASS; OMIM:603470), which when mutated leads to classic citrullinemia.
50	F57F5.1	F57F5.1	3.0000000000000004e-81	chrV 12,003,793	contains similarity to Pfam domain PF00112 Papain family cysteine protease contains similarity to Interpro domains IPR013128 (Peptidase C1A, papain), IPR000169 (Peptidase, cysteine peptidase active site), IPR000668 (Peptidase C1A, papain C-terminal)