UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	cka-1	C28D4.2	0	chrIV 9,734,654	cka-1 encodes an isoform of choline kinase whose activity has been verified in vitro, and that has a strong preference for choline over ethanolamine; CKA-1 and CKA-2 comprise a related group ('A') of choline kinases.
2	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
3	pme-2	E02H1.4	n/a	chrII 9,594,003	pme-2 encodes a poly(ADP-ribose) polymerase (PARP) orthologous to human PARP2 (OMIM:607725); PME-2 has a predicted C-terminal catalytic domain; PME-2 has PARP activity in vitro, which is blocked by mammalian PARP inhibitors; since these inhibitors also cause embryonic lethality in worms exposed to ionizing radiation, PME-1 is likely to be required in vivo for repairing broken DNA.
4	T27E9.6	T27E9.6	n/a	chrIII 13,475,636	contains similarity to Bradyrhizobium japonicum Bsl1006 protein.; TR:Q89VN9
5	R05D3.8	R05D3.8	n/a	chrIII 8,357,800	contains similarity to Pfam domain PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) contains similarity to Interpro domains IPR012677 (Nucleotide-binding, alpha-beta plait), IPR000504 (RNA recognition motif, RNP-1)
6	nhr-257	C17A2.1	n/a	chrII 3,853,795	C. elegans NHR-257 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
7	F13E9.1	F13E9.1	n/a	chrIV 10,868,951	contains similarity to Pfam domains PF00560 (Leucine Rich Repeat) (4), PF00787 (PX domain) contains similarity to Interpro domains IPR001611 (Leucine-rich repeat), IPR001683 (Phox-like), IPR003591 (Leucine-rich repeat, typical subtype)
8	ilys-2	C45G7.2	n/a	chrIV 2,468,243	C. elegans ILYS-2 protein; contains similarity to Pfam domain PF05497 Destabilase contains similarity to Interpro domain IPR008597 (Destabilase)
9	uev-1	F39B2.2	n/a	chrI 14,790,521	uev-1 encodes a ubiquitin-conjugating enzyme (UBC or E2) variant that contains the characteristic UBC motif, but lacks the critical active-site cysteine residue necessary for catalytic activity; as loss of UEV-1 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of UEV-1 in C. elegans development and/or behavior is not yet known; UEV-1 does, however, interact with a number of proteins, such as UBC-13, that are likely involved in the response to DNA damage; thus, UEV-1 may play a role in ubiquitination and protein turnover in conjunction with DNA repair or the DNA damage checkpoint pathway.
10	B0205.9	B0205.9	n/a	chrI 10,722,143	contains similarity to Pfam domain PF04435 Domain of unknown function (DUF545) contains similarity to Interpro domain IPR006570 (SPK)
11	sri-42	T10D4.9	n/a	chrII 3,141,931	C. elegans SRI-42 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
12	srx-86	F38B7.7	n/a	chrV 11,563,703	C. elegans SRX-86 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
13	srh-181	ZK228.6	n/a	chrV 18,475,360	C. elegans SRH-181 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
14	ced-5	C02F4.1	n/a	chrIV 10,488,503	The ced-5 gene a homolog of the human protein DOCK180 that is required for the cell engulfment stage of programmed cell death.
15	ZK829.7	ZK829.7	n/a	chrIV 11,960,692	contains similarity to Pfam domains PF00107 (Zinc-binding dehydrogenase) , PF08240 (Alcohol dehydrogenase GroES-like domain) contains similarity to Interpro domains IPR013149 (Alcohol dehydrogenase, zinc-binding), IPR011032 (GroES-like), IPR013154 (Alcohol dehydrogenase GroES-like), IPR002085 (Alcohol dehydrogenase superfamily, zinc-containing), IPR016040 (NAD(P)-binding)
16	secs-1	D1054.13	n/a	chrV 10,803,314	C. elegans SECS-1 protein; contains similarity to Pfam domain PF05889 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen) contains similarity to Interpro domains IPR015424 (Pyridoxal phosphate-dependent transferase, major region), IPR008829 (Soluble liver antigen/liver pancreas antigen)
17	C44C10.3	C44C10.3	n/a	chrX 11,703,337	contains similarity to Pfam domains PF07690 (Major Facilitator Superfamily) , PF00083 (Sugar (and other) transporter) contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR005828 (General substrate transporter), IPR016196 (MFS general substrate transporter)
18	sre-9	C17E7.3	n/a	chrV 3,896,569	C. elegans SRE-9 protein; contains similarity to Pfam domain PF03125 C. elegans Sre G protein-coupled chemoreceptor contains similarity to Interpro domain IPR004151 (C. elegans Sre G protein-coupled chemoreceptor)
19	clec-144	T27D12.3	n/a	chrII 11,831,976	C. elegans CLEC-144 protein; contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
20	C50C3.1	C50C3.1	n/a	chrIII 8,192,662	contains similarity to Pfam domain PF00642 Zinc finger C-x8-C-x5-C-x3-H type (and similar) contains similarity to Interpro domain IPR000571 (Zinc finger, CCCH-type)
21	F26E4.5	F26E4.5	n/a	chrI 9,769,984	F26E4.5 encodes an SH2 domain-containing tyrosine kinase related to the vertebrate FER non-receptor protein tyrosine kinase; loss of F26E4.5 activity in an RNAi-hypersensitive strain results in axon guidance defects indicating that F26E4.5 likely plays a role in regulation of axon navigation.
22	opt-1	C06G8.2	n/a	chrIV 10,792,535	opt-1 encodes a high-affinity, proton-coupled oligopeptide transporter; when expressed in Xenopus ooctyes, OPT-1 exhibits proton-coupled transport activity for a broad spectrum of peptide substrates; opt-1 mRNA is detected at all stages of development, but is expressed at highest levels in late larval and adult stages; additionally, an opt-1::GFP reporter exhibits expression primarily in vulval, pharyngeal, and anal muscles; as loss of opt-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of opt-1 in C. elegans development and/or behavior is not yet known.
23	kin-4	C10C6.1	n/a	chrIV 11,441,819	C. elegans KIN-4 protein; contains similarity to Pfam domains PF08926 (Domain of unknown function (DUF1908)) , PF00595 (PDZ domain (Also known as DHR or GLGF)) , PF00069 (Protein kinase domain) contains similarity to Interpro domains IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR015022 (Region of unknown function DUF1908), IPR000719 (Protein kinase, core), IPR001478 (PDZ/DHR/GLGF), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related), IPR000961 (Protein kinase, C-terminal)
24	C29H12.5	C29H12.5	n/a	chrII 6,111,947	contains similarity to Pfam domain PF00385 'chromo' (CHRromatin Organisation MOdifier) domain contains similarity to Interpro domains IPR002290 (Serine/threonine protein kinase), IPR000953 (Chromo domain), IPR011009 (Protein kinase-like), IPR000719 (Protein kinase, core), IPR016197 (Chromo domain-like)
25	K07A12.1	K07A12.1	n/a	chrI 8,668,182	contains similarity to Pfam domain PF04910 Protein of unknown function, DUF654 contains similarity to Interpro domains IPR006994 (Basic helix-loop-helix, Nulp1-type), IPR000294 (Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)
26	K02B7.2	K02B7.2	n/a	chrII 14,692,031	contains similarity to Pfam domains PF07735 (F-box associated) , PF00646 (F-box domain) contains similarity to Interpro domains IPR001810 (Cyclin-like F-box), IPR012885 (F-box associated type 2)
27	F13G3.6	F13G3.6	n/a	chrI 7,304,082	contains similarity to Pfam domain PF00535 Glycosyl transferase family 2 contains similarity to Interpro domains IPR001173 (Glycosyl transferase, family 2), IPR016040 (NAD(P)-binding)
28	C06A12.3	C06A12.3	n/a	chrIV 17,428,622	contains similarity to Pfam domain PF05303 Protein of unknown function (DUF727) contains similarity to Interpro domain IPR007967 (Protein of unknown function DUF727)
29	K03B4.1	K03B4.1	n/a	chrV 4,690,455
30	M18.6	M18.6	n/a	chrIV 12,122,042	contains similarity to Interpro domain IPR003111 (Peptidase S16, lon N-terminal)
31	spd-3	H34C03.1	n/a	chrIV 6,763,933	C. elegans SPD-3 protein ;
32	dct-12	Y57A10C.7	n/a	chrII 12,431,464	C. elegans DCT-12 protein ;
33	C41A3.1	C41A3.1	n/a	chrX 5,427,831	contains similarity to Pfam domains PF02801 (Beta-ketoacyl synthase, C-terminal domain) (5), PF01370 (NAD dependent epimerase/dehydratase family) , PF08659 (KR domain) (2), PF00501 (AMP-binding enzyme) , PF00668 (Condensation domain) , PF00106 (short chain dehydrogenase) , PF00109 (Beta-ketoacyl synthase, N-terminal domain) (5), PF00550 (Phosphopantetheine attachment site) (8), PF00698 (Acyl transferase domain) (2)contains similarity to Interpro domains IPR016035 (Acyl transferase/acyl hydrolase/lysophospholipase), IPR006163 (Phosphopantetheine-binding), IPR001242 (Condensation domain), IPR016038 (Thiolase-like, subgroup), IPR013968 (Polyketide synthase, KR), IPR000794 (Beta-ketoacyl synthase), IPR001509 (NAD-dependent epimerase/dehydratase), IPR014031 (Beta-ketoacyl synthase, C-terminal), IPR014043 (Acyl transferase), IPR014030 (Beta-ketoacyl synthase, N-terminal), IPR008262 (Lipase, active site), IPR006162 (Phosphopantetheine attachment site), IPR000873 (AMP-dependent synthetase and ligase), IPR002198 (Short-chain dehydrogenase/reductase SDR), IPR016039 (Thiolase-like), IPR016040 (NAD(P)-binding), IPR009081 (Acyl carrier protein-like), IPR001227 (Acyl transferase region)
34	scrm-3	C04E12.7	n/a	chrV 3,356,584	scrm-3 encodes a putative phospholipid scramblase homologous to human PLSCR1-5, and paralogous to other C. elegans SCRMs (e.g., SCRM-1); SCRM-3 is expressed in neurons, anal depressor muscle, and occasionally in body wall muscle cells; however, in apoptotic germline cells, SCRM-3 is fully dispensable for normally rapid engulfment and largely dispensable for phosphatidylserine exposure; SCRM-3 does not bind WAH-1 in vitro, and scrm-3(tm631) mutants have no obvious phenotype.
35	E02H4.2	E02H4.2	n/a	chrX 14,279,950	contains similarity to Homo sapiens Type-1 protein phosphatase skeletal muscle glycogen targeting subunit; ENSEMBL:ENSP00000284601
36	R07G3.5	R07G3.5	n/a	chrII 7,598,098	contains similarity to Pfam domain PF00300 Phosphoglycerate mutase family contains similarity to Interpro domain IPR013078 (Phosphoglycerate mutase)
37	clec-265	M02F4.7	n/a	chrX 3,032,455	C. elegans CLEC-265 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin), IPR002353 (Type II antifreeze protein)
38	nhr-135	VC5.5	n/a	chrV 7,092,716	C. elegans NHR-135 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
39	osm-11	F11C7.5	n/a	chrX 17,420,817	C. elegans OSM-11 protein ;
40	xpa-1	K07G5.2	n/a	chrI 7,160,236	xpa-1 encodes an ortholog of human XPA, the xeroderma pigmentosum complementation group A protein (OMIM:278700, mutations are associated with sensitivity to ultraviolet light and carcinomata at an early age); by homology, XPA-1 is predicted to function as a DNA-binding protein that is required for nucleotide excision repair of damaged DNA; in C. elegans, loss of xpa-1 activity via mutation or RNA-mediated interference (RNAi) results in increased sensitivity to UV irradiation at all stages of development; xpa-1 mRNA is detected in eggs and mixed stage populations.
41	F28C10.1	F28C10.1	n/a	chrX 543,683
42	math-37	R52.9	n/a	chrII 2,121,460	C. elegans MATH-37 protein; contains similarity to Pfam domain PF00917 MATH domain contains similarity to Interpro domains IPR008974 (TRAF-like), IPR002083 (MATH)
43	C09G5.2	C09G5.2	n/a	chrII 10,708,359	C09G5.2 encodes an ortholog of S. cerevisiae DPH2/YKL191W and human DPH2L2 (OMIM:603456); C09G5.2 is a putative protein component of diphtamide synthesis; C09G5.2 has no obvious function in mass RNAi assays.
44	W03H9.2	W03H9.2	n/a	chrII 14,144,403	contains similarity to Homo sapiens Conserved hypothetical protein; HI:HIT000046554
45	clec-44	R07C3.12	n/a	chrII 921,144	C. elegans CLEC-44 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR000859 (CUB), IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
46	C47D12.2	C47D12.2	n/a	chrII 11,677,666	C47D12.2 encodes an ortholog of human FLJ20071/FLJ90130 (dymeclin, OMIM:607461, mutated in Dyggve-Melchior-Clausen dysplasia and Smith-McCort dysplasia), which has no obvious function in mass RNAi assays
47	F13A2.2	F13A2.2	n/a	chrV 4,384,088
48	F19C7.6	F19C7.6	n/a	chrIV 4,595,282
49	R105.1	R105.1	n/a	chrIV 4,635,811	contains similarity to Pfam domain PF03762 Vitelline membrane outer layer protein I (VOMI) contains similarity to Interpro domain IPR005515 (Vitelline membrane outer layer protein I (VOMI))
50	C41D11.1	C41D11.1	n/a	chrI 4,458,028