UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	mef-2	W10D5.1	2e-137	chrI 9,097,999	mef-2 encodes a transcription factor that is the sole C. elegans member of the MEF2 subgroup of MADS box transcription factors; loss of mef-2 activity does not result in a strong visible phenotype, although mef-2 mutant adults are slightly dumpy (Dpy); in vitro, MEF-2 is able to bind a consensus MEF2 DNA binding site and interact with the class II histone deacetylase encoded by C10E2.3 (hda-4/hda-7); mef-2 mRNA is detected at all stages of development and expression of mef-2 reporter gene fusions begins in neurons during late embryogenesis and continues in all tissues throughout postembryonic development; mef-2 mutations do not appear to interact with mutations in other myogenic factors such as hlh-1, hlh-8, pha-1, and unc-120.
2	nhr-79	T26H2.9	n/a	chrV 19,209,750	C. elegans NHR-79 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
3	pax-3	F27E5.2	n/a	chrII 10,149,568	pax-3 encodes a divergent paired-like homeodomain protein that does not belong to the Q50, K50, or S50 classes; PAX-3 is required for locomotion and vulval development; pax-3(RNAi) animals have consistent Pvl and Unc phenotypes (as well as less consistent Bmd, Rup, and Stp phenotypes).
4	cyp-13A3	T10B9.5	n/a	chrII 9,791,013	C. elegans CYP-13A3 protein; contains similarity to Pfam domain PF00067 Cytochrome P450 contains similarity to Interpro domains IPR001128 (Cytochrome P450), IPR002401 (Cytochrome P450, E-class, group I), IPR002402 (Cytochrome P450, E-class, group II), IPR002403 (Cytochrome P450, E-class, group IV), IPR002397 (Cytochrome P450, B-class)
5	F36G9.7	F36G9.7	n/a	chrV 15,968,760	contains similarity to Methanosarcina mazei Hypothetical protein MM0083.; TR:Q8Q0Q3
6	F26D11.2	F26D11.2	n/a	chrV 7,960,124
7	clec-59	ZK666.5	n/a	chrII 10,478,656	C. elegans CLEC-59 protein; contains similarity to Pfam domain PF00092 von Willebrand factor type A domain contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin), IPR002035 (von Willebrand factor, type A)
8	ptr-16	T21H3.2	n/a	chrV 1,172,902	ptr-16 encodes a nematode-specific member of the sterol sensing domain (SSD) proteins, distantly paralogous to Drosophila PATCHED (PTC) and human PTCH (OMIM:601309, mutated in basal cell nevus syndrome); PTR-16 is partially required for normal molting from L2 to L3 larval stages; however, PTR-16 and PTR-1 together are strongly required for both molting and viability, with double ptr-1/-16 RNAi animals showing pronounced molting defects and lethality; PTR-16 is also required for normal growth to full size and locomotion.
9	C31B8.4	C31B8.4	n/a	chrV 2,897,526	contains similarity to Homo sapiens cDNA FLJ77065, highly similar to Homo sapiens golgi autoantigen, golgin subfamily a, 4 (GOLGA4), mRNA; ENSEMBL:ENSP00000349305
10	F47E1.2	F47E1.2	n/a	chrX 9,059,694	contains similarity to Pfam domain PF03137 Organic Anion Transporter Polypeptide (OATP) family contains similarity to Interpro domains IPR004156 (Organic anion transporter polypeptide OATP), IPR016196 (MFS general substrate transporter)
11	C05D11.13	C05D11.13	n/a	chrIII 6,443,485	contains similarity to Drosophila melanogaster Flybase gene name is CG2839-PA;; FLYBASE:CG2839
12	C07D10.1	C07D10.1	n/a	chrII 7,399,714	contains similarity to Pfam domain PF00646 F-box domain contains similarity to Interpro domain IPR001810 (Cyclin-like F-box)
13	C32D5.1	C32D5.1	n/a	chrII 6,344,783
14	str-171	T01G5.5	n/a	chrV 15,131,482	C. elegans STR-171 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
15	C11D2.1	C11D2.1	n/a	chrIV 6,191,401
16	M03A1.3	M03A1.3	n/a	chrII 4,558,668	M03A1.3 encodes a protein with ~10 predicted transmembrane sequences; it has an internal repeat (in residues 74-351 and 377-668), with some similarity in these repeated domains to worm C05D12.1 and C13B4.1, and to mammalian stromal cell derived factor receptor 2.
17	T09D3.3	T09D3.3	n/a	chrV 5,348,079	contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR013032 (EGF-like region, conserved site)
18	R06B9.1	R06B9.1	n/a	chrII 13,764,398	contains similarity to Pfam domains PF00339 (Arrestin (or S-antigen), N-terminal domain) , PF02752 (Arrestin (or S-antigen), C-terminal domain) contains similarity to Interpro domains IPR014756 (Immunoglobulin E-set), IPR011022 (Arrestin-like, C-terminal), IPR000698 (Arrestin), IPR014752 (Arrestin, C-terminal), IPR011021 (Arrestin-like, N-terminal)
19	clec-249	Y51A2A.7	n/a	chrV 18,304,784	C. elegans CLEC-249 protein; contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
20	srw-33	T26H5.5	n/a	chrV 15,450,551	C. elegans SRW-33 protein; contains similarity to Pfam domain PF06976 Protein of unknown function (DUF1300) contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR010726 (Protein of unknown function DUF1300), IPR003945 (NADH-plastoquinone oxidoreductase, chain 5), IPR000276 (GPCR, rhodopsin-like)
21	tyr-3	F21C3.2	n/a	chrI 7,276,425	C. elegans TYR-3 protein; contains similarity to Pfam domains PF00264 (Common central domain of tyrosinase) , PF01549 (ShK domain-like) (4)contains similarity to Interpro domains IPR008922 (Di-copper centre-containing), IPR002227 (Tyrosinase), IPR003582 (Metridin-like ShK toxin)
22	B0554.1	B0554.1	n/a	chrV 438,570
23	cyp-13A7	T10B9.10	n/a	chrII 9,804,455	cyp-13A7 encodes a homolog of cytochrome P450 proteins; these proteins are membrane proteins with a heme prosthetic group that catalyse the synthesis of steroid hormones (and bile salts), and also detoxify foreign substances (xenobiotic compounds).
24	T27F2.4	T27F2.4	n/a	chrV 11,650,405	contains similarity to Interpro domain IPR004827 (Basic-leucine zipper (bZIP) transcription factor)
25	C31H5.6	C31H5.6	n/a	chrI 9,045,096	contains similarity to Pfam domains PF08840 (BAAT / Acyl-CoA thioester hydrolase C terminal) , PF04775 (Acyl-CoA thioester hydrolase / Bile acid-CoA amino acid N-acetyltransferase) contains similarity to Interpro domains IPR006862 (Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase), IPR014940 (BAAT/Acyl-CoA thioester hydrolase C-terminal), IPR016662 (Acyl-CoA thioesterase, long chain)
26	ztf-11	F52F12.6	n/a	chrI 9,907,414	C. elegans ZTF-11 protein; contains similarity to Pfam domain PF01530 Zinc finger, C2HC type contains similarity to Interpro domain IPR002515 (Zinc finger, C2HC-type)
27	str-45	T09F5.3	n/a	chrV 15,159,744	C. elegans STR-45 protein ; contains similarity to Homo sapiens 42 kDa protein; VG:OTTHUMP00000169906
28	F47B8.3	F47B8.3	n/a	chrV 14,322,155	contains similarity to Pfam domain PF00462 Glutaredoxin contains similarity to Interpro domains IPR002109 (Glutaredoxin), IPR012336 (Thioredoxin-like fold)
29	glt-5	Y53C12A.2	n/a	chrII 9,707,756	glt-5 encodes an ortholog of glutamate/aspartate and neutral amino acid transporters.
30	Y57G11C.20	Y57G11C.20	n/a	chrIV 14,844,297	contains similarity to Interpro domain IPR000003 ()
31	srw-120	K12D9.5	n/a	chrV 2,995,551	C. elegans SRW-120 protein; contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
32	F19F10.3	F19F10.3	n/a	chrV 7,552,413
33	sre-23	ZK265.5	n/a	chrI 8,257,642	C. elegans SRE-23 protein; contains similarity to Pfam domain PF03125 C. elegans Sre G protein-coupled chemoreceptor contains similarity to Interpro domain IPR004151 (C. elegans Sre G protein-coupled chemoreceptor)
34	ZK337.2	ZK337.2	n/a	chrI 14,977,996	contains similarity to Pfam domain PF00096 Zinc finger, C2H2 type contains similarity to Interpro domains IPR015880 (Zinc finger, C2H2-like), IPR007086 (Zinc finger, C2H2-subtype), IPR013087 (Zinc finger, C2H2-type/integrase, DNA-binding), IPR003656 (Zinc finger, BED-type predicted), IPR007087 (Zinc finger, C2H2-type)
35	srbc-20	C45H4.11	n/a	chrV 2,147,858	C. elegans SRBC-20 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
36	F27E5.1	F27E5.1	n/a	chrII 10,140,416	contains similarity to Pfam domain PF02275 Linear amide C-N hydrolases, choloylglycine hydrolase family contains similarity to Interpro domains IPR003199 (Choloylglycine hydrolase), IPR016699 (Acid ceramidase-like)
37	srx-20	R13H7.1	n/a	chrIV 6,868,598	C. elegans SRX-20 protein ;
38	nlp-10	F37A8.4	n/a	chrIII 3,934,743	nlp-10 encodes four predicted neuropeptide-like proteins; nlp-10 is part of a GGxY neuropeptide family that has members in several other nematode species; nlp-10 is expressed in a variety of neurons, including ASK, ADL, CAN, two lateral neurons, two anterior pharyngeal neurons, one tail neuron, and one male tail neuron; as loss of nlp-10 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of nlp-10-encoded peptides in development and/or behavior is not yet known.
39	C12D5.3	C12D5.3	n/a	chrV 7,676,566	contains similarity to Interpro domain IPR002194 (Chaperonin TCP-1, conserved site)
40	K01D12.10	K01D12.10	n/a	chrV 12,406,600	contains similarity to Interpro domains IPR002952 (Eggshell protein), IPR003072 (Orphan nuclear receptor, NOR1 type), IPR003982 (Leukotriene B4 type 2 receptor)
41	C36C5.12	C36C5.12	n/a	chrV 3,158,933	contains similarity to Pfam domain PF01579 Domain of unknown function DUF19 contains similarity to Interpro domains IPR016638 (Uncharacterised conserved protein UPF0376), IPR002542 (Protein of unknown function DUF19)
42	nhr-18	F44C8.3	n/a	chrV 2,228,092	The nhr-18 gene encodes a member of the superfamily of nuclear receptors, which is one of the most abundant class of transcriptional regulators; nuclear receptors have a well conserved DNA binding domain and a less conserved C-terminal ligand binding domain; the human homolog of nhr-18, CYP21, when mutated leads to congenital adrenal hyperplasia (OMIM:201910).
43	T28F4.4	T28F4.4	n/a	chrI 7,488,371	contains similarity to Brugia malayi Putative uncharacterized protein BMBAC01P19.05a.; TR:Q8IHI4
44	ocr-3	T10B10.7	n/a	chrX 15,171,101	ocr-3 encodes a predicted TRPV channel (transient receptor potential cation channel, subfamily V) containing six membrane-spanning regions, cytoplasmic ankyrin repeats, and a long, unconserved cytoplasmic tail that is related to the mammalian TRPV1 cation channel (OMIM:602076) activated by capsaicin and other noxious stimuli; although the precise role of OCR-3 in C. elegans development and/or behavior is not yet known, OCR-3 expression is detected solely in the rectal gland cells and occasionally the glial socket cells of the head, suggesting that OCR-3 may function in sensory signal transduction in these cell types.
45	try-2	C07G1.1	n/a	chrIV 8,213,133	try-2 encodes a homolog of human TRYP1 and ELA2; mutation of human TRYP1 or ELA2 leads, respectively, to hereditary pancreatitis (OMIM:276000) or cyclic haematopoiesis (OMIM:162800).
46	C13A2.7	C13A2.7	n/a	chrV 7,266,655
47	glb-15	F35B12.8	n/a	chrV 11,617,517	glb-15 encodes a globin with no obvious function in mass RNAi assays.
48	K07C11.3	K07C11.3	n/a	chrV 8,207,597	contains similarity to Interpro domains IPR008993 (TIMP-like, OB-fold), IPR001820 (Proteinase inhibitor I35, tissue inhibitor of metalloproteinase), IPR001134 (Netrin, C-terminal)
49	F49C12.6	F49C12.6	n/a	chrIV 9,308,209	contains similarity to Pfam domains PF06800 (Sugar transport protein) , PF07857 (CEO family (DUF1632)) contains similarity to Interpro domains IPR012435 (Protein of unknown function DUF1632), IPR010651 (Sugar transport), IPR005384 (Duffy antigen/chemokine receptor)
50	F56H6.1	F56H6.1	n/a	chrI 12,281,908	contains similarity to Pfam domain PF01762 Galactosyltransferase contains similarity to Interpro domain IPR002659 (Glycosyl transferase, family 31)