UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	T24D1.3	T24D1.3	6e-130	chrI 9,959,459	contains similarity to Interpro domain IPR001841 (Zinc finger, RING-type)
2	bra-2	F23H11.1	n/a	chrIII 911,744	The bra-2 gene encodes a homolog of the human BMP receptor-associated molecule (BRAM1), paralogous to bra-1, that may act upon the SMA-6 TGF-beta signalling pathway
3	H02I12.5	H02I12.5	n/a	chrIV 11,402,613
4	egg-2	R01H2.3	n/a	chrIII 7,059,489	C. elegans EGG-2 protein; contains similarity to Pfam domain PF00057 Low-density lipoprotein receptor domain class A contains similarity to Interpro domain IPR002172 (Low density lipoprotein-receptor, class A, cysteine-rich)
5	egg-5	R12E2.10	n/a	chrI 4,170,287	C. elegans EGG-5 protein; contains similarity to Pfam domain PF00102 Protein-tyrosine phosphatase contains similarity to Interpro domains IPR003595 (Protein-tyrosine phosphatase, catalytic), IPR000242 (Protein-tyrosine phosphatase, receptor/non-receptor type), IPR000387 (Protein-tyrosine phosphatase), IPR000340 (Protein-tyrosine phosphatase, dual specificity)
6	F54D10.5	F54D10.5	n/a	chrII 3,807,652
7	T27A10.6	T27A10.6	n/a	chrX 3,592,684	contains similarity to Interpro domain IPR006150 (Cysteine-rich repeat)
8	puf-7	B0273.2	n/a	chrIV 5,488,347	puf-7 encodes a protein 97% identical to PUF-6 and functions redundantly with the other PUF genes, fbf-1, fbf-2, puf-6, and puf-8, during primordial germ cell development, based on combinatorial RNAi; interacts with NOS-2 in yeast two-hybrid screens.
9	C16C8.4	C16C8.4	n/a	chrII 3,443,969	contains similarity to Pfam domain PF00240 Ubiquitin family contains similarity to Interpro domain IPR000626 (Ubiquitin)
10	klp-15	M01E11.6	n/a	chrI 5,578,180	C. elegans KLP-15 protein; contains similarity to Pfam domain PF00225 Kinesin motor domain contains similarity to Interpro domain IPR001752 (Kinesin, motor region)
11	K04C1.5	K04C1.5	n/a	chrX 14,248,813	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR000719 (Protein kinase, core), IPR017442 (Serine/threonine protein kinase-related)
12	F17E9.4	F17E9.4	n/a	chrIV 8,348,753
13	clec-222	C03E10.6	n/a	chrV 11,271,884	C. elegans CLEC-222 protein; contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR001304 (C-type lectin)
14	W02F12.3	W02F12.3	n/a	chrV 6,703,798	contains similarity to Leishmania braziliensis Proteophosphoglycan ppg4.; TR:A4HM87
15	H02I12.1	H02I12.1	n/a	chrIV 11,375,266	H02I12.1 encodes a large (1319-residue) protein with 12 chitin-binding peritrophin-A domains; H02I12.1(RNAi) animals have an osmotically-sensitive embryonic lethal phenotype, perhaps because of defects in chitin and eggshell synthesis; like CEJ-1 and CPG-2, H02I12.1 may participate in eggshell synthesis and early embryonic development; H02I12.1's multiple peritrophin-A domains might enable mechanical cross-linking of chitin.
16	R02F2.4	R02F2.4	n/a	chrIII 5,485,028	R02F2.4 encodes a protein with six chitin-binding peritrophin-A domains; R02F2.4 transcripts are enriched during oogenesis; like CEJ-1 and CPG-2, R02F2.4 might participate in eggshell synthesis and early embryonic development, and R02F2.4's multiple peritrophin-A domains might enable mechanical cross-linking of chitin; however, R02F2.4 has no obvious function in mass RNAi assays; while R02F2.4 is more closely similar to CPG-2 than CEJ-1, it may be less strongly expressed (since it has substantially fewer ESTs) and thus be less important in development.
17	C30F12.4	C30F12.4	n/a	chrI 6,972,971	contains similarity to Triticum aestivum Gamma-gliadin precursor.; SW:P08453
18	rmd-1	T05G5.7	n/a	chrIII 9,759,548	C. elegans RMD-1 protein; contains similarity to Interpro domain IPR011990 (Tetratricopeptide-like helical)
19	C48B4.9	C48B4.9	n/a	chrIII 9,562,829	contains similarity to Arabidopsis thaliana Hypothetical protein (At1g32400/F5D14_22) (Tobamovirus multiplications2A).; TR:Q9C5W7
20	F14D7.2	F14D7.2	n/a	chrV 14,292,817	contains similarity to Homo sapiens Similar to Dentin sialophosphoprotein preproprotein; ENSEMBL:ENSP00000282478
21	sdz-27	R07H5.4	n/a	chrIV 11,187,603	C. elegans SDZ-27 protein
22	R04D3.4	R04D3.4	n/a	chrX 13,288,277	contains similarity to Rattus norvegicus Copper-transporting ATPase 1 (EC 3.6.3.4) (Copper pump 1) (Menkessdisease-associated protein homolog).; SW:AT7A_RAT
23	Y75B12B.1	Y75B12B.1	n/a	chrV 15,185,232	Y75B12B.1 encodes a probable transposase, with many C. elegans paralogs and distant similarity to rotifer and insect transposases; Y75B12B.1 has no known function in mass RNAi assays; Y75B12B.1 mRNA is stabilized by bound GLD-1.
24	nos-2	ZK1127.1	n/a	chrII 7,066,218	nos-2 encodes one of three genes in C. elegans that contains a putative zinc-binding domain similar to the one found in Drosophila nanos; nos-2 affects incorporation of primordial germ cells into the somatic gonad, is required redundantly with nos-1 to prevent primordial germ cells from dividing in starved animals and to maintain germ cell viability during larval development in hermaphrodites and in males, and also functions together with nos-1 and nos-3 in the hermaphrodite switch from spermatogenesis to oogenesis; nos-2 is expressed in the primordial germ cells around the time of gastrulation from a maternal RNA associated with P granules, and it is expressed coordinately with nos-1in a dynamic fashion until the embryonic 200-cell stage.
25	C14B1.2	C14B1.2	n/a	chrIII 3,702,706	contains similarity to Bacillus anthracis Hypothetical protein.; TR:Q81T15
26	C48B4.6	C48B4.6	n/a	chrIII 9,557,903	contains similarity to Plateumaris constricticollis toyamensis Cytochrome oxidase subunit I (Fragment).; TR:Q85QH2
27	zyg-11	C08B11.1	n/a	chrII 8,019,153	zyg-11 encodes a protein containing four diverged leucine-rich repeats and an armadillo-like helical domain and is conserved in metazoa, but not found in Drosophila; during development, ZYG-11 functions as the substrate-recognition subunit for a CUL-2-based ubiquitin-ligase complex that is required for a number of biological processes including progression through meiotic anaphase II, mitotic chromosome condensation, and establishment of anterior/posterior polarity in the early embryo; ZYG-11 interacts with CUL-2 in vivo and with ELC-1/elongin C in vitro.
28	C14B1.9	C14B1.9	n/a	chrIII 3,725,339	contains similarity to Homo sapiens Hypothetical protein; ENSEMBL:ENSP00000307805
29	T05F1.2	T05F1.2	n/a	chrI 9,623,710	T05F1.2 encodes a novel protein; in situ hybridization studies indicate that T05F1.2 mRNA is expressed in the medial germline.
30	hus-1	H26D21.1	n/a	chrI 3,698,705	hus-1 encodes the C. elegans ortholog of the Schizosaccharomyces pombe Hus1 DNA damage checkpoint protein; in C. elegans, hus-1 activity is required for DNA damage-induced cell cycle arrest and apoptosis, telomere maintenance, and hence, genome stability and development; specifically, hus-1 is required for the CEP-1/p53-dependent increase in germline egl-1 expression following irradiation; a HUS-1::GFP fusion protein is detected in the nuclei of mitotic and meiotic germ cells, mature oocytes, embryos, and somatic larval cells, particularly those that are proliferating; while HUS-1 localization is generally diffuse throughout these nuclei, following irradiation, HUS-1 localizes to discrete foci that overlap with chromatin; HUS-1 nuclear localization is dependent upon the Rad9 homologue HPR-9 and upon the checkpoint protein MRT-2, with which it interacts in yeast two-hybrid and in vitro assays.
31	gln-5	F26D10.10	n/a	chrIV 17,272,909	C. elegans GLN-5 protein; contains similarity to Pfam domains PF03951 (Glutamine synthetase, beta-Grasp domain) , PF00120 (Glutamine synthetase, catalytic domain) contains similarity to Interpro domains IPR008147 (Glutamine synthetase, beta-Grasp), IPR014746 (Glutamine synthetase/guanido kinase, catalytic region), IPR008146 (Glutamine synthetase, catalytic region)
32	C27D9.1	C27D9.1	n/a	chrII 4,754,512	contains similarity to Pfam domain PF06542 Protein of unknown function (DUF1114) contains similarity to Interpro domain IPR009497 (Protein of unknown function DUF1114)
33	F27C8.6	F27C8.6	n/a	chrIV 9,587,998	F27C8.6 encodes a putative arylacetamide deacetylase and microsomal lipase; F27C8.6 is required for sperm to normally migrate towards a PUFA-based signal exuded by oocytes; F27C8.6(RNAi) hermaphrodites are infertile, both through aberrant loss of their own sperm and through failure of males to effectively inseminate them.
34	fbxa-215	Y45F10C.3	n/a	chrIV 13,666,087	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
35	tbh-1	H13N06.6	n/a	chrX 15,501,790	tbh-1 encodes a putative dopamine beta-hydroxylate orthologous to human DBH (OMIM:609312, mutated in dopamine beta-hydroxylase deficiency).
36	F08F3.6	F08F3.6	n/a	chrV 5,419,025	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
37	gln-6	C28D4.3	n/a	chrIV 9,740,184	C. elegans GLN-6 protein; contains similarity to Pfam domains PF03951 (Glutamine synthetase, beta-Grasp domain) , PF00120 (Glutamine synthetase, catalytic domain) contains similarity to Interpro domains IPR008147 (Glutamine synthetase, beta-Grasp), IPR014746 (Glutamine synthetase/guanido kinase, catalytic region), IPR008146 (Glutamine synthetase, catalytic region)
38	rev-1	ZK675.2	n/a	chrII 7,902,571	C. elegans REV-1 protein; contains similarity to Pfam domains PF00817 (impB/mucB/samB family) , PF00533 (BRCA1 C Terminus (BRCT) domain) contains similarity to Interpro domains IPR001126 (UMUC-like DNA-repair protein), IPR012112 (DNA repair protein, Rev1), IPR001357 (BRCT)
39	Y18D10A.11	Y18D10A.11	n/a	chrI 12,862,741	contains similarity to Homo sapiens Putative uncharacterized protein DKFZp779H0156; ENSEMBL:ENSP00000344380
40	cpar-1	F54C8.2	n/a	chrIII 9,434,486	cpar-1 encodes one of two C. elegans proteins homologous to the inner kinetochore histone H3 variant CENP-A (the other is encoded by hcp-3); loss of cpar-1 and hcp-3 activity via RNAi results in mitotic chromosome segregation defects, but no significant defects in meiotic chromosome segregation; when expressed in the germline using the pie-1 promoter, a CPAR-1::GFP fusion protein localizes to meiotic chromosomes during late prophase/prometaphase of meiosis I, but is not seen on chromosomes during meiosis II.
41	R04D3.2	R04D3.2	n/a	chrX 13,285,808	contains similarity to Plasmodium falciparum Putative uncharacterized protein PFD0207c.; TR:Q8I1Y6
42	C53B7.2	C53B7.2	n/a	chrX 6,846,844	C53B7.2 encodes a putative secreted TIL-domain protease inhibitor paralogous to SWM-1, ISL-1, and the products of 11 other C. elegans genes; C53B7.2 and its relatives are collectively similar to other TIL-domain protease inhibitors from nematodes, insects, and vertebrates; C53B7.2 has no obvious function in mass RNAi assays.
43	msh-4	T02G5.6	n/a	chrII 7,078,297	C. elegans MSH-4 protein; contains similarity to Pfam domain PF00488 MutS domain V contains similarity to Interpro domain IPR000432 (DNA mismatch repair protein MutS, C-terminal)
44	cpg-2	B0280.5	n/a	chrIII 7,102,966	cpg-2 encodes a protein with six chitin-binding peritrophin-A domains and three mucin-like regions; CPG-2 is individually dispensable for normal embryonic development; however, CPG-2 and CPG-1 are jointly required for osmotic integrity of early embryos, error-free chromosomal segregation during meiosis, polar body extrusion, association of the sperm pronucleus/centrosome complex (SPCC) with the early embryonic cortex, localization of PAR-2 in early embryos, posterior localization of P granules or PIE-1, and pseudocleavage; CPG-2, like CPG-1, is covalently linked to chondroitin, which itself is required for vulval morphogenesis, polar-body extrusion, and separation of the eggshell from the embryonic plasma membrane; cpg-2 mRNA, like that of cpg-1, is expressed specifically in the adult hermaphrodite germ line and is bound by GLD-1; CPG-2 has 34 potential chondroitin attachment sites, four of them verified by mass spectrometry, and transgenic CPG-2 synthesized in mammalian cells carries chondroitin sulfate chains; CPG-2's multiple peritrophin-A domains may enable mechanical cross-linking of chitin.
45	cgh-1	C07H6.5	n/a	chrIII 7,496,952	cgh-1 encodes a putative DEAD-box RNA helicase, orthologous to budding yeast Dhh1p, fission yeast Ste13p, Drosophila ME31B, and human DDX6 (OMIM:600326); CGH-1 inhibits physiological apoptosis in oocytes, keeping it down to a normal level of ~50% in hermaphrodite gonads; independently of apoptosis, CGH-1 is also required for sperm function, oocyte fertilization, and early embryonic cytokinesis; by orthology with budding yeast, CGH-1 is expected to enable decapping-dependent mRNA degradation; CGH-1 is expressed in meiotic germ cells, oocytes, sperm, early embryonic P granules, other unidentified cytoplasmic foci of the gonad core and early embryos, and the germline precursors Z2 and Z3; cgh-1(RNAi) hermaphrodites lose ~100% of their oocytes to physiological apoptosis; gonadal CGH-1 accumulation is suppressed by either glh-1/4 RNAi or gld-1(q485);gld-2(q497) mutations, yet physiological apoptosis (which would normally be elevated by loss of CGH-1) is also abnormally low in these genotypes; cgh-1(RNAi) males have sterile sperm with abnormally short pseudopods; CGH-1 associates with CAR-1, DCAP-2, and CEY-2/3/4 in P granules and cytoplasmic particles of the early embryo; CGH-1 is required for normal CAR-1 localization in early embyros, and binds CAR-1 in an RNA-dependent manner.
46	zif-1	F59B2.6	n/a	chrIII 9,003,725	zif-1 encodes a SOCS-box protein that promotes establishment of the germ line by targetting germline proteins for cullin-dependent degradation in non-germline (somatic) cells; ZIF-1 binds germline CCCH-(zinc)-finger proteins and the E3 ubiquitin ligase subunit elongin C (ELC-1); while ZIF-1 has no obvious homologs, it may be analogous to the Drosophila SOCS-box protein GUSTAVUS, which is required for VASA localization to the germline and which does have mammalian homologs.
47	T04A8.8	T04A8.8	n/a	chrIII 4,694,596	contains similarity to Homo sapiens;Mus musculus;Rattus norvegicus;Bos taurus;Sus scrofa Ubiquitin-like protein SMT3B (Sentrin 2) (HSMT3).; SW:SM32_HUMAN
48	H04M03.3	H04M03.3	n/a	chrIV 5,892,434	contains similarity to Pfam domain PF00106 short chain dehydrogenase contains similarity to Interpro domains IPR002347 (Glucose/ribitol dehydrogenase), IPR002198 (Short-chain dehydrogenase/reductase SDR), IPR016040 (NAD(P)-binding)
49	C03D6.6	C03D6.6	n/a	chrI 9,657,459	contains similarity to Saccharomyces cerevisiae Involved in cell cycle control and ion homeostasis; SGD:YKR072C
50	B0393.3	B0393.3	n/a	chrIII 4,758,450	contains similarity to Pfam domains PF00560 (Leucine Rich Repeat) , PF00646 (F-box domain) contains similarity to Interpro domains IPR001810 (Cyclin-like F-box), IPR006553 (Leucine-rich repeat, cysteine-containing subtype)