UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	vab-9	T22C8.8	3.9999999999999996e-100	chrII 8,636,902	vab-9 encodes a claudin homolog orthologous to human brain cell membrane protein 1 (BCMP1) and Drosophila CG6982; VAB-9 colocalizes with HMP-1 to an apical layer of the adherens junctions of all epithelial cells, one layer more apically than AJM-1; vab-9 mutants have disorganized F-actin at the adherens junction, implying that VAB-9 links junctions to circumferential actin filaments; VAB-9 is also expressed in the nerve ring; VAB-9 requires the cadherin HMR-1 to localize to the cell membrane, and both alpha-catenin (HMP-1) and beta-catenin (HMP-2) to remain at the cell junction after membrane localization.
2	nhr-79	T26H2.9	n/a	chrV 19,209,750	C. elegans NHR-79 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
3	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
4	cwp-4	K11D12.1	n/a	chrV 5,055,031	cwp-4 encodes a protein with some similarity to mucins that is predicted to be secreted, and is alleged to be coexpressed with polycystins; CWP-4 is dispensable for viability and gross morphology in mass RNAi screens.
5	lin-66	B0513.1	n/a	chrIV 13,891,003	lin-66 encodes an unfamiliar protein, with visible homologs only in nematodes, that was identified in screens for molecules that interact with GEX-3, a homolog of mammalian protein ligands of the small GTPase Rac1, that is essential for ventral enclosure during embryonic development; LIN-66 is expressed in body wall and vulval muscles, and is also detected in the intestine, neurons, and probably the hypodermis.
6	K06A1.3	K06A1.3	n/a	chrII 6,442,625	contains similarity to Pfam domain PF00100 Zona pellucida-like domain contains similarity to Interpro domain IPR001507 (Endoglin/CD105 antigen)
7	ZK265.7	ZK265.7	n/a	chrI 8,265,494	contains similarity to Drosophila yakuba Salivary glue protein Sgs-3 precursor.; SW:P13728
8	F22E5.1	F22E5.1	n/a	chrII 2,676,663	contains similarity to Pfam domain PF07801 Protein of unknown function (DUF1647) contains similarity to Interpro domain IPR012444 (Protein of unknown function DUF1647)
9	R06A10.1	R06A10.1	n/a	chrI 1,087,211	contains similarity to Interpro domain IPR016196 (MFS general substrate transporter)
10	F14B8.6	F14B8.6	n/a	chrX 6,930,764
11	ZC84.3	ZC84.3	n/a	chrIII 9,188,742	contains similarity to Pfam domain PF02985 HEAT repeat contains similarity to Interpro domains IPR000357 (HEAT), IPR016024 (Armadillo-type fold)
12	blmp-1	F25D7.3	n/a	chrI 10,411,592	C. elegans BLMP-1 protein; contains similarity to Pfam domain PF00096 Zinc finger, C2H2 type contains similarity to Interpro domains IPR001214 (SET), IPR015880 (Zinc finger, C2H2-like), IPR007086 (Zinc finger, C2H2-subtype), IPR013087 (Zinc finger, C2H2-type/integrase, DNA-binding), IPR003656 (Zinc finger, BED-type predicted), IPR007087 (Zinc finger, C2H2-type)
13	W05H9.3	W05H9.3	n/a	chrX 6,252,987
14	srw-20	T05E12.4	n/a	chrV 17,079,045	C. elegans SRW-20 protein; contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
15	sru-3	C33A12.11	n/a	chrIV 9,497,224	C. elegans SRU-3 protein; contains similarity to Pfam domain PF02688 Domain of unknown function DUF215 contains similarity to Interpro domain IPR003839 (Protein of unknown function DUF215)
16	R09B5.11	R09B5.11	n/a	chrV 1,440,531	contains similarity to Pfam domains PF07690 (Major Facilitator Superfamily) , PF00083 (Sugar (and other) transporter) contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR005829 (Sugar transporter, conserved site), IPR005828 (General substrate transporter), IPR003663 (Sugar transporter), IPR016196 (MFS general substrate transporter)
17	gon-1	F25H8.3	n/a	chrIV 9,940,393	gon-1 encodes a functional metalloprotease that defines a new sub-family of secreted proteases known as MPT (metalloprotease with thrombospondin type 1 repeats); the other two members of this family are the bovine procollagen I N-protease ( PINP ) and the murine enzyme ADAMTS-1; gon-1 is essential for hermaphrodite gonadal morphogenesis; sequence homology with other metalloproteases suggests that it functions by remodelling the extracellular matrix; GON-1 is expressed at high levels within the gonadal distal tip cell during migration.
18	klp-6	R144.1	n/a	chrIII 5,034,241	klp-6 encodes a predicted monomeric kinesin and member of the UNC-104 family.
19	C27F2.8	C27F2.8	n/a	chrIII 4,994,766	contains similarity to Interpro domain IPR000694 (Proline-rich region)
20	fbxa-141	D1025.3	n/a	chrX 14,512,622	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
21	K09B3.1	K09B3.1	n/a	chrIV 3,795,512	contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domain IPR003582 (Metridin-like ShK toxin)
22	T20F7.5	T20F7.5	n/a	chrX 16,850,352	contains similarity to Interpro domain IPR000694 (Proline-rich region)
23	R08B4.3	R08B4.3	n/a	chrX 11,119,911	contains similarity to Homo sapiens 23 kDa protein; VG:OTTHUMP00000170038
24	Y41C4A.13	Y41C4A.13	n/a	chrIII 11,735,378	contains similarity to Homo sapiens Rabconnectin; ENSEMBL:ENSP00000251076
25	C55C3.2	C55C3.2	n/a	chrIV 5,707,741
26	F56F11.2	F56F11.2	n/a	chrIII 2,883,625
27	F57G12.2	F57G12.2	n/a	chrX 12,158,178	contains similarity to Mus musculus Nuclear protein ZAP3.; SW:ZAP3_MOUSE
28	F23A7.5	F23A7.5	n/a	chrX 16,233,076	contains similarity to Homo sapiens Isoform 3 of Cyclin-L1; VG:OTTHUMP00000173336
29	ltd-1	K02C4.4	n/a	chrII 8,090,520	ltd-1 encodes a protein with LIM and transglutaminase domains; LTD-1 is homologous to the mouse KY protein (MGI:96709, mutated in kyphoscoliosis), and to the HILLARIN protein of Hirudo medicinalis, found at axon hillocks; ltd-1 is expressed in hypodermal cells from the twofold stage embryo to adulthood, but has no obvious function in mass RNAi assays.
30	elt-3	K02B9.4	n/a	chrX 13,939,895	The elt-3 gene encodes a GATA transcription factor expressed in the embryonic hypodermis; specifically, it is expressed in expressed in all of the major hypodermal cells except the lateral seam cells.
31	C03F11.1	C03F11.1	n/a	chrX 5,392,402	contains similarity to Pfam domains PF03530 (Calcium-activated SK potassium channel) , PF02888 (Calmodulin binding domain) , PF07885 (Ion channel) contains similarity to Interpro domains IPR004178 (Calmodulin-binding), IPR015449 (Potassium channel, calcium-activated, SK), IPR011996 (Potassium channel, calcium-activated, SK, conserved region), IPR003091 (Voltage-dependent potassium channel), IPR013099 (Ion transport 2)
32	srg-67	ZC317.4	n/a	chrV 5,462,245	C. elegans SRG-67 protein; contains similarity to Interpro domain IPR000609 (Serpentine gamma receptor, Caenorhabditis species)
33	ndx-1	T26E3.2	n/a	chrI 12,680,484	The ndx-1 gene encodes a NUDIX hydrolase.
34	arr-1	F53H8.2	n/a	chrX 952,505	arr-1 encodes the C. elegans beta-arrestin ortholog (OMIM:107940, 107941, mice lacking beta-arrestin family members display defects in G protein-coupled receptor desensitization); by homology, ARR-1 is predicted to be a multifunctional adaptor protein that interacts with intracellular signaling molecules as well as activated and phosphorylated G protein-coupled and TGF-beta receptors to: 1) downregulate receptor signaling, 2) promote receptor endocytosis, and 3) activate MAP kinase- and Src-dependent signaling pathways; in vivo, arr-1 activity is required for normal egg laying and for proper olfactory adaptation and recovery to volatile odorants; in addition, animals doubly mutant for arr-1 and grk-2, which encodes a G protein-coupled receptor kinase, are sick and slow growing; ARR-1 is detected throughout the nervous system and is highly expressed in the amphid chemosensory neurons; in neuronal cells, ARR-1 appears to be largely cytoplasmic; ARR-1 interacts physically with clathrin and beta2-adaptin, two proteins involved in receptor endocytosis.
35	aat-1	F27C8.1	n/a	chrIV 9,600,317	aat-1 encodes an amino acid transporter catalytic subunit; when co-expressed in Xenopus oocytes with the ATG-2 glycoprotein subunit, AAT-1 is able to facilitate amino acid uptake and exchange, showing a relatively high affinity for small and some large neutral amino acids; in addition, AAT-1 is able to covalently associate with ATG-2 or ATG-1 to form heterodimers in the Xenopus expression system; when co-expressed with ATG-2, AAT-1 localizes to the cell surface of oocytes, but when expressed alone or with ATG-1, AAT-1 localizes intracellularly.
36	F54B11.9	F54B11.9	n/a	chrX 13,607,737	contains similarity to Plasmodium falciparum Hypothetical protein.; TR:Q8I5W3
37	srt-72	C36C5.9	n/a	chrV 3,148,851	C. elegans SRT-72 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domains IPR002651 (Protein of unknown function DUF32), IPR000215 (Protease inhibitor I4, serpin)
38	F13D11.1	F13D11.1	n/a	chrX 5,830,678	contains similarity to Pfam domain PF00328 Histidine acid phosphatase contains similarity to Interpro domain IPR000560 (Histidine acid phosphatase)
39	W06B11.1	W06B11.1	n/a	chrX 5,850,462	contains similarity to Pfam domain PF05301 Protein of unknown function (DUF738) contains similarity to Interpro domain IPR007965 (Protein of unknown function DUF738)
40	F59A3.1	F59A3.1	n/a	chrI 5,525,077	F59A3.1 encodes one of two C. elegans carboxypeptidase D homologs; loss of F59A3.1 activity via large-scale RNAi screens in a sensitized, rrf-3 mutant background results in larval lethality, abnormal locomotion, and abnormal morphogenesis of the vulval epithelium resulting in rupture; high-throughput expression studies report F59A3.1 expression in the pharynx only.
41	Y57G11C.21	Y57G11C.21	n/a	chrIV 14,846,701	contains similarity to Interpro domain IPR000358 (Ribonucleotide reductase)
42	F15D3.4	F15D3.4	n/a	chrI 11,568,010	contains similarity to Interpro domain IPR000215 (Protease inhibitor I4, serpin)
43	ZK1240.1	ZK1240.1	n/a	chrII 2,330,574	contains similarity to Pfam domain PF00097 Zinc finger, C3HC4 type (RING finger) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR000315 (Zinc finger, B-box)
44	rsr-1	F28D9.1	n/a	chrI 11,179,945	C. elegans RSR-1 protein; contains similarity to Pfam domain PF01480 PWI domain contains similarity to Interpro domains IPR002483 (Splicing factor PWI), IPR000694 (Proline-rich region), IPR005819 (Histone H5), IPR002185 (Dopamine D4 receptor)
45	C37C3.11	C37C3.11	n/a	chrV 7,864,144
46	tba-9	F40F4.5	n/a	chrX 3,254,559	tba-9 encodes one of nine C. elegans alpha tubulins; by homology, TBA-9 is predicted to be a component of microtubules; as loss of tba-9 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, TBA-9 likely functions redundantly with other alpha tubulins as a basic component of cellular architecture that may play additional roles in processes such as cell division, cell movement, and intracellular transport.
47	C08H9.1	C08H9.1	n/a	chrII 9,876,448	contains similarity to Pfam domain PF00450 Serine carboxypeptidase contains similarity to Interpro domain IPR001563 (Peptidase S10, serine carboxypeptidase)
48	gcy-3	R134.1	n/a	chrII 9,504,941	gcy-3 is predicted to encode a guanylate cyclase.
49	frm-3	H05G16.1	n/a	chrX 11,578,915	frm-3 encodes a protein containing a FERM domain (Band 4.1 family); expressed in a few cells in the head.
50	T10B10.5	T10B10.5	n/a	chrX 15,197,450	contains similarity to Pfam domain PF00168 C2 domain contains similarity to Interpro domains IPR008973 (C2 calcium/lipid-binding region, CaLB), IPR000008 (C2 calcium-dependent membrane targeting)