UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	T21F4.1	T21F4.1	0	chrX 5,631,021	T21F4.1 is orthologous to the human gene ARGINASE TYPE I ERYTHROID VARIANT (ARG1; OMIM:207800), which when mutated leads to argininemia.
2	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
3	upp-1	ZK783.2	n/a	chrIII 7,642,087	C. elegans UPP-1 protein; contains similarity to Pfam domain PF01048 Phosphorylase family contains similarity to Interpro domains IPR010059 (Uridine phosphorylase, eukaryotic), IPR000845 (Nucleoside phosphorylase)
4	Y12A6A.1	Y12A6A.1	n/a	chrX 13,620,760
5	F38A1.9	F38A1.9	n/a	chrIV 1,244,866
6	glc-2	F25F8.2	n/a	chrI 4,886,565	glc-2 encodes the beta subunit of a glutamate-gated chloride channel; in vivo, GLC-2 is capable of forming homomeric glutamate-activated channels, as well as heteromeric channels with GLC-1 that can be activated by glutamate and avermectins, antihelmintics that inhibit pharyngeal pumping; as loss of glc-2 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of GLC-2 in development and/or behavior is not yet known; however, GLC-2 expression is generally restricted to the pm4 pharyngeal muscles of larvae and adults, suggesting a role for GLC-2 in regulation of glutamatergic inhibition of pharyngeal pumping.
7	ptr-8	F44F4.4	n/a	chrII 10,891,194	ptr-8 encodes a nematode-specific member of the sterol sensing domain (SSD) proteins, distantly paralogous to Drosophila PATCHED (PTC) and human PTCH (OMIM:601309, mutated in basal cell nevus syndrome); PTR-8 is weakly required for normal molting from L4 to adult stages; PTR-8 is also required for normal growth to full size and locomotion; PTR-8 is expressed in hypodermis.
8	F14D7.7	F14D7.7	n/a	chrV 14,306,660	contains similarity to Chlorobium tepidum Peptidyl-prolyl cis-trans isomerase, PpiC-type.; TR:Q8KFW7
9	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
10	C44C8.2	C44C8.2	n/a	chrIV 900,230
11	acl-3	ZK809.2	n/a	chrIV 11,651,359	acl-3 encodes a phosphate acyltransferase that is orthologous to human tafazzin (TAZ; OMIM:300394, mutated in Barth syndrome); by homology, ACL-3 is predicted to be a mitochondrial protein that plays a role in phospholipid metabolism, although loss of acl-3 activity via large-scale RNAi screens results in no obvious defects.
12	srx-86	F38B7.7	n/a	chrV 11,563,703	C. elegans SRX-86 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
13	math-15	C16C4.5	n/a	chrII 1,867,089	C. elegans MATH-15 protein; contains similarity to Pfam domain PF00917 MATH domain contains similarity to Interpro domains IPR008974 (TRAF-like), IPR002083 (MATH)
14	zig-7	F54D7.4	n/a	chrI 4,791,457	zig-7 encodes a predicted secreted protein that is a member of the immunoglobulin superfamily of proteins; loss of zig-7 activity via RNAi has been reported to result in aldicarb resistance; a zig-7::gfp reporter fusion is expressed in body wall muscle.
15	T20B12.4	T20B12.4	n/a	chrIII 7,368,549	T20B12.4 is orthologous to the human gene INTERLEUKIN 2 RECEPTOR, GAMMA (SEVERE COMBINED IMMUNODEFICIENCY) (IL2RG; OMIM:308380), which when mutated leads to disease.
16	srw-8	F59D6.5	n/a	chrV 3,033,490	C. elegans SRW-8 protein; contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
17	clec-7	F10G2.3	n/a	chrV 7,329,181	C. elegans CLEC-7 protein; contains similarity to Pfam domains PF00431 (CUB domain) , PF00059 (Lectin C-type domain) (2)contains similarity to Interpro domains IPR000859 (CUB), IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
18	F46B6.4	F46B6.4	n/a	chrV 9,778,673	contains similarity to Pfam domain PF01926 GTPase of unknown function contains similarity to Interpro domains IPR016496 (GTP-binding protein, HflX), IPR002917 (GTP-binding protein, HSR1-related), IPR003593 (AAA+ ATPase, core), IPR006073 (GTP1/OBG)
19	clec-160	F09G8.8	n/a	chrIII 8,274,384	C. elegans CLEC-160 protein; contains similarity to Pfam domains PF00092 (von Willebrand factor type A domain) , PF00059 (Lectin C-type domain) contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin), IPR002035 (von Willebrand factor, type A)
20	fbxa-59	T12B5.8	n/a	chrIII 942,155	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
21	nhr-257	C17A2.1	n/a	chrII 3,853,795	C. elegans NHR-257 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
22	bch-1	F25H2.13	n/a	chrI 10,574,565	C. elegans BCH-1 protein; contains similarity to Pfam domain PF06733 DEAD_2 contains similarity to Interpro domains IPR014013 (Helicase, superfamily 1 and 2, ATP-binding, DinG/Rad3-type), IPR010614 (DEAD2), IPR002464 (DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site), IPR006554 (Helicase-like, DEXD box c2 type), IPR006555 (Helicase, ATP-dependent, c2 type), IPR014001 (DEAD-like helicase, N-terminal), IPR013020 (DNA helicase (DNA repair), Rad3 type)
23	F22H10.4	F22H10.4	n/a	chrX 16,684,977
24	F19C7.6	F19C7.6	n/a	chrIV 4,595,282
25	F41C3.1	F41C3.1	n/a	chrII 4,752,652	contains similarity to Pfam domain PF06887 Protein of unknown function (DUF1265) contains similarity to Interpro domain IPR009676 (Protein of unknown function DUF1265)
26	B0222.1	B0222.1	n/a	chrV 9,134,798	contains similarity to Pfam domain PF01705 CX module contains similarity to Interpro domains IPR003566 (T-cell surface glycoprotein CD5), IPR002619 (Protein of unknown function CX), IPR000694 (Proline-rich region)
27	M02F4.2	M02F4.2	n/a	chrX 3,033,806
28	F48E8.4	F48E8.4	n/a	chrIII 5,456,244	contains similarity to Interpro domain IPR009011 (Mannose-6-phosphate receptor, binding)
29	W07G4.1	W07G4.1	n/a	chrV 13,033,814	contains similarity to Interpro domain IPR009050 ()
30	C06A12.3	C06A12.3	n/a	chrIV 17,428,622	contains similarity to Pfam domain PF05303 Protein of unknown function (DUF727) contains similarity to Interpro domain IPR007967 (Protein of unknown function DUF727)
31	unc-31	ZK897.1	n/a	chrIV 12,780,334	unc-31 encodes a pleckstrin homology (PH) domain-containing protein that is the C. elegans ortholog of human CADPS/CAPS (calcium-dependent activator protein for secretion OMIM:604667); UNC-31 functions in post-docking calcium-regulated dense-core vesicle fusion that is required for egg laying, locomotion, pharyngeal pumping, and recovery from the dauer larval stage; in addition, UNC-31 functions in the insulin receptor signaling pathway that regulates adult life span where it may control Ca[2+]-regulated secretion of an insulin-like ligand; UNC-31 is not required for synaptic vesicle exocytosis; unc-31::gfp transcriptional reporters are expressed in most, if not all, neurons, vulval muscles, vulval cells, the spermatheca, and secretory cells such as the uterine UV1 cells; UNC-31::GFP translational fusions localize to neuronal cell bodies, axonal projections and to sites of synaptic contact, consistent with other dense-core vesicle proteins.
32	K02D7.1	K02D7.1	n/a	chrIV 293,550	K02D7.1 is orthologous to the human gene PURINE NUCLEOSIDE PHOSPHORYLASE (NP; OMIM:164050), which when mutated leads to disease.
33	W01A11.1	W01A11.1	n/a	chrV 6,500,809	contains similarity to Pfam domains PF06441 (Epoxide hydrolase N terminus) , PF00561 (alpha/beta hydrolase fold) contains similarity to Interpro domains IPR016292 (Epoxide hydrolase), IPR000073 (Alpha/beta hydrolase fold-1), IPR000639 (Epoxide hydrolase-like), IPR010497 (Epoxide hydrolase, N-terminal)
34	C12D12.5	C12D12.5	n/a	chrX 3,505,953	contains similarity to Pfam domain PF00505 HMG (high mobility group) box contains similarity to Interpro domains IPR000910 (High mobility group box, HMG1/HMG2), IPR009071 (High mobility group box, HMG)
35	Y47H9C.9	Y47H9C.9	n/a	chrI 11,900,113	contains similarity to Pfam domain PF06918 Protein of unknown function (DUF1280) contains similarity to Interpro domain IPR009689 (Protein of unknown function DUF1280)
36	R07B7.5	R07B7.5	n/a	chrV 12,069,626	contains similarity to Pfam domain PF01494 FAD binding domain contains similarity to Interpro domains IPR003042 (Aromatic-ring hydroxylase), IPR002938 (Monooxygenase, FAD-binding)
37	T25B2.1	T25B2.1	n/a	chrX 6,175,044	contains similarity to Pfam domains PF00620 (RhoGAP domain) , PF00130 (Phorbol esters/diacylglycerol binding domain (C1 domain)) contains similarity to Interpro domains IPR001060 (Cdc15/Fes/CIP4), IPR008936 (Rho GTPase activation protein), IPR000533 (Tropomyosin), IPR002219 (Protein kinase C, phorbol ester/diacylglycerol binding), IPR000695 (H+ transporting ATPase, proton pump), IPR000198 (RhoGAP)
38	F25E5.5	F25E5.5	n/a	chrV 7,448,059	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
39	K11H12.7	K11H12.7	n/a	chrIV 666,215
40	mes-2	R06A4.7	n/a	chrII 14,386,115	mes-2 encodes a SET domain-containing protein that is orthologous to the Drosophila Polycomb group protein Enhancer of zeste [E(Z)]; as a member of a Polycomb-like chromatin repressive complex with MES-3 and MES-6, MES-2 is required maternally for normal germline development and during larval development, for anteroposterior patterning; during germline development, the MES-2/MES-3/MES-6 complex is believed to be essential for maintaining repression of the X chromosome, and in transgenic animals, the complex is necessary for germline repression of repetitive transgenes; in axial patterning, the MES-2/MES-3/MES-6 complex is required in somatic tissues for maintaining homeotic gene repression, acting upstream of the Hox genes lin-39, mab-5, and egl-5, as well as the egl-5 target gene lin-32; in addition, MES-2 activity is required for normal levels and localization of MES-3 in >24-cell-stage embryos; MES-2 expression is detected in the primordial germ cells and germline nuclei throughout development, in all nuclei in early embryos, and in somatic nuclei, including those of the male tail, in L2 and L3 larvae; in the nucleus, MES-2 appears to localize to chromatin.
41	T27A8.3	T27A8.3	n/a	chrX 16,062,905	contains similarity to Pfam domain PF00557 metallopeptidase family M24 contains similarity to Interpro domains IPR000994 (Peptidase M24, catalytic core), IPR011991 (Winged helix repressor DNA-binding)
42	kin-4	C10C6.1	n/a	chrIV 11,441,819	C. elegans KIN-4 protein; contains similarity to Pfam domains PF08926 (Domain of unknown function (DUF1908)) , PF00595 (PDZ domain (Also known as DHR or GLGF)) , PF00069 (Protein kinase domain) contains similarity to Interpro domains IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR015022 (Region of unknown function DUF1908), IPR000719 (Protein kinase, core), IPR001478 (PDZ/DHR/GLGF), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related), IPR000961 (Protein kinase, C-terminal)
43	clec-265	M02F4.7	n/a	chrX 3,032,455	C. elegans CLEC-265 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin), IPR002353 (Type II antifreeze protein)
44	tag-179	T24D1.4	n/a	chrI 9,961,143	C. elegans TAG-179 protein; contains similarity to Pfam domain PF04922 DIE2/ALG10 family contains similarity to Interpro domains IPR016900 (Alpha-1, 2 glucosyltransferase Alg10), IPR007006 (DIE2/ALG10)
45	T06E6.10	T06E6.10	n/a	chrV 15,418,719	contains similarity to Pfam domain PF01826 Trypsin Inhibitor like cysteine rich domain contains similarity to Interpro domains IPR002919 (Protease inhibitor I8, cysteine-rich trypsin inhibitor-like), IPR013032 (EGF-like region, conserved site)
46	T24C2.5	T24C2.5	n/a	chrX 14,538,539	contains similarity to Homo sapiens Nuclear receptor co-repressor 1; ENSEMBL:ENSP00000268712
47	K07A12.1	K07A12.1	n/a	chrI 8,668,182	contains similarity to Pfam domain PF04910 Protein of unknown function, DUF654 contains similarity to Interpro domains IPR006994 (Basic helix-loop-helix, Nulp1-type), IPR000294 (Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)
48	srh-220	F47C12.5	n/a	chrIV 3,977,216	C. elegans SRH-220 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
49	vha-7	C26H9A.1	n/a	chrIV 12,646,915	vha-7 encodes an ortholog of subunit a of the membrane-bound (V0) domain of vacuolar proton-translocating ATPase (V-ATPase); VHA-7 is orthologous to human ATP6N1A (OMIM:192130), ATP6V0A2, ATP6V0A4 (OMIM:605239, mutated in distal renal tubular acidosis), and TCIRG1 (OMIM:604592, mutated in osteopetrosis); vha-7 is expressed in hypodermis and uterus; VHA-7 is dispensable for viability, since vha-7(RNAi) animals develop to normal, healthy adults; in S. cerevisiae, different V0 a-subunits (Stv1p and Vph1p) direct the assembly of V-ATPases to different membranes and organelles, suggesting that the profusion of such subunits in C. elegans (co-orthologous VHA-5, VHA-6, VHA-7, and six UNC-32 isoforms) may have a similar function; VHA-7 is predicted to capture protons from V-ATPase transmembrane rotor components and export the protons across the membrane.
50	F45F2.10	F45F2.10	n/a	chrV 8,515,924	contains similarity to Pfam domain PF00023 Ankyrin repeat contains similarity to Interpro domain IPR002110 (Ankyrin)