UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	T01B6.1	T01B6.1	0	chrX 2,342,147	n/a
2	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
3	R04B3.1	R04B3.1	n/a	chrX 2,468,815	contains similarity to Interpro domain IPR000998 (MAM)
4	unc-29	T08G11.5	n/a	chrI 8,899,525	unc-29 encodes an non-alpha subunit of the nicotinic acetylcholine receptor (nAChR) superfamily; UNC-29 is required for normal locomotion and egg-laying, and functions as a subunit of a ligand-gated ion channel that likely mediates fast actions of acetylcholine at neuromuscular junctions and in the nervous system; when coexpressed with LEV-1, a non-alpha nAChR subunit, and UNC-38 or UNC-63, alpha AChR subunits, the resulting multimer can form levamisole-gated channels; UNC-29 is expressed in body wall muscle.
5	R13.4	R13.4	n/a	chrIV 10,819,150	contains similarity to Pfam domain PF02891 MIZ/SP-RING zinc finger contains similarity to Interpro domain IPR004181 (Zinc finger, MIZ-type)
6	T05A1.3	T05A1.3	n/a	chrIV 9,563,673	contains similarity to Pfam domain PF00560 Leucine Rich Repeat contains similarity to Interpro domains IPR000483 (Cysteine-rich flanking region, C-terminal), IPR001611 (Leucine-rich repeat), IPR003591 (Leucine-rich repeat, typical subtype)
7	srx-90	H12C20.5	n/a	chrV 11,581,770	C. elegans SRX-90 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR002651 (Protein of unknown function DUF32), IPR000276 (GPCR, rhodopsin-like)
8	dgn-2	F56C3.6	n/a	chrX 1,366,491	C. elegans DGN-2 protein ;
9	hum-7	F56A6.2	n/a	chrI 596,704	hum-7 encodes a class IX unconventional myosin heavy chain that contains a myosin motor domain in the head region and zinc-finger and rhoGAP (rho GTPase activating protein) domains in the tail region; HUM-7 is required during embryogenesis for cytokinesis and normal cytoplasmic rearrangements, and by homology, may function in organization of the actin cytoskeleton; the precise expression and localization patterns of HUM-7 are not yet known.
10	R02D5.1	R02D5.1	n/a	chrV 14,508,925	contains similarity to Saccharomyces cerevisiae Delayed Anaerobic Gene; SGD:YJR151C
11	lgc-34	T27A1.4	n/a	chrII 528,462	C. elegans LGC-34 protein; contains similarity to Pfam domain PF02931 Neurotransmitter-gated ion-channel ligand binding domain contains similarity to Interpro domains IPR000585 (Hemopexin), IPR006028 (Gamma-aminobutyric acid A receptor), IPR006201 (Neurotransmitter-gated ion-channel), IPR006202 (Neurotransmitter-gated ion-channel ligand-binding)
12	clec-151	F10F2.7	n/a	chrIII 4,629,753	C. elegans CLEC-151 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
13	clec-229	H02K04.1	n/a	chrV 15,340,763	C. elegans CLEC-229 protein; contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin), IPR001202 (WW/Rsp5/WWP)
14	C17E4.11	C17E4.11	n/a	chrI 9,420,385	contains similarity to Pfam domain PF08241 Methyltransferase domain contains similarity to Interpro domain IPR013216 (Methyltransferase type 11)
15	C04F6.2	C04F6.2	n/a	chrX 3,397,298
16	B0207.11	B0207.11	n/a	chrI 5,963,581	B0207.11 encodes a nematode-specific protein probably required for a normally high ovulation rate; B0207.11 has no obvious non-nematode homologs, but does have a putative N-terminal coiled-coil domain and an SH2 motif, and is is paralogous to four other C. elegans proteins (F42G4.6, F44F4.10, T08G11.2, and Y81G3A.1); B0207.11(tm322) hermaphrodites show abnormal egg-laying, retaining significantly fewer eggs than wild-type (perhaps due to a lowered ovulation rate) while retaining late-stage embryos; B0207.11 has no obvious phenotype in mass RNAi experiments, possibly because of genetic redundancy with its paralogs.
17	clc-2	C01C10.1	n/a	chrX 7,432,451	clc-2 encodes a claudin homolog, closely similar to CLC-1, that is required for normal cohesion of apical junctions in epithelia; claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water; CLC-2 maintains the impermeability ('barrier function') of epithelia, since clc-1(RNAi) animals have abnormal permeability of the hypodermis to dyes; clc-2 is expressed in hypodermal seam cells, with two diffuse lines of CLC-2 protein.
18	T25G12.6	T25G12.6	n/a	chrX 17,227,557	contains similarity to Pfam domain PF00092 von Willebrand factor type A domain contains similarity to Interpro domain IPR002035 (von Willebrand factor, type A)
19	C31H2.4	C31H2.4	n/a	chrX 5,157,381	C31H2.4 encodes a possible 4-hydroxyphenylpyruvate dioxygenase, orthologous to human HPDL/GLOXD1, and paralogous to HPD-1 and human HPD (OMIM:609695, mutated in tyrosinemia type III); C31H2.4 has no obvious function in mass RNAi experiments.
20	syg-2	C26G2.1	n/a	chrX 14,658,836	syg-2 encodes a transmembrane protein that is a member of the immunoglobulin superfamily of proteins; during larval development, SYG-2 activity is required in vulval epithelial cells for proper synaptic specificity of the HSNL neuron; in regulating synapse formation, SYG-2 acts as a guidepost protein for the SYG-1 receptor that interacts with SYG-2 and acts within HSNL to regulate synaptic specificity; a SYG-2::GFP fusion protein is expressed in the primary vulval cell lineages beginning at the L3 larval stage, with expression increasing during the L4 stage and finally disappearing by adulthood; in embryos, SYG-2::GFP expression is detected in some head neurons and body wall muscles, the latter of which also express the reporter during the L1 and L2 larval stages.
21	K10C9.3	K10C9.3	n/a	chrV 1,064,729	contains similarity to Pfam domain PF00445 Ribonuclease T2 family contains similarity to Interpro domain IPR001568 (Ribonuclease T2)
22	lrk-1	T27C10.6	n/a	chrI 10,886,998	lrk-1 encodes a homolog of GbpC, the primary high-affinity cGMP-binding protein in Dictyostelium discoideum, which is required for normal phosphorylation and cytoskeletal assembly of myosin during chemotaxis; GbpC is generally conserved in eukaryotes, with homologs in mammals and flies.
23	cst-2	C24A8.4	n/a	chrX 4,334,568	C. elegans CST-2 protein; contains similarity to Pfam domains PF07714 (Protein tyrosine kinase) , PF00069 (Protein kinase domain) contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)
24	K08D10.9	K08D10.9	n/a	chrIV 4,159,983
25	dyb-1	F47G6.1	n/a	chrI 1,486,779	The dyb-1 gene encodes a homolog of mammalian alpha-dystrobrevin (DTNA; OMIM:601239), mutation of which can lead to left ventricular noncompaction with congenital heart defects.
26	C16C10.9	C16C10.9	n/a	chrIII 4,156,357	contains similarity to Bacillus anthracis MutS2 family protein.; TR:Q81L40
27	let-19	K08F8.6	n/a	chrII 8,776,425	The let-19 gene encodes a protein related to human TRAP240 (thyroid hormone receptor-associated protein 240, OMIM:300182), a transcriptional co-activation complex subunit conserved in yeast, Drosophila, and humans; LET-19 is required for proper asymmetric cell divisions and cell fusions regulated by LIN-44/Wnt and LIN-17/frizzled, as well as for proper development of secondary vulval cell fates as regulated by Notch signaling.
28	C34E7.4	C34E7.4	n/a	chrX 12,933,527	contains similarity to Interpro domain IPR000345 (Cytochrome c heme-binding site)
29	F02D10.4	F02D10.4	n/a	chrX 13,458,404	contains similarity to Emericella nidulans Anucleate primary sterigmata protein B.; SW:APSB_EMENI
30	F13B6.1	F13B6.1	n/a	chrIV 7,457,398
31	C43G2.2	C43G2.2	n/a	chrIV 6,569,098	contains similarity to Interpro domain IPR000533 (Tropomyosin)
32	C44B7.4	C44B7.4	n/a	chrII 6,869,836	contains similarity to Rattus norvegicus Protein FAM26F.; SW:Q561R8
33	rpm-1	C01B7.6	n/a	chrV 8,812,661	rpm-1 encodes an E3 ubiquitin ligase that contains an N-terminal RCC1 (regulator of chromosome condensation)-like guanine nucleotide exchange factor (GEF) domain and that is orthologous to Drosophila highwire and murine Phr1; RPM-1 functions autonomously within several different types of neurons to regulate presynaptic differentiation; in regulating axon termination, RPM-1 acts through the GLO-4 guanine nucleotide exchange factor that positively regulates vesicular trafficking through GLO-1/Rab; in regulating synaptogenesis, RPM-1 functions as part of an SCF-like ubiquitin ligase complex that negatively regulates signaling through the DLK-1 MAP kinase cascade; RPM-1 is expressed in most, if not all, neurons from the comma stage of embryogenesis through adulthood; RPM-1 expression is also seen in the pharynx, coelomocytes, and distal tip cells; in neurons, RPM-1 localizes to presynaptic terminals.
34	K07D4.6	K07D4.6	n/a	chrII 4,017,758	contains similarity to Drosophila melanogaster Flybase gene name is CG31439-PA;; FLYBASE:CG31439
35	Y116A8C.23	Y116A8C.23	n/a	chrIV 17,054,490	contains similarity to Interpro domain IPR000694 (Proline-rich region)
36	srt-26	C24B9.2	n/a	chrV 2,716,136	C. elegans SRT-26 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
37	ZC328.2	ZC328.2	n/a	chrI 6,389,348	contains similarity to Pfam domain PF00096 Zinc finger, C2H2 type contains similarity to Interpro domains IPR015880 (Zinc finger, C2H2-like), IPR007086 (Zinc finger, C2H2-subtype), IPR013087 (Zinc finger, C2H2-type/integrase, DNA-binding), IPR007087 (Zinc finger, C2H2-type)
38	ctbp-1	F49E10.5	n/a	chrX 5,867,998	tag-45 encodes a D-isomer specific 2-hydroxyacid dehydrogenase.
39	Y45F10A.3	Y45F10A.3	n/a	chrIV 13,511,278	contains similarity to Mus musculus Probable arylformamidase (EC 3.5.1.9) (Kynurenine formamidase) (KF).; SW:Q8K4H1
40	K07E8.6	K07E8.6	n/a	chrII 638,824	contains similarity to Pfam domain PF08565 Cdc37 Hsp90 binding domain contains similarity to Interpro domains IPR004918 (Cdc37), IPR013874 (Cdc37, Hsp90 binding)
41	pqn-67	T16G1.1	n/a	chrV 12,926,198	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
42	rbc-1	F54E4.1	n/a	chrX 14,617,784	rbc-1 encodes an ortholog of S. cerevisiae RAV1; like RAV1, RBC-1 may be required for the reassociation of vacuolar proton-translocating ATPase (V-ATPase) after temporary glucose starvation.
43	T23G5.6	T23G5.6	n/a	chrIII 9,241,340	contains similarity to Pfam domain PF02178 AT hook motif contains similarity to Interpro domain IPR000637 (HMG-I and HMG-Y, DNA-binding)
44	tag-278	C02F12.7	n/a	chrX 3,686,384	C. elegans TAG-278 protein; contains similarity to Interpro domain IPR000533 (Tropomyosin)
45	tag-304	F53E2.1	n/a	chrV 1,469,424	C. elegans TAG-304 protein; contains similarity to Pfam domain PF08513 LisH contains similarity to Interpro domains IPR006594 (LisH dimerisation motif), IPR013144 (CT11-RanBPM), IPR013720 (LisH dimerisation motif, subgroup), IPR006595 (CTLH, C-terminal to LisH motif)
46	Y56A3A.6	Y56A3A.6	n/a	chrIII 11,874,979	contains similarity to Interpro domains IPR003072 (Orphan nuclear receptor, NOR1 type), IPR000694 (Proline-rich region), IPR002951 (Atrophin)
47	ZC404.7	ZC404.7	n/a	chrV 6,779,108
48	valv-1	B0496.7	n/a	chrIV 7,444,987	B0496.7 encodes a LIM domain-containing protein.
49	C34F11.1	C34F11.1	n/a	chrII 5,213,423	contains similarity to Pfam domain PF00097 Zinc finger, C3HC4 type (RING finger) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR011016 (Zinc finger, variant RING-type)
50	T05C1.2	T05C1.2	n/a	chrII 4,482,363