UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	set-15	R11E3.4	0	chrIV 4,777,653	set-15 encodes a SET domain-containing protein required for normally short lifespan; SET-15 has no non-nematode orthologs, but several paralogs (SET-6, SET-13, SET-19, SET-20, SET-21, and SET-32); other than extending lifespan, set-15(RNAi) has no obvious phenotype.
2	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
3	pyr-1	D2085.1	n/a	chrII 8,654,903	pyr-1 is orthologous to the human gene CARBAMYL PHOSPHATE SYNTHETASE I (CPS1, which when mutated leads to hyperammonemia (OMIM:237300); PYR-1 protein is predicted to be mitochondrial with 68% accuracy.
4	ptr-1	C24B5.3	n/a	chrV 9,179,855	ptr-1 encodes an ortholog of Drosophila and human PTCHD3, which defines one of seven paralogous families of sterol sensing domain (SSD) proteins; individually, PTR-1 is weakly required for normal molting from L4 to adult stages; however, PTR-1, in conjunction with either PTR-16 alone or with PTR-6 and PTR-10, is strongly required for both molting and viability, with double ptr-1/-16 or triple ptr-1/-6/-10 RNAi animals showing pronounced molting defects and lethality; PTR-1 is also required for normal adult alae formation, growth to full size, locomotion, and male tail development.
5	F49E12.6	F49E12.6	n/a	chrII 8,414,691	The F49E12.6 gene encodes a protein with two E2F domains that may be involved in apoptosis.
6	K01A2.5	K01A2.5	n/a	chrII 303,020	contains similarity to Pfam domain PF00561 alpha/beta hydrolase fold contains similarity to Interpro domains IPR000073 (Alpha/beta hydrolase fold-1), IPR003089 (Alpha/beta hydrolase)
7	C15C6.1	C15C6.1	n/a	chrI 12,202,933	contains similarity to Caulobacter crescentus Hypothetical protein CC0499.; TR:Q9AAU5
8	erd-2	F09B9.3	n/a	chrX 10,158,581	erd-2 encodes a protein with homology to human ER lumen protein retaining receptor 1.
9	gosr-2.1	B0272.2	n/a	chrX 9,440,914	C. elegans GOSR-2.1 protein; contains similarity to Pfam domain PF05008 Vesicle transport v-SNARE protein contains similarity to Interpro domain IPR007705 (Vesicle transport v-SNARE)
10	H40L08.1	H40L08.1	n/a	chrX 15,082,354	contains similarity to Pfam domain PF00627 UBA/TS-N domain contains similarity to Interpro domains IPR009060 (UBA-like), IPR000533 (Tropomyosin), IPR000449 (Ubiquitin-associated/translation elongation factor EF1B, N-terminal)
11	C46H11.7	C46H11.7	n/a	chrI 5,042,625	contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domains IPR002919 (Protease inhibitor I8, cysteine-rich trypsin inhibitor-like), IPR003582 (Metridin-like ShK toxin)
12	gana-1	R07B7.11	n/a	chrV 12,088,053	gana-1 encodes a protein with homology to both human alpha-galactosidase (alpha-GAL) and alpha-N-acetylgalactosaminidase (alpha-NAGA) enzymes; these dual enzymatic activities were detected in mixed culture homogenates; immunofluorescence studies show cytoplasmic expression of GANA-1 in body wall muscle and intestinal cells and in coelomocytes; the human gene alpha-galactosidase B (GALB; OMIM:104170), when mutated leads to Schindler disease, Kanzaki disease, or NAGA deficiency.
13	sft-4	C54H2.5	n/a	chrX 5,779,970	sft-4 encodes a member of the SURF family highly conserved with the mouse Surf-4 gene, and conservation includes an encoded dilysine motif that is implicated in endoplasmic reticulum localization of the mouse protein.
14	T03G6.1	T03G6.1	n/a	chrX 2,609,102
15	pat-6	T21D12.4	n/a	chrIV 263,062	pat-6 encodes the worm ortholog of alpha-parvin; it is required for muscle assembly and function, with mutations leading to embryonic lethality.
16	ZC13.3	ZC13.3	n/a	chrX 885,679	contains similarity to Interpro domain IPR000998 (MAM)
17	C07E3.10	C07E3.10	n/a	chrII 10,346,620	contains similarity to Saccharomyces cerevisiae Ring finger protein involved in the DNA damage response with possible recombination role; genetically identified by synthetic lethality with SGS1 (DNA helicase) and TOP3 (DNA topoisomerase); sporulation role; interacts with Slx8p and Lin1p; SGD:YDL013W
18	C34F6.8	C34F6.8	n/a	chrX 11,216,944	contains similarity to Pfam domain PF00180 Isocitrate/isopropylmalate dehydrogenase contains similarity to Interpro domains IPR004790 (Isocitrate dehydrogenase NADP-dependent, eukaryotic), IPR001804 (Isocitrate/isopropylmalate dehydrogenase)
19	hke-4.2	H13N06.5	n/a	chrX 15,506,879	C. elegans HKE-4.2 protein; contains similarity to Pfam domain PF02535 ZIP Zinc transporter contains similarity to Interpro domains IPR002395 (HMW kininogen), IPR003689 (Zinc/iron permease)
20	stc-1	F54C9.2	n/a	chrII 8,564,862	C. elegans STC-1 protein; contains similarity to Pfam domain PF00012 Hsp70 protein contains similarity to Interpro domains IPR001023 (Heat shock protein Hsp70), IPR013126 (Heat shock protein 70)
21	F46C8.8	F46C8.8	n/a	chrX 7,552,792
22	F40E10.5	F40E10.5	n/a	chrX 14,702,656	contains similarity to Onchocerca volvulus OV39 antigen (Fragment).; SW:P31730
23	nrs-2	F25G6.6	n/a	chrV 8,547,557	nrs-2 encodes a predicted asparaginyl-tRNA synthetase (AsnRS), a class II aminoacyl-tRNA synthetase that catalyzes the attachment of asparagine to its cognate tRNA and is thus required for protein biosynthesis; loss of nrs-2 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities.
24	T22D1.4	T22D1.4	n/a	chrIV 6,911,758	contains similarity to Pfam domain PF04597 Ribophorin I contains similarity to Interpro domain IPR007676 (Ribophorin I)
25	dre-1	K04A8.6	n/a	chrV 6,535,821	dre-1 encodes an ortholog of human FBXO11/PRMT9 (OMIM:607871, associated with vitiligo and otitis media) that is required, in conjunction with DAF-12 and its partners, for global developmental timing of the transistion from larval to adult cell fates; DRE-1 has an N-terminal F-box domain, three central tandem C-terminal CASH domains, and a C-terminal zinc finger; hypomorphic dre-1 mutations are synthetically heterochronic with loss-of-function daf-12 alleles, inducing defective distal tip cell migration and precocious fusion of seam cells; five different hypomorphic dre-1 alleles alter conserved glycine residues in the CASH domain region, whereas the null dre-1(hd60) allele is lethal at the three-fold embryo stage; DRE-1 is expressed in many tissues, including epidermal and distal tip cells, and localizes to both nucleus and cytoplasm; strong loss-of-function of dre-1 (the dh99 mutant fed RNAi) induces defects at all four molts; dre-1 also has synthetic phenotypes with daf-9(k182), daf-36(k114), and lin-29(n546); dre-1-like enhancement of daf-12 is also seen in skr-1(RNAi), cul-1(RNAi), or rbx-1/2(RNAi) animals; DRE-1 and SKR-1 bind one another, as do their human orthologs; DRE-1 affects lin-29 expression, and is suppressed by lin-42(RNAi); DRE-1 is paralogous to C. elegans BE0003N10.3.
26	C26B9.3	C26B9.3	n/a	chrX 5,339,194
27	cyn-6	F42G9.2	n/a	chrIII 773,770	cyn-6 encodes a cyclophilin most similar to human secreted cyclophilin type B isoforms that is functional when expressed in E. coli; it is expressed in the intestine.
28	his-41	C50F4.5	n/a	chrV 9,546,148	his-41 encodes an H2B histone.
29	F53F1.5	F53F1.5	n/a	chrV 13,415,573	contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR001859 (Ribosomal protein P2), IPR013286 (Annexin, type VII)
30	grl-10	C26F1.5	n/a	chrV 7,775,086	grl-10 encodes a hedgehog-like protein, with an N-terminal signal sequence and a C-terminal Ground-like (Grl) domain; the Grl domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins.
31	fkb-4	ZC455.10	n/a	chrV 12,786,120	fkb-4 encodes a peptidylprolyl cis/trans isomerase homologous to mammalian FK506 immunosuppressant-binding protein 9; FKB-4 expression is positively regulated by signaling through the DAF-2 insulin receptor-like pathway and in part, through the activity of the DAF-16 fork-head transcription factor suggesting that FKB-4 could play a role in metabolism and longevity; as loss of FKB-4 function via RNA-mediated interference does not result in any abnormalities, the precise role of FKB-4 in C. elegans development and/or behavior is not yet known; FKB-4 contains a predicted endoplasmic reticulum (ER) retention sequence and is thus proposed to localize to the ER.
32	pqn-55	R09E10.7	n/a	chrIV 10,289,947	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
33	ost-1	C44B12.2	n/a	chrIV 1,109,128	ost-1 encodes the C. elegans ortholog of the conserved basement membrane glycoprotein component osteonectin/SPARC/BM-40; loss of ost-1 function via RNAi indicates that ost-1 activity is required for embryonic and larval development, as well as for normal gut development, body size, and fecundity; an OST-1::GFP reporter fusion protein localizes to the basement membranes along body wall and sex muscles, as well as around the pharynx and gonad, with particular concentration at the spermatheca and distal tip cells.
34	C03H12.1	C03H12.1	n/a	chrX 15,692,830	contains similarity to Interpro domain IPR012336 (Thioredoxin-like fold)
35	M01A10.3	M01A10.3	n/a	chrI 5,549,799	contains similarity to Pfam domain PF05817 Ribophorin II (RPN2) contains similarity to Interpro domain IPR008814 (Ribophorin II)
36	M02G9.1	M02G9.1	n/a	chrII 10,330,867	contains similarity to Pfam domain PF02363 Cysteine rich repeat contains similarity to Interpro domains IPR003341 (Cysteine rich repeat, tripleX), IPR015333 (Pollen allergen ole e 6)
37	pfn-3	K03E6.6	n/a	chrX 1,080,056	C. elegans PFN-3 protein; contains similarity to Pfam domain PF00235 Profilin contains similarity to Interpro domains IPR002097 (Profilin/allergen), IPR005455 (Profilin, plant)
38	R04B3.3	R04B3.3	n/a	chrX 2,474,889
39	lgc-22	F15E6.2	n/a	chrIV 4,302,863	C. elegans LGC-22 protein; contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domains IPR006201 (Neurotransmitter-gated ion-channel), IPR006202 (Neurotransmitter-gated ion-channel ligand-binding), IPR003582 (Metridin-like ShK toxin)
40	F53A2.7	F53A2.7	n/a	chrIII 13,345,704	contains similarity to Pfam domains PF02803 (Thiolase, C-terminal domain) , PF00108 (Thiolase, N-terminal domain) contains similarity to Interpro domains IPR016038 (Thiolase-like, subgroup), IPR002155 (Thiolase), IPR016039 (Thiolase-like)
41	hog-1	W06B11.4	n/a	chrX 5,852,661	hog-1 encodes a hedgehog-like protein, with a solitary Hint/Hog domain; the function of HOG-1's isolated Hint/Hog domain is unknown; in proteins where they coexist with other, N-terminal, domains, the Hint/Hog domain is predicted to cut its host protein into two halves and then covalently link cholesterol to the C-terminus of the N-terminal domain; HOG-1 is weakly required for normal molting; HOG-1 is also required for normal adult alae formation, growth to full size, cuticle adhesion, and locomotion; all of these requirements may reflect common defects in cholesterol-dependent hedgehog-like signalling or in vesicle trafficking.
42	rad-23	ZK20.3	n/a	chrII 11,652,044	C. elegans RAD-23 protein; contains similarity to Pfam domains PF09280 (XPC-binding domain) , PF00627 (UBA/TS-N domain) (2), PF00240 (Ubiquitin family) contains similarity to Interpro domains IPR004806 (UV excision repair protein Rad23), IPR003072 (Orphan nuclear receptor, NOR1 type), IPR000104 (Antifreeze protein, type I), IPR014761 (UV excision repair protein Rad23, C-terminal), IPR000626 (Ubiquitin), IPR009060 (UBA-like), IPR006636 (Heat shock chaperonin-binding), IPR000449 (Ubiquitin-associated/translation elongation factor EF1B, N-terminal), IPR015940 (Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote), IPR015360 (XPC-binding domain)
43	F26G1.5	F26G1.5	n/a	chrII 4,770,962	contains similarity to Pfam domain PF01682 DB module contains similarity to Interpro domain IPR002602 (Protein of unknown function DB)
44	cogc-6	K07C11.9	n/a	chrV 8,219,777	cogc-6 encodes an ortholog of mammalian COG-6, a subunit of lobe B of the conserved oligomeric Golgi complex (COGC); COGC-6 is weakly required for normal gonadal distal tip cell migration, a process that also requires seven other orthologs of COGC subunits; like other lobe B subunits in both C. elegans and S. cerevisiae, COGC-6 is only partially required for normal function, while lobe A subunits are strongly required in either worms or yeast.
45	F22F4.1	F22F4.1	n/a	chrX 6,005,723
46	T06E4.8	T06E4.8	n/a	chrV 9,622,529	contains similarity to Interpro domain IPR000694 (Proline-rich region)
47	T19B10.2	T19B10.2	n/a	chrV 11,222,045
48	M03F8.1	M03F8.1	n/a	chrV 5,952,583
49	his-7	F45F2.4	n/a	chrV 8,533,548	his-7 encodes an H2A histone.
50	F47G9.3	F47G9.3	n/a	chrV 11,315,117	contains similarity to Pfam domains PF00100 (Zona pellucida-like domain) , PF00024 (PAN domain) (2)contains similarity to Interpro domains IPR003609 (Apple-like), IPR003014 (N/apple PAN), IPR001507 (Endoglin/CD105 antigen)