UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	F59E11.2	F59E11.2	0	chrV 9,002,297	contains similarity to Pfam domain PF00106 short chain dehydrogenase contains similarity to Interpro domains IPR002424 (Insect alcohol dehydrogenase family), IPR002347 (Glucose/ribitol dehydrogenase), IPR002198 (Short-chain dehydrogenase/reductase SDR), IPR016040 (NAD(P)-binding)
2	bbs-2	F20D12.3	n/a	chrIV 7,935,876	bbs-2 is orthologous to human BBS2 (OMIM:606151, mutated in Bardet-Biedl syndrome 2); while the function of BBS-2 is unknown, it shares conserved domains with its human paralogs BBS1 and BBS7, which also are mutated in other Bardet-Biedl syndromes.
3	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
4	dep-1	F44G4.8	n/a	chrII 9,012,700	dep-1 encodes a class III receptor protein tyrosine phosphatase (R-PTP) orthologous to human R-PTPs such as PTPRJ/Dep-1 (mutated in epithelial cancers; OMIM:600925); DEP-1 is required, redundantly with LIP-1 and LET-60, and downstream of LIN-12, to promote secondary over primary vulval fate in the P5.p and P7.p lineages; DEP-1 is expressed in P5.p and P7.p lineages, and dep-1 acts cell-autonomously in these lineages; DEP-1 colocalizes with LET-23 in punctae, and binds LET-23 in vitro; DEP-1, with LIP-1, is also required for normal duct cell and excretory pore development; dep-1 mutations are wild-type in isolation, but have vulval phenotypes with added mutations in lin-15, lip-1, or let-60; DEP-1 laterally inhibits secondary vulval fates in parallel with LIN-12/Notch signalling; in primary (P5.p) vulval cells, LET-60/RAS-activated SUR-2 inhibits dep-1 and lin-12 expression; since RNAi of 125 out of 165 predicted C. elegans protein phosphatase genes fails to enhance lip-1 mutations, the LIP-1/DEP-1 interaction is likely to be highly specific.
5	dgn-1	T21B6.1	n/a	chrX 10,922,297	C. elegans DGN-1 protein; contains similarity to Interpro domains IPR015919 (Cadherin-like), IPR013783 (Immunoglobulin-like fold), IPR006644 (Dystroglycan-type cadherin-like), IPR003992 (Pertactin virulence factor, N-terminal)
6	kel-1	C47D12.7	n/a	chrII 11,692,402	kel-1 encodes a BTB/POZ- and Kelch motif-containing protein orthologous to Drosophila Kelch, which is essential for actin organization in ovarian ring canals; in C. elegans, kel-1 is required for regulating feeding during larval development and more specifically, for pharyngeal isthmus peristalsis and efficient trapping of food in the pharynx; KEL-1 is first expressed at the 1.5-fold stage of embryogenesis in the pharyngeal lumen and the nerve ring; later adult and larval expression is confined to the pharyngeal gland cells in which KEL-1 may be required for maintenance of gland cell-specific structures.
7	F21H7.10	F21H7.10	n/a	chrV 16,255,295	contains similarity to Interpro domain IPR003066 (Salmonella invasion protein InvJ)
8	B0310.6	B0310.6	n/a	chrX 530,795
9	srw-95	H06H21.2	n/a	chrIV 4,813,069	C. elegans SRW-95 protein; contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
10	F47C12.1	F47C12.1	n/a	chrIV 4,001,937	contains similarity to Pfam domains PF00008 (EGF-like domain) (4), PF00754 (F5/8 type C domain) , PF07645 (Calcium binding EGF domain) (2), PF07699 (GCC2 and GCC3) (3), PF00431 (CUB domain) , PF07974 (EGF-like domain) , PF02494 (HYR domain) (2), PF00084 (Sushi domain (SCR repeat)) (6)contains similarity to Interpro domains IPR001438 (EGF-like, type 2), IPR000742 (EGF-like, type 3), IPR003410 (Hyalin), IPR000436 (Sushi/SCR/CCP), IPR006209 (EGF-like), IPR000152 (Aspartic acid and asparagine hydroxylation site), IPR006210 (EGF), IPR002049 (EGF-like, laminin), IPR008979 (Galactose-binding like), IPR000859 (CUB), IPR011641 (GCC2 and GCC3), IPR001881 (EGF-like calcium-binding), IPR016060 (Complement control module), IPR009030 (Growth factor, receptor), IPR013032 (EGF-like region, conserved site), IPR000421 (Coagulation factor 5/8 type, C-terminal), IPR013111 (EGF, extracellular), IPR013091 (EGF calcium-binding)
11	Y69H2.7	Y69H2.7	n/a	chrV 18,693,003	contains similarity to Saccharomyces cerevisiae appears to control expression of spliceosome components PRP4 and PRP3; SGD:YDR464W
12	irx-1	C36F7.1	n/a	chrI 9,538,707	irx-1 encodes a homeodomain-containing protein that is most similar to members of the Iroquois subclass of TALE (three amino acid loop extension) superclass atypical homeodomain proteins; IRX-1 is predicted to function as a transcriptional regulator during development, but as loss of irx-1 activity via RNAi results in no obvious defects, the precise role of irx-1 in C. elegans development and/or behavior is not yet known.
13	dpy-26	C25G4.5	n/a	chrIV 12,448,610	dpy-26 encodes a novel, acidic protein that is highly conserved in other Caenorhabditis species; during development, dpy-26 activity is required for both dosage compensation and meiotic chromosome segregation; DPY-26 localizes to all meiotic chromosomes in the germline and to the hermaphrodite X chromosomes in somatic cells; SDC-1, SDC-2, and SDC-3 proteins form a complex and these three proteins, in turn, colocalize with DPY-26, DPY-27, and MIX-1 proteins both on the X chromosome and on a transgenic her-1(+) array.
14	sedl-1	W05H7.3	n/a	chrX 1,439,758	C. elegans SEDL-1 protein; contains similarity to Pfam domain PF04628 Sedlin, N-terminal conserved region contains similarity to Interpro domains IPR011012 (Longin-like), IPR006722 (Sedlin)
15	C25H3.1	C25H3.1	n/a	chrII 5,700,590	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR000719 (Protein kinase, core), IPR017442 (Serine/threonine protein kinase-related)
16	ife-4	C05D9.5	n/a	chrX 1,105,125	The ife-4 gene encodes a member of the Initiation Factor 4E (eIF4E) family.
17	sdz-1	B0303.8	n/a	chrIII 8,699,816	C. elegans SDZ-1 protein ;
18	T05H4.10	T05H4.10	n/a	chrV 6,420,809	contains similarity to Pfam domain PF02985 HEAT repeat contains similarity to Interpro domains IPR000357 (HEAT), IPR016024 (Armadillo-type fold)
19	W05H7.1	W05H7.1	n/a	chrX 1,451,500	contains similarity to Homo sapiens hypothetical protein LOC283767; ENSEMBL:ENSP00000347269
20	dmd-5	F10C1.5	n/a	chrII 5,773,110	C. elegans DMD-5 protein; contains similarity to Pfam domain PF00751 DM DNA binding domain contains similarity to Interpro domain IPR001275 (DM DNA-binding)
21	B0454.9	B0454.9	n/a	chrII 3,053,483	contains similarity to Pfam domain PF03353 DUF278 contains similarity to Interpro domain IPR005020 (Protein of unknown function DUF278)
22	D2005.3	D2005.3	n/a	chrI 7,814,395	contains similarity to Pfam domain PF01984 Double-stranded DNA-binding domain contains similarity to Interpro domain IPR002836 (DNA-binding TFAR19-related protein)
23	amx-1	R13G10.2	n/a	chrIII 3,824,311	C. elegans AMX-1 protein; contains similarity to Pfam domains PF01593 (Flavin containing amine oxidoreductase) , PF01266 (FAD dependent oxidoreductase) contains similarity to Interpro domains IPR006076 (FAD dependent oxidoreductase), IPR001613 (Flavin-containing amine oxidase), IPR000960 (Flavin-containing monooxygenase FMO), IPR002937 (Amine oxidase), IPR016040 (NAD(P)-binding), IPR007526 (SWIRM)
24	F10E7.5	F10E7.5	n/a	chrII 7,112,410	contains similarity to Pfam domain PF00466 Ribosomal protein L10 contains similarity to Interpro domain IPR001790 (Ribosomal protein L10)
25	C44C1.1	C44C1.1	n/a	chrX 981,899
26	F16H11.1	F16H11.1	n/a	chrX 4,670,622	contains similarity to Pfam domain PF07690 Major Facilitator Superfamily contains similarity to Interpro domains IPR011701 (Major facilitator superfamily MFS-1), IPR016196 (MFS general substrate transporter)
27	K04G2.4	K04G2.4	n/a	chrI 8,036,493	contains similarity to Tetrahymena thermophila Histone H1.; SW:H1_TETTH
28	M151.1	M151.1	n/a	chrII 3,642,785
29	K09F6.8	K09F6.8	n/a	chrII 2,295,399
30	fbxa-156	C06H5.1	n/a	chrV 17,896,012	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
31	C09F9.2	C09F9.2	n/a	chrII 14,708,961	contains similarity to Pfam domains PF01390 (SEA domain) , PF01826 (Trypsin Inhibitor like cysteine rich domain) (3), PF07974 (EGF-like domain) , PF03351 (DOMON domain) (4)contains similarity to Interpro domains IPR000742 (EGF-like, type 3), IPR006210 (EGF), IPR005018 (DOMON related), IPR002919 (Protease inhibitor I8, cysteine-rich trypsin inhibitor-like), IPR000082 (SEA), IPR008960 (Carbohydrate-binding family 9/cellobiose dehydrogenase, cytochrome), IPR013032 (EGF-like region, conserved site), IPR013111 (EGF, extracellular), IPR013050 (DOMON)
32	tag-175	D2013.10	n/a	chrII 9,324,253	tag-175 encodes an ortholog of human TMEM41B, whose protein family is ancient (conserved in both animals and plants) but functionally uncharacterized; TAG-175 is broadly expressed (in hypodermis, muscle, neurons, intestine, spermetheca, and vulva); TAG-175 has no known function in vivo, since neither tag-175(RNAi) nor tag-175(gk278) has obvious phenotypes.
33	C33A12.1	C33A12.1	n/a	chrIV 9,524,313	C33A12.1 encodes the C. elegans ortholog of the NDUFA5/B13 subunit of the mitochondrial NADH dehydrogenase (ubiquinone) complex (complex I).
34	F19C6.3	F19C6.3	n/a	chrX 10,007,249	contains similarity to Pfam domains PF00008 (EGF-like domain) , PF00093 (von Willebrand factor type C domain) contains similarity to Interpro domains IPR000742 (EGF-like, type 3), IPR008037 (Proteinase inhibitor I19, pacifastin), IPR006209 (EGF-like), IPR000152 (Aspartic acid and asparagine hydroxylation site), IPR006210 (EGF), IPR001881 (EGF-like calcium-binding), IPR013032 (EGF-like region, conserved site), IPR001007 (von Willebrand factor, type C)
35	ZC196.5	ZC196.5	n/a	chrV 8,731,102	contains similarity to Pfam domain PF05218 Protein of unknown function (DUF713) contains similarity to Interpro domain IPR007883 (Protein of unknown function DUF713)
36	F07A5.3	F07A5.3	n/a	chrI 7,355,830	contains similarity to Pfam domain PF01130 CD36 family contains similarity to Interpro domain IPR002159 (CD36 antigen)
37	fbxb-14	W08F4.9	n/a	chrII 582,428	C. elegans FBXB-14 protein; contains similarity to Pfam domain PF07735 F-box associated contains similarity to Interpro domain IPR012885 (F-box associated type 2)
38	sru-9	Y45F10B.11	n/a	chrIV 13,589,633	C. elegans SRU-9 protein; contains similarity to Pfam domain PF02688 Domain of unknown function DUF215 contains similarity to Interpro domain IPR003839 (Protein of unknown function DUF215)
39	glc-4	C27H5.8	n/a	chrII 7,173,524	glc-4 encodes a predicted glutamate-gated chloride channel that affects ivermectin sensitivity and reversal behavior and genetically interacts with avr-14; expressed in neurons.
40	C01A2.5	C01A2.5	n/a	chrI 13,385,906	contains similarity to Pfam domain PF04641 Protein of unknown function, DUF602 contains similarity to Interpro domain IPR006735 (Protein of unknown function DUF602)
41	sem-5	C14F5.5	n/a	chrX 7,960,532	sem-5 encodes a Src homology (SH) domain 2 and 3-containing protein, orthologous to human GRB2 (OMIM:108355), that functions in multiple signaling pathways during development; these pathways include those regulating sex myoblast migration, muscle membrane extension, vulval induction, fluid balance, viability, and formation of the male tail; SEM-5 acts downstream of the LET-23 epidermal growth factor receptor to negatively regulate RAS-, MAP-, as well as IP-3-, mediated signal transduction.
42	rnp-7	K04G7.10	n/a	chrIII 7,160,025	C. elegans RNP-7 protein; contains similarity to Pfam domain PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) contains similarity to Interpro domains IPR002952 (Eggshell protein), IPR012677 (Nucleotide-binding, alpha-beta plait), IPR000504 (RNA recognition motif, RNP-1)
43	C07E3.6	C07E3.6	n/a	chrII 10,368,675	contains similarity to Pfam domain PF00046 Homeobox domain contains similarity to Interpro domains IPR012287 (Homeodomain-related), IPR001356 (Homeobox), IPR009057 (Homeodomain-like)
44	acr-23	F59B1.9	n/a	chrV 3,655,579	acr-23 encodes an alpha 7-like homomer-forming subunit of the nicotinic acetylcholine receptor (nAChR) superfamily which encode ligand-gated ion channels that regulate fast action of acetylcholine at neuromuscular junctions and in the nervous system; ACR-23 is a member of the DEG-3-like group of nAChR subunits which appears to be unique to nematodes.
45	syd-2	F59F5.6	n/a	chrX 10,552,111	syd-2 encodes alpha-liprin, a member of the liprin family of proteins that interact with LAR (leukocyte common antigen related)-type receptor tyrosine phosphatases (RPTPs) to facilitate clustering of RPTPs to focal adhesions; SYD-2 is required for establishing normal presynaptic density, and is expressed in all neurons and muscles; SYD-2 is required cell autonomously in neurons for differentiation of presynaptic active zones, where SYD-2 is localized.
46	C06E2.2	C06E2.2	n/a	chrX 8,879,967
47	srab-8	C36C5.2	n/a	chrV 3,177,218	C. elegans SRAB-8 protein ;
48	C25A1.4	C25A1.4	n/a	chrI 10,171,209	contains similarity to Pfam domain PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) contains similarity to Interpro domains IPR012677 (Nucleotide-binding, alpha-beta plait), IPR000504 (RNA recognition motif, RNP-1)
49	F58D2.1	F58D2.1	n/a	chrIV 13,184,996	contains similarity to Interpro domains IPR001611 (Leucine-rich repeat), IPR016024 (Armadillo-type fold)
50	col-105	F58F6.2	n/a	chrIV 1,358,519	C. elegans COL-105 protein; contains similarity to Pfam domains PF01484 (Nematode cuticle collagen N-terminal domain) , PF01391 (Collagen triple helix repeat (20 copies)) (2)contains similarity to Interpro domains IPR002486 (Nematode cuticle collagen, N-terminal), IPR003979 (Tropoelastin), IPR000694 (Proline-rich region), IPR008161 (Collagen helix repeat), IPR008160 (Collagen triple helix repeat)