UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	F37C12.2	F37C12.2	1e-164	chrIII 7,182,949	contains similarity to Pfam domain PF07264 Etoposide-induced protein 2.4 (EI24) contains similarity to Interpro domain IPR009890 (Etoposide-induced 2.4)
2	kbp-3	F26H11.1	n/a	chrII 14,389,558	C. elegans KBP-3 protein ; contains similarity to Homo sapiens similar to Kinesin heavy chain isoform 5C; ENSEMBL:ENSP00000334176
3	C49C3.6	C49C3.6	n/a	chrIV 17,331,938	contains similarity to Saccharomyces cerevisiae a homologue of BUL1; SGD:YML111W
4	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
5	mig-32	F11A10.3	n/a	chrIV 12,090,700	C. elegans MIG-32 protein; contains similarity to Pfam domain PF00097 Zinc finger, C3HC4 type (RING finger) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type)
6	ani-2	K10B2.5	n/a	chrII 6,363,196	ani-2 encodes one of three C. elegans anillins; ANI-2 activity is required in the syncytial gonad for proper gonad structure and oocyte formation; specifically, ANI-2 appears to be required for maintaining the structure of the rachis, the syncytial compartment of germline cytoplasm that connects developing ooctyes; in the adult gonad, ANI-2 localizes to the surface of the rachis.
7	K02E7.3	K02E7.3	n/a	chrII 1,077,813	contains similarity to Pfam domain PF06869 Protein of unknown function (DUF1258) contains similarity to Interpro domain IPR009667 (Protein of unknown function DUF1258)
8	pqn-45	F56F3.1	n/a	chrIII 4,473,243	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
9	pch-2	F10B5.5	n/a	chrII 8,159,065	pch-2 encodes a putative AAA+-type ATPase orthologous to budding yeast PCH2 and human TRIP13 (OMIM:604507); PCH-2 is required for the apoptosis of pachytene cells induced by unsynapsed chromosomal pairing centers, but is dispensable for meiotic apoptosis induced by DNA damage; PCH-2-mediated apoptosis is inhibited by SYP-1 and SYP-2, while it requires HIM-8 (and probably HIM-8's paralogs, ZIM-1/-3 and C02F5.12); however, PCH-2-mediated apoptosis does not require SPO-11; pch-2 transcripts are enriched during oogenesis; the excess germline apoptosis of syp-1(me17) mutants is partially suppressed by pch-2(tm1458), and fully suppressed by pch-2(tm1458);spo-11(ok79).
10	fbxa-192	F57G4.8	n/a	chrV 17,645,592	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
11	ZC404.11	ZC404.11	n/a	chrV 6,803,107	contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR000276 (GPCR, rhodopsin-like)
12	F41E6.7	F41E6.7	n/a	chrV 8,598,409
13	ugt-32	F47C10.6	n/a	chrV 3,842,918	C. elegans UGT-32 protein; contains similarity to Pfam domain PF00201 UDP-glucoronosyl and UDP-glucosyl transferase contains similarity to Interpro domain IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase)
14	gei-6	C05C8.4	n/a	chrV 7,228,595	C. elegans GEI-6 protein; contains similarity to Interpro domain IPR000694 (Proline-rich region)
15	ZC168.3	ZC168.3	n/a	chrIV 10,733,704	contains similarity to Homo sapiens Origin recognition complex subunit 5; ENSEMBL:ENSP00000297431
16	F21D5.2	F21D5.2	n/a	chrIV 8,729,166	contains similarity to Pfam domain PF02338 OTU-like cysteine protease contains similarity to Interpro domain IPR003323 (Ovarian tumour, otubain)
17	gna-2	T23G11.2	n/a	chrI 7,700,248	gna-2 encodes a glucosamine 6-phosphate N-acetyltransferase required for synthesis of UDP-N-acetylglucosamine (UDP-GlcNAc), N-acetylgalactosamine (UDP-GalNAc), alpha-GalNAc-modifications of mucin-like proteins, and chitin; GNA-2 is also required for eggshell synthesis and osmotic integrity, progression past meiosis metaphase I, error-free chromosomal segregation during meiosis, polar body extrusion, association of the sperm pronucleus/centrosome complex (SPCC) with the early embryonic cortex, localization of PAR-2 in early embryos, posterior localization of P granules or PIE-1, and pseudocleavage; gna-2 transcription is elevated during oogenesis; gna-2 mRNA is posttranslationally inhibited both by GLD-1 repression and by nonsense-mediated mRNA decay (NMD), with GLD-1 predominating in distal gonads and NMD (incompletely) predominating in proximal ones; gna-2 mRNA has two upstream open reading frames (uORFs) with premature stop codons, which normally cause NMD of this mRNA unless it is protected by GLD-1 binding to the gna-2 mRNA's 5' UTR; conversely, gna-2 mRNA is translationally repressed by bound GLD-1 during pachytene meiosis, and must be freed from this repression during diplotene meiosis for eggshell synthesis to proceed; gna-2(qa705) is suppressed by sup-46 mutations, but only in a gna-1(+) background.
18	clec-255	F11D11.1	n/a	chrV 18,770,210	C. elegans CLEC-255 protein; contains similarity to Interpro domains IPR013278 (Apoptosis regulator, Bcl-2), IPR000694 (Proline-rich region), IPR000480 (Glutelin), IPR003882 (Pistil-specific extensin-like protein)
19	F14H3.4	F14H3.4	n/a	chrV 16,054,667	contains similarity to Interpro domain IPR000215 (Protease inhibitor I4, serpin)
20	C17H12.2	C17H12.2	n/a	chrIV 6,788,223	contains similarity to Drosophila melanogaster Flybase gene name is CG7289-PA;; FLYBASE:CG7289
21	R11G11.14	R11G11.14	n/a	chrV 522,961	contains similarity to Pfam domains PF04083 (ab-hydrolase associated lipase region) , PF00561 (alpha/beta hydrolase fold) contains similarity to Interpro domains IPR006693 (AB-hydrolase associated lipase region), IPR000073 (Alpha/beta hydrolase fold-1), IPR008262 (Lipase, active site)
22	nhr-273	T12C9.1	n/a	chrII 4,436,140	C. elegans NHR-273 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
23	prom-1	F26H9.1	n/a	chrI 9,288,599	prom-1 encodes an F-box protein orthologous to to human FBXO47 (OMIM:609498, deleted in renal cell carcinoma) and paralogous to F54D5.9, that is required during meiotic prophase I for homologous chromosome pairing and rapid meiotic progression; prom-1 mutants exhibit increased germline apoptosis, reduced and variable bivalent formation in meiotic prophase, reduced meiotic recombination, delayed meiotic entry, delayed and asynchronous nuclear reorganization in meiotic prophase, high embryonic lethality (averaging ~90%, but varying from 46-99% even in a null prom-1[ok1140] mutant strain), decreased brood sizes, and an abnormally high frequency of male progeny (22%, probably due to nonsegregating X chromsomes); the apoptotic phenotype of prom-1 is suppressed by spo-11(ok79), and prom-1 mutants show accumulated RAD-51 protein in meiotic nuclei, indicating that prom-1 meiotic defects arises from a failure to resolve meiotic double-stranded DNA breaks.
24	F56D2.2	F56D2.2	n/a	chrIII 5,588,134	contains similarity to Pfam domains PF05773 (RWD domain) , PF01485 (IBR domain) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR006575 (RWD), IPR016135 (Ubiquitin-conjugating enzyme/RWD-like), IPR002867 (Zinc finger, C6HC-type)
25	daf-18	T07A9.6	n/a	chrIV 422,580	daf-18 encodes a lipid phosphatase homologous to the human PTEN tumor suppresor (OMIM:601728, mutated in Cowden disease and several cancers); DAF-18 negatively regulates insulin-like signaling mediated by DAF-2/IR and AGE-1/PI3K and thus plays a role in metabolism, development, and longevity; based on sequence and genetic analysis, DAF-18 is predicted to dephosphorylate AGE-1-generated PIP3 in order to limit activation of the downstream AKT-1 and AKT-2 kinases that negatively regulate DAF-16.
26	T01C3.9	T01C3.9	n/a	chrV 15,005,731	contains similarity to Foot-and-mouth disease virus O Polyprotein.; TR:Q80B22
27	srd-18	F53F1.10	n/a	chrV 13,426,143	C. elegans SRD-18 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domains IPR003002 (7TM chemoreceptor, subfamily 1), IPR000276 (GPCR, rhodopsin-like)
28	F43D2.1	F43D2.1	n/a	chrV 14,613,051	contains similarity to Pfam domain PF00134 Cyclin, N-terminal domain contains similarity to Interpro domains IPR006670 (Cyclin), IPR011028 (Cyclin-like), IPR013763 (Cyclin-related), IPR006671 (Cyclin, N-terminal), IPR015429 (Transcription regulator cyclin)
29	tag-296	F49D11.9	n/a	chrI 10,934,755	C. elegans TAG-296 protein; contains similarity to Pfam domain PF08718 Glycolipid transfer protein (GLTP) contains similarity to Interpro domain IPR014830 (Glycolipid transfer protein, GLTP)
30	C50F4.4	C50F4.4	n/a	chrV 9,537,163	contains similarity to Streptomyces coelicolor Hypothetical protein SCO3733.; TR:Q9L0X1
31	C28A5.2	C28A5.2	n/a	chrIII 4,437,117	contains similarity to Interpro domain IPR001564 (Nucleoside diphosphate kinase)
32	F21F8.2	F21F8.2	n/a	chrV 8,275,167	contains similarity to Pfam domain PF00026 Eukaryotic aspartyl protease contains similarity to Interpro domains IPR009007 (Peptidase aspartic, catalytic), IPR001461 (Peptidase A1)
33	nex-3	C28A5.3	n/a	chrIII 4,443,071	nex-3 encodes an annexin, a member of a family of calcium-dependent phospholipid binding proteins; by homology, NEX-3 could function in a number of processes, such as membrane fusion, cytoskeletal interactions, and intracellular signaling; however, as loss of nex-3 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of NEX-3 in C. elegans development and/or behavior is not yet known.
34	C46A5.5	C46A5.5	n/a	chrIV 7,758,797
35	C07E3.9	C07E3.9	n/a	chrII 10,351,043	contains similarity to Pfam domain PF00068 Phospholipase A2 contains similarity to Interpro domains IPR016090 (Phospholipase A2), IPR001211 (Phospholipase A2, eukaryotic), IPR013090 (Phospholipase A2, active site)
36	hcp-3	F58A4.3	n/a	chrIII 9,615,787	The hcp-3 gene encodes a centromere protein (CENP)-A homolog required for kinetochore function; inactivation of hcp-3 in one-cell embryos by RNAi causes a complete loss of kinetochores, with total failure of chromosomes to segregate properly during mitosis, to recruit components to the kinetochore other than HCP-3, or to assemble a stable mitotic spindle; in addition, HCP-4 fails to localize properly to the kinetochore in hcp-3(RNAi) embryos.
37	T09A5.8	T09A5.8	n/a	chrII 7,856,638	contains similarity to Pfam domain PF00385 'chromo' (CHRromatin Organisation MOdifier) domain contains similarity to Interpro domains IPR000953 (Chromo domain), IPR016197 (Chromo domain-like), IPR001525 (C-5 cytosine-specific DNA methylase)
38	Y102A5C.2	Y102A5C.2	n/a	chrV 16,919,147	contains similarity to Saccharomyces cerevisiae anti-silencing protein that causes depression of silent loci when overexpressed; SGD:YJL115W
39	T04A8.15	T04A8.15	n/a	chrIII 4,713,844	contains similarity to Saccharomyces cerevisiae Ubiquitin-specific protease; SGD:YDL122W
40	C47D12.2	C47D12.2	n/a	chrII 11,677,666	C47D12.2 encodes an ortholog of human FLJ20071/FLJ90130 (dymeclin, OMIM:607461, mutated in Dyggve-Melchior-Clausen dysplasia and Smith-McCort dysplasia), which has no obvious function in mass RNAi assays
41	xbx-5	T24A11.2	n/a	chrIII 3,803,450	C. elegans XBX-5 protein ;
42	Y54G9A.5	Y54G9A.5	n/a	chrII 13,723,894
43	srbc-68	T24A6.13	n/a	chrV 3,546,145	C. elegans SRBC-68 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR002651 (Protein of unknown function DUF32)
44	mxl-2	F40G9.11	n/a	chrIII 187,571	C. elegans MXL-2 protein; contains similarity to Pfam domain PF00010 Helix-loop-helix DNA-binding domain contains similarity to Interpro domains IPR001092 (Basic helix-loop-helix dimerisation region bHLH), IPR011598 (Helix-loop-helix DNA-binding)
45	xpa-1	K07G5.2	n/a	chrI 7,160,236	xpa-1 encodes an ortholog of human XPA, the xeroderma pigmentosum complementation group A protein (OMIM:278700, mutations are associated with sensitivity to ultraviolet light and carcinomata at an early age); by homology, XPA-1 is predicted to function as a DNA-binding protein that is required for nucleotide excision repair of damaged DNA; in C. elegans, loss of xpa-1 activity via mutation or RNA-mediated interference (RNAi) results in increased sensitivity to UV irradiation at all stages of development; xpa-1 mRNA is detected in eggs and mixed stage populations.
46	sago-1	K12B6.1	n/a	chrV 6,306,024	sago-1 encodes an Argonaute homolog that is partially required for the amplification phase of RNAi responses; a multiply mutant strain (MAGO), consisting of ppw-1(tm914), sago-1(tm1195), sago-2(tm894), F58G1.1(tm1019), C06A1.4(tm887), and M03D4.6(tm1144) alleles, is completely resistant to both germline and somatic RNAi; sago-1 is genetically redundant with ppw-1 and sago-2, with any one of these genes being able to transgenically partially restore the deficiency of MAGO worms; GFP-tagged SAGO-1 binds small secondary siRNAs produced by RNAi against GFP; MAGO is not transgenically rescued by rde-1; strains overexpressing GFP::SAGO-1 exhibited an enhanced level of RNAi overall, suggesting that SAGO-1 and its congeners are rate-limiting in vivo for RNAi.
47	VF39H2L.1	VF39H2L.1	n/a	chrI 8,645,323	contains similarity to Pfam domain PF05739 SNARE domain contains similarity to Interpro domains IPR010989 (t-SNARE), IPR000727 (Target SNARE coiled-coil region)
48	F49C5.5	F49C5.5	n/a	chrII 12,546,186
49	K05C4.4	K05C4.4	n/a	chrI 14,736,077	contains similarity to Homo sapiens Hypothetical protein KIAA1185; ENSEMBL:ENSP00000253061
50	his-64	F22B3.1	n/a	chrIV 11,407,277	his-64 encodes an H4 histone.