UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	E01G4.5	E01G4.5	0	chrII 13,473,085	contains similarity to Interpro domains IPR002345 (Lipocalin), IPR000215 (Protease inhibitor I4, serpin)
2	srx-17	F55B12.8	n/a	chrV 13,841,443	C. elegans SRX-17 protein; contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
3	Y75B12B.8	Y75B12B.8	n/a	chrV 15,201,905	contains similarity to Homo sapiens Xylosyltransferase I; ENSEMBL:ENSP00000261381
4	T22H9.1	T22H9.1	n/a	chrV 361,718	contains similarity to Pfam domain PF06102 Domain of unknown function (DUF947) contains similarity to Interpro domain IPR009292 (Protein of unknown function DUF947)
5	srx-59	T07H8.3	n/a	chrV 6,972,490	C. elegans SRX-59 protein; contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
6	B0496.4	B0496.4	n/a	chrIV 7,428,290	contains similarity to Interpro domains IPR011009 (Protein kinase-like), IPR000719 (Protein kinase, core)
7	tbx-32	ZK380.1	n/a	chrX 1,656,225	C. elegans TBX-32 protein; contains similarity to Pfam domain PF00907 T-box contains similarity to Interpro domains IPR008967 (p53-like transcription factor, DNA-binding), IPR001699 (Transcription factor, T-box)
8	C47F8.3	C47F8.3	n/a	chrI 12,315,930	contains similarity to Pfam domain PF01762 Galactosyltransferase contains similarity to Interpro domain IPR002659 (Glycosyl transferase, family 31)
9	R02E12.5	R02E12.5	n/a	chrX 3,997,923
10	gcy-5	ZK970.6	n/a	chrII 10,313,230	gcy-5 encodes a predicted guanylate cyclase with strong similarity to rat atrial natriuretic peptide receptor A; expressed in ASER.
11	C04B4.4	C04B4.4	n/a	chrX 12,291,546	contains similarity to Saccharomyces cerevisiae Nucleolar protein involved in exit from mitosis; SGD:YJL076W
12	C32B5.6	C32B5.6	n/a	chrII 969,468
13	hsd-2	ZC8.1	n/a	chrX 5,006,115	The ZC8.1 gene encodes a homolog of the human gene 3BH1, which when mutated leads to giant cell hepatitis (OMIM:231100).
14	F31A9.4	F31A9.4	n/a	chrX 1,779,978
15	F58H7.1	F58H7.1	n/a	chrIV 933,095	contains similarity to Homo sapiens Isoform 8 of Collagen alpha-2(XI) chain precursor; ENSEMBL:ENSP00000355123
16	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
17	T26G10.1	T26G10.1	n/a	chrIII 9,405,416	contains similarity to Pfam domains PF00270 (DEAD/DEAH box helicase) , PF00271 (Helicase conserved C-terminal domain) contains similarity to Interpro domains IPR011545 (DNA/RNA helicase, DEAD/DEAH box type, N-terminal), IPR000629 (RNA helicase, ATP-dependent, DEAD-box, conserved site), IPR014021 (Helicase, superfamily 1 and 2, ATP-binding), IPR014014 (RNA helicase, DEAD-box type, Q motif), IPR014001 (DEAD-like helicase, N-terminal), IPR001650 (DNA/RNA helicase, C-terminal)
18	srz-14	K05D4.3	n/a	chrV 16,184,163	C. elegans SRZ-14 protein ;
19	T20D4.9	T20D4.9	n/a	chrV 3,404,051	T20D4.9 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; T20D4.9 has no clear orthologs in other organisms.
20	C08G5.1	C08G5.1	n/a	chrII 736,664	contains similarity to Pfam domain PF02206 Domain of unknown function contains similarity to Interpro domain IPR003125 (Protein of unknown function WSN)
21	T05H4.3	T05H4.3	n/a	chrV 6,444,929	contains similarity to Pfam domain PF00560 Leucine Rich Repeat contains similarity to Interpro domains IPR001611 (Leucine-rich repeat), IPR003591 (Leucine-rich repeat, typical subtype), IPR003603 (U2A'/phosphoprotein 32 family A, C-terminal)
22	srw-59	H24D24.1	n/a	chrV 15,950,332	C. elegans SRW-59 protein; contains similarity to Pfam domain PF06976 Protein of unknown function (DUF1300) contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR010726 (Protein of unknown function DUF1300), IPR000276 (GPCR, rhodopsin-like)
23	cyp-14A4	R04D3.1	n/a	chrX 13,283,058	C. elegans CYP-14A4 protein; contains similarity to Pfam domain PF00067 Cytochrome P450 contains similarity to Interpro domains IPR001128 (Cytochrome P450), IPR002401 (Cytochrome P450, E-class, group I), IPR002403 (Cytochrome P450, E-class, group IV), IPR002397 (Cytochrome P450, B-class)
24	F22G12.1	F22G12.1	n/a	chrI 13,140,448	contains similarity to Interpro domain IPR000423 (Flagellar protein FlgJ type-1)
25	atf-6	F45E6.2	n/a	chrX 12,482,840	atf-6 is an ortholog of mammalian ATF6alpha, a proximal sensor required for the unfolded protein response (UPR) in the endoplasmic reticulum (ER); ATF6alpha is a transmembrane protein, with a bZIP transcription factor domain in its cytosolic amino terminus that is released and activated by proteolytic cleavage upon ER stress; either ire-1 or xbp-1 deletions are synthetically lethal with atf-6 or pek-1 deletions, producing arrest in L2 larvae; RNAi of Y56A3A.2 (a S2P protease homolog) is synthetically lethal with ire-1(RNAi), consistent with the hypothesis that Y56A3A.2 cleaves ATF-6; atf-6 regulates few genes that are transcriptionally induced by UPR, but regulates roughly one-quarter of genes that require UPR constitutively; pdr-1 transcripts are strongly upregulated in a atf-6(ok551) mutant background, but atf-6(ok551);pdr-1(lg103) double mutants have a grossly normal phenotype ; atf-6 is dispensable for proper localization of GLR-1 glutamate receptors.
26	C11H1.3	C11H1.3	n/a	chrX 14,309,889	contains similarity to Pfam domain PF00097 Zinc finger, C3HC4 type (RING finger) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type)
27	K02D10.5	K02D10.5	n/a	chrIII 8,777,270	contains similarity to Pfam domain PF05739 SNARE domain contains similarity to Interpro domain IPR000727 (Target SNARE coiled-coil region)
28	ZK488.5	ZK488.5	n/a	chrV 594,476	contains similarity to Pfam domain PF01697 Domain of unknown function contains similarity to Interpro domain IPR008166 (Protein of unknown function DUF23)
29	rbr-2	ZK593.4	n/a	chrIV 10,923,428	rbr-2 encodes a histone H3 lysine 4 (H3K4) demethylase that is required for normally short lifespan and reliable vulval development, that regulates genome-wide levels of H3K4 trimethylation, and that interacts genetically with CLK-2, GLP-1, LIN-15, and SEM-5; RBR-2 is orthologous to budding yeast Jhd2p, Drosophila LID, and human JARID1A (OMIM:180202), JARID1B (OMIM:605393), JARID1C (OMIM:314690, mutated in mental retardation), and JARID1D (OMIM:426000); rbr-2(tm1231) homozygotes display excess trimethylated H3K4 (H3K4me3) and erratic vulval development (either vulvaless or multivulva); rbr-2(RNAi) animals show extended lifespans, a strong synthetic multivulva and H3K4me3 phenotype in a lin-15(n765ts) mutant background at permissive temperature, and abnormally slow growth with clk-2(mn159), glp-1(or178), or sem-5(n2019) mutant backgrounds.
30	C34C6.2	C34C6.2	n/a	chrII 8,681,696	contains similarity to Homo sapiens KIAA1219; ENSEMBL:ENSP00000302059
31	cdh-6	F15B9.7	n/a	chrV 13,026,200	cdh-6 encodes a cadherin homolog, with a domain resembling seven transmembrane-sequence receptors, that may be orthologous to the Drosophila cadherin STAN; both CDH-6 and STAN are homologous to secretin-type receptors, have extracellular domains of similar lengths and domain compositions (with similar numbers of cadherin, EGF, laminin G, GFS, and HormR domains); however, the cytoplasmic domains of CDH-6 and STAN are dissimilar.
32	K08F4.5	K08F4.5	n/a	chrIV 10,135,380	contains similarity to Paramecium tetraurelia Chromosome undetermined scaffold_96, whole genome shotgun sequence.; TR:A0EH68
33	sdc-2	C35C5.1	n/a	chrX 11,528,006	The sdc-2 gene encodes a protein that represses transcription of X chromosomes to achieve dosage compensation, and that also represses the male sex-determination gene her-1 to elicit hermaphrodite differentiation.
34	syd-2	F59F5.6	n/a	chrX 10,552,111	syd-2 encodes alpha-liprin, a member of the liprin family of proteins that interact with LAR (leukocyte common antigen related)-type receptor tyrosine phosphatases (RPTPs) to facilitate clustering of RPTPs to focal adhesions; SYD-2 is required for establishing normal presynaptic density, and is expressed in all neurons and muscles; SYD-2 is required cell autonomously in neurons for differentiation of presynaptic active zones, where SYD-2 is localized.
35	C34D4.14	C34D4.14	n/a	chrIV 7,139,438	contains similarity to Pfam domains PF06701 (Mib_herc2) , PF07738 (Sad1 / UNC-like C-terminal) , PF02985 (HEAT repeat) , PF00023 (Ankyrin repeat) (2), PF00632 (HECT-domain (ubiquitin-transferase)) contains similarity to Interpro domains IPR012919 (Sad1/UNC-like, C-terminal), IPR011989 (Armadillo-like helical), IPR000569 (HECT), IPR008979 (Galactose-binding like), IPR002110 (Ankyrin), IPR010606 (Mib-herc2), IPR016024 (Armadillo-type fold)
36	C10C6.6	C10C6.6	n/a	chrIV 11,476,280	contains similarity to Pfam domains PF00122 (E1-E2 ATPase) , PF00702 (haloacid dehalogenase-like hydrolase) contains similarity to Interpro domains IPR008250 (E1-E2 ATPase-associated region), IPR006069 (ATPase, P-type cation exchange, alpha subunit), IPR006544 (P-type ATPase of unknown pump specificity (type V)), IPR001757 (ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter), IPR005834 (Haloacid dehalogenase-like hydrolase)
37	M04C9.2	M04C9.2	n/a	chrI 9,347,132	contains similarity to Pfam domain PF06162 Caenorhabditis elegans protein of unknown function (DUF976) contains similarity to Interpro domains IPR010381 (Protein of unknown function DUF976, Caenorhabditis species), IPR016125 (Peptidase C15, pyroglutamyl peptidase I-like)
38	gpa-8	F56H9.3	n/a	chrV 12,639,639	gpa-8 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases; expressed in URX, AQR, and PQR sensory cells.
39	srsx-37	M01B2.7	n/a	chrV 15,258,341	C. elegans SRSX-37 protein; contains similarity to Pfam domain PF00001 7 transmembrane receptor (rhodopsin family) contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR000276 (GPCR, rhodopsin-like)
40	R06A10.1	R06A10.1	n/a	chrI 1,087,211	contains similarity to Interpro domain IPR016196 (MFS general substrate transporter)
41	C02E7.10	C02E7.10	n/a	chrV 4,931,908
42	F56C3.5	F56C3.5	n/a	chrX 1,363,402
43	srh-282	T21D12.5	n/a	chrIV 272,850	C. elegans SRH-282 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
44	srg-25	T09D3.5	n/a	chrV 5,343,042	C. elegans SRG-25 protein; contains similarity to Pfam domain PF02118 C.elegans Srg family integral membrane protein contains similarity to Interpro domain IPR000609 (Serpentine gamma receptor, Caenorhabditis species)
45	ZK1067.2	ZK1067.2	n/a	chrII 9,218,954	contains similarity to Pfam domain PF01422 NF-X1 type zinc finger contains similarity to Interpro domains IPR000967 (Zinc finger, NF-X1-type), IPR000694 (Proline-rich region), IPR001555 (Phosphoribosylglycinamide formyltransferase, active site), IPR000169 (Peptidase, cysteine peptidase active site)
46	F57G4.6	F57G4.6	n/a	chrV 17,643,424	contains similarity to Interpro domains IPR013048 (Meiotic recombination Spo11), IPR006578 (MADF)
47	aps-1	F29G9.3	n/a	chrV 6,018,404	aps-1 encodes an adaptin: specifically, it encodes an ortholog of the sigma1 subunit of adaptor protein complex 1 (AP-1).
48	ckb-1	B0285.8	n/a	chrIII 4,366,386	ckb-1 encodes a putative choline kinase; CKB-1 through CKB-4 comprise a related group ('B') of choline kinases.
49	gcy-33	F57F5.2	n/a	chrV 11,998,799	gcy-33 encodes a soluble guanylyl cyclase; a gcy-33::GFP reporter is expressed in the ciliated BAG head sensory neurons.
50	kgb-1	T07A9.3	n/a	chrIV 407,854	kgb-1 encodes a serine/threonine kinase that is a member of the JNK (Jun-N-terminal kinase) subfamily of MAP (mitogen-activated protein)kinases; loss of kgb-1 activity results in temperature-sensitive sterility in hermaphrodites and males; in hermaphrodites, this sterility is associated with disorganized gonads and endomitotic oocytes that have likely failed to undergo oocyte maturation; in kgb-1 mutant males, sperm is present, but is non-functional; KGB-1 interacts in vitro with all four C. elegans germline helicases, GLH-1, -2, -3, and -4, that localize to P granules in vivo; Northern analyses indicate that kgb-1 mRNA is present in both somatic and germline tissues.