UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	lam-2	C54D1.5	0	chrX 7,147,481	lam-2 encodes a laminin gamma subunit; lam-2 activity is required for embryonic development and for regulation of muscle arm extension; loss of lam-2 function via large-scale RNAi screens results in embryonic, larval, and adult lethality, sterility, body morphology defects, and abnormal locomotion.
2	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
3	F44D12.2	F44D12.2	n/a	chrIV 10,015,214	contains similarity to Pfam domain PF01064 Activin types I and II receptor domain contains similarity to Interpro domain IPR000472 (TGF-beta receptor/activin receptor, type I/II)
4	R06A4.8	R06A4.8	n/a	chrII 14,354,036	R06A4.8 is orthologous to the human gene GLYCOGEN DEBRANCHING ENZYME ISOFORM 6 (AGL; OMIM:232400), which when mutated leads to glycogen storage disease, type III.
5	Y45F10A.3	Y45F10A.3	n/a	chrIV 13,511,278	contains similarity to Mus musculus Probable arylformamidase (EC 3.5.1.9) (Kynurenine formamidase) (KF).; SW:Q8K4H1
6	nhr-79	T26H2.9	n/a	chrV 19,209,750	C. elegans NHR-79 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
7	C56G2.3	C56G2.3	n/a	chrIII 6,347,461	contains similarity to Pfam domain PF01746 tRNA (Guanine-1)-methyltransferase contains similarity to Interpro domains IPR016009 (tRNA (guanine-N1-)-methyltransferase), IPR007356 (tRNA (guanine-N1-)-methyltransferase, eukaryotic)
8	W08F4.7	W08F4.7	n/a	chrII 576,333
9	xrn-2	Y48B6A.3	n/a	chrII 14,160,796	C. elegans XRN-2 protein; contains similarity to Pfam domain PF03159 XRN 5'-3' exonuclease N-terminus contains similarity to Interpro domains IPR017151 (5'-3' exoribonuclease 2), IPR004859 (Putative 5-3 exonuclease), IPR002952 (Eggshell protein), IPR001878 (Zinc finger, CCHC-type)
10	rpm-1	C01B7.6	n/a	chrV 8,812,661	rpm-1 encodes an E3 ubiquitin ligase that contains an N-terminal RCC1 (regulator of chromosome condensation)-like guanine nucleotide exchange factor (GEF) domain and that is orthologous to Drosophila highwire and murine Phr1; RPM-1 functions autonomously within several different types of neurons to regulate presynaptic differentiation; in regulating axon termination, RPM-1 acts through the GLO-4 guanine nucleotide exchange factor that positively regulates vesicular trafficking through GLO-1/Rab; in regulating synaptogenesis, RPM-1 functions as part of an SCF-like ubiquitin ligase complex that negatively regulates signaling through the DLK-1 MAP kinase cascade; RPM-1 is expressed in most, if not all, neurons from the comma stage of embryogenesis through adulthood; RPM-1 expression is also seen in the pharynx, coelomocytes, and distal tip cells; in neurons, RPM-1 localizes to presynaptic terminals.
11	W03D8.8	W03D8.8	n/a	chrI 2,793,293	contains similarity to Pfam domains PF08840 (BAAT / Acyl-CoA thioester hydrolase C terminal) , PF04775 (Acyl-CoA thioester hydrolase / Bile acid-CoA amino acid N-acetyltransferase) contains similarity to Interpro domains IPR006862 (Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase), IPR014940 (BAAT/Acyl-CoA thioester hydrolase C-terminal), IPR016662 (Acyl-CoA thioesterase, long chain)
12	T28D9.11	T28D9.11	n/a	chrII 6,491,500
13	F02D10.4	F02D10.4	n/a	chrX 13,458,404	contains similarity to Emericella nidulans Anucleate primary sterigmata protein B.; SW:APSB_EMENI
14	slt-1	F40E10.4	0.000000000005	chrX 14,678,771	slt-1 encodes the sole C. elegans homolog of Drosophila Split, a secreted extracellular protein containing leucine-rich and EGF-like repeats that functions as a ligand for the Robo receptor; during C. elegans larval development, slt-1 acts via the SAX-3/Robo receptor, and in parallel with UNC-6/Netrin, to direct ventral axon guidance and guidance at the midline; during embryonic development, slt-1 also functions to regulate anterior-posterior migrations of the CAN neurons; slt-1::gfp reporters are initially expressed at high levels in the anterior part of the embryo, with more moderate levels seen in dorsal tail muscles and lower levels seen in cells in the center of the body; in L1 larvae, slt-1::gfp is expressed in both dorsal and ventral muscles, with higher levels seen in dorsal muscle cells; slt-1::gfp is also expressed in a number of additional cells including some neurons, pharyngeal cells, and the anal sphincter muscle.
15	clec-151	F10F2.7	n/a	chrIII 4,629,753	C. elegans CLEC-151 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
16	sre-27	Y57A10C.3	n/a	chrII 12,416,469	C. elegans SRE-27 protein; contains similarity to Pfam domain PF03125 C. elegans Sre G protein-coupled chemoreceptor contains similarity to Interpro domain IPR004151 (C. elegans Sre G protein-coupled chemoreceptor)
17	ZK262.8	ZK262.8	n/a	chrV 18,439,253	contains similarity to Pfam domains PF07735 (F-box associated) , PF00646 (F-box domain) contains similarity to Interpro domains IPR001810 (Cyclin-like F-box), IPR012885 (F-box associated type 2)
18	F52G3.1	F52G3.1	n/a	chrX 16,968,223	contains similarity to Pfam domain PF07001 BAT2 N-terminus contains similarity to Interpro domains IPR009738 (BAT2, N-terminal), IPR000694 (Proline-rich region)
19	C06H5.6	C06H5.6	n/a	chrV 17,884,381	contains similarity to Pfam domains PF00083 (Sugar (and other) transporter) , PF07690 (Major Facilitator Superfamily) contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR005828 (General substrate transporter), IPR016196 (MFS general substrate transporter)
20	T10F2.4	T10F2.4	n/a	chrIII 5,171,158	contains similarity to Pfam domains PF08606 (Prp19/Pso4-like) , PF00400 (WD domain, G-beta repeat) (6)contains similarity to Interpro domains IPR003613 (U box), IPR011046 (WD40 repeat-like), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR009053 (Prefoldin), IPR001680 (WD40 repeat), IPR013915 (Pre-mRNA-splicing factor 19), IPR011042 (Six-bladed beta-propeller, TolB-like), IPR015943 (WD40/YVTN repeat-like)
21	cyp-37A1	F01D5.9	n/a	chrII 14,015,298	C. elegans CYP-37A1 protein; contains similarity to Pfam domain PF00067 Cytochrome P450 contains similarity to Interpro domains IPR001128 (Cytochrome P450), IPR002401 (Cytochrome P450, E-class, group I), IPR002402 (Cytochrome P450, E-class, group II), IPR002403 (Cytochrome P450, E-class, group IV)
22	xrn-1	Y39G8C.1	n/a	chrII 14,076,171	xrn-1 encodes a 5'-3' exoribonuclease that is orthologous to Saccharomyces cerevisiae Xrnp1, a key component of the yeast 5'-3' mRNA degradation pathway; in C. elegans, XRN-1 activity is required during embryogenesis for completion of ventral enclosure, the morphogenetic process whereby the ventral epithelial cells cover and seal the interior cells of the embryo; in addition, XRN-1 also plays a role in facilitating RNA interference (RNAi), likely acting in the same pathway as the DCR-1/Dicer ribonuclease; to date, XRN-1 expression has been reported in adult hypodermal and rectal cells.
23	T24B8.4	T24B8.4	n/a	chrII 9,067,183	contains similarity to Pfam domain PF02205 WH2 motif contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR003124 (Actin-binding WH2)
24	R13A5.10	R13A5.10	n/a	chrIII 7,582,468	contains similarity to Pfam domain PF00383 Cytidine and deoxycytidylate deaminase zinc-binding region contains similarity to Interpro domains IPR002125 (CMP/dCMP deaminase, zinc-binding), IPR016193 (Cytidine deaminase-like)
25	ceh-31	C33D12.1	n/a	chrX 3,069,626	ceh-31 encodes a protein containing a homeobox domain.
26	R08C7.5	R08C7.5	n/a	chrIV 4,431,281	contains similarity to Pfam domain PF03941 Inner centromere protein, ARK binding region contains similarity to Interpro domains IPR005819 (Histone H5), IPR005635 (Inner centromere protein, ARK binding region)
27	F21F8.6	F21F8.6	n/a	chrV 8,266,564
28	F39E9.1	F39E9.1	n/a	chrII 3,318,116	contains similarity to Pfam domain PF03409 Protein of unknown function (DUF274) contains similarity to Interpro domain IPR005071 (Protein of unknown function DUF274)
29	T19C3.5	T19C3.5	n/a	chrIII 626,220	contains similarity to Pfam domains PF02886 (LBP / BPI / CETP family, C-terminal domain) , PF01273 (LBP / BPI / CETP family, N-terminal domain) contains similarity to Interpro domain IPR001124 (Lipid-binding serum glycoprotein)
30	F53G12.4	F53G12.4	n/a	chrI 135,809
31	fbxb-107	F29A7.2	n/a	chrII 2,760,240	C. elegans FBXB-107 protein; contains similarity to Pfam domain PF07735 F-box associated contains similarity to Interpro domain IPR012885 (F-box associated type 2)
32	lgc-21	C33G3.3	n/a	chrX 14,065,977	C. elegans LGC-21 protein; contains similarity to Pfam domain PF02931 Neurotransmitter-gated ion-channel ligand binding domain contains similarity to Interpro domains IPR006201 (Neurotransmitter-gated ion-channel), IPR006202 (Neurotransmitter-gated ion-channel ligand-binding)
33	dyb-1	F47G6.1	n/a	chrI 1,486,779	The dyb-1 gene encodes a homolog of mammalian alpha-dystrobrevin (DTNA; OMIM:601239), mutation of which can lead to left ventricular noncompaction with congenital heart defects.
34	C35D10.12	C35D10.12	n/a	chrIII 4,873,622	contains similarity to Pfam domains PF08242 (Methyltransferase domain) , PF08241 (Methyltransferase domain) contains similarity to Interpro domains IPR011644 (Haem NO binding), IPR013217 (Methyltransferase type 12), IPR013216 (Methyltransferase type 11)
35	F58H7.2	F58H7.2	n/a	chrIV 942,839	contains similarity to Pfam domain PF01425 Amidase contains similarity to Interpro domains IPR000120 (Amidase signature enzyme), IPR015830 (Amidase, fungi type)
36	T12E12.6	T12E12.6	n/a	chrIV 5,570,564	contains similarity to Pfam domain PF01433 Peptidase family M1 contains similarity to Interpro domains IPR014782 (Peptidase M1, membrane alanine aminopeptidase, N-terminal), IPR006025 (Peptidase M, neutral zinc metallopeptidases, zinc-binding site), IPR001930 (Peptidase M1, membrane alanine aminopeptidase)
37	str-30	T27C4.3	n/a	chrV 3,725,910	C. elegans STR-30 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
38	F39B1.1	F39B1.1	n/a	chrX 15,240,527	contains similarity to Pfam domains PF00454 (Phosphatidylinositol 3- and 4-kinase) , PF00168 (C2 domain) , PF00787 (PX domain) , PF02809 (Ubiquitin interaction motif) , PF00613 (Phosphoinositide 3-kinase family, accessory domain (PIK domain)) , PF00792 (Phosphoinositide 3-kinase C2) contains similarity to Interpro domains IPR001263 (Phosphoinositide 3-kinase accessory region PIK), IPR002420 (Phosphoinositide 3-kinase, C2), IPR001683 (Phox-like), IPR011009 (Protein kinase-like), IPR000694 (Proline-rich region), IPR003903 (Ubiquitin interacting motif), IPR000403 (Phosphatidylinositol 3- and 4-kinase, catalytic), IPR008973 (C2 calcium/lipid-binding region, CaLB), IPR015433 (Phosphatidylinositol Kinase), IPR016024 (Armadillo-type fold), IPR000341 (Phosphoinositide 3-kinase, ras-binding), IPR000008 (C2 calcium-dependent membrane targeting)
39	tag-278	C02F12.7	n/a	chrX 3,686,384	C. elegans TAG-278 protein; contains similarity to Interpro domain IPR000533 (Tropomyosin)
40	F22E12.1	F22E12.1	n/a	chrV 10,455,572	contains similarity to Pfam domain PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain contains similarity to Interpro domains IPR002223 (Proteinase inhibitor I2, Kunitz metazoa), IPR000694 (Proline-rich region)
41	Y56A3A.6	Y56A3A.6	n/a	chrIII 11,874,979	contains similarity to Interpro domains IPR003072 (Orphan nuclear receptor, NOR1 type), IPR000694 (Proline-rich region), IPR002951 (Atrophin)
42	haf-8	Y57G11C.1	n/a	chrIV 14,696,948	The haf-8 gene encodes a homolog of human CHM, which when mutated leads to choroideraemia (OMIM:303100).
43	mep-1	M04B2.1	n/a	chrIV 11,526,270	mep-1 is required for repression by the fem-3 3' UTR in vivo, and for maintenance of somatic (versus germline) differentiation; MEP-1 protein has zinc-finger domains and a glutamine/asparagine-rich domain.
44	VT23B5.2	VT23B5.2	n/a	chrIV 12,671,338	VT23B5.2 encodes a BEACH-WD40 domain-containing protein that is orthologous to human WDFY3 (WD repeat and FYVE domain containing 3); loss of VT23B5.2 activity via mutation or large-scale RNAi screens in a wild-type background results in no obvious abnormalities.
45	F09E10.5	F09E10.5	n/a	chrX 1,492,033
46	hum-7	F56A6.2	n/a	chrI 596,704	hum-7 encodes a class IX unconventional myosin heavy chain that contains a myosin motor domain in the head region and zinc-finger and rhoGAP (rho GTPase activating protein) domains in the tail region; HUM-7 is required during embryogenesis for cytokinesis and normal cytoplasmic rearrangements, and by homology, may function in organization of the actin cytoskeleton; the precise expression and localization patterns of HUM-7 are not yet known.
47	tag-192	T04D1.4	n/a	chrI 4,692,225	C. elegans TAG-192 protein; contains similarity to Pfam domains PF00271 (Helicase conserved C-terminal domain) , PF07533 (Associated with TFs and helicases) , PF00385 ('chromo' (CHRromatin Organisation MOdifier) domain) , PF00176 (SNF2 family N-terminal domain) contains similarity to Interpro domains IPR000953 (Chromo domain), IPR000330 (SNF2-related), IPR000104 (Antifreeze protein, type I), IPR001005 (SANT, DNA-binding), IPR000694 (Proline-rich region), IPR016197 (Chromo domain-like), IPR014021 (Helicase, superfamily 1 and 2, ATP-binding), IPR006576 (BRK), IPR009057 (Homeodomain-like), IPR014001 (DEAD-like helicase, N-terminal), IPR001650 (DNA/RNA helicase, C-terminal)
48	Y45G12B.3	Y45G12B.3	n/a	chrV 2,691,488	contains similarity to Pfam domain PF01266 FAD dependent oxidoreductase contains similarity to Interpro domains IPR006076 (FAD dependent oxidoreductase), IPR000447 (FAD-dependent glycerol-3-phosphate dehydrogenase), IPR016040 (NAD(P)-binding)
49	C01H6.2	C01H6.2	n/a	chrI 7,206,143	contains similarity to Pfam domain PF00023 Ankyrin repeat contains similarity to Interpro domain IPR002110 (Ankyrin)
50	nxf-1	C15H11.3	n/a	chrV 14,414,076	nxf-1 encodes a homolog of human TAP protein, a member of the NXF family of shuttling transport receptors for nuclear export of mRNA; binds RNA directly and its function has been shown to be conserved with the NXF family.