UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	lec-4	C44F1.3	3e-168	chrIII 3,772,356	lec-4 encodes a predicted galectin that exhibits sugar binding properties in vitro.
2	F57G4.5	F57G4.5	n/a	chrV 17,642,359	contains similarity to Mus musculus Dentin sialophosphoprotein precursor (Dentin matrix protein-3) (DMP-s3) [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP);sDentin sialoprotein (DSP)].; SW:DSPP_MOUSE
3	ttr-46	T07C12.7	n/a	chrV 9,951,666	C. elegans TTR-46 protein; contains similarity to Pfam domain PF01060 Transthyretin-like family contains similarity to Interpro domain IPR001534 (Transthyretin-like)
4	F22B3.8	F22B3.8	n/a	chrIV 11,423,572	contains similarity to Pfam domains PF07714 (Protein tyrosine kinase) , PF00069 (Protein kinase domain) contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related), IPR000980 (SH2 motif), IPR008266 (Tyrosine protein kinase, active site)
5	F42G2.2	F42G2.2	n/a	chrII 2,423,776	contains similarity to Pfam domain PF01827 FTH domain contains similarity to Interpro domain IPR002900 (Protein of unknown function DUF38, Caenorhabditis species)
6	ubc-23	C28G1.1	n/a	chrX 8,846,276	ubc-23 encodes a predicted conjugating enzyme (UBCs/E2s) of the ubiquitin-conjugation system; expressed in larvae and adults in cells around the pharynx and in intestinal cells.
7	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
8	W07B8.3	W07B8.3	n/a	chrV 1,125,705
9	C50F7.3	C50F7.3	n/a	chrIV 7,733,257	contains similarity to Interpro domain IPR001478 (PDZ/DHR/GLGF)
10	pat-10	F54C1.7	n/a	chrI 5,019,533	pat-10 encodes body wall muscle troponin C, the calcium-binding component of the troponin complex of actin thin filaments; PAT-10 is essential for muscle contraction and thus for completion of embryonic morphogenesis and elongation; by homology, PAT-10 likely functions to regulate body wall muscle contraction in response to changes in intracellular calcium; PAT-10 is expressed in body wall muscle but is also detected in vulval and anal muscles; expression in body wall muscle begins during early embryonic morphogenesis, concurrent with expression of other body wall muscle structural components.
11	C01H6.6	C01H6.6	n/a	chrI 7,223,298	C01H6.6 encodes a predicted transmembrane protein orthologous to human ACDP1-ACDP4 and S. cerevisiae MAM3, and paralogous to C33D12.2, C52D10.12, M02F4.3, R04E5.2, and R13G10.4; by orthology with MAM3, C01H6.6 may participate in metal homoeostasis; C01H6.6, MAM3, and ACDP1-ACDP4 belong to a family of proteins (sharing an ACD domain) from bacteria, yeast, plants, and metazoa; murine Acdp1 is a plasma membrane protein; bacterial proteins containing the ACD domain include CorC from Salmonella typhimurium, which is involved in magnesium and cobalt efflux; C01H6.6 has no obvious function in RNAi assays.
12	ncr-1	F02E8.6	n/a	chrX 4,476,155	ncr-1 encodes a large transmembrane glycoprotein with a patched-like domain that is orthologous to human NPC1 (OMIM:257220, mutated in Niemann-Pick type C disease); NCR-1 and NPC1 are eukaryotic members of the resistance-nodulation-division (RND) family of membrane permeases, and have a putative sterol-sensing domain; by homology, NCR-1 is predicted to function in intracellular cholesterol and glycolipid trafficking; in C. elegans, NCR-1 is required for growth and survival in the absence of cholesterol, newly hatched ncr-1 mutant larvae grow poorly on cholesterol-free medium and die at the L1 or L2 stage; NCR-1 is also involved in negative regulation of dauer formation, being required redundantly with NCR-2, a second C. elegans NPC1-like protein, for preventing constitutive dauer formation; dauer formation in ncr-1; ncr-2 double mutants is suppressed by mutations in daf-12, which encodes a steroid hormone receptor, and by overexpression of daf-9, which encodes a cytochrome P450, suggesting that NCR-1 and NCR-2 may function to transport a sterol precursor that is metabolized by DAF-9 to then serve as the DAF-12 ligand.
13	F33C8.4	F33C8.4	n/a	chrX 14,733,294	contains similarity to Interpro domain IPR006209 (EGF-like domain)
14	ZC416.4	ZC416.4	n/a	chrIV 3,607,952	n/a
15	C30F12.7	C30F12.7	n/a	chrI 6,975,813	contains similarity to Pfam domain PF00180 Isocitrate/isopropylmalate dehydrogenase contains similarity to Interpro domains IPR004434 (Isocitrate dehydrogenase NAD-dependent, mitochondrial), IPR001804 (Isocitrate/isopropylmalate dehydrogenase)
16	F47D12.3	F47D12.3	n/a	chrIII 6,298,853	contains similarity to Pfam domain PF02214 K+ channel tetramerisation domain contains similarity to Interpro domains IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR003131 (Potassium channel, voltage dependent, Kv, tetramerisation)
17	srz-1	F14F8.3	n/a	chrV 16,676,674	srz-1 encodes a predicted seven-pass G protein-coupled receptor; as loss of srz-1 activity via large-scale RNAi screens results in no obvious abnormalities, the precise role of SRZ-1 in C. elegans development and/or behavior is not yet known.
18	hmit-1.2	Y51A2D.5	n/a	chrV 18,526,923	hmit-1.2 encodes one of three C. elegans proton (H+)-dependent myo-inositol transporters; loss of hmit-1.2 activity via large-scale RNAi result in no obvious abnormalities but by homology, HMIT-1.2 is predicted to function as a plasma membrane protein required for the regulated uptake of myo-inositol and thus potentially for regulation of cell signaling and intracellular osmolarity.
19	T20D4.12	T20D4.12	n/a	chrV 3,397,421	contains similarity to Pfam domain PF01579 Domain of unknown function DUF19 contains similarity to Interpro domains IPR016638 (Uncharacterised conserved protein UPF0376), IPR002542 (Protein of unknown function DUF19)
20	R02D5.3	R02D5.3	n/a	chrV 14,483,717	contains similarity to Arabidopsis thaliana Putative RNA-binding protein.; TR:Q9SHZ5
21	sulp-4	K12G11.1	n/a	chrV 11,877,220	sulp-4 encodes one of eight C. elegans members of the sulfate permease family of anion transporters; by homology, SULP-4 is predicted to function as an anion transporter that regulates cellular pH and volume via transmembrane movement of electrolytes and fluids and when expressed in Xenopus oocytes, SULP-4 exhibits robust transport of sulfate and more modest transport of chloride ions and oxalate; a SULP-4::GFP fusion is expressed in the apical canaliculae of the excretory cell and also in some head neurons.
22	C34G6.1	C34G6.1	n/a	chrI 5,912,249	contains similarity to Pfam domain PF02985 HEAT repeat contains similarity to Interpro domains IPR011989 (Armadillo-like helical), IPR000357 (HEAT), IPR016024 (Armadillo-type fold)
23	F38A1.9	F38A1.9	n/a	chrIV 1,244,866
24	srh-115	Y61B8A.2	n/a	chrV 17,256,442	C. elegans SRH-115 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
25	F37C4.2	F37C4.2	n/a	chrIV 3,887,244	contains similarity to Pfam domain PF01757 Acyltransferase family contains similarity to Interpro domain IPR002656 (Acyltransferase 3)
26	C14B1.3	C14B1.3	n/a	chrIII 3,704,316	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
27	egl-23	Y37A1B.11	n/a	chrIV 14,007,827	egl-23 encodes one of 44 C. elegans TWK (two-P domain K+) potassium channel subunits that contain two pore-forming domains and four transmembrane domains; egl-23 was originally defined by gain-of-function mutations that result in defects in locomotion, egg-laying, and enteric muscle activation; loss of egl-23 function via reversion or RNA-mediated interference (RNAi) does not result in any abnormalities suggesting that EGL-23 may function redundantly with other TWK channels; egl-23 does not, however, interact genetically with the UNC-93 group of TWKs encoded by unc-93, sup-9, and sup-10; the EGL-23 expression pattern is not yet known.
28	acr-21	F27B3.2	n/a	chrIII 6,584,504	acr-21 encodes an alpha subunit of nicotinic acetylcholine receptor (nAChR); ACR-21 is a highly divergent member of the 'ACR-16' class of nAChR subunits, which includes ACR-7, ACR-9, ACR-10, ACR-11, ACR-14, ACR-15, ACR-16, and ACR-19, and is most closely related to the alpha-7 subunits of vertebrate nAChRs.
29	C04E12.6	C04E12.6	n/a	chrV 3,355,089	contains similarity to Pfam domain PF06162 Caenorhabditis elegans protein of unknown function (DUF976) contains similarity to Interpro domains IPR010381 (Protein of unknown function DUF976, Caenorhabditis species), IPR016125 (Peptidase C15, pyroglutamyl peptidase I-like)
30	lips-13	T13B5.7	n/a	chrII 1,116,848	C. elegans LIPS-13 protein; contains similarity to Pfam domain PF01674 Lipase (class 2) contains similarity to Interpro domain IPR002918 (Lipase, class 2)
31	K04F1.8	K04F1.8	n/a	chrV 1,667,509
32	F59A6.3	F59A6.3	n/a	chrII 5,009,745	contains similarity to Interpro domains IPR000436 (Sushi/SCR/CCP), IPR016060 (Complement control module)
33	cpb-1	C40H1.1	n/a	chrIII 9,323,513	cpb-1 encodes a cytoplasmic polyadenylation element binding (CPEB) protein homolog involved in two steps of spermatogenesis; two CPEB proteins have distinct functions in spermatogenesis, with FOG-1 specifying sperm cell fate, and CPB-1 conversely executing that decision, being required for progression through meiosis; cpb-1(RNAi) spermatocytes fail to undergo meiotic cell divisions; CPB-1 protein is present in the germ line just prior to overt spermatogenesis, but once sperm differentiation begins, CPB-1 disappears; CPB-1 physically interacts with EBF, which, like CPEB, regulates genes by binding the 3' UTRs of mRNAs; while CPB-1 is required for spermatogenesis, it is dispensable for oogenesis; this is in contrast to CPEBs in vertebrates (Xenopus), arthropods (Drosophila), and molluscs (Spisula), which all participate in oogenesis.
34	grd-8	C37C3.4	n/a	chrV 7,843,402	grd-8 encodes a hedgehog-like protein, with an N-terminal signal sequence, a central low-complexity proline-rich domain, and a C-terminal Ground domain; GRD-8 is expressed in larval intestine and neurons; the grd-8 gene is directly bound by DAF-12 and requires DAF-12 for full transcription; GRD-8's Ground domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins; GRD-8 is weakly required for normal molting; GRD-8 is also required for normal adult alae formation, growth to full size, locomotion, and male tail development; all of these requirements may reflect common defects in cholesterol-dependent hedgehog-like signalling or in vesicle trafficking.
35	dhs-30	T25G12.7	n/a	chrX 17,233,193	dhs-30 encodes a member of the short-chain dehydrogenases/reductases family (SDR) homologous to HSD, which when mutated leads to cortisol 11-beta ketoreductase deficiency (OMIM:218030).
36	C36C5.14	C36C5.14	n/a	chrV 3,165,115	contains similarity to Pfam domain PF01579 Domain of unknown function DUF19 contains similarity to Interpro domains IPR016638 (Uncharacterised conserved protein UPF0376), IPR002542 (Protein of unknown function DUF19)
37	D1007.3	D1007.3	n/a	chrI 4,576,495
38	C24A11.6	C24A11.6	n/a	chrI 5,396,389
39	C05C12.4	C05C12.4	n/a	chrIV 11,247,231	contains similarity to Interpro domains IPR002049 (EGF-like, laminin), IPR013032 (EGF-like region, conserved site)
40	F42C5.4	F42C5.4	n/a	chrIV 7,290,079	contains similarity to Interpro domain IPR001841 (Zinc finger, RING-type)
41	C33H5.16	C33H5.16	n/a	chrIV 7,802,511	contains similarity to Pfam domain PF00102 Protein-tyrosine phosphatase contains similarity to Interpro domains IPR003595 (Protein-tyrosine phosphatase, catalytic), IPR016130 (Protein-tyrosine phosphatase, active site), IPR000242 (Protein-tyrosine phosphatase, receptor/non-receptor type), IPR000387 (Protein-tyrosine phosphatase)
42	F38E1.3	F38E1.3	n/a	chrV 8,376,994	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)
43	C06G4.4	C06G4.4	n/a	chrIII 7,977,442
44	Y11D7A.1	Y11D7A.1	n/a	chrIV 9,229,724	contains similarity to Interpro domains IPR003702 (Acetyl-CoA hydrolase/transferase), IPR001220 (Legume lectin, beta domain)
45	col-64	F52F12.2	n/a	chrI 9,894,637	C. elegans COL-64 protein; contains similarity to Pfam domains PF01484 (Nematode cuticle collagen N-terminal domain) , PF01391 (Collagen triple helix repeat (20 copies)) (2)contains similarity to Interpro domains IPR002486 (Nematode cuticle collagen, N-terminal), IPR008161 (Collagen helix repeat), IPR008160 (Collagen triple helix repeat)
46	cyp-33C9	C50H11.15	n/a	chrV 3,093,157	C. elegans CYP-33C9 protein; contains similarity to Pfam domain PF00067 Cytochrome P450 contains similarity to Interpro domains IPR001128 (Cytochrome P450), IPR002401 (Cytochrome P450, E-class, group I), IPR002403 (Cytochrome P450, E-class, group IV), IPR002397 (Cytochrome P450, B-class)
47	str-96	T10H4.2	n/a	chrV 15,293,203	C. elegans STR-96 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
48	twk-1	F21C3.1	n/a	chrI 7,270,700	C. elegans TWK-1 protein; contains similarity to Pfam domain PF07885 Ion channel contains similarity to Interpro domains IPR003280 (Potassium channel, two pore-domain), IPR013099 (Ion transport 2)
49	C48E7.6	C48E7.6	n/a	chrI 6,244,688	contains similarity to Drosophila pseudoobscura GA10211-PA (Fragment).; TR:Q29MP8
50	lite-1	C14F11.3	n/a	chrX 6,228,375	C. elegans LITE-1 protein; contains similarity to Pfam domain PF08395 7tm Chemosensory receptor contains similarity to Interpro domains IPR009318 (Trehalose receptor), IPR013604 (7TM chemoreceptor)