UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	ceh-37	C37E2.5	6e-134	chrX 14,203,216	ceh-37 encodes one of three C. elegans proteins with an OTX-like homeodomain; however, CEH-37 lacks other domains found in OTX proteins, and the CEH-37 homeodomain is predicted to resemble the Myb domain of telomere-binding proteins; CEH-37 binds the telomeric sequence 'TTAGGC' if it is repeated at least 1.5 times, and is mainly localized to the telomere in vivo; ceh-37 mutants have a weak increase in chromosomal nondisjunction; CEH-37 is involved in specifying some aspects of the AWB olfactory neuron fate, such as expression of an AWB-specific odorant receptor and a LIM-class homeodomain protein, LIM-4; CEH-37 is expressed broadly in the early embryo, while in larvae and adults it is expressed solely in the excretory cell.
2	srx-97	F19B10.7	n/a	chrII 3,667,915	C. elegans SRX-97 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
3	C29H12.6	C29H12.6	n/a	chrII 6,116,301
4	glc-4	C27H5.8	n/a	chrII 7,173,524	glc-4 encodes a predicted glutamate-gated chloride channel that affects ivermectin sensitivity and reversal behavior and genetically interacts with avr-14; expressed in neurons.
5	T14G12.6	T14G12.6	n/a	chrX 3,758,129	contains similarity to Pfam domain PF02343 Domain of unknown function DUF130 contains similarity to Interpro domain IPR003326 (Protein of unknown function DUF130)
6	bbs-2	F20D12.3	n/a	chrIV 7,935,876	bbs-2 is orthologous to human BBS2 (OMIM:606151, mutated in Bardet-Biedl syndrome 2); while the function of BBS-2 is unknown, it shares conserved domains with its human paralogs BBS1 and BBS7, which also are mutated in other Bardet-Biedl syndromes.
7	F49E8.6	F49E8.6	n/a	chrIV 7,553,994	contains similarity to Interpro domain IPR000694 (Proline-rich region)
8	btb-12	ZC204.3	n/a	chrII 1,655,685	C. elegans BTB-12 protein; contains similarity to Pfam domain PF00651 BTB/POZ domain contains similarity to Interpro domains IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
9	F59B10.3	F59B10.3	n/a	chrII 10,511,687	contains similarity to Interpro domain IPR016196 (MFS general substrate transporter)
10	ZC190.6	ZC190.6	n/a	chrV 8,675,924
11	srw-117	C44C3.6	n/a	chrV 2,982,800	C. elegans SRW-117 protein; contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
12	fbxb-100	Y63D3A.2	n/a	chrI 14,093,529	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
13	irx-1	C36F7.1	n/a	chrI 9,538,707	irx-1 encodes a homeodomain-containing protein that is most similar to members of the Iroquois subclass of TALE (three amino acid loop extension) superclass atypical homeodomain proteins; IRX-1 is predicted to function as a transcriptional regulator during development, but as loss of irx-1 activity via RNAi results in no obvious defects, the precise role of irx-1 in C. elegans development and/or behavior is not yet known.
14	Y37H2C.4	Y37H2C.4	n/a	chrV 18,271,444	contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
15	K04G11.4	K04G11.4	n/a	chrX 14,351,065	contains similarity to Pfam domain PF00400 WD domain, G-beta repeat contains similarity to Interpro domains IPR011046 (WD40 repeat-like), IPR000694 (Proline-rich region), IPR001680 (WD40 repeat), IPR011042 (Six-bladed beta-propeller, TolB-like), IPR001632 (G-protein, beta subunit), IPR015943 (WD40/YVTN repeat-like)
16	T21B4.3	T21B4.3	n/a	chrII 12,495,897	contains similarity to Pfam domain PF01681 C6 domain contains similarity to Interpro domain IPR002601 (Protein of unknown function C6)
17	ZC518.4	ZC518.4	n/a	chrIV 12,367,373	contains similarity to Neurospora crassa Hypothetical protein B8B8.120.; TR:Q872S5
18	F43C1.5	F43C1.5	n/a	chrIII 4,229,767	contains similarity to Pfam domain PF02845 CUE domain contains similarity to Interpro domains IPR003892 (Ubiquitin system component Cue), IPR009060 (UBA-like)
19	str-144	C09H5.5	n/a	chrV 8,071,381	C. elegans STR-144 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
20	T05B4.10	T05B4.10	n/a	chrV 4,120,294	contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domain IPR003582 (Metridin-like ShK toxin)
21	sem-5	C14F5.5	n/a	chrX 7,960,532	sem-5 encodes a Src homology (SH) domain 2 and 3-containing protein, orthologous to human GRB2 (OMIM:108355), that functions in multiple signaling pathways during development; these pathways include those regulating sex myoblast migration, muscle membrane extension, vulval induction, fluid balance, viability, and formation of the male tail; SEM-5 acts downstream of the LET-23 epidermal growth factor receptor to negatively regulate RAS-, MAP-, as well as IP-3-, mediated signal transduction.
22	Y116A8B.5	Y116A8B.5	n/a	chrIV 17,228,490	contains similarity to Pfam domain PF00001 7 transmembrane receptor (rhodopsin family) contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR000276 (GPCR, rhodopsin-like)
23	W08F4.11	W08F4.11	n/a	chrII 593,637
24	H01G02.2	H01G02.2	n/a	chrIV 11,799,864	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR008351 (JNK MAP kinase), IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)
25	chw-1	F22E12.2	n/a	chrV 10,463,355	C. elegans CHW-1 protein; contains similarity to Pfam domains PF00071 (Ras family) , PF08477 (Miro-like protein) contains similarity to Interpro domains IPR002041 (Ran GTPase), IPR003577 (Ras small GTPase, Ras type), IPR013684 (Miro-like), IPR003578 (Ras small GTPase, Rho type), IPR005225 (Small GTP-binding protein), IPR001806 (Ras GTPase), IPR003579 (Ras small GTPase, Rab type), IPR013753 (Ras)
26	F11D11.3	F11D11.3	n/a	chrV 18,759,090	contains similarity to Pfam domain PF03409 Protein of unknown function (DUF274) contains similarity to Interpro domain IPR005071 (Protein of unknown function DUF274)
27	C43H6.4	C43H6.4	n/a	chrX 2,405,689
28	F19C7.4	F19C7.4	n/a	chrIV 4,604,373	contains similarity to Pfam domain PF05577 Serine carboxypeptidase S28 contains similarity to Interpro domain IPR008758 (Peptidase S28)
29	fbxa-137	T27B7.7	n/a	chrV 2,280,414	C. elegans FBXA-137 protein; contains similarity to Pfam domain PF01827 FTH domain contains similarity to Interpro domain IPR002900 (Protein of unknown function DUF38, Caenorhabditis species)
30	C17E4.11	C17E4.11	n/a	chrI 9,420,385	contains similarity to Pfam domain PF08241 Methyltransferase domain contains similarity to Interpro domain IPR013216 (Methyltransferase type 11)
31	rgs-6	C41G11.3	n/a	chrX 5,724,513	rgs-6 encodes a regulator of G protein signaling; by homology, RGS-6 is predicted to function as a GTPase-activating protein that binds G protein alpha subunits and negatively regulates heterotrimeric G protein signaling; loss of rgs-6 activity via RNAi or a deletion mutation results in no obvious defects, and likewise, rgs-6 overexpression has no measurable effect on egg-laying behavior, locomotion, or viability; the rgs-6 expression pattern has not yet been reported.
32	Y57G11A.4	Y57G11A.4	n/a	chrIV 14,484,352	contains similarity to Interpro domain IPR005018 (DOMON related)
33	C33B4.2	C33B4.2	n/a	chrII 11,371,111	contains similarity to Aristolochia gigantea RPB140 (EC 2.7.7.6) (DNA-directed RNA polymerase beta chain)s(Fragment).; TR:O48912
34	tsp-17	C02F12.1	n/a	chrX 3,682,658	C. elegans TSP-17 protein; contains similarity to Pfam domain PF00335 Tetraspanin family contains similarity to Interpro domains IPR000301 (CD9/CD37/CD63 antigen), IPR008952 (Tetraspanin)
35	mec-6	W02D3.3	n/a	chrI 6,726,624	mec-6 is homologous to the human PARAOXONASE 1 gene (PON1, OMIM:168820), which in some allelic forms is associated with susceptibility to coronary artery disease; MEC-6 protein interacts physically with the MEC-4 degenerin ion channel, is colocalized with it in vivo, and is required for MEC-4 punctate expression along touch-receptor neural processes.
36	F53A2.1	F53A2.1	n/a	chrIII 13,321,932	contains similarity to Pfam domain PF06542 Protein of unknown function (DUF1114) contains similarity to Interpro domains IPR001810 (Cyclin-like F-box), IPR009497 (Protein of unknown function DUF1114), IPR009010 (Aspartate decarboxylase-like fold)
37	C46C11.3	C46C11.3	n/a	chrX 4,630,409
38	ZK1055.3	ZK1055.3	n/a	chrV 6,590,794
39	T20B6.3	T20B6.3	n/a	chrIII 2,899,911	contains similarity to Interpro domains IPR002952 (Eggshell protein), IPR000817 (Prion protein), IPR008119 (Dense granule Gra6 protein)
40	Y50F7A.2	Y50F7A.2	n/a	chrII 1,183,626
41	nlp-17	Y45F10A.5	n/a	chrIV 13,505,484	C. elegans NLP-17 protein ;
42	C41H7.4	C41H7.4	n/a	chrII 3,004,748	contains similarity to Pfam domain PF03353 DUF278 contains similarity to Interpro domain IPR005020 (Protein of unknown function DUF278)
43	M176.4	M176.4	n/a	chrII 9,421,150	contains similarity to Pfam domain PF07947 YhhN-like protein contains similarity to Interpro domains IPR012506 (YhhN-like), IPR003492 (Batten's disease protein Cln3)
44	mec-10	F16F9.5	n/a	chrX 8,467,984	The mec-10 gene encodes an amiloride-sensitive Na+ channel protein (degenerin) required to sense gentle mechanical stimuli (e.g. touch) along the body wall; it is paralogous to mec-4, which has similar function in vivo.
45	F25D1.4	F25D1.4	n/a	chrV 10,543,032	contains similarity to Pfam domain PF00858 Amiloride-sensitive sodium channel contains similarity to Interpro domain IPR001873 (Na+ channel, amiloride-sensitive)
46	H42K12.2	H42K12.2	n/a	chrX 1,319,512
47	srw-60	T11F1.1	n/a	chrII 2,960,240	C. elegans SRW-60 protein; contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
48	C45G7.4	C45G7.4	n/a	chrIV 2,434,709	contains similarity to Pfam domain PF00097 Zinc finger, C3HC4 type (RING finger) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type)
49	fbxb-76	H02I12.2	n/a	chrIV 11,378,732	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
50	gpn-1	F59D12.4	n/a	chrX 15,684,484	gpn-1 encodes a glypican, a heparan sulfate proteoglycan anchored to the cell membrane by a GPI linkage, that is orthologous to Drosophila Dally-like (Dlp) and mammalian glypicans (OMIM:312870, mutated in Simpson-Golabi-Behmel overgrowth syndrome); by homology, GPN-1 is predicted to function as a cell surface protein that regulates intercellular signaling, perhaps within the context of cell division and growth regulation; however, as loss of gpn-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of GPN-1 in C. elegans development and/or behavior is not yet known.