UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	C28A5.2	C28A5.2	0	chrIII 4,437,117	contains similarity to Interpro domain IPR001564 (Nucleoside diphosphate kinase)
2	his-47	B0035.7	n/a	chrIV 11,324,148	his-47 encodes an H2A histone; by homology, HIS-47 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-47 is a replication-dependent histone locus that resides in a histone gene-rich region on chromosome IV.
3	ced-12	Y106G6E.5	n/a	chrI 10,224,961	ced-12 is required both for phagocytotic engulfment of dying (apoptotic) cells, and for normal migrations of healthy cells during development.
4	osm-11	F11C7.5	n/a	chrX 17,420,817	C. elegans OSM-11 protein ;
5	pqn-45	F56F3.1	n/a	chrIII 4,473,243	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
6	F45C12.2	F45C12.2	n/a	chrII 1,732,740	contains similarity to Interpro domains IPR001356 (Homeobox), IPR009057 (Homeodomain-like)
7	wve-1	R06C1.3	n/a	chrI 11,927,136	wve-1 encodes a homolog of the mammalian WAVE protein; based on homology WVE-1 might be involved in actin cytoskeletal dynamics; wve-1 is required for early cell migrations in the epidermis during embryonic morphogenesis and may require gex-2 and gex-3 for its function.
8	C06A5.1	C06A5.1	n/a	chrI 6,017,022	contains similarity to Drosophila melanogaster Flybase gene name is CG3173-PA;; FLYBASE:CG3173
9	his-63	F22B3.2	n/a	chrIV 11,406,611	his-63 encodes an H3 histone; by homology, HIS-63 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-63 is a replication-dependent histone locus.
10	efl-1	Y102A5C.18	n/a	chrV 16,962,099	efl-1 encodes a homolog of mammalian E2F that is required for embryonic asymmetry and that functions as a transcriptional repressor; during vulval development, efl-1, a class B synMuv gene, acts with class B synMuv genes dpl-1 and lin-35/Rb to antagonize receptor tyrosine kinase and Ras-mediated signaling; EFL-1 also negatively regulates the G1 to S phase cell cycle transition.
11	his-62	F55G1.3	n/a	chrIV 7,486,714	his-62 encodes an H2B histone.
12	F10E7.11	F10E7.11	n/a	chrII 7,121,124	contains similarity to Pfam domain PF01448 ELM2 domain contains similarity to Interpro domains IPR001005 (SANT, DNA-binding), IPR000949 (ELM2)
13	C41D11.1	C41D11.1	n/a	chrI 4,458,028
14	coq-4	T03F1.2	n/a	chrI 3,869,644	coq-4 encodes an ortholog of S. cerevisiae COQ4; while COQ-4 is conserved between eukaryotes and bacteria, its biochemical function is unknown; by orthology, COQ-4 is predicted to peripherally associate with the matrix face of the mitochondrial inner membrane, in a complex with COQ-3 (and perhaps COQ-6), and to be required to maintain a steady-state level of CLK-1/COQ-7 protein; COQ-4 is required for ubiquinone (coenzyme Q9) biosynthesis and for normally short lifespan; coq-4(RNAi) animals have reduced levels of coenzyme Q9 and superoxide, and have abnormally long lifespans.
15	F22F7.4	F22F7.4	n/a	chrV 2,104,867	contains similarity to Pfam domain PF01697 Domain of unknown function contains similarity to Interpro domains IPR008167 (Protein of unknown function DUF23, C-terminal), IPR008166 (Protein of unknown function DUF23)
16	mes-2	R06A4.7	n/a	chrII 14,386,115	mes-2 encodes a SET domain-containing protein that is orthologous to the Drosophila Polycomb group protein Enhancer of zeste [E(Z)]; as a member of a Polycomb-like chromatin repressive complex with MES-3 and MES-6, MES-2 is required maternally for normal germline development and during larval development, for anteroposterior patterning; during germline development, the MES-2/MES-3/MES-6 complex is believed to be essential for maintaining repression of the X chromosome, and in transgenic animals, the complex is necessary for germline repression of repetitive transgenes; in axial patterning, the MES-2/MES-3/MES-6 complex is required in somatic tissues for maintaining homeotic gene repression, acting upstream of the Hox genes lin-39, mab-5, and egl-5, as well as the egl-5 target gene lin-32; in addition, MES-2 activity is required for normal levels and localization of MES-3 in >24-cell-stage embryos; MES-2 expression is detected in the primordial germ cells and germline nuclei throughout development, in all nuclei in early embryos, and in somatic nuclei, including those of the male tail, in L2 and L3 larvae; in the nucleus, MES-2 appears to localize to chromatin.
17	C01F6.9	C01F6.9	n/a	chrIV 9,095,971	The C01F6.9 gene resides in an operon that also contains the genes icl-1 and lpl-1.
18	F48E8.4	F48E8.4	n/a	chrIII 5,456,244	contains similarity to Interpro domain IPR009011 (Mannose-6-phosphate receptor, binding)
19	taf-6.1	W09B6.2	n/a	chrII 1,130,167	C. elegans TAF-6.1 protein; contains similarity to Pfam domains PF07571 (Protein of unknown function (DUF1546)) , PF02969 (TATA box binding protein associated factor (TAF)) contains similarity to Interpro domains IPR009072 (Histone-fold), IPR004823 (TATA box binding protein associated factor (TAF)), IPR011442 (Protein of unknown function DUF1546)
20	his-44	F08G2.1	n/a	chrII 13,826,823	his-44 encodes an H2B histone.
21	cdc-25.1	K06A5.7	n/a	chrI 6,470,859	cdc-25.1 encodes a CDC25 phosphatase homolog that affects embryonic viability, meiosis, mitosis, proliferation of the intestine (E cell lineage), and germ line proliferation; it is expressed in the developing germline, in the nuclei of oocytes, embryonic nuclei, nuclei of embryonic cortical membranes, and sperm pronuclei, and in the germline precursors Z2 and Z3.
22	C29H12.5	C29H12.5	n/a	chrII 6,111,947	contains similarity to Pfam domain PF00385 'chromo' (CHRromatin Organisation MOdifier) domain contains similarity to Interpro domains IPR002290 (Serine/threonine protein kinase), IPR000953 (Chromo domain), IPR011009 (Protein kinase-like), IPR000719 (Protein kinase, core), IPR016197 (Chromo domain-like)
23	cdk-8	F39H11.3	n/a	chrI 8,704,132	cdk-8 encodes a member of the cyclin-dependent serine/threonine protein kinase family orthologous to human CDK8 (OMIM:603184) which functions in transcriptional regulation with the positive regulatory factor cyclin C, is associated with the RNA polymerase II holoenzyme, and may regulate gene-specific activators; CDK-8 also contains a glutamine/asparagine-rich domain; loss of cdk-8 function via RNA-mediated interference (RNAi) results in sterility in the injected hermaphrodite, suggesting that in C. elegans, CDK-8 may play a role in germ-line development.
24	C07A4.1	C07A4.1	n/a	chrX 10,169,900	contains similarity to Pfam domain PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) contains similarity to Interpro domains IPR012677 (Nucleotide-binding, alpha-beta plait), IPR003954 (RNA recognition, region 1), IPR000504 (RNA recognition motif, RNP-1)
25	C27A12.2	C27A12.2	n/a	chrI 6,043,841	contains similarity to Pfam domain PF00096 Zinc finger, C2H2 type contains similarity to Interpro domains IPR015880 (Zinc finger, C2H2-like), IPR007086 (Zinc finger, C2H2-subtype), IPR013087 (Zinc finger, C2H2-type/integrase, DNA-binding), IPR007087 (Zinc finger, C2H2-type)
26	fem-2	T19C3.8	n/a	chrIII 633,323	A CB5161 ortholog of fem-2, Cbn-fem-2, has been isolated from the sibling Caenorhabditis species CB5161.
27	C01H6.9	C01H6.9	n/a	chrI 7,231,276	C01H6.9 encodes a homolog of haploid germ cell-specific nuclear protein kinase (haspin) that specifically binds GOA-1 in yeast two-hybrid assays; C01H6.9 is expressed in PHB sensory neurons and PVT interneurons in the tail, several unidentified neurons in the head (with projections to the nose and nerve ring), and intestinal cells, with mainly nuclear localization; C01H6.9 has no obvious function or phenotype in RNAi assays, either alone or with inactivation of a close paralog (F22H10.5).
28	ZC404.11	ZC404.11	n/a	chrV 6,803,107	contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR000276 (GPCR, rhodopsin-like)
29	F56A6.4	F56A6.4	n/a	chrI 622,086
30	F08F1.9	F08F1.9	n/a	chrX 8,410,171	contains similarity to Pfam domain PF00134 Cyclin, N-terminal domain contains similarity to Interpro domains IPR006670 (Cyclin), IPR011028 (Cyclin-like), IPR013763 (Cyclin-related), IPR006671 (Cyclin, N-terminal)
31	F56G4.4	F56G4.4	n/a	chrI 11,377,362	contains similarity to Interpro domains IPR003604 (Zinc finger, U1-type), IPR000533 (Tropomyosin), IPR001202 (WW/Rsp5/WWP)
32	ani-3	Y43F8C.14	n/a	chrV 19,696,771	ani-3 encodes one of three C. elegans anillins.
33	hcf-1	C46A5.9	n/a	chrIV 7,772,495	C. elegans HCF-1 protein; contains similarity to Pfam domains PF01344 (Kelch motif) (3), PF00041 (Fibronectin type III domain) , PF07646 (Kelch motif) (4)contains similarity to Interpro domains IPR011043 (Galactose oxidase/kelch, beta-propeller), IPR008957 (Fibronectin, type III-like fold), IPR003961 (Fibronectin, type III), IPR006652 (Kelch repeat type 1), IPR011498 (Kelch repeat type 2), IPR015915 (Kelch-type beta propeller)
34	dpf-2	C27C12.7	n/a	chrX 14,834,928	C. elegans DPF-2 protein; contains similarity to Pfam domains PF00930 (Dipeptidyl peptidase IV (DPP IV) N-terminal region) , PF00326 (Prolyl oligopeptidase family) contains similarity to Interpro domains IPR001375 (Peptidase S9, prolyl oligopeptidase active site region), IPR002469 (Peptidase S9B, dipeptidylpeptidase IV N-terminal)
35	F55A3.3	F55A3.3	n/a	chrI 10,791,127	contains similarity to Pfam domains PF08512 (Histone chaperone Rttp106-like) , PF08644 (FACT complex subunit (SPT16/CDC68)) , PF00557 (metallopeptidase family M24) contains similarity to Interpro domains IPR013719 (Region of unknown function DUF1747, eukaryote), IPR000994 (Peptidase M24, catalytic core), IPR013953 (FACT complex subunit Spt16p/Cdc68p)
36	K02E7.3	K02E7.3	n/a	chrII 1,077,813	contains similarity to Pfam domain PF06869 Protein of unknown function (DUF1258) contains similarity to Interpro domain IPR009667 (Protein of unknown function DUF1258)
37	his-60	F55G1.11	n/a	chrIV 7,487,766	his-60 encodes an H4 histone; by homology, HIS-60 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-60 expression is detected in early embryos, beginning at the 28-cell stage and continuing through the comma stage (early morphogenesis); his-60 is a replication-dependent histone locus that resides in a histone gene-rich region on chromosome IV.
38	K10D11.2	K10D11.2	n/a	chrIV 12,980,447	contains similarity to Pfam domain PF02408 CUB-like domain contains similarity to Interpro domain IPR003366 (CUB-like region)
39	Y38C9A.1	Y38C9A.1	n/a	chrV 112,782	contains similarity to Leishmania major strain Friedlin Proteophosphoglycan ppg4.; TR:Q4FX63
40	M03C11.2	M03C11.2	n/a	chrIII 10,402,129	contains similarity to Pfam domain PF06733 DEAD_2 contains similarity to Interpro domains IPR014013 (Helicase, superfamily 1 and 2, ATP-binding, DinG/Rad3-type), IPR010614 (DEAD2), IPR006554 (Helicase-like, DEXD box c2 type), IPR006555 (Helicase, ATP-dependent, c2 type), IPR014001 (DEAD-like helicase, N-terminal), IPR013020 (DNA helicase (DNA repair), Rad3 type)
41	F41C3.1	F41C3.1	n/a	chrII 4,752,652	contains similarity to Pfam domain PF06887 Protein of unknown function (DUF1265) contains similarity to Interpro domain IPR009676 (Protein of unknown function DUF1265)
42	srw-121	K12D9.3	n/a	chrV 2,990,948	C. elegans SRW-121 protein; contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
43	K11E4.2	K11E4.2	n/a	chrX 13,718,299	contains similarity to Pfam domain PF00017 SH2 domain contains similarity to Interpro domains IPR006020 (Phosphotyrosine interaction region), IPR000980 (SH2 motif)
44	R05F9.11	R05F9.11	n/a	chrII 4,913,028
45	F59H6.3	F59H6.3	n/a	chrII 2,018,441
46	sru-42	C55A1.8	n/a	chrV 15,651,414	C. elegans SRU-42 protein; contains similarity to Pfam domain PF02688 Domain of unknown function DUF215 contains similarity to Interpro domains IPR002208 (SecY protein), IPR003839 (Protein of unknown function DUF215)
47	srj-4	C27A7.7	n/a	chrV 12,163,847	C. elegans SRJ-4 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
48	tag-189	T04A8.12	n/a	chrIII 4,706,131	C. elegans TAG-189 protein ; contains similarity to Cricetulus griseus Post-GPI-attachment to proteins 2.; TR:Q2ABP2
49	duo-3	Y106G6H.12	n/a	chrI 10,467,681	C. elegans DUO-3 protein; contains similarity to Pfam domains PF00443 (Ubiquitin carboxyl-terminal hydrolase) , PF02338 (OTU-like cysteine protease) contains similarity to Interpro domains IPR003323 (Ovarian tumour, otubain), IPR001394 (Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)
50	cash-1	K07C5.8	n/a	chrV 10,364,141	cash-1 encodes an ortholog of Drosophila CKA and the human striatins STRN, STRN3, and STRN4 that is required for vulval development; CASH-1 has an N-terminal region which may bind caveolin or calmodulin, and a C-terminal region with five tandem WD domains; by its orthology with CKA and striatins, CASH-1 is predicted to act as a scaffold linking signal transduction proteins (such as JKK-1 and JNK-1) to transcription factors (such as JUN-1 or FOS-1); CASH-1 is expressed broadly, in both larval and adult pharynx, intestine, rectal epithelium, hypodermis, and neurons, as well as the developing vulva and the adult reproductive system.