UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	nhr-259	C27C7.8	2e-99	chrI 11,437,084	C. elegans NHR-259 protein; contains similarity to Pfam domain PF00104 Ligand-binding domain of nuclear hormone receptor contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
2	T17H7.1	T17H7.1	n/a	chrIII 741,822	contains similarity to Pfam domain PF02520 Domain of unknown function DUF148 contains similarity to Interpro domains IPR002952 (Eggshell protein), IPR003677 (Protein of unknown function DUF148)
3	mab-9	T27A1.6	n/a	chrII 518,813	mab-9 encodes a member of the T-box family of transcriptional regulators containing a 200-amino acid T-box DNA-binding domain most similar to mouse Brachyury; mab-9 is involved in hindgut and male tail development, specifically affecting the fate of two posterior blast cells in the hindgut, B and F; in the male this results in a grossly abnormal tail lacking spicules, and renders them incapable of mating; in the hermaphrodite this results in hindgut defects; mab-9 may also be part of a network of T-box genes that includes tbx-8, tbx-9 and vab-7 and is important for the correct patterning of posterior cells in the developing embryo; mab-9 affects movement to some extent though the basis for this defect is unknown; MAB-9 localizes to the nucleus of B and F and their descendents during development.
4	C34F6.1	C34F6.1	n/a	chrX 11,194,603	contains similarity to Pfam domain PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain contains similarity to Interpro domains IPR002223 (Proteinase inhibitor I2, Kunitz metazoa), IPR000694 (Proline-rich region), IPR006150 (Cysteine-rich repeat)
5	cpt-4	K11D12.4	n/a	chrV 5,025,698	C. elegans CPT-4 protein; contains similarity to Pfam domain PF00755 Choline/Carnitine o-acyltransferase contains similarity to Interpro domains IPR000542 (Acyltransferase ChoActase/COT/CPT), IPR000169 (Peptidase, cysteine peptidase active site)
6	F42A10.3	F42A10.3	n/a	chrIII 6,156,244	contains similarity to Pfam domain PF01234 NNMT/PNMT/TEMT family contains similarity to Interpro domain IPR000940 (Methyltransferase, NNMT/PNMT/TEMT)
7	nhr-244	ZK1025.6	2e-48	chrI 11,455,105	C. elegans NHR-244 protein; contains similarity to Pfam domain PF00104 Ligand-binding domain of nuclear hormone receptor contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
8	nhr-73	C27C7.4	2e-52	chrI 11,434,790	nhr-73 encodes a member of the superfamily of nuclear receptors, which is one of the most abundant class of transcriptional regulators; nuclear receptors have a well conserved DNA binding domain and a less conserved C-terminal ligand binding domain; expression studies using GFP fusions indicate that nhr-73 is expressed exclusively in lateral seam cells; expression of nhr-73 is seen in early embryonic lateral hypodermal cells and continues to persist in the daughter cell that continues to divide and is lost in the daughter cell that differentiates; nhr-73 expression is diminished by knocking down genes (via RNA interference) that are involved in seam cell development like elt-5 and ceh-16/engrailed.
9	F13D12.9	F13D12.9	n/a	chrII 11,708,413	contains similarity to Pfam domains PF02353 (Cyclopropane-fatty-acyl-phospholipid synthase) , PF08242 (Methyltransferase domain) , PF08241 (Methyltransferase domain) contains similarity to Interpro domains IPR003333 (Cyclopropane-fatty-acyl-phospholipid synthase), IPR013217 (Methyltransferase type 12), IPR013216 (Methyltransferase type 11)
10	C53C9.2	C53C9.2	n/a	chrX 7,687,874	contains similarity to Pfam domain PF00402 Calponin family repeat contains similarity to Interpro domains IPR003096 (SM22/calponin), IPR000557 (Calponin repeat)
11	mlt-11	W01F3.3	n/a	chrV 20,668,250	C. elegans MLT-11 protein; contains similarity to Pfam domains PF00014 (Kunitz/Bovine pancreatic trypsin inhibitor domain) (10), PF00086 (Thyroglobulin type-1 repeat) contains similarity to Interpro domains IPR000716 (Thyroglobulin type-1), IPR002223 (Proteinase inhibitor I2, Kunitz metazoa), IPR000694 (Proline-rich region), IPR006150 (Cysteine-rich repeat)
12	pgp-9	C47A10.1	n/a	chrV 17,760,286	pgp-9 encodes an ATP-binding protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; PGP-9 is predicted to function as a transmembrane protein that couples energy to transport of various molecules across membranes, and loss of pgp-9 activity via RNAi can result in embryonic lethality; pgp-9 promoter-gfp fusion proteins are expressed in the pharynx (first and second bulbs) and in the intestine.
13	R05G6.9	R05G6.9	n/a	chrIV 7,515,301	R05G9.6 encodes a protein with a predicted signal sequence and EGF-like repeats that are related to those of Notch family members.
14	F01D5.5	F01D5.5	n/a	chrII 14,001,897	contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domain IPR003582 (Metridin-like ShK toxin)
15	nhr-45	F16H11.5	n/a	chrX 4,658,348	C. elegans NHR-45 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
16	C45B2.2	C45B2.2	n/a	chrX 6,084,923
17	atp-2	C34E10.6	n/a	chrIII 5,229,290	atp-2 encodes the beta subunit of the soluble, catalytic F1 portion of ATP synthase (mitochondrial respiratory chain [MRC] complex V); atp-2 activity is required for embryonic and larval development past the L3 stage, as well as for normal mobility, pharyngeal pumping, defecation, growth rate, and larval lifespan; in males, atp-2 activity is also required cell autonomously in male-specific sensory neurons for response to hermaphrodite contact, the first step in a series of stereotypical male mating behaviors; in vitro, the N-terminus of ATP-2 interacts directly with the conserved PLAT domains of human polycystin (PC)-1 and C. elegans LOV-1, which is expressed exclusively in adult male sensory neurons and is also required for the response to hermaphrodite contact; atp-2 is widely expressed throughout development in both sexes; ATP-2 localizes to mitochondria and to cilia of male-specific neurons; in the male-specific CEM neurons ATP-2 colocalizes with PKD-2, the C. elegans homolog of human polycystin (PC)-2.
18	Y39A1A.9	Y39A1A.9	n/a	chrIII 10,631,671	contains similarity to Homo sapiens Isoform 2 of Uncharacterized protein FLJ35848; ENSEMBL:ENSP00000323874
19	T21B6.3	T21B6.3	n/a	chrX 10,946,988	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
20	mec-12	C44B11.3	n/a	chrIII 3,135,388	mec-12 encodes a novel C. elegans alpha-tubulin that is unique amongst C. elegans alpha tubulins in that it may be subject to post-translational acetylation; MEC-12 is required for normal mechanosensory response to gentle touch, and specifically for formation of the 15-protofilament microtubule bundle present in the touch receptor neurons; mec-12 interacts genetically with mec-5, which encodes a unique C. elegans collagen secreted by the hypodermis; MEC-12 is highly expressed in the touch neurons as well as in several other neurons that do not contains the microfilament bundle, such as the ventral cord motorneurons.
21	clec-68	F56D6.1	n/a	chrIV 3,927,681	C. elegans CLEC-68 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
22	ZC247.1	ZC247.1	n/a	chrI 10,271,766	contains similarity to Drosophila melanogaster Flybase gene name is CG32377-PA;; FLYBASE:CG32377
23	dpy-8	C31H2.2	n/a	chrX 5,149,633	dpy-8 encodes a collagen with a nematode-specific N-terminal domain that is required for normal body morphology and (perhaps) for a normal embryonic cell division rate; dpy-8 interacts genetically with emb-5 and glp-1.
24	F19H8.4	F19H8.4	n/a	chrII 14,619,275	contains similarity to Pfam domain PF04870 Protein of unknown function, DUF644 contains similarity to Interpro domain IPR006954 (Protein of unknown function DUF644)
25	B0272.4	B0272.4	n/a	chrX 9,429,267	contains similarity to Pfam domain PF00378 Enoyl-CoA hydratase/isomerase family contains similarity to Interpro domain IPR001753 (Crotonase, core)
26	F59A1.10	F59A1.10	n/a	chrV 17,661,006	contains similarity to Pfam domain PF03982 Diacylglycerol acyltransferase contains similarity to Interpro domain IPR007130 (Diacylglycerol acyltransferase)
27	M79.2	M79.2	n/a	chrX 10,628,258	contains similarity to Homo sapiens 1-acyl-sn-glycerol-3-phosphate acyltransferase theta; ENSEMBL:ENSP00000264409
28	fbxa-150	Y38H6C.11	n/a	chrV 20,518,929	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
29	T20D4.3	T20D4.3	n/a	chrV 3,420,496	contains similarity to Pfam domain PF04721 Domain of unknown function (DUF750) contains similarity to Interpro domain IPR006588 (Protein of unknown function PAW)
30	erv-46	K09E9.2	n/a	chrX 15,615,388	C. elegans ERV-46 protein; contains similarity to Pfam domain PF07970 Protein of unknown function (DUF1692) contains similarity to Interpro domain IPR012936 (Protein of unknown function DUF1692)
31	ZK1025.7	ZK1025.7	n/a	chrI 11,466,357	contains similarity to Pfam domain PF01697 Domain of unknown function contains similarity to Interpro domain IPR008166 (Protein of unknown function DUF23)
32	Y45G12C.3	Y45G12C.3	n/a	chrV 2,556,848	contains similarity to Pfam domain PF02798 Glutathione S-transferase, N-terminal domain contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR012335 (Thioredoxin fold), IPR004045 (Glutathione S-transferase, N-terminal), IPR010987 (Glutathione S-transferase, C-terminal-like)
33	F23H12.5	F23H12.5	n/a	chrV 12,361,146	contains similarity to Interpro domains IPR008085 (Thrombospondin, subtype 1), IPR000884 (Thrombospondin, type I)
34	sec-23	Y113G7A.3	n/a	chrV 20,093,804	C. elegans SEC-23 protein; contains similarity to Pfam domains PF04811 (Sec23/Sec24 trunk domain) , PF04815 (Sec23/Sec24 helical domain) , PF04810 (Sec23/Sec24 zinc finger) , PF00626 (Gelsolin repeat) , PF08033 (Sec23/Sec24 beta-sandwich domain) contains similarity to Interpro domains IPR006900 (Sec23/Sec24 helical region), IPR012990 (Sec23/Sec24 beta-sandwich), IPR006896 (Sec23/Sec24 trunk region), IPR006895 (Zinc finger, Sec23/Sec24-type), IPR007123 (Gelsolin region)
35	C49C3.4	C49C3.4	n/a	chrIV 17,324,683	contains similarity to Interpro domains IPR000742 (EGF-like, type 3), IPR006210 (EGF), IPR002049 (EGF-like, laminin), IPR013032 (EGF-like region, conserved site)
36	dnj-7	C55B6.2	n/a	chrX 7,196,372	This gene encodes a protein containing a DnaJ ('J') domain that is predicted to be mitochondrial.
37	twk-42	W06D12.2	n/a	chrV 17,728,557	C. elegans TWK-42 protein; contains similarity to Pfam domain PF07885 Ion channel contains similarity to Interpro domains IPR003280 (Potassium channel, two pore-domain), IPR013099 (Ion transport 2)
38	R03H4.6	R03H4.6	n/a	chrV 9,023,568	contains similarity to Pfam domain PF01757 Acyltransferase family contains similarity to Interpro domain IPR002656 (Acyltransferase 3)
39	R03D7.1	R03D7.1	n/a	chrII 10,928,740	R03D7.1 is orthologous to the human gene METHIONINE SYNTHASE (MTR; OMIM:156570), which when mutated leads to disease.
40	R05C11.3	R05C11.3	n/a	chrIV 2,087,977	R05C11.3 encodes a calcium-transporting ATPase; large-scale RNAi screens indicate that R05C11.3 activity is required for locomotion and normal rates of postembryonic growth.
41	ptr-14	R09H10.4	n/a	chrIV 10,618,200	ptr-14 encodes a nematode-specific member of the sterol sensing domain (SSD) proteins, distantly paralogous to Drosophila PATCHED (PTC) and human PTCH (OMIM:601309, mutated in basal cell nevus syndrome); PTR-14 is weakly required for normal molting from L4 to adult stages; PTR-14 is also required for normal growth to full size and locomotion.
42	let-75	R06C7.10	n/a	chrI 7,263,197	let-75 encodes a pharynx-specific type II myosin heavy chain (MHC D); LET-75 is required for pharyngeal muscle contraction and thus for normal feeding behavior and post-embryonic development; in vitro, the LET-75 tail domain interacts with ITR-1, an IP3 receptor, and this interaction has been proposed to mediate, in vivo, increased pharnygeal pumping in response to food; LET-75 is expressed exclusively in pharyngeal muscle.
43	grsp-4	F07C4.7	n/a	chrV 7,625,659	C. elegans GRSP-4 protein; contains similarity to Interpro domains IPR000217 (Tubulin), IPR002952 (Eggshell protein), IPR000817 (Prion protein)
44	clec-186	ZK896.7	n/a	chrIV 12,867,615	C. elegans CLEC-186 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
45	tbb-6	T04H1.9	n/a	chrV 12,262,563	C. elegans TBB-6 protein; contains similarity to Pfam domains PF00091 (Tubulin/FtsZ family, GTPase domain) , PF03953 (Tubulin/FtsZ family, C-terminal domain) contains similarity to Interpro domains IPR002454 (Gamma tubulin), IPR002452 (Alpha tubulin), IPR002453 (Beta tubulin), IPR000217 (Tubulin), IPR003008 (Tubulin/FtsZ, GTPase), IPR004057 (Epsilon tubulin), IPR002967 (Delta tubulin), IPR008280 (Tubulin/FtsZ, C-terminal)
46	F23C8.7	F23C8.7	n/a	chrI 2,423,740	contains similarity to Pfam domains PF07714 (Protein tyrosine kinase) , PF00069 (Protein kinase domain) , PF00017 (SH2 domain) contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related), IPR000980 (SH2 motif), IPR008266 (Tyrosine protein kinase, active site)
47	F27E5.3	F27E5.3	n/a	chrII 10,142,746	contains similarity to Homo sapiens Isoform 1 of Cell division cycle 2-related protein kinase 7; ENSEMBL:ENSP00000300647
48	Y75B8A.4	Y75B8A.4	n/a	chrIII 12,110,492	contains similarity to Pfam domains PF07726 (ATPase family associated with various cellular activities (AAA)) , PF00004 (ATPase family associated with various cellular activities (AAA)) , PF05362 (Lon protease (S16) C-terminal proteolytic domain) , PF07728 (ATPase family associated with various cellular activities (AAA)) contains similarity to Interpro domains IPR003959 (AAA ATPase, core), IPR000767 (Disease resistance protein), IPR011704 (ATPase associated with various cellular activities, AAA-5), IPR011703 (ATPase associated with various cellular activities, AAA-3), IPR004815 (Peptidase S16, ATP-dependent protease La), IPR008269 (Peptidase S16, lon C-terminal), IPR003111 (Peptidase S16, lon N-terminal), IPR003593 (AAA+ ATPase, core), IPR001984 (Peptidase S16, Lon protease)
49	rol-6	T01B7.7	n/a	chrII 8,733,614	The rol-6 gene encodes a cuticle collagen related to human collagen alpha 1 (III) chain precursor (OMIM:120180), and is required for normal cuticular morphology; ROL-6 interacts with SQT-1, a closely related cuticle collagen, and is expressed at all stages from L2 to adult with transcripts detected at each of the molts preceding these stages.
50	dod-21	C32H11.10	n/a	chrIV 12,937,319	C. elegans DOD-21 protein; contains similarity to Pfam domain PF02408 CUB-like domain contains similarity to Interpro domain IPR003366 (CUB-like region)