UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	C25F9.6	C25F9.6	1e-33	chrV 19,405,134	contains similarity to Ectromelia virus EVM128.; TR:Q8JL89
2	Y17G7B.14	Y17G7B.14	n/a	chrII 12,066,182	contains similarity to Pfam domains PF00339 (Arrestin (or S-antigen), N-terminal domain) , PF02752 (Arrestin (or S-antigen), C-terminal domain) contains similarity to Interpro domains IPR014756 (Immunoglobulin E-set), IPR011022 (Arrestin-like, C-terminal), IPR014752 (Arrestin, C-terminal), IPR011021 (Arrestin-like, N-terminal)
3	ctl-1	Y54G11A.6	n/a	chrII 14,304,828	ctl-1 encodes one of three C. elegans catalases; CTL-1 exhibits catalase activity in vitro, and thus likely functions in vivo as an antioxidant enzyme that protects cells from reactive oxygen species; ctl-1 activity contributes to the extended lifespan seen in daf-2 mutant animals; in addition, ctl-1 expression is negatively regulated by DAF-2-mediated insulin signaling; as CTL-1 does not possess a C-terminal peroxisomal targeting signal (PTS), it is predicted to be a cytosolic catalase.
4	pgp-12	F22E10.1	n/a	chrX 12,734,558	pgp-12 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of ATP-binding cassette (ABC) transporters; although loss of pgp-12 function via mutation or RNAi results in no obvious defects, pgp-12 promoter fusion constructs reveal expression in the excretory cell, consistent with a role for pgp-12 in metabolite transporter activity; pgp-12 expression is regulated by the DCP-66 transcription factor which binds the pgp-12 Ex-1 promoter element in yeast one-hybrid and EMSA experiments.
5	F13D11.1	F13D11.1	n/a	chrX 5,830,678	contains similarity to Pfam domain PF00328 Histidine acid phosphatase contains similarity to Interpro domain IPR000560 (Histidine acid phosphatase)
6	clec-256	Y17D7B.6	n/a	chrV 18,772,129	C. elegans CLEC-256 protein; contains similarity to Pfam domain PF08277 PAN-like domain contains similarity to Interpro domains IPR006583 (CW), IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
7	unc-98	F08C6.7	n/a	chrX 7,571,972	unc-98 encodes a protein with four C2H2 zinc fingers and several possible nuclear localization and export sequences; UNC-98 is required for normal mobility, M-line structures, and dense body (Z-line analog) structures; UNC-98 binds UNC-97/PINCH, HUM-6, and MEP-1; UNC-98 is located in M-lines, muscle cell nuclei, and perhaps dense bodies.
8	C24B5.1	C24B5.1	n/a	chrV 9,193,748	contains similarity to Pfam domain PF00001 7 transmembrane receptor (rhodopsin family) contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR000276 (GPCR, rhodopsin-like)
9	nhr-79	T26H2.9	n/a	chrV 19,209,750	C. elegans NHR-79 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
10	C24A11.2	C24A11.2	n/a	chrI 5,381,597
11	K06A1.3	K06A1.3	n/a	chrII 6,442,625	contains similarity to Pfam domain PF00100 Zona pellucida-like domain contains similarity to Interpro domain IPR001507 (Endoglin/CD105 antigen)
12	kin-21	W08D2.8	n/a	chrIV 9,833,852	C. elegans KIN-21 protein; contains similarity to Pfam domains PF07714 (Protein tyrosine kinase) , PF00069 (Protein kinase domain) , PF00017 (SH2 domain) contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related), IPR000980 (SH2 motif), IPR008266 (Tyrosine protein kinase, active site)
13	C30F12.6	C30F12.6	n/a	chrI 6,990,585	contains similarity to Pfam domain PF00001 7 transmembrane receptor (rhodopsin family) contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR008365 (Prostanoid receptor), IPR002120 (Thyrotrophin-releasing hormone receptor), IPR009144 (Thyrotropin-releasing hormone receptor), IPR000276 (GPCR, rhodopsin-like)
14	T09F3.1	T09F3.1	n/a	chrII 10,386,641	contains similarity to Pfam domain PF00096 Zinc finger, C2H2 type contains similarity to Interpro domains IPR015880 (Zinc finger, C2H2-like), IPR003656 (Zinc finger, BED-type predicted), IPR007087 (Zinc finger, C2H2-type)
15	nas-29	F58A6.4	n/a	chrII 5,140,235	C. elegans NAS-29 protein; contains similarity to Pfam domains PF00431 (CUB domain) , PF01400 (Astacin (Peptidase family M12A)) contains similarity to Interpro domains IPR017050 (Peptidase M12A, astacin, nematode), IPR006025 (Peptidase M, neutral zinc metallopeptidases, zinc-binding site), IPR001506 (Peptidase M12A, astacin), IPR006026 (Peptidase, metallopeptidases), IPR000859 (CUB), IPR013032 (EGF-like region, conserved site)
16	T24F1.4	T24F1.4	n/a	chrII 11,313,796	contains similarity to Danio rerio Delta-like protein A precursor (DeltaA protein).; SW:Q6DI48
17	F36H2.3	F36H2.3	n/a	chrI 9,258,077	contains similarity to Pfam domain PF00084 Sushi domain (SCR repeat) contains similarity to Interpro domains IPR000436 (Sushi/SCR/CCP), IPR016060 (Complement control module)
18	T11B7.2	T11B7.2	n/a	chrIV 8,844,038	contains similarity to Homo sapiens remodeling and spacing factor 1; ENSEMBL:ENSP00000311513
19	vab-9	T22C8.8	n/a	chrII 8,636,902	vab-9 encodes a claudin homolog orthologous to human brain cell membrane protein 1 (BCMP1) and Drosophila CG6982; VAB-9 colocalizes with HMP-1 to an apical layer of the adherens junctions of all epithelial cells, one layer more apically than AJM-1; vab-9 mutants have disorganized F-actin at the adherens junction, implying that VAB-9 links junctions to circumferential actin filaments; VAB-9 is also expressed in the nerve ring; VAB-9 requires the cadherin HMR-1 to localize to the cell membrane, and both alpha-catenin (HMP-1) and beta-catenin (HMP-2) to remain at the cell junction after membrane localization.
20	gon-1	F25H8.3	n/a	chrIV 9,940,393	gon-1 encodes a functional metalloprotease that defines a new sub-family of secreted proteases known as MPT (metalloprotease with thrombospondin type 1 repeats); the other two members of this family are the bovine procollagen I N-protease ( PINP ) and the murine enzyme ADAMTS-1; gon-1 is essential for hermaphrodite gonadal morphogenesis; sequence homology with other metalloproteases suggests that it functions by remodelling the extracellular matrix; GON-1 is expressed at high levels within the gonadal distal tip cell during migration.
21	T14D7.2	T14D7.2	n/a	chrII 8,850,480	T14D7.2 encodes an acyltransferase; large-scale RNAi experiments indicate that T14D7.2 activity is required for egg laying, coordination locomotion, and normal vulval morphology.
22	F37B12.1	F37B12.1	n/a	chrII 9,028,078	contains similarity to Scyliorhinus canicula Homeodomain protein Otx1 (Fragment).; TR:Q90XZ0
23	F41C6.7	F41C6.7	n/a	chrX 6,883,839	contains similarity to Pfam domain PF01545 Cation efflux family contains similarity to Interpro domain IPR002524 (Cation efflux protein)
24	nas-32	T02B11.7	n/a	chrV 897,042	C. elegans NAS-32 protein; contains similarity to Pfam domains PF01549 (ShK domain-like) , PF01400 (Astacin (Peptidase family M12A)) contains similarity to Interpro domains IPR017050 (Peptidase M12A, astacin, nematode), IPR006025 (Peptidase M, neutral zinc metallopeptidases, zinc-binding site), IPR001506 (Peptidase M12A, astacin), IPR006026 (Peptidase, metallopeptidases), IPR000859 (CUB), IPR013032 (EGF-like region, conserved site), IPR003582 (Metridin-like ShK toxin)
25	cwp-4	K11D12.1	n/a	chrV 5,055,031	cwp-4 encodes a protein with some similarity to mucins that is predicted to be secreted, and is alleged to be coexpressed with polycystins; CWP-4 is dispensable for viability and gross morphology in mass RNAi screens.
26	F13B6.1	F13B6.1	n/a	chrIV 7,457,398
27	Y41E3.6	Y41E3.6	n/a	chrIV 15,006,683	contains similarity to Bacillus halodurans Stress-and starvation-induced gene controlled by sigma-B.; TR:Q9KE40
28	grsp-2	T28C6.1	n/a	chrIV 8,817,412	C. elegans GRSP-2 protein; contains similarity to Interpro domains IPR002952 (Eggshell protein), IPR000817 (Prion protein), IPR008119 (Dense granule Gra6 protein), IPR001151 (GPR6 orphan receptor)
29	sel-7	K04G11.2	n/a	chrX 14,336,558	sel-7 encodes a novel protein with two predicted PEST sequences that is conserved in the related nematode C. briggsae and several parasitic nematodes, but has no known homologs in other organisms; sel-7 was identified in screens for suppressors of dominant lin-12 mutations that result in vulvaless and egg-laying defective animals; although loss of SEL-7 function via mutation or RNAi results in no obvious defects in a wild-type background, genetic studies suggests that SEL-7 acts downstream of LIN-12/Notch to positively regulate LIN-12 signaling, perhaps by regulating the activity or formation of the LAG-1, LIN-12(intra), SEL-8 nuclear complex; in vitro, SEL-7 self-associates and also interacts with TIR-1 (F13B10.1B), a protein that contains sterile alpha and Toll interleukin receptor motifs, and MDT-29 (K08E3.8), a glutamine-rich protein similar to mediator complex subunits, however the functional significance of these interactions is not yet known; a SEL-7::GFP translational fusion reveals expression in the nuclei of several cell types, including vulval precursor cells and those of the developing gonad.
30	F54C9.11	F54C9.11	n/a	chrII 8,584,206	contains similarity to Interpro domain IPR008126 (Outer membrane adhesion, Yersinia)
31	K04F10.1	K04F10.1	n/a	chrI 6,365,571	The K04F10.1 gene encodes a homolog of SCA1, which when mutated leads to spinocerebellar ataxia 1 (OMIM:164400).
32	tba-9	F40F4.5	n/a	chrX 3,254,559	tba-9 encodes one of nine C. elegans alpha tubulins; by homology, TBA-9 is predicted to be a component of microtubules; as loss of tba-9 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, TBA-9 likely functions redundantly with other alpha tubulins as a basic component of cellular architecture that may play additional roles in processes such as cell division, cell movement, and intracellular transport.
33	clec-199	C30H6.1	n/a	chrIV 17,352,393	C. elegans CLEC-199 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
34	Y43F4A.4	Y43F4A.4	n/a	chrIII 13,245,650	contains similarity to Homo sapiens Putative uncharacterized protein DKFZp313C0640; ENSEMBL:ENSP00000367438
35	his-16	ZK131.10	n/a	chrII 13,817,860	his-16 encodes an H2A histone; his-16 is contained within the histone gene cluster HIS3.
36	C25E10.4	C25E10.4	n/a	chrV 9,034,575	contains similarity to Interpro domains IPR000802 (Arsenical pump membrane protein), IPR016196 (MFS general substrate transporter)
37	clec-241	F49H6.2	n/a	chrV 17,012,698	C. elegans CLEC-241 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
38	glb-23	R13A1.8	n/a	chrIV 7,218,772	glb-23 encodes a globin; glb-23 transcription is higher in L3 and dauers than in young adults; glb-23 has no obvious function in mass RNAi assays.
39	ZK892.4	ZK892.4	n/a	chrII 10,007,287	ZK892.4 is orthologous to the human gene ALPHA-METHYLACYL-CoA RACEMASE (AMACR; OMIM:604489), which when mutated leads to AMACR deficiency.
40	F35C8.2	F35C8.2	n/a	chrX 5,375,578	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)
41	Y45F3A.8	Y45F3A.8	n/a	chrIII 10,591,217	contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domain IPR003582 (Metridin-like ShK toxin)
42	Y41C4A.8	Y41C4A.8	n/a	chrIII 11,707,793	contains similarity to Aedes aegypti Hypothetical conserved protein (Putative uncharacterized protein).; TR:Q1HQM0
43	R90.1	R90.1	n/a	chrV 12,893,678	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)
44	sre-42	Y57A10B.4	n/a	chrII 12,385,670	C. elegans SRE-42 protein; contains similarity to Pfam domain PF03125 C. elegans Sre G protein-coupled chemoreceptor contains similarity to Interpro domains IPR004151 (C. elegans Sre G protein-coupled chemoreceptor), IPR001356 (Homeobox)
45	ZK228.3	ZK228.3	n/a	chrV 18,459,731	contains similarity to Interpro domain IPR016181 (Acyl-CoA N-acyltransferase)
46	cyp-33C9	C50H11.15	n/a	chrV 3,093,157	C. elegans CYP-33C9 protein; contains similarity to Pfam domain PF00067 Cytochrome P450 contains similarity to Interpro domains IPR001128 (Cytochrome P450), IPR002401 (Cytochrome P450, E-class, group I), IPR002403 (Cytochrome P450, E-class, group IV), IPR002397 (Cytochrome P450, B-class)
47	C37C3.11	C37C3.11	n/a	chrV 7,864,144
48	psa-1	Y113G7B.23	n/a	chrV 20,239,752	psa-1 encodes an ortholog of SWI3, a component of the SWI/SNF complex that is conserved from yeast to mammals and that is involved in chromatin remodeling; psa-1 is probably required during mitosis of the T cells for asymmetric cell division, and in addition, is required for embryonic and larval development, as well as normal levels of fertility; psa-1 exhibits strong genetic interactions with lin-35/Rb, as psa-1 larval lethality and sterility at 20 degrees C are greatly enhanced in lin-35;psa-1 double mutants.
49	arr-1	F53H8.2	n/a	chrX 952,505	arr-1 encodes the C. elegans beta-arrestin ortholog (OMIM:107940, 107941, mice lacking beta-arrestin family members display defects in G protein-coupled receptor desensitization); by homology, ARR-1 is predicted to be a multifunctional adaptor protein that interacts with intracellular signaling molecules as well as activated and phosphorylated G protein-coupled and TGF-beta receptors to: 1) downregulate receptor signaling, 2) promote receptor endocytosis, and 3) activate MAP kinase- and Src-dependent signaling pathways; in vivo, arr-1 activity is required for normal egg laying and for proper olfactory adaptation and recovery to volatile odorants; in addition, animals doubly mutant for arr-1 and grk-2, which encodes a G protein-coupled receptor kinase, are sick and slow growing; ARR-1 is detected throughout the nervous system and is highly expressed in the amphid chemosensory neurons; in neuronal cells, ARR-1 appears to be largely cytoplasmic; ARR-1 interacts physically with clathrin and beta2-adaptin, two proteins involved in receptor endocytosis.
50	ZC132.9	ZC132.9	n/a	chrV 4,318,616