UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	folt-1	C06H2.4	0	chrV 11,142,257	folt-1 encodes a folate transporter required for folate uptake; FOLT-1 is orthologous to human SLC19A1 (OMIM:600424), SLC19A2 (OMIM:603941, mutated in thiamine-responsive megaloblastic anemia syndrome), and SLC19A3 (OMIM:606152, mutated in biotin-responsive basal ganglia disease); heterologously expressed FOLT-1 transports folate in vitro; FOLT-1 activity is acid-dependent, is sodium-independent, and is inhibited by folate derivatives, sulfasalazine, or anion transport inhibitors such as 4,4''-diisothio-cyanatostilbene-2,2''-disulphonic acid (DIDS); folt-1(ok1460) and folt-1(RNAi) animals show significantly lowered folate uptake; folt-1 is expressed in several tissues, including (most strongly) pharynx and posterior intestine, as well as head, body wall, and vulva muscles, and gonad sheath cells; FOLT-1's intestinal expression diminishes with age from larvae to adults; both FOLT-1 intestinal expression and whole-animal folate uptake are lowered in folate-supplemented food media; FOLT-1 has no obvious function in mass RNAi assays, perhaps because of genetic redundancy with its paralogs FOLT-2 and FOLT-3; however, folt-1(ok1460) mutants are sluggish and sterile, which might instead indicate that FOLT-1 is required for locomotion and fertility.
2	pac-1	C04D8.1	n/a	chrIII 8,508,167	C. elegans PAC-1 protein; contains similarity to Pfam domains PF00620 (RhoGAP domain) , PF00169 (PH domain) contains similarity to Interpro domains IPR008936 (Rho GTPase activation protein), IPR001849 (Pleckstrin-like), IPR000104 (Antifreeze protein, type I), IPR011993 (Pleckstrin homology-type), IPR000198 (RhoGAP)
3	F23F1.4	F23F1.4	n/a	chrII 26,912
4	Y6B3B.9	Y6B3B.9	n/a	chrI 13,743,033	contains similarity to Pfam domain PF04031 Las1-like contains similarity to Interpro domain IPR007174 (Las1-like)
5	cdr-1	F35E8.11	n/a	chrV 15,922,065	cdr-1 encodes a member of the cadmium-inducible lysosomal family that affects susceptibility to cadmium toxicity; expressed in intestinal cells.
6	math-11	C16C4.16	n/a	chrII 1,874,693	C. elegans MATH-11 protein; contains similarity to Pfam domain PF00917 MATH domain contains similarity to Interpro domains IPR008974 (TRAF-like), IPR002083 (MATH)
7	T10F2.4	T10F2.4	n/a	chrIII 5,171,158	contains similarity to Pfam domains PF08606 (Prp19/Pso4-like) , PF00400 (WD domain, G-beta repeat) (6)contains similarity to Interpro domains IPR003613 (U box), IPR011046 (WD40 repeat-like), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR009053 (Prefoldin), IPR001680 (WD40 repeat), IPR013915 (Pre-mRNA-splicing factor 19), IPR011042 (Six-bladed beta-propeller, TolB-like), IPR015943 (WD40/YVTN repeat-like)
8	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
9	ZK742.3	ZK742.3	n/a	chrV 7,809,120	contains similarity to Pfam domain PF00724 NADH:flavin oxidoreductase / NADH oxidase family contains similarity to Interpro domains IPR013785 (Aldolase-type TIM barrel), IPR001155 (NADH:flavin oxidoreductase/NADH oxidase, N-terminal)
10	Y47H9C.2	Y47H9C.2	n/a	chrI 11,842,812	contains similarity to Pfam domain PF01529 DHHC zinc finger domain contains similarity to Interpro domain IPR001594 (Zinc finger, DHHC-type)
11	clec-187	ZK896.6	n/a	chrIV 12,870,360	C. elegans CLEC-187 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR003990 (Pancreatitis-associated protein), IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
12	dcs-1	Y113G7A.9	n/a	chrV 20,084,683	dcs-1 encodes a scavenger mRNA decapping enzyme; dcs-1 exhibits hydrolase activity in vitro, with specificity for 7meGMP in its primary nucleoside monophosphate binding site; dcs-1 is the upstream gene in an operon with fre-1, which encodes an NADPH-dependent flavin reductase; reporter fusions using dcs-1 upstream sequence direct expression throughout the life cycle in neurons and pharyngeal muscle; expression is present in dauer larvae and enhanced by heat shock.
13	clec-149	K02F3.5	n/a	chrIII 824,783	K02F3.5 encodes a protein with a C-terminal C-type lectin domain that inhibits CEP-1- and HUS-1-dependent germline apoptosis, as do BMK-1, RAD-50, and RAD-51.
14	F09G8.3	F09G8.3	n/a	chrIII 8,266,869	contains similarity to Pfam domain PF00380 Ribosomal protein S9/S16 contains similarity to Interpro domains IPR000754 (Ribosomal protein S9), IPR014721 (Ribosomal protein S5 domain 2-type fold)
15	C35B1.2	C35B1.2	n/a	chrIV 4,094,546	n/a
16	F59B10.3	F59B10.3	n/a	chrII 10,511,687	contains similarity to Interpro domain IPR016196 (MFS general substrate transporter)
17	C52B9.8	C52B9.8	n/a	chrX 4,300,505	contains similarity to Pfam domains PF00271 (Helicase conserved C-terminal domain) , PF07529 (HSA) , PF04851 (Type III restriction enzyme, res subunit) , PF00176 (SNF2 family N-terminal domain) contains similarity to Interpro domains IPR006935 (Restriction endonuclease, type I, R subunit/Type III, Res subunit), IPR013999 (HAS subgroup), IPR014012 (Helicase/SANT-associated, DNA binding), IPR000330 (SNF2-related), IPR014021 (Helicase, superfamily 1 and 2, ATP-binding), IPR006562 (HSA), IPR005448 (Voltage-dependent calcium channel, P/Q-type, alpha-1 subunit), IPR014001 (DEAD-like helicase, N-terminal), IPR001650 (DNA/RNA helicase, C-terminal)
18	sid-2	ZK520.2	n/a	chrIII 13,680,827	sid-2 encodes a novel, single-pass transmembrane protein; SID-2 is required for environmental-mediated (i.e. ingestion or soaking) RNA interference (RNAi); SID-2::GFP is expressed strongly in the intestine where it localizes to the apical (lumenal) membrane; SID-2::GFP is also expressed at much lower levels in the excretory duct cells; when expressed in Caenorhabditis briggsae, a related nematode species deficient for environmental RNAi, SID-2 is able to confer environmental RNAi.
19	rnf-1	C06A5.9	n/a	chrI 6,010,654	C. elegans RNF-1 protein; contains similarity to Pfam domain PF00097 Zinc finger, C3HC4 type (RING finger) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type)
20	F49E8.6	F49E8.6	n/a	chrIV 7,553,994	contains similarity to Interpro domain IPR000694 (Proline-rich region)
21	F53E10.1	F53E10.1	n/a	chrV 2,617,140	contains similarity to Pfam domains PF03473 (MOSC domain) , PF03476 (MOSC N-terminal beta barrel domain) contains similarity to Interpro domains IPR005303 (MOSC, N-terminal beta barrel), IPR005302 (Molybdenum cofactor sulphurase, C-terminal), IPR011037 (Pyruvate kinase, beta-barrel-like)
22	T07D3.4	T07D3.4	n/a	chrII 889,513	T07D3.4 is orthologous to the human gene FUKUTIN (FCMD; OMIM:253800), which when mutated leads to disease.
23	gst-12	F37B1.2	n/a	chrII 13,617,244	C. elegans GST-12 protein; contains similarity to Pfam domains PF00043 (Glutathione S-transferase, C-terminal domain) , PF02798 (Glutathione S-transferase, N-terminal domain) contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR012335 (Thioredoxin fold), IPR004046 (Glutathione S-transferase, C-terminal), IPR004045 (Glutathione S-transferase, N-terminal), IPR010987 (Glutathione S-transferase, C-terminal-like)
24	srx-36	T01C4.6	n/a	chrV 7,130,371	C. elegans SRX-36 protein; contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR000276 (GPCR, rhodopsin-like)
25	goa-1	C26C6.2	n/a	chrI 7,524,411	goa-1 encodes an ortholog of the heterotrimeric G protein alpha subunit Go (Go/Gi class) that affects normal locomotion, egg-laying, and male mating; it genetically interacts with the egl-30 pathway, and is expressed in all neurons and sex-specific muscles.
26	lgc-40	T24D8.1	n/a	chrX 2,362,451	C. elegans LGC-40 protein; contains similarity to Pfam domains PF02931 (Neurotransmitter-gated ion-channel ligand binding domain) , PF02932 (Neurotransmitter-gated ion-channel transmembrane region) contains similarity to Interpro domains IPR006028 (Gamma-aminobutyric acid A receptor), IPR006201 (Neurotransmitter-gated ion-channel), IPR006202 (Neurotransmitter-gated ion-channel ligand-binding), IPR006029 (Neurotransmitter-gated ion-channel transmembrane region)
27	C06H5.6	C06H5.6	n/a	chrV 17,884,381	contains similarity to Pfam domains PF00083 (Sugar (and other) transporter) , PF07690 (Major Facilitator Superfamily) contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR005828 (General substrate transporter), IPR016196 (MFS general substrate transporter)
28	E02C12.6	E02C12.6	n/a	chrV 9,370,290	contains similarity to Pfam domains PF02958 (Domain of unknown function (DUF227)) , PF07914 (Protein of unknown function (DUF1679)) contains similarity to Interpro domains IPR011009 (Protein kinase-like), IPR012877 (Protein of unknown function DUF1679, Caenorhabditis species), IPR004119 (Protein of unknown function DUF227), IPR015897 (CHK kinase-like)
29	F54E2.5	F54E2.5	n/a	chrV 2,814,230	contains similarity to Pfam domain PF04789 Protein of unknown function (DUF621) contains similarity to Interpro domains IPR006874 (Protein of unknown function DUF621), IPR003091 (Voltage-dependent potassium channel)
30	nlp-17	Y45F10A.5	n/a	chrIV 13,505,484	C. elegans NLP-17 protein ;
31	K10H10.1	K10H10.1	n/a	chrII 14,491,241	contains similarity to Pfam domain PF07690 Major Facilitator Superfamily contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR016196 (MFS general substrate transporter)
32	F38B6.3	F38B6.3	n/a	chrX 6,693,910
33	C46C11.3	C46C11.3	n/a	chrX 4,630,409
34	Y47D3B.1	Y47D3B.1	n/a	chrIII 11,385,678	contains similarity to Pfam domain PF01697 Domain of unknown function contains similarity to Interpro domains IPR008166 (Protein of unknown function DUF23), IPR000276 (GPCR, rhodopsin-like)
35	srd-43	R04D3.9	n/a	chrX 13,304,796	C. elegans SRD-43 protein ;
36	R02E12.4	R02E12.4	n/a	chrX 4,005,562	contains similarity to Pfam domains PF03148 (Tektin family) , PF00097 (Zinc finger, C3HC4 type (RING finger)) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR000435 (Tektin), IPR013083 (Zinc finger, RING/FYVE/PHD-type)
37	Y57G11A.4	Y57G11A.4	n/a	chrIV 14,484,352	contains similarity to Interpro domain IPR005018 (DOMON related)
38	C01F1.2	C01F1.2	n/a	chrII 4,300,243	C01F1.2 is orthologous to the human gene SCO (CYTOCHROME OXIDASE DEFICIENT, YEAST) HOMOLOG 1 (SCO1; OMIM:603644), which when mutated leads to early-onset hepatic failure; the C01F1.2 protein is predicted to be mitochondrial with 68% accuracy.
39	Y32B12B.1	Y32B12B.1	n/a	chrV 16,536,916	contains similarity to Leptospira kirschneri serovar grippotyphosa Hypothetical protein.; TR:Q8KWV2
40	F09E10.5	F09E10.5	n/a	chrX 1,492,033
41	Y45F10D.6	Y45F10D.6	n/a	chrIV 13,797,043
42	D2021.8	D2021.8	n/a	chrX 8,552,722	contains similarity to Pfam domain PF00023 Ankyrin repeat contains similarity to Interpro domain IPR002110 (Ankyrin)
43	K08B12.3	K08B12.3	n/a	chrV 6,236,378	contains similarity to Pfam domain PF00702 haloacid dehalogenase-like hydrolase contains similarity to Interpro domains IPR006355 (HAD-superfamily hydrolase, subfamily IIA, hypothetical 2), IPR006357 (HAD-superfamily hydrolase, subfamily IIA), IPR005834 (Haloacid dehalogenase-like hydrolase)
44	K03B8.8	K03B8.8	n/a	chrV 11,410,221	contains similarity to Interpro domains IPR006030 (Molluscan rhodopsin C-terminal tail), IPR000694 (Proline-rich region)
45	F32G8.4	F32G8.4	n/a	chrV 10,559,356	contains similarity to Pfam domain PF01062 Bestrophin contains similarity to Interpro domain IPR000615 (Bestrophin)
46	F10E7.10	F10E7.10	n/a	chrII 7,114,773	contains similarity to Pfam domain PF00100 Zona pellucida-like domain contains similarity to Interpro domain IPR001507 (Endoglin/CD105 antigen)
47	fbxb-100	Y63D3A.2	n/a	chrI 14,093,529	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
48	cyp-43A1	E03E2.1	n/a	chrX 5,716,005	C. elegans CYP-43A1 protein; contains similarity to Pfam domain PF00067 Cytochrome P450 contains similarity to Interpro domains IPR001128 (Cytochrome P450), IPR002401 (Cytochrome P450, E-class, group I), IPR002402 (Cytochrome P450, E-class, group II), IPR002403 (Cytochrome P450, E-class, group IV)
49	tra-3	LLC1.1	n/a	chrIV 14,440,241	tra-3 encodes an atypical calpain regulatory protease that lacks calcium-binding EF hand domains; during development, TRA-3 likely promotes female development in XX hermaphrodites by cleaving the membrane-associated TRA-2A protein to generate a TRA-2 peptide likely to have feminizing activity; in addition, TRA-3 is one of several proteases that mediate necrotic cell death during neurodegeneration.
50	Y4C6B.6	Y4C6B.6	n/a	chrIV 5,347,749	The Y4C6B.6 gene encodes a homolog of the human gene GLCM, which when mutated leads to Gaucher disease type I (OMIM:230800).