UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	srp-2	C05E4.1	0	chrV 763,702	srp-2 encodes an ovalbumin-like serpin (ov-serpin) member of the serine protease inhibitor superfamily that is orthologous to human NEUROSERPIN (OMIM:602445, mutated in familial encephalopathy with neuroserpin inclusion bodies); SRP-2 is predicted to function as a suicide substrate that inhibits the proteolytic activity of serine proteases, and in vitro, recombinant SRP-2 is able to inhibit granzyme B activity; however, as loss of srp-2 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of SRP-2 in C. elegans development and/or behavior is not yet known; srp-2 expression is detected in hypodermal cells, particularly in the lateral seam cells.
2	T13F2.6	T13F2.6	n/a	chrIV 9,779,719
3	C42C1.2	C42C1.2	n/a	chrIV 12,266,886	contains similarity to Pfam domain PF00481 Protein phosphatase 2C contains similarity to Interpro domains IPR001932 (Protein phosphatase 2C-related), IPR000222 (), IPR014045 (Protein phosphatase 2C, N-terminal), IPR015655 (Protein phosphatase 2C)
4	Y57G11C.18	Y57G11C.18	n/a	chrIV 14,841,760	contains similarity to Interpro domain IPR000767 (Disease resistance protein)
5	gna-2	T23G11.2	n/a	chrI 7,700,248	gna-2 encodes a glucosamine 6-phosphate N-acetyltransferase required for synthesis of UDP-N-acetylglucosamine (UDP-GlcNAc), N-acetylgalactosamine (UDP-GalNAc), alpha-GalNAc-modifications of mucin-like proteins, and chitin; GNA-2 is also required for eggshell synthesis and osmotic integrity, progression past meiosis metaphase I, error-free chromosomal segregation during meiosis, polar body extrusion, association of the sperm pronucleus/centrosome complex (SPCC) with the early embryonic cortex, localization of PAR-2 in early embryos, posterior localization of P granules or PIE-1, and pseudocleavage; gna-2 transcription is elevated during oogenesis; gna-2 mRNA is posttranslationally inhibited both by GLD-1 repression and by nonsense-mediated mRNA decay (NMD), with GLD-1 predominating in distal gonads and NMD (incompletely) predominating in proximal ones; gna-2 mRNA has two upstream open reading frames (uORFs) with premature stop codons, which normally cause NMD of this mRNA unless it is protected by GLD-1 binding to the gna-2 mRNA's 5' UTR; conversely, gna-2 mRNA is translationally repressed by bound GLD-1 during pachytene meiosis, and must be freed from this repression during diplotene meiosis for eggshell synthesis to proceed; gna-2(qa705) is suppressed by sup-46 mutations, but only in a gna-1(+) background.
6	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
7	C50B6.1	C50B6.1	n/a	chrV 13,308,835	contains similarity to Synechocystis sp Hypothetical protein slr1813.; TR:P73698
8	M02B7.1	M02B7.1	n/a	chrIV 3,806,054
9	C49C8.3	C49C8.3	n/a	chrIV 8,644,987
10	C16C4.1	C16C4.1	n/a	chrII 1,894,512
11	ref-1	T01E8.2	n/a	chrII 10,219,169	ref-1 encodes a protein with two basic helix-loop-helix (bHLH) domains that is distantly related to the hairy/Enhancer of split subfamily of bHLH transcription factors; REF-1 is required in hermaphrodites during early larval development for regulating the pattern of posterior Pn.p hypodermal cell fusions, primarily through regulation of MAB-5 homeodomain protein activity; REF-1 is also required for head morphogenesis and specification of the V6 lateral seam cell fate; in males, ref-1 is a target of MAB-3 transcriptional repression which in turn, promotes expression of LIN-32, a proneural bHLH transcription factor.
12	F46F5.14	F46F5.14	n/a	chrII 800,774	contains similarity to Pfam domain PF03314 Protein of unknown function, DUF273 contains similarity to Interpro domain IPR004988 (Protein of unknown function DUF273)
13	ZC155.4	ZC155.4	n/a	chrIII 5,213,465	contains similarity to Pfam domain PF03009 Glycerophosphoryl diester phosphodiesterase family contains similarity to Interpro domain IPR004129 (Glycerophosphoryl diester phosphodiesterase)
14	lgg-3	B0336.8	n/a	chrIII 5,697,730	lgg-3 encodes a hydrophilic protein that is orthologous to Saccharomyces cerevisiae autophagy protein Apg12p; by homology, LGG-3 is predicted to function as a modifier protein required for a protein conjugation system essential for autophagy; in the context of this conjugation system, LGG-3 is predicted to interact with Apg7p and Apg5p homologs (encoded by M7.5 and Y71G12B.12a, respectively) to effect bulk degradation of cytoplasmic components under conditions of starvation or cellular remodeling; free LGG-3 is predicted to localize to the cytoplasm, while LGG-3 conjugated to the Apg5p homolog is predicted to associate with membrane compartments; loss of lgg-3 activity via large-scale RNAi screens results in no obvious developmental or behavioral abnormalities.
15	W03G9.2	W03G9.2	n/a	chrI 4,963,346	contains similarity to Interpro domains IPR000994 (Peptidase M24, catalytic core), IPR001545 (Gonadotropin, beta chain)
16	C01G6.4	C01G6.4	n/a	chrII 9,272,092	contains similarity to Pfam domain PF00097 Zinc finger, C3HC4 type (RING finger) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR011016 (Zinc finger, variant RING-type)
17	K08D9.6	K08D9.6	n/a	chrV 3,233,173	contains similarity to Pfam domain PF01697 Domain of unknown function contains similarity to Interpro domains IPR008167 (Protein of unknown function DUF23, C-terminal), IPR008166 (Protein of unknown function DUF23)
18	F57E7.2	F57E7.2	n/a	chrV 16,482,980	contains similarity to Psilotum nudum Hypothetical protein.; TR:Q8WHW9
19	F15D4.2	F15D4.2	n/a	chrII 13,216,307	contains similarity to Strongylocentrotus purpuratus Protein ENDO16 (Fragment).; SW:P13665
20	ttr-30	T08A9.2	n/a	chrX 7,331,455	C. elegans TTR-30 protein; contains similarity to Pfam domain PF01060 Transthyretin-like family contains similarity to Interpro domain IPR001534 (Transthyretin-like)
21	D2007.1	D2007.1	n/a	chrIII 8,155,633
22	C47D12.5	C47D12.5	n/a	chrII 11,685,843
23	F07G11.2	F07G11.2	n/a	chrV 7,304,229	contains similarity to Pfam domain PF01482 Domain of unknown function DUF13 contains similarity to Interpro domain IPR002485 (Protein of unknown function DUF13)
24	H43I07.1	H43I07.1	n/a	chrV 4,206,564	contains similarity to Interpro domains IPR010754 (Optic atrophy 3-like), IPR005819 (Histone H5)
25	M04F3.5	M04F3.5	n/a	chrI 4,775,768	contains similarity to Pfam domain PF08397 IRSp53/MIM homology domain contains similarity to Interpro domain IPR013606 (IRSp53/MIM homology domain (IMD))
26	Y106G6H.16	Y106G6H.16	n/a	chrI 10,475,167	contains similarity to Salmonella typhimurium Putative cytoplasmic protein (STMF1.42 protein).; TR:Q9L9K2
27	spp-6	T08A9.10	n/a	chrX 7,317,449	spp-6 encodes a predicted transmembrane protein containing a saposin (B) domain that is a member of a saposin-like protein superfamily containing mammalian NK-lysin and granulysin and the protozoan amoebapores; SPP-6 is predicted to function as a lipid-binding protein that may possess pore-forming, cytotoxic activity; as loss of SPP-6 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of SPP-6 in C. elegans development and/or behavior is not yet known.
28	T20D4.7	T20D4.7	n/a	chrV 3,409,192	contains similarity to Pfam domains PF08534 (Redoxin) , PF00578 (AhpC/TSA family) contains similarity to Interpro domains IPR011594 (Thioredoxin-like), IPR013740 (Redoxin), IPR012336 (Thioredoxin-like fold), IPR012335 (Thioredoxin fold), IPR000866 (Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen), IPR006662 (Thioredoxin-related)
29	srbc-68	T24A6.13	n/a	chrV 3,546,145	C. elegans SRBC-68 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR002651 (Protein of unknown function DUF32)
30	M116.1	M116.1	n/a	chrIV 8,411,585
31	B0416.2	B0416.2	n/a	chrX 9,299,586
32	R02D5.4	R02D5.4	n/a	chrV 14,484,482	contains similarity to Homo sapiens Splice isoform 1 of P49639 Homeobox protein Hox-A1; ENSEMBL:ENSP00000325321
33	T20F10.4	T20F10.4	n/a	chrI 10,305,153	contains similarity to Streptococcus mutans Putative 16S rRNA processing protein.; TR:Q8DUN7
34	EEED8.13	EEED8.13	n/a	chrII 5,411,874	contains similarity to Interpro domain IPR011038 (Calycin-like)
35	sra-14	F35C5.2	n/a	chrII 12,886,826	C. elegans SRA-14 protein; contains similarity to Pfam domain PF02117 C.elegans Sra family integral membrane protein contains similarity to Interpro domains IPR002184 (Serpentine beta receptor), IPR000344 (Nematode chemoreceptor, Sra)
36	acl-1	F59F4.4	n/a	chrX 15,850,758	acl-1 encodes a 1-acyl-sn-glycerol-3-phosphate acyltransferase; ACL-1 is predicted to be a membrane protein that plays a role in phospholipid biosynthesis, but as loss of acl-1 activity via large-scale RNAi experiments results in no obvious defects, the precise role of ACL-1 in C. elegans development and/or behavior is not yet known.
37	fbxb-35	F07E5.2	n/a	chrII 2,052,208	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function.
38	ZK858.1	ZK858.1	n/a	chrI 9,119,671	contains similarity to Pfam domains PF03828 (Poly(A) polymerase) , PF01909 (Nucleotidyltransferase domain) contains similarity to Interpro domains IPR002934 (Nucleotidyltransferase), IPR002058 (PAP/25A-associated)
39	his-8	F45F2.12	n/a	chrV 8,532,878	his-8 encodes an H2B histone; his-8 is contained within the histone gene cluster HIS2.
40	F57A8.4	F57A8.4	n/a	chrV 10,067,924	contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR000276 (GPCR, rhodopsin-like)
41	F35E8.7	F35E8.7	n/a	chrV 15,914,552	contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domains IPR000104 (Antifreeze protein, type I), IPR003582 (Metridin-like ShK toxin)
42	F17E9.2	F17E9.2	n/a	chrIV 8,356,187
43	hlh-12	C28C12.8	n/a	chrIV 8,478,993	C. elegans HLH-12 protein; contains similarity to Pfam domain PF00010 Helix-loop-helix DNA-binding domain contains similarity to Interpro domains IPR001092 (Basic helix-loop-helix dimerisation region bHLH), IPR011598 (Helix-loop-helix DNA-binding), IPR002418 (Transcription regulator Myc)
44	Y37D8A.21	Y37D8A.21	n/a	chrIII 12,929,839	contains similarity to Pfam domain PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) contains similarity to Interpro domains IPR012677 (Nucleotide-binding, alpha-beta plait), IPR000504 (RNA recognition motif, RNP-1)
45	Y57G11B.1	Y57G11B.1	n/a	chrIV 14,550,857	contains similarity to Trichomonas vaginalis G3 Viral A-type inclusion protein, putative.; TR:A2EJ43
46	prom-1	F26H9.1	n/a	chrI 9,288,599	prom-1 encodes an F-box protein orthologous to to human FBXO47 (OMIM:609498, deleted in renal cell carcinoma) and paralogous to F54D5.9, that is required during meiotic prophase I for homologous chromosome pairing and rapid meiotic progression; prom-1 mutants exhibit increased germline apoptosis, reduced and variable bivalent formation in meiotic prophase, reduced meiotic recombination, delayed meiotic entry, delayed and asynchronous nuclear reorganization in meiotic prophase, high embryonic lethality (averaging ~90%, but varying from 46-99% even in a null prom-1[ok1140] mutant strain), decreased brood sizes, and an abnormally high frequency of male progeny (22%, probably due to nonsegregating X chromsomes); the apoptotic phenotype of prom-1 is suppressed by spo-11(ok79), and prom-1 mutants show accumulated RAD-51 protein in meiotic nuclei, indicating that prom-1 meiotic defects arises from a failure to resolve meiotic double-stranded DNA breaks.
47	str-135	F21F8.10	n/a	chrV 8,280,076	C. elegans STR-135 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
48	ZK632.9	ZK632.9	n/a	chrIII 9,825,065	contains similarity to Barley yellow dwarf virus Coat protein.; SW:COAT_BYDVN
49	K02A2.1	K02A2.1	n/a	chrII 7,435,459	contains similarity to Pfam domain PF01738 Dienelactone hydrolase family contains similarity to Interpro domain IPR002925 (Dienelactone hydrolase)
50	sago-1	K12B6.1	n/a	chrV 6,306,024	sago-1 encodes an Argonaute homolog that is partially required for the amplification phase of RNAi responses; a multiply mutant strain (MAGO), consisting of ppw-1(tm914), sago-1(tm1195), sago-2(tm894), F58G1.1(tm1019), C06A1.4(tm887), and M03D4.6(tm1144) alleles, is completely resistant to both germline and somatic RNAi; sago-1 is genetically redundant with ppw-1 and sago-2, with any one of these genes being able to transgenically partially restore the deficiency of MAGO worms; GFP-tagged SAGO-1 binds small secondary siRNAs produced by RNAi against GFP; MAGO is not transgenically rescued by rde-1; strains overexpressing GFP::SAGO-1 exhibited an enhanced level of RNAi overall, suggesting that SAGO-1 and its congeners are rate-limiting in vivo for RNAi.