UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	let-756	C05D11.4	0	chrIII 6,408,515	let-756 encodes an fibroblast growth factor (FGF)-like ligand that is required for progression through early larval development; LET-756 is expressed from late embryogenesis to adulthood, with a peak of expression in larvae; with EGL-17, LET-756 is redundantly required to activate EGL-15/FGFR, which in turn activates protein degradation in adult muscle cells; homozygotes for partial loss-of-function alleles are small, clear, and scrawny, but viable, while those for a null allele arrest in early larval development.
2	C40A11.6	C40A11.6	n/a	chrII 2,144,971	contains similarity to Pfam domain PF02214 K+ channel tetramerisation domain contains similarity to Interpro domains IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR003131 (Potassium channel, voltage dependent, Kv, tetramerisation)
3	srv-32	T13A10.12	n/a	chrIV 6,281,179	C. elegans SRV-32 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR002651 (Protein of unknown function DUF32), IPR000366 (Fungal pheromone mating factor STE2 GPCR)
4	C30E1.7	C30E1.7	n/a	chrX 16,915,205
5	C15C8.4	C15C8.4	n/a	chrV 12,746,483	contains similarity to Pfam domain PF06401 Alpha-2-macroglobulin RAP, C-terminal domain contains similarity to Interpro domains IPR010483 (Alpha-2-macroglobulin RAP, C-terminal), IPR009066 (Alpha-2-macroglobulin receptor-associated protein, domain 1)
6	ZC190.2	ZC190.2	n/a	chrV 8,682,033	contains similarity to Pfam domain PF03125 C. elegans Sre G protein-coupled chemoreceptor contains similarity to Interpro domains IPR004151 (C. elegans Sre G protein-coupled chemoreceptor), IPR000366 (Fungal pheromone mating factor STE2 GPCR)
7	C33A12.12	C33A12.12	n/a	chrIV 9,483,553	contains similarity to Interpro domains IPR000225 (Armadillo), IPR016024 (Armadillo-type fold)
8	sup-10	R09G11.1	n/a	chrX 17,529,998	C. elegans SUP-10 protein ;
9	sra-25	T26E3.9	n/a	chrI 12,687,150	C. elegans SRA-25 protein; contains similarity to Pfam domain PF02117 C.elegans Sra family integral membrane protein contains similarity to Interpro domains IPR003945 (NADH-plastoquinone oxidoreductase, chain 5), IPR000344 (Nematode chemoreceptor, Sra)
10	ZK1248.7	ZK1248.7	n/a	chrII 5,813,080	contains similarity to Pfam domain PF02171 Piwi domain contains similarity to Interpro domains IPR003165 (Stem cell self-renewal protein Piwi), IPR012337 (Polynucleotidyl transferase, Ribonuclease H fold)
11	fbxa-118	M162.8	n/a	chrV 19,772,016	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
12	utx-1	D2021.1	n/a	chrX 8,560,128	utx-1 encodes a putative histone H3 di/trimethyllysine-27 (H3K27me2/me3) demethylase, required for embryonic viability and vulval development, and for high brood sizes, locomotion, and growth sizes; UTX-1 contains a JmjC domain, is orthologous to human UTX and UTY, and is paralogous to human JMJD3; by orthology, UTX-1 is expected to antagonize transcriptional repression by polycomb repressor complexes, which mark stem cells (and presumably germline) by H3K27me3-mediated repression of somatic genes.
13	T10B5.3	T10B5.3	n/a	chrV 1,866,374	contains similarity to Pfam domain PF08162 NUC189 domain contains similarity to Interpro domain IPR012979 (Protein of unknown function NUC189, C-terminal)
14	W03C9.6	W03C9.6	n/a	chrII 11,957,465	contains similarity to Interpro domains IPR006052 (Tumor Necrosis Factor), IPR016196 (MFS general substrate transporter)
15	F59A1.13	F59A1.13	n/a	chrV 17,689,072	contains similarity to Pfam domains PF00610 (Domain found in Dishevelled, Egl-10, and Pleckstrin) , PF00595 (PDZ domain (Also known as DHR or GLGF)) , PF02377 (Dishevelled specific domain) contains similarity to Interpro domains IPR003351 (Dishevelled protein), IPR011991 (Winged helix repressor DNA-binding), IPR001478 (PDZ/DHR/GLGF), IPR015506 (Dishevelled related protein), IPR008339 (Dishevelled region), IPR000591 (Pleckstrin/ G-protein, interacting region)
16	fbxa-11	T12B5.4	n/a	chrIII 951,455	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
17	ugt-32	F47C10.6	n/a	chrV 3,842,918	C. elegans UGT-32 protein; contains similarity to Pfam domain PF00201 UDP-glucoronosyl and UDP-glucosyl transferase contains similarity to Interpro domain IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase)
18	F16B12.1	F16B12.1	n/a	chrX 14,087,466	contains similarity to Pfam domain PF00431 CUB domain contains similarity to Interpro domain IPR000859 (CUB)
19	srh-199	ZK697.11	n/a	chrV 1,750,776	C. elegans SRH-199 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
20	mkk-4	F42G10.2	n/a	chrX 10,028,926	mkk-4 encodes a MAP (mitogen-activated protein) kinase kinase that is a member of the MKK4 family of MAPKK's; MKK-4 activity is required in presynaptic neurons, in a dose-dependent manner, for normal presynaptic development and morphology; in regulating presynaptic organization, MKK-4 acts upstream of PMK-3/MAPK and downstream of DLK-1/MAPKKK, whose levels are negatively regulated by the RPM-1 ubiquitin ligase; a functional MKK-4::GFP fusion protein is expressed in the cytoplasm of many neurons as well as in other cell types, including the pharyngeal muscles.
21	W05H12.2	W05H12.2	n/a	chrI 13,412,326	contains similarity to Pfam domain PF01612 3'-5' exonuclease contains similarity to Interpro domains IPR002562 (3'-5' exonuclease), IPR012337 (Polynucleotidyl transferase, Ribonuclease H fold)
22	T10D4.11	T10D4.11	n/a	chrII 3,149,102	contains similarity to Pfam domain PF02343 Domain of unknown function DUF130 contains similarity to Interpro domain IPR003326 (Protein of unknown function DUF130)
23	F52H2.6	F52H2.6	n/a	chrX 2,561,931	F52H2.6 is orthologous to the human gene 3BETA-HYDROXYSTEROL DELTA 24 REDUCTASE (DHCR24; OMIM:606418), which when mutated leads to disease.
24	ZK1307.7	ZK1307.7	n/a	chrII 9,638,262	contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR000276 (GPCR, rhodopsin-like)
25	pqn-29	F10F2.9	n/a	chrIII 4,645,137	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
26	T19B10.9	T19B10.9	n/a	chrV 11,249,483	contains similarity to Interpro domain IPR000694 (Proline-rich region)
27	knl-2	K06A5.4	n/a	chrI 6,462,350	C. elegans KNL-2 protein; contains similarity to Pfam domain PF09133 SANTA (SANT Associated) contains similarity to Interpro domain IPR015216 (SANT associated)
28	W02F12.2	W02F12.2	n/a	chrV 6,696,417	contains similarity to Pfam domain PF05875 Alkaline phytoceramidase (aPHC) contains similarity to Interpro domain IPR008901 (Alkaline phytoceramidase)
29	F47B3.3	F47B3.3	n/a	chrI 3,964,844	contains similarity to Pfam domain PF01284 Membrane-associating domain contains similarity to Interpro domain IPR008253 (Marvel)
30	wrt-7	ZK1037.10	n/a	chrV 15,336,119	wrt-7 encodes a hedgehog-like protein, with (from N- to C-terminus) a signal sequence, a Wart domain, and a Hint/Hog domain; the Hint/Hog domain is predicted to cut WRT-7 into two halves and then covalently link cholesterol to the C-terminus of the Wart domain; the Wart domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins; WRT-7 is required for normal growth to full size and locomotion; both of these requirements may reflect common defects in cholesterol-dependent hedgehog-like signalling or in vesicle trafficking.
31	W05H9.2	W05H9.2	n/a	chrX 6,269,009
32	F52G3.3	F52G3.3	n/a	chrX 16,946,368	contains similarity to Medicago truncatula Putative uncharacterized protein.; TR:A2Q378
33	F54H12.4	F54H12.4	n/a	chrIII 7,962,097
34	D2023.5	D2023.5	n/a	chrV 11,826,462	contains similarity to Interpro domain IPR001763 (Rhodanese-like)
35	F40F8.5	F40F8.5	n/a	chrII 11,133,818	contains similarity to Oryctolagus cuniculus Sarcoplasmic reticulum histidine-rich calcium-binding proteinsprecursor.; SW:P16230
36	ins-34	F52B11.6	n/a	chrIV 14,107,090	ins-34 encodes an insulin-like peptide.
37	C54F6.5	C54F6.5	n/a	chrV 7,529,245
38	T08G11.3	T08G11.3	n/a	chrI 8,923,130	contains similarity to Bos taurus Hypothetical LOC539526.; TR:Q32KR7
39	W03F9.1	W03F9.1	n/a	chrV 125,395	contains similarity to Pfam domain PF03367 ZPR1 zinc-finger domain contains similarity to Interpro domain IPR004457 (Zinc finger, ZPR1-type)
40	C02C2.5	C02C2.5	n/a	chrIII 7,877,970	contains similarity to Pfam domain PF00881 Nitroreductase family contains similarity to Interpro domain IPR000415 (Nitroreductase)
41	K04G2.9	K04G2.9	n/a	chrI 8,056,298	contains similarity to Pfam domain PF01284 Membrane-associating domain contains similarity to Interpro domain IPR008253 (Marvel)
42	F23F1.6	F23F1.6	n/a	chrII 36,279	contains similarity to Pfam domain PF00324 Amino acid permease contains similarity to Interpro domains IPR004755 (Cationic amino acid transport permease), IPR004841 (Amino acid permease-associated region), IPR002293 (Amino acid/polyamine transporter I)
43	F54D8.6	F54D8.6	n/a	chrIII 5,104,430	contains similarity to Interpro domain IPR000694 (Proline-rich region)
44	ceh-23	ZK652.5	n/a	chrIII 7,840,469	The ceh-23 gene encodes a homeodomain protein required for a specific differentiated trait of the thermosensory interneuron AIY.
45	C08B6.3	C08B6.3	n/a	chrV 10,111,050	contains similarity to Pfam domain PF01697 Domain of unknown function contains similarity to Interpro domain IPR008166 (Protein of unknown function DUF23)
46	C53A5.6	C53A5.6	n/a	chrV 14,544,748	contains similarity to Pfam domains PF01344 (Kelch motif) (5), PF00097 (Zinc finger, C3HC4 type (RING finger)) , PF07646 (Kelch motif) (4)contains similarity to Interpro domains IPR011043 (Galactose oxidase/kelch, beta-propeller), IPR001841 (Zinc finger, RING-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR006652 (Kelch repeat type 1), IPR011498 (Kelch repeat type 2), IPR015916 (Galactose oxidase, beta-propeller), IPR013089 (Kelch related), IPR006651 (Kelch), IPR015915 (Kelch-type beta propeller)
47	lys-9	C54C8.6	n/a	chrI 12,455,280	C. elegans LYS-9 protein; contains similarity to Interpro domain IPR017853 (Glycoside hydrolase, catalytic core)
48	F42G8.6	F42G8.6	n/a	chrIV 8,131,368	contains similarity to Pfam domains PF05237 (MoeZ/MoeB domain) , PF00581 (Rhodanese-like domain) , PF00899 (ThiF family) contains similarity to Interpro domains IPR001763 (Rhodanese-like), IPR003016 (2-oxo acid dehydrogenase, lipoyl-binding site), IPR009036 (Molybdenum cofactor biosynthesis), IPR000594 (UBA/THIF-type NAD/FAD binding fold), IPR007901 (MoeZ/MoeB), IPR016040 (NAD(P)-binding)
49	C01A2.3	C01A2.3	n/a	chrI 13,389,622	contains similarity to Pfam domain PF02096 60Kd inner membrane protein contains similarity to Interpro domain IPR001708 (60 kDa inner membrane insertion protein)
50	ugt-41	F10D2.11	n/a	chrV 7,162,312	C. elegans UGT-41 protein; contains similarity to Pfam domain PF00201 UDP-glucoronosyl and UDP-glucosyl transferase contains similarity to Interpro domain IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase)