UCSC S. cerevisiae Gene Sorter

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UCSC S. cerevisiae Gene Sorter

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#	Name	SGD ORF	Module	BLASTP E-Value	Genome Position	Description
1	GLN3	YER040W	577	n/a	chrV 230,891	Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), localization and activity regulated by quality of nitrogen source
2	COX11	YPL132W	577	n/a	chrXVI 302,167	Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
3	MSN1	YOL116W	577	n/a	chrXV 100,383	Transcriptional activator involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress localizes to the nucleus
4	PEX4	YGR133W	577	n/a	chrVII 757,171	Peroxisomal ubiquitin conjugating enzyme required for peroxisomal matrix protein import and peroxisome biogenesis
5	MKK2	YPL140C	577	n/a	chrXVI 288,274	Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity upon activation by Bck1p phosphorylates downstream target, Slt2p functionally redundant with Mkk1p
6	PEX5	YDR244W	577	n/a	chrIV 951,482	Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import also proposed to have PTS1-receptor independent functions
7	SLM4	YBR077C	577	n/a	chrII 392,049	Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p gene exhibits synthetic genetic interaction with MSS4
8	MTC4	YBR255W	577	n/a	chrII 725,498	Protein of unknown function, required for normal growth rate at 15 degrees C green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern mtc4 is synthetically sick with cdc13-1
9	MDM31	YHR194W	577	n/a	chrVIII 489,526	Mitochondrial inner membrane protein with similarity to Mdm32p, required for normal mitochondrial morphology and inheritance interacts genetically with MMM1, MDM10, MDM12, and MDM34
10	JHD1	YER051W	577	n/a	chrV 255,395	JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe
11	TOK1	YJL093C	577	n/a	chrX 255,774	Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium carboxy tail functions to prevent inner gate closures target of K1 toxin
12	YJR061W	YJR061W	577	n/a	chrX 551,914	Putative protein of unknown function non-essential gene with similarity to Mnn4, a putative membrane protein involved in glycosylation transcription repressed by Rm101p
13	THI6	YPL214C	577	n/a	chrXVI 149,380	Bifunctional enzyme with thiamine-phosphate pyrophosphorylase and 4-methyl-5-beta-hydroxyethylthiazole kinase activities, required for thiamine biosynthesis GFP-fusion protein localizes to the cytoplasm in a punctate pattern
14	SAP155	YFR040W	577	n/a	chrVI 235,746	Protein that forms a complex with the Sit4p protein phosphatase and is required for its function member of a family of similar proteins including Sap4p, Sap185p, and Sap190p
15	AVT4	YNL101W	577	n/a	chrXIV 436,069	Vacuolar transporter, exports large neutral amino acids from the vacuole member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
16	ERP6	YGL002W	577	5e-115	chrVII 494,842	Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
17	CDC55	YGL190C	577	n/a	chrVII 146,599	Non-essential regulatory subunit B of protein phosphatase 2A (PP2A) involved in regulation of mitotic exit required for correct nuclear division and chromosome segregation in meiosis maintains sequestration of the phosphatase Cdc14p in nucleolus during early meiosis, which is essential for meiosis I spindle assembly limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion found in nucleus, bud neck and bud of most cells
18	SPP2	YOR148C	577	n/a	chrXV 608,918	Essential protein that promotes the first step of splicing and is required for the final stages of spliceosome maturation interacts with Prp2p, which may release Spp2p from the spliceosome following the first cleavage reaction
19	YDR090C	YDR090C	577	n/a	chrIV 625,532	Putative protein of unknown function
20	CAB5	YDR196C	577	n/a	chrIV 850,636	Probable dephospho-CoA kinase (DPCK) that catalyzes the last step in coenzyme A biosynthesis null mutant lethality is complemented by E. coli coaE (encoding DPCK) detected in purified mitochondria in high-throughput studies
21	YDR186C	YDR186C	577	n/a	chrIV 834,175	Putative protein of unknown function may interact with ribosomes, based on co-purification experiments green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
22	ITT1	YML068W	577	n/a	chrXIII 138,247	Protein that modulates the efficiency of translation termination, interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic of the TRIAD class of proteins
23	NSE3	YDR288W	577	n/a	chrIV 1,037,650	Essential subunit of the Mms21-Smc5-Smc6 complex protein of unknown function required for DNA repair and growth
24	PDR8	YLR266C	577	n/a	chrXII 676,671	Transcription factor targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon
25	ARR1	YPR199C	577	n/a	chrXVI 938,590	Transcriptional activator of the basic leucine zipper (bZIP) family, required for transcription of genes involved in resistance to arsenic compounds
26	ESA1	YOR244W	577	n/a	chrXV 793,199	Catalytic subunit of the histone acetyltransferase complex (NuA4) that acetylates four conserved internal lysines of histone H4 N-terminal tail required for cell cycle progression and transcriptional silencing at the rDNA locus
27	AFT2	YPL202C	577	n/a	chrXVI 168,713	Iron-regulated transcriptional activator activates genes involved in intracellular iron use and required for iron homeostasis and resistance to oxidative stress similar to Aft1p
28	ATG11	YPR049C	577	n/a	chrXVI 662,905	Adapter protein for pexophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway directs receptor-bound cargo to the phagophore assembly site (PAS) for packaging into vesicles required for recruiting other proteins to the (PAS)
29	LAG2	YOL025W	577	n/a	chrXV 275,948	Protein that negatively regulates the SCF E3-ubiquitin ligase by interacting with and preventing neddyation of the cullin subunit, Cdc53p longevity determinant that is preferentially expressed in young cells similar to mammalian Cand1