UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	spat-3	T13H2.5a	0	chrX 4,600,959	spat-3 encodes, by transcription from alternative promoters, two large (1092- and 2471-residues) proteins; while residues 162-228 of the larger SPAT-3 protein encode a Ring1 type of zinc-finger domain (like that seen in SEX COMBS EXTRA, an E3 ubiquitin-protein ligase RING1 protein of Drosophila melanogaster), the bulk of SPAT-3 has no obvious similarities to other proteins; SPAT-3 is specifically required for PAR protein-dependent cell-polarity, and this requirement is independent of PAR-2 activity; as with par-3, par-6, pkc-3, and cdc-42, inactivation of spat-3 (by RNAi or mutation) strongly suppresses the embryonic lethality of par-2(it5ts) at restrictive temperature; as with nos-3, spat-3 also suppresses par-2(lw32), a strong loss-of-function allele; while spat-3 par-2 double mutant embryos require PAR-1 for viability, PAR-1 does not regain posterial cortical localization in these embryos, but is instead diffused through their cytoplasm.