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COL1A2 — SMAD5

Text-mined interactions from Literome

Wendling et al., Mol Pharmacol 2003 : Together, these results identify 5-FU as a potent inhibitor of TGF-beta/SMAD signaling, capable of blocking TGF-beta induced , SMAD-driven up-regulation of COL1A2 gene expression in a JNK dependent manner
Kanamaru et al., Nephron. Experimental nephrology 2003 : The functional role of p300 in TGF-beta1/Smad-pathway mediated COL1A2 transcription was investigated in cotransfection experiments using a COL1A2 promoter-luciferase reporter gene construct and p300 expression plasmids
He et al., Zhonghua Kou Qiang Yi Xue Za Zhi 2004 : Transient overexpression of Smad1 or Smad5 was enhanced , while overexpression of Smad6 inhibited BMP-2 induced COL1A2 promoter activity
Lee et al., J Ethnopharmacol 2007 : Panax ginseng induces human Type I collagen synthesis through activation of Smad signaling
Ponticos et al., Arthritis Rheum 2009 (Disease Models, Animal...) : The enhanced Col1a2 promoter activity in fibroblasts from bleomycin treated lungs was partly dependent on Smad signaling, whereas CTGF acted on the Col1a2 promoter by a mechanism that was independent of the Smad binding site, but was, instead, dependent on the ERK-1/2 and JNK MAPK pathways