We have a suspicion that you are an automated web bot software, not a real user.
To keep our site fast for other users, we have slowed down this page.
The slowdown will gradually disappear.
If you think this is a mistake, please contact us at genome-www@soe.ucsc.edu.
Also note that all data for hgGeneGraph can be obtained through our public MySQL server and
all our software source code is available and can be installed locally onto your own computer.
If you are unsure how to use these resources, do not hesitate to contact us.
Hopfer et al., J Biol Chem 2006
:
Suppression of Morg1 or PHD3 by stealth RNA leads to a marked increase of HIF-1 activity
Su et al., Br J Cancer 2010
(Adenocarcinoma...) :
Prolyl hydroxylase-3 (PHD3) regulates degradation of HIF-1a Fujita et al., J Biol Chem 2012
(Intervertebral Disc Displacement) :
Expression of prolyl hydroxylases ( PHDs ) is selectively controlled by HIF-1 and HIF-2 proteins in nucleus pulposus cells of the intervertebral disc : distinct roles of PHD2 and PHD3 proteins in controlling HIF-1a activity in hypoxia ... Reporter analysis shows that the hypoxic induction of the PHD2 promoter is HIF-1a dependent, whereas PHD3 promoter/enhancer activity is dependent on both HIF-1a and HIF-2a ... In contrast, in hypoxia, PHD3 enhances HIF-1a transcriptional activity without affecting protein levels