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DHFR — E2F5
Text-mined interactions from Literome
Fry et al., J Biol Chem 1999
:
Previously, we have demonstrated that cell cycle regulation of murine
dihydrofolate reductase (dhfr) expression
requires E2F mediated activation of the dhfr promoter in S phase
Sahin et al., International journal of biological sciences 2010
:
For example,
E2F-1 acts as part of the repression complex with pRB in the expression of
DHFR , b-myb, TK and cdc2 in asynchronously growing cells ; on the other hand, E2F-1 acts as an activator in the expression of the same genes in cells that are re-entering the cycle
Blake et al., Mol Cell Biol 1989
:
Thus, the interaction of
E2F with the DHFR promoter is
required for efficient expression of the
DHFR gene
Margolis et al., J Virol 1995
:
Interaction of the 72-kilodalton human cytomegalovirus IE1 gene product with E2F1 coincides with
E2F dependent activation of
dihydrofolate reductase transcription
Slansky et al., Mol Cell Biol 1993
:
In this study, we focused on the
role of
E2F in the growth regulation of
DHFR