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TLR3 — TRAF6

Pathways - manually collected, often from reviews:

• BioCarta toll-like receptor pathway: Poly (I:c)TLR3/TLR3/MYD88/IRAK complex (IRAK1-MYD88-TLR3) → TRAF6 (modification, activates)
• Reactome Reaction: TLR3 → TRAF6 (reaction) Kishimoto et al., J Biol Chem 2000, Deng et al., Cell 2000, Jiang et al., Mol Cell Biol 2002, Jiang et al., J Biol Chem 2003, Kaiser et al., J Immunol 2005, Sato et al., Nat Immunol 2005, Shim et al., Genes Dev 2005, Häcker et al., Nature 2006, Adhikari et al., Oncogene 2007, Sasai et al., Mol Immunol 2010*, Arch et al., Genes Dev 1998
• Reactome Reaction: TLR3 → TRAF6 (indirect_complex) Deng et al., Cell 2000, Kaiser et al., J Immunol 2005, Häcker et al., Nature 2006, Lamothe et al., J Biol Chem 2007, Sasai et al., Mol Immunol 2010*, Arch et al., Genes Dev 1998

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: TLR3 — TRAF6 (physical association, affinity chromatography technology) Jiang et al., J Biol Chem 2003
• IRef Biogrid Interaction: TLR3 — TRAF6 (physical association, affinity chromatography technology) Cusson-Hermance et al., J Biol Chem 2005
• IRef Biogrid Interaction: TLR3 — TRAF6 (physical association, affinity chromatography technology) Yang et al., J Exp Med 2011
• IRef Hprd Interaction: TLR3 — TRAF6 (in vivo) Jiang et al., J Biol Chem 2003
• IRef Hprd Interaction: Complex of 26 proteins (in vivo) Jiang et al., J Biol Chem 2003

Text-mined interactions from Literome

Zhang et al., Infect Immun 2005 (Pseudomonas Infections) : We also determined that MyD88, IRAK, TRAF6 , and Toll interacting protein (Tollip), but not TIRAP, were involved in the TLR mediated response to P. aeruginosa in HAECs
Leppert et al., J Immunol 2007 : The soluble variant surface glycoprotein of African trypanosomes is recognized by a macrophage scavenger receptor and induces I kappa B alpha degradation independently of TRAF6 mediated TLR signaling ... Activation of RAW 264.7 cells by sVSG following treatment of the cells with the TRAF6 inhibitory peptide DIVK resulted in enhanced NF-kappaB signaling, suggesting both that TRAF6 dependent TLR activation of the pathway alone is not required for signaling and that TLR pathway components may negatively regulate expression of sVSG induced signaling
Clark et al., Proc Natl Acad Sci U S A 2011 : Toll-like receptor ( TLR ) ligands that signal via TIR-domain containing adapter inducing IFNß ( TRIF ) activate the I?B kinase ( IKK ) -related kinases, TRAF associated NF?B activator ( TANK) binding kinase-1 (TBK1 ) and IKKe, which then phosphorylate IRF3 and induce the production of IFNß
Jono et al., PloS one 2012 (MAP Kinase Signaling System) : PKC? synergizes with TLR dependent TRAF6 signaling pathway to upregulate MUC5AC mucin via CARMA1
Inomata et al., Biochem Biophys Res Commun 2013 : Furthermore, Atg5 deficiency increased formation of the MyD88-TRAF6 signaling complex induced by TLR stimulation, and it enhanced activation of NF-?B signaling but not MAPKs and Akt