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IGF1 — RAC2

Text-mined interactions from Literome

Okamoto et al., Mol Cell Biol 2000 : Both S1P and IGF I induced a biphasic increase in the amount of the GTP bound active form of Rac ... In EDG5 cells, S1P stimulated PI 3-kinase activity as it did in EDG1 cells but inhibited the basal Rac activity and totally abolished IGF I-induced Rac activation, which involved stimulation of Rac-GTPase activating protein activity rather than inhibition of Rac-guanine nucleotide exchange activity
Nagasawa et al., Biochem J 2005 : EP2 stimulation failed to inhibit tyrosine phosphorylation either of IGF-I receptor or IRS-1 ( insulin receptor substrate-1 ), or activation of phosphoinositide 3-kinase or Akt in response to IGF-I, but potently and dose-dependently inhibited IGF-I induced activation of cellular Rac activity and membrane ruffling ... The inhibitory effects of PGE2 on IGF-I induced chemotaxis, membrane ruffling and Rac activation were faithfully reproduced by a low concentration of forskolin, which induced a comparable extent of cAMP elevation as with 10 ( -8 ) M PGE2, and were potentiated by isobutylmethylxanthine