Eom et al., Biochem Biophys Res Commun 2001
(Necrosis) :
Rac and p38 kinase mediate 5-lipoxygenase translocation and cell death
Lee et al., Biochem J 2002
(Astrocytoma...) :
Consistent with those findings, Abeta ( 25-35 ) Rac-dependently stimulated translocation of 5-LO to the nuclear envelope and increased intracellular levels of leukotriene B ( 4 ), while exogenous application of leukotriene B ( 4 ) increased intracellular H ( 2 ) O ( 2 ) via BLT, its cell-surface receptor