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FAS — PLD6

Text-mined interactions from Literome

Han et al., Arch Biochem Biophys 1999 : Fas mediated activation of phospholipase D is coupled to the stimulation of phosphatidylcholine-specific phospholipase C in A20 cells ... Fas cross linking resulted in a both dose- and time dependent increases in phospholipase D activity ... Pretreatment of D609 also effectively inhibited the translocation of protein kinase C betaI and betaII from the cytosol to the membrane and the activation of phospholipase D induced by Fas cross linking, suggesting that 1, 2-diacylglycerol released from the cellular phosphatidylcholine pool through phosphatidylcholine-specific phospholipase C plays a major role in protein kinase C/phospholipase D activation ... Therefore, these results suggest that Fas mediated phospholipase D activation may be a consequence of primary stimulation of phosphatidylcholine-specific phospholipase C and that phospholipase D may play a role in Fas cross linking signaling downstream from phosphatidylcholine-specific phospholipase C
Shin et al., Biochem Biophys Res Commun 2000 : We have previously reported that Fas cross linking resulted in an increase in phospholipase D activity in A20 murine cells ( J.-S ... These data suggest that Ras GTPase is essential in transmitting phospholipase D activation signal induced by Fas cross linking and is located at phosphatidylcholine-specific phospholipase C upstream in Fas signaling cascades
Shin et al., Comp Biochem Physiol B Biochem Mol Biol 2000 : We have previously reported that Fas cross linking resulted in the activation of phosphatidylcholine-specific phospholipase C ( PC-PLC ) and the subsequent activation of protein kinase C ( PKC ) and phospholipase D ( PLD ) in A20 cells ... In an attempt to correlate the existence of PC-PLC activity and activation of PLD by Fas activation among various Fas expressing murine cell lines, we have investigated the effect of anti-Fas monoclonal antibody on PC-PLC and PLD activities in A20, P388D1 and YAC-1 cell lines ... These findings suggest that the activation of PC-PLC is a necessary requirement for the activation of PLD by Fas cross linking and cell lines devoid of functional PC-PLC activity could exhibit enhanced PLD activity by exogenous addition of PC-PLC
Han et al., Cell Signal 2000 : When phosphatidylcholine-specific phospholipase C ( PC-PLC ) was inhibited by D609, the Fas induced changes in PLD activity, DAG content, and PKC translocation were inhibited ... In contrast, D609 had no effect on Fas induced alterations in sphingolipid metabolism, suggesting that changes in ceramide content do not account for Fas induced PLD activation ... Furthermore, C6-ceramide had no effect on Fas induced PLD activation and PKC translocation
Kim et al., Exp Mol Med 2001 (Lymphoma) : D609-sensitive tyrosine phosphorylation is involved in Fas mediated phospholipase D activation ... Both Fas and PMA can activate phospholipase D via activation of protein kinase Cbeta in A20 cells ... The possible involvement of tyrosine phosphorylation in Fas induced activation of phospholipase D was investigated ... A tyrosine kinase inhibitor, genistein, can partially inhibit Fas induced phospholipase D activation ... These results strongly indicate that tyrosine phosphorylation may in part account for the increase in phospholipase D activity by Fas cross linking and D609 can block not only PC-PLC activity but also tyrosine phosphorylation involved in Fas induced phospholipase D activation