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ADRBK1 — CXCR4

Pathways - manually collected, often from reviews:

• BioCarta role of ß-arrestins in the activation and targeting of map kinases: atp:[beta-adrenergic-receptor] phosphotransferase (ADRBK1) → Ligand/GPCR/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1) (modification, activates)
  
• BioCarta role of ß-arrestins in the activation and targeting of map kinases: atp:[beta-adrenergic-receptor] phosphotransferase (ADRBK1) → Ligand/GPCR(+)/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1) (modification, activates)
  
• KEGG Endocytosis: ADRBK1/ADRBK2/GRK1/GRK4/GRK5/GRK6/GRK7 → ADRB1/ADRB2/ADRB3/CCR5/CXCR1/CXCR2/CXCR4/F2R (protein-protein, phosphorylation)
  
• KEGG Chemokine signaling pathway: ADRBK1/ADRBK2/GRK1/GRK4/GRK5/GRK6/GRK7 → CCR1/CCR10/CCR2/CCR3/CCR4/CCR5/CCR6/CCR7/CCR8/CCR9/CX3CR1/CXCR1/CXCR2/CXCR3/CXCR4/CXCR5/CXCR6/XCR1 (protein-protein, phosphorylation)
  
• NCI Pathway Database CXCR4-mediated signaling events: GRK2 (ADRBK1) → SDF1/CXCR4 complex (CXCL12-CXCR4) (modification, activates)
  Orsini et al., J Biol Chem 1999*
  Evidence: mutant phenotype
• WikiPathways Chemokine signaling pathway: ADRBK1/GRK4/GRK5/GRK1/GRK6 → CXCR5/CCR6/CXCR2/CXCR3/CXCR4/CCR1/CCR9/CCR1/CCR3/CCR2/CCR4/CCR2/CCR7/CCR8/CCR10/CX3CR1/CXCR2/XCR1/CXCR6 (activation)