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BRCA1 — GADD45A
Text-mined interactions from Literome
Yun et al., Mol Cell Biol 2003
:
In a
BRCA1 dependent manner, ZBRK1 represses
Gadd45a transcription through binding to a specific sequence in intron 3
Desjardins et al., J Hum Genet 2008
(Breast Neoplasms...) :
Following genotoxic stress, the p53 protein activates GADD45A transcription, whereas in absence of DNA damage,
BRCA1 represses
GADD45A expression through interaction with the zinc finger protein ZNF350 ... Moreover,
BRCA1 can
activate GADD45A gene expression through interactions with transcription factors binding to the gene promoter
Tront et al., Cancer Res 2010
(Mammary Neoplasms, Animal...) :
Because
Gadd45a is a
target for
BRCA1 and p53, these findings have implications regarding BRCA1/p53 tumor suppressor functions