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UCSC Genome Browser Gene Interaction Graph
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Gene interactions and pathways from curated databases and text-mining
◀ Back to FOXO3
FOXO3 — YWHAH
Pathways - manually collected, often from reviews:
NCI Pathway Database Class I PI3K signaling events mediated by Akt :
FOXO1-3a-4/14-3-3 family complex (FOXO3_FOXO4_FOXO1-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB)
→
14-3-3 family (YWHAH/YWHAZ/YWHAQ/SFN/YWHAE/YWHAG/YWHAB)
(modification, collaborate)
Brunet et al., Cell 1999 , Kops et al., Nature 1999 , Rena et al., J Biol Chem 1999 , Brunet et al., J Cell Biol 2002
mutant phenotype, assay, physical interaction
NCI Pathway Database Class I PI3K signaling events mediated by Akt :
FOXO1-3a-4/14-3-3 family complex (FOXO3_FOXO4_FOXO1-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB)
→
FOXO1-3a-4-inactive (FOXO3/FOXO4/FOXO1)
(modification, collaborate)
Brunet et al., Cell 1999 , Kops et al., Nature 1999 , Rena et al., J Biol Chem 1999 , Brunet et al., J Cell Biol 2002
mutant phenotype, assay, physical interaction
NCI Pathway Database Class I PI3K signaling events mediated by Akt :
14-3-3 family (YWHAH/YWHAZ/YWHAQ/SFN/YWHAE/YWHAG/YWHAB)
→
FOXO1-3a-4-inactive (FOXO3/FOXO4/FOXO1)
(modification, collaborate)
Brunet et al., Cell 1999 , Kops et al., Nature 1999 , Rena et al., J Biol Chem 1999 , Brunet et al., J Cell Biol 2002
mutant phenotype, assay, physical interaction
NCI Pathway Database Trk receptor signaling mediated by PI3K and PLC-gamma :
FOXO3a/14-3-3 family complex (FOXO3-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB)
→
FOXO3A (FOXO3)
(translocation, collaborate)
Brunet et al., Cell 1999 , Brunet et al., J Cell Biol 2002
mutant phenotype, physical interaction
NCI Pathway Database Trk receptor signaling mediated by PI3K and PLC-gamma :
FOXO3a/14-3-3 family complex (FOXO3-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB)
→
14-3-3 family (YWHAH/YWHAZ/YWHAQ/SFN/YWHAE/YWHAG/YWHAB)
(translocation, collaborate)
Brunet et al., Cell 1999 , Brunet et al., J Cell Biol 2002
mutant phenotype, physical interaction
NCI Pathway Database Trk receptor signaling mediated by PI3K and PLC-gamma :
FOXO3A (FOXO3)
→
14-3-3 family (YWHAH/YWHAZ/YWHAQ/SFN/YWHAE/YWHAG/YWHAB)
(translocation, collaborate)
Brunet et al., Cell 1999 , Brunet et al., J Cell Biol 2002
mutant phenotype, physical interaction
NCI Pathway Database FoxO family signaling :
FOXO3A/14-3-3 complex (FOXO3-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB)
→
FOXO3A (FOXO3)
(modification, collaborate)
Brunet et al., Cell 1999 , Lehtinen et al., Cell 2006
mutant phenotype, physical interaction
NCI Pathway Database FoxO family signaling :
FOXO3A/14-3-3 complex (FOXO3-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB)
→
14-3-3 family (YWHAH/YWHAZ/YWHAQ/SFN/YWHAE/YWHAG/YWHAB)
(modification, collaborate)
Brunet et al., Cell 1999 , Lehtinen et al., Cell 2006
mutant phenotype, physical interaction
NCI Pathway Database FoxO family signaling :
FOXO3A (FOXO3)
→
14-3-3 family (YWHAH/YWHAZ/YWHAQ/SFN/YWHAE/YWHAG/YWHAB)
(modification, collaborate)
Brunet et al., Cell 1999 , Lehtinen et al., Cell 2006
mutant phenotype, physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *