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Afshar et al., Cancer Res 2006
(Glioma) :
In a system of inducible E2F1 activity, E2F1 activated caspase-8 and, accordingly, decreased cellular viability, effects that were abolished by caspase-8 siRNA
Ebelt et al., Cardiovasc Res 2008
(Hypertrophy) :
Expression of E2F2 in vivo did not increase the percentage of apoptotic cardiomyocytes but down-regulated the expression of the pro-apoptotic genes caspase-6 and apaf-1