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CASP6 — DFFA
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Zhang et al., J Neurochem 1999
(Brain Injuries) :
DFF40 is typically bound to the 45-kDa subunit of DFF ( DFF45 ), and activation of DFF40 may occur as a result of
caspase-3 mediated cleavage of
DFF45 into 30- and 11-kDa fragments
Rasola et al., FASEB J 1999
:
This process needs the
caspase dependent release of
ICAD/DFF-45 , the inhibitory subunit of DFF
Yang et al., Neoplasia (New York, N.Y.) 2001
(Neuroblastoma) :
DFF45 is the chaperon of DFF40, and both molecules are
necessary for
caspase 3 to induce apoptosis
Wu et al., J Biol Chem 2003
(Osteosarcoma) :
PML/TNFalpha induced cell death is associated with DNA fragmentation,
activation of
caspase-3 , -7, and -8, and degradation of DNA fragmentation
factor/inhibitor of CAD
Zhang et al., Biochem Pharmacol 2003
(Colonic Neoplasms) :
With a serial of Western blot analysis, it is revealed that gossypol induced cell cycle arrest is involved in P21 up-regulation and cyclin D1 down-regulation ; gossypol induced apoptosis triggers down-regulation of anti-apoptosis Bcl-2 members : Bcl-X ( L ), Bag-1 and Mcl-1, up-regulation of pro-apoptosis Bcl-2 member Bak, activation of
caspase-3 , -6, -7, -8, and -9, up-regulation of Apaf-1, release of cytochrome c ( cyto-c ) from mitochondria, and
activation of both
DFF45 and PARP
Doonan et al., J Neurosci 2003
(Disease Models, Animal...) :
DNA fragmentation occurs in the absence of
caspase mediated
ICAD ( inhibitor of caspase activated DNase ) proteolysis, suggesting that an alternative endonuclease is responsible for DNA cleavage in these models
Sacco et al., Virology 2003
:
Furthermore, we found that core protein expression increases a steady-state level of
ICAD protein, possibly through enhancing its promoter activity, and
inhibits caspase-3 activity induced by anti-Fas antibody
Zheng et al., J Asian Nat Prod Res 2006
:
Effects of julibrosideJ8 on induction of DNA fragmentation,
caspase-3 activation and downregulation of
ICAD expression were effectively inhibited by a caspase-3 inhibitor, z-DEVD-fmk
Qi et al., Oncol Rep 2007
(Leukemia, Promyelocytic, Acute) :
GP7 induced the release of cytochrome-c from mitochondria,
activations of
caspase-3 , -8, and -9, cleavage of
DFF45/inhibitor of caspase activated DNase, activation of DFF40/caspase activated DNase, and apoptotic DNA fragmentation in NB4 cells
Kikuchi et al., Gene 2008
:
GCN5 and BCR signalling collaborate to induce pre-mature B cell apoptosis through depletion of
ICAD and IAP2 and
activation of
caspase activities
Callus et al., J Mol Biol 2008
:
In BaF ( 3 ) cells, expression of Puma caused rapid
caspase mediated cleavage of
ICAD ( inhibitor of caspase activated deoxyribonuclease ) and Mcl-1 ( myeloid cell leukemia 1 ), leading to complete loss of cell viability
Khan et al., Mol Carcinog 2012
:
Also, BCDD decreased the activity of Bid and Bax in cytosol, caused d? ( mt ) loss, releasing pro-apoptotic cytochrome c, SMAC/DIABLO leading to
caspase-9 mediated down stream activation of caspase-3,
ICAD , and PARP1 cleavage
Tang et al., J Biol Chem 1998
:
Conversely, others have reported that
caspase 3 is
essential for the cleavage and activation of
DFF-45/ICAD
Inohara et al., J Biol Chem 1999
:
During apoptosis, DFF-40/CAD is activated by
caspase-3 mediated cleavage of
DFF45/ICAD ... Deletion of the catalytic domain ( residues 290-345 ) abrogated the
caspase-3 induced nuclease activity of DFF40/CAD but not its ability to interact with
DFF45/ICAD
Wöhrl et al., Biochem Biophys Res Commun 1999
:
These changes are accomplished by
caspase mediated cleavage of DNA fragmenting factor
DFF45 , an inhibitor of the effector molecule DFF40