Chen et al., J Immunol 1999
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Finally, human hsp60 induces gene expression of the Th1 promoting cytokines IL-12 and IL-15
Breloer et al., Eur J Immunol 2001
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The presence of Hsp60 induces IFN-gamma and up-regulation of CD69 in T cell/PEC cocultures even in the absence of antigenic peptide and this induction of IFN-gamma is strictly dependent on the ability of the macrophages to produce IL-12 Osterloh et al., J Biol Chem 2007
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Hsp60 specifically binds bacterial LPS and both molecules synergistically enhanced IL-12p40 production in APC and IFNgamma release in antigen dependent T cell activation
Osterloh et al., Int Immunol 2008
:
LPS-free Hsp60 did not induce IL-6, IL-12 or tumor necrosis factor alpha production in APC nor were these cytokines needed for Hsp60 mediated T cell co-stimulation in the absence of LPS