Gene interactions and pathways from curated databases and text-mining

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CD4 — IL12A

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Sin et al., J Immunol 1999 : IL-12 gene as a DNA vaccine adjuvant in a herpes mouse model : IL-12 enhances Th1-type CD4+ T cell mediated protective immunity against herpes simplex virus-2 challenge
Carter et al., J Exp Med 1999 : In response to antigen, CD8 ( + ) T cells can produce IFN-gamma independently of IL-12, whereas CD4 ( + ) T cells require IL-12 and Stat4 activation
McRae et al., Blood 2000 : In addition, IFN-alpha/beta treated DC secreted less IL-12 upon stimulation with Staphylococcus aureus Cowan strain or with CD4 ( + ) T cells, and this decrease correlated directly with their inability to support CD4 ( + ) T-cell secretion of IFN-gamma, even though T-cell lymphotoxin production was unaffected
Young et al., AIDS Res Hum Retroviruses 2001 (HIV Seropositivity) : IL-12 increased cell recovery in cultures of PBMC from HIV-seropositive individuals with CD4 counts > 500 cells/microl and also increased the precursor CTL frequency
Martin et al., Infect Immun 2001 : In a coculture system, CT-treated CD4 ( + ) T cells induced significantly less TNF-alpha and IL-12 p70 production by both autologous monocytes and monocyte derived dendritic cells than either LT-IIa- or LT-IIb treated CD4 ( + ) T cells
Del Río et al., Infect Immun 2001 (Disease Models, Animal...) : The lack of IL-12 resulted in few infiltrating CD4 ( + ) T cells in the liver relative to the number in WT mice, although the number of CD8 ( + ) T cells was slightly higher
Iwasaki et al., Eur J Immunol 2001 (Calcium Signaling) : A critical role for IL-12 in CCR5 induction on T cell receptor triggered mouse CD4 ( + ) and CD8 ( + ) T cells
Shaw et al., Infect Immun 2002 (Chlamydia Infections) : Immunity generated by infection or ex vivo antigen pulsed DC correlates with a chlamydia-specific interleukin 12 (IL-12) dependent CD4 ( + ) Th1 immune response
Yoo et al., J Immunol 2002 : These results suggest that PI3K/Akt pathway is critical for mediating IL-12 induced CD4 ( + ) T cell responses such as T cell proliferation and survival
Pan et al., Mol Ther 2002 (Colonic Neoplasms...) : The results demonstrated that OX40 ligation of CD4 ( + ) T cells facilitated the development of primary and memory CTL responses against tumorcells and that coordinated immune activation by IL-12 , anti-4-1BB, and anti-OX40 resulted in a significantly higher survival rate in mice with large tumor burdens
Soumelis et al., Springer Semin Immunopathol 2004 (Hypersensitivity...) : TSLP activated human DCs produce Th2 attracting chemokines but no IL-12 , and induce naive CD4 ( + ) and CD8 ( + ) T cell differentiation into effector cells with a typical pro-allergic phenotype
Tazaki et al., Cell Immunol 2004 (Asthma) : Significant increases in the expression of IL-12R beta2 chain before and after stimulation of CD4 ( + ) T cells with IL-12 or IFN-gamma were observed in RIT treated patients compared with that in control patients
Li et al., Cancer Res 2005 (Fibrosarcoma) : IL-12 and IL-18 stimulated CD4 ( + ) TDLN cells and enhanced IFNgamma production by CD4 ( + ) cells to a greater extent than by CD8 ( + ) cells
Gruber et al., Cancer Gene Ther 2005 (Philadelphia Chromosome...) : We found that IL-12 was able to eliminate pre established leukemia, and that this protection was mediated by CD4 , CD8, and NK cells in combination
King et al., J Immunol 2005 : Cutting edge : IL-12 induces CD4+CD25- T cell activation in the presence of T regulatory cells
Wells et al., J Allergy Clin Immunol 2007 (Inflammation...) : Adoptive transfer of transgenic antigen-specific CD8, but not CD4 , cells resulted in increased IL-12 levels and reduced IL-13 and IL-5 levels in bronchoalveolar lavage fluid, coupled with substantially reduced airway eosinophilia after repeated allergen inhalation, a process mimicked by intranasal administration of IL-12 and inhibited by anti-IL-12 antibody
Pakpour et al., J Immunol 2008 (Leishmaniasis, Cutaneous) : In this study, we show that the Leishmania-specific central memory CD4 ( + ) T cells require IL-12 to produce IFN-gamma, demonstrating that this population needs additional signals to develop into Th1 cells
Iborra et al., Microbes Infect 2008 (Leishmaniasis, Cutaneous) : This protection was associated with the induction of an IL-12 dependent specific-IFN-gamma response mediated mainly by CD4 ( + ) T cell, albeit a minor contribution of CD8 ( + ) T cells can not be ruled out
Brahmachari et al., J Immunol 2009 : IL-12p40 ( 2 ) dose-dependently inhibited the expression of Foxp3 and CD25, but not CD4
Hamza et al., International journal of molecular sciences 2010 : IL-12 induces interferon-gamma (IFN-gamma) production and triggers CD4 ( + ) T cells to differentiate into type 1 T helper ( Th1 ) cells
Abdi et al., Scand J Immunol 2010 : Moreover, antigen activated CD4 ( + ) T cells from wild type or IFN-?-deficient mice both initiated IL-12p75 production from DCs
Ramer-Tait et al., Cell Immunol 2011 (Leishmaniasis, Cutaneous) : Neutralization of IL-2 enhanced CD4 ( + ) T cell proliferation in response to IL-12
Ma et al., Blood 2012 : We previously found that IL-12 mediates the differentiation of human CD4 ( + ) T cells to the Tfh lineage, because IL-12 induces naive human CD4 ( + ) T cells to acquire expression of IL-21, BCL6, ICOS, and CXCR5, which typify Tfh cells
Zhong et al., Blood 2012 (Purpura, Thrombocytopenic, Idiopathic) : Th-1 polarizing cytokine IL-12 , secreted after direct contact of patient T-cell and CD16 ( + ) monocytes, was responsible for the inhibitory effect on Treg and IL-17 ( + ) CD4 ( + ) cell proliferation
Cargnelutti et al., Immunol Cell Biol 2013 : In addition, we found that CD4 ( + ) T cells from TNFRp55 ( -/- ) mice controlled antigen-specific IL-12/23 ( p40 ) production in recipient WT mice
Rahim et al., J Immunol 2013 (Melanoma, Experimental) : Furthermore, Ly49Q expression on pDC, but not myeloid dendritic cells, is necessary for optimal IL-12 secretion, MHC-II expression, activation of CD4 ( + ) T cell proliferation, and nuclear translocation of the master IFN-a regulator IFN regulatory factor 7 in response to TLR9 agonists
Nastala et al., J Immunol 1994 (Adenocarcinoma...) : These results indicate that IL-12 is an effective and minimally toxic antitumor agent in murine tumor models and leads to an immune mediated rejection involving, at least in part, IFN-gamma, CD4+ , and CD8+ cells
Bianchi et al., J Immunol 1996 (Hypersensitivity, Delayed...) : In vitro and in vivo cell depletion experiments suggested the following : 1 ) the exogenous IL-12 required both CD4+ and CD8+ cells for activity ; 2 ) the immune response initiated by IL-12 relied on later production of IL-12 by the host ; and 3 ) the early adjuvanticity of the exogenous IL-12 involved improved recognition of class II-restricted epitopes of this otherwise poorly immunogenic tumor peptide
Maruo et al., J Immunol 1997 : IL-12 production was dependent on the presence of CD4+ , but not of CD8+, T cells, and inhibited by addition of anti-CD40 ligand (CD40L) mAb
Flynn et al., J Exp Med 1998 : Furthermore, T cell stimulation through OX40 inhibits IFN-gamma expression in both CD8 T cells and IL-12 stimulated CD4 T cells
Harada et al., Cancer Res 1998 (Melanoma, Experimental) : The in vivo depletion of either CD4+ or CD8+ T cells abrogated the antitumor activity of IL-12 and diminished the apparent autocrine stimulation of IL-12 release seen after IL-12 treatment
Suzuki et al., J Virol 1999 : Among them, interleukin-12 (IL-12) and IL-4 induce naive CD4 ( + ) T cells to become T-helper 1 ( Th1 ) or Th2 cells, respectively