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ANGPT2 — RNF19A

Text-mined interactions from Literome

Touyz et al., J Hypertens 2004 : Ang II and ET-1 increased MAPK phosphorylation ( P < 0.01 ). Pre-treatment with Tiron and Tempol, *O2 scavengers, attenuated agonist stimulated phosphorylation of p38MAPK , c-Jun N-terminal kinases (JNK) and ERK5, but not of ERK1/2 ( extracellular signal regulated kinases ). Apocynin and diphenylene iodinium ( DPI ), NAD ( P ) H oxidase inhibitors, decreased Ang II-induced responses 60-70 %. ET-1 mediated MAPK phosphorylation was unaffected by apocynin but was reduced ( > 50 % ) by thenoyltrifluoroacetone ( TIFT ) and carboxyl cyanide-m-chlorophenylhydrazone ( CCCP ), mitochondrial inhibitors
Saito et al., Regul Pept 2005 : Ang II and H2O2 also activated p38MAPK , and they were blocked by pre-treatment with NAC
Guo et al., Peptides 2006 (MAP Kinase Signaling System) : These results also demonstrate that Ang II leads to MAPK phosphorylation and p38MAPK pathway induced NF-kappaB activation
Lee et al., J Pharmacol Sci 2007 : Ang II enhanced RASMC migration, which was chemotaxis directed, and induced the phosphorylation of p38 mitogen activated protein kinase ( MAPK ), extracellular signal regulated kinase 1/2 ( ERK1/2 ), and heat shock protein 27 (Hsp27)
Morales et al., Int J Biochem Cell Biol 2012 (Fibrosis) : The increase in pro-fibrotic factors levels was paralleled by enhanced p38MAPK and ERK1/2 phosphorylation in response to Ang-II