◀ Back to IGF1

ANGPT2 — IGF1

Text-mined interactions from Literome

Brink et al., Hypertension 1999 (Hypertrophy, Left Ventricular) : To study the effect of Ang II on cardiac IGF-I , we infused rats for 3, 7, or 14 days with Ang II through osmotic minipumps ... Treatment with hydralazine abolished the induction of IGF-I mRNA, which indicates that Ang II induces cardiac IGF-I mRNA expression through a pressor mediated mechanism
Serneri et al., Circ Res 2001 (Cardiomyopathy, Dilated...) : Ang II induced IGF-I and ET-1 synthesis by isolated NF myocytes, whereas failing myocytes were unable to respond to Ang II stimulation
Phelps et al., Am J Physiol Cell Physiol 2006 : Transcriptional and posttranscriptional regulation of angiopoietin-2 expression mediated by IGF and PDGF in vascular smooth muscle cells
Ma et al., Endocrinology 2006 (MAP Kinase Signaling System) : To determine how Ang II transcriptionally regulates IGF-IR expression in VSMCs, we generated 5'-end deletions of the IGF-IR promoter and measured Ang II-induced promoter-luciferase activity in VSMCs. Activities from these promoter sequences suggested that the Ang II-responsive region is located between -270 and -135 of the IGF-IR promoter ... Our results indicate that the mechanism by which Ang II stimulates IGF-IR expression in VSMCs involves NF-kappaB binding to NF-kappaB sites in the IGF-IR promoter, leading to expression of IGF-IR through both Ras/MAPK kinase 1-and inhibitory-kappaB kinase dependent pathways
Chu et al., J Cell Physiol 2012 (Cardiomegaly...) : Histone acetylation is essential for ANG-II induced IGF-IIR gene expression in H9c2 cardiomyoblast cells and pathologically hypertensive rat heart
Delafontaine et al., J Biol Chem 1993 : This increase was completely inhibited by actinomycin D. Nuclear run-on assays indicated that ang II stimulated IGF I gene transcription 3.6-fold ... Thus, ang II regulates transcription of the IGF I gene in VSMC and IGF I is required for ang II-induced DNA synthesis
Ververis et al., Circ Res 1993 : PDGF and FGF but not Ang II regulate vascular IGF I receptors through a PKC dependent pathway