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CXCL12 — TCF4
Text-mined interactions from Literome
Lee et al., Mol Cancer Res 2004
(Breast Neoplasms...) :
Stromal cell derived factor 1alpha ( SDF-1alpha ; CXCL12 ) stimulation of breast cancer cells
resulted in phosphoinositide 3-kinase (PI-3K) activation, AKT phosphorylation, and activation of the FKHRL1
transcription factor
Luo et al., Neurosci Lett 2006
:
Here, we report that
SDF1alpha/CXCR4 signaling
activates beta-catenin/TCF transcriptional activity in embryonic rat spinal cord neural progenitors ... Concomitant with beta-catenin accumulation in the cytoplasm,
SDF1alpha enhanced nuclear translocation of beta-catenin and its binding to nuclear
transcription factor T cell-specific transcription factor/lymphoid enhancer binding factor ( TCF/LEF )
Appaiah et al., Cancer Biol Ther 2010
(Breast Neoplasms...) :
CXCL12 , a CXCR4 ligand,
increased ITF2 expression in MDA-MB-231 cells
Hamdan et al., Mol Cancer Res 2011
:
Chromatin immunoprecipitation showed that the ELK-1
transcription factor binds to the pdgf-b promoter in
response to
SDF-1a