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APEH — CASP3

Text-mined interactions from Literome

Segal et al., Am J Physiol Cell Physiol 2001 : In this cell-free system, a pH above 7.4 severely suppressed the activation of procaspase-3 but not the activity of caspase-3
Melnikov et al., J Clin Invest 2002 (Disease Models, Animal...) : OPH-001 significantly reduced the increase in caspase-1 activity and IL-18 and prevented neutrophil infiltration in the kidney during ischemic ARF
Vera et al., Biol Reprod 2005 : Q-VD-OPH at this dose markedly inhibited caspase 3 activation and significantly prevented ( by 67.0 % ) heat induced germ cell apoptosis
Ribas et al., Oncogene 2006 : Furthermore, the death process is not altered either by the presence of Q-VD-OPh , a broad-spectrum caspase inhibitor , or the overexpression of Bcl-2 and Bcl-XL proteins
Dunys et al., J Biol Chem 2007 : In support of an apoptosis rather than necrosis process, Aph-1 and Pen-2 also lower staurosporine- and etoposide induced caspase-3 expression and diminished caspase-3 activity and poly ( ADP-ribose ) polymerase inactivation
Carlson et al., J Appl Physiol 2007 (Burns...) : Experimental groups included 1 ) sham burn given vehicle, 400 microl DMSO ; 2 ) sham burn given Q-VD-OPh ( 6 mg/kg ), a highly specific and stable caspase inhibitor , 24 and 1 h prior to sham burn ; 3 ) burn given vehicle, DMSO as above ; 4 ) burn given Q-VD-OPh ( 6 mg/kg ) 24 and 1 h prior to burn
Kozmar et al., J Innate Immun 2010 : Treatment of actinomycin treated Jurkat cells with Q-VD-OPh , an irreversible inhibitor of caspase activity, blocked apoptosis, as assessed by the inhibition of PtdSer exposure ; however, the cells maintained anti-inflammatory activity
Chen-Deutsch et al., Leuk Res 2012 (Leukemia, Myeloid, Acute) : This was studied in blasts obtained from nine patients with AML and one patient with CML by ex vivo culture in the presence of Q-VD-OPh ( QVD ), a pan caspase inhibitor
Rodríguez-Enfedaque et al., Biochim Biophys Acta 2012 : Q-VD-OPh , another caspase inhibitor , also increased both loss of d?m and caspase-9 cleavage in etoposide treated MEFs