Speck et al., Nature structural & molecular biology 2005
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ATPase dependent cooperative binding of ORC and Cdc6 to origin DNA
Speck et al., J Biol Chem 2007
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Cdc6 ATPase activity regulates ORC x Cdc6 stability and the selection of specific DNA sequences as origins of DNA replication ... Here we analyzed the role of the Cdc6 ATPase on ORC x Cdc6 complex stability in the presence or absence of specific DNA sequences
Takehara et al., Biochem J 2008
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To reveal the role of this ATPase activity in Saccharomyces cerevisiae ( baker 's yeast ) ORC , we mutated the Orc1p sensor 1 and sensor 2 regions, which are important for ATPase activity in AAA ( + ) proteins